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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer: a phase II study</title><author><name sortKey="Allen, M J" sort="Allen, M J" uniqKey="Allen M" first="M J" last="Allen">M J Allen</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Vaughan, M" sort="Vaughan, M" uniqKey="Vaughan M" first="M" last="Vaughan">M. Vaughan</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Webb, A" sort="Webb, A" uniqKey="Webb A" first="A" last="Webb">A. Webb</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Johnston, S" sort="Johnston, S" uniqKey="Johnston S" first="S" last="Johnston">S. Johnston</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Savage, P" sort="Savage, P" uniqKey="Savage P" first="P" last="Savage">P. Savage</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eisen, T" sort="Eisen, T" uniqKey="Eisen T" first="T" last="Eisen">T. Eisen</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bate, S" sort="Bate, S" uniqKey="Bate S" first="S" last="Bate">S. Bate</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Moore, J" sort="Moore, J" uniqKey="Moore J" first="J" last="Moore">J. Moore</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ahern, R" sort="Ahern, R" uniqKey="Ahern R" first="R" last="Ahern">R. Ahern</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gore, M E" sort="Gore, M E" uniqKey="Gore M" first="M E" last="Gore">M E Gore</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10993642</idno><idno type="pmc">2363554</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363554</idno><idno type="RBID">PMC:2363554</idno><idno type="doi">10.1054/bjoc.2000.1418</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">000001</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000001</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Protracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer: a phase II study</title><author><name sortKey="Allen, M J" sort="Allen, M J" uniqKey="Allen M" first="M J" last="Allen">M J Allen</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Vaughan, M" sort="Vaughan, M" uniqKey="Vaughan M" first="M" last="Vaughan">M. Vaughan</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Webb, A" sort="Webb, A" uniqKey="Webb A" first="A" last="Webb">A. Webb</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Johnston, S" sort="Johnston, S" uniqKey="Johnston S" first="S" last="Johnston">S. Johnston</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Savage, P" sort="Savage, P" uniqKey="Savage P" first="P" last="Savage">P. Savage</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Eisen, T" sort="Eisen, T" uniqKey="Eisen T" first="T" last="Eisen">T. Eisen</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bate, S" sort="Bate, S" uniqKey="Bate S" first="S" last="Bate">S. Bate</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Moore, J" sort="Moore, J" uniqKey="Moore J" first="J" last="Moore">J. Moore</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ahern, R" sort="Ahern, R" uniqKey="Ahern R" first="R" last="Ahern">R. Ahern</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gore, M E" sort="Gore, M E" uniqKey="Gore M" first="M E" last="Gore">M E Gore</name><affiliation><nlm:aff id="aff1">Royal Marsden Hospital, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our purpose was to assess the activity of alpha-interferon (IFN-α), interleukin-2 (IL-2) and 5 fluorouracil (5FU) administered by protracted venous infusion (PVI) as opposed to bolus injection. 55 patients with advanced renal cell cancer were treated as follows: IL-2 and IFN-α according to the schedule originally described by Atzpodien, with PVI 5FU 200 mg m<sup>–2</sup> day<sup>–1</sup> during weeks 5–9. 42 patients (76%) were of moderate or poor prognosis as defined by previous studies. The response rate by intention to treat was 31% (17 of 55, three complete response, 14 partial response; 95% CI = 19–45%) and in evaluable patients (completed one cycle, <italic>n</italic> = 42), it was 40% (95% CI = 26–57%). In addition, 24% (13 of 55) patients achieved disease stabilization. The overall median survival was 11 months with a 1-year survival of 45%. The median survival for evaluable patients was 18 months with 1- and 2-year survivals of 60% and 40% respectively. The median survival of responding patients was 31 months and the three patients achieving complete response remain progression-free at 14+, 18+ and 23+ months. Evaluable patients with poor prognostic features achieved a response rate of 54% and median survival of 18 months. Toxicity was significant yet manageable with 12 patients unable to complete one cycle due to side-effects and 36% experiencing grade 3–4 toxicities. The three on-treatment deaths were considered unlikely to be due to toxicity. The schedule of IFN-α, IL-2 and PVI 5FU has significant activity in advanced renal cell cancer with manageable toxicity. It is of particular interest that this regimen appears to have high activity in fit patients with poor prognostic features. © 2000 Cancer Research Campaign</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-comment> Original-type: ra</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10993642</article-id><article-id pub-id-type="pmc">2363554</article-id><article-id pub-id-type="pii">6691418</article-id><article-id pub-id-type="doi">10.1054/bjoc.2000.1418</article-id><article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject></subj-group></article-categories><title-group><article-title>Protracted venous infusion 5-fluorouracil in combination with subcutaneous interleukin-2 and alpha-interferon in patients with metastatic renal cell cancer: a phase II study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Allen</surname><given-names>M J</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vaughan</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Webb</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Johnston</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Savage</surname><given-names>P</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Eisen</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bate</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ahern</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gore</surname><given-names>M E</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Royal Marsden Hospital, London, UK</aff><pub-date pub-type="ppub"><month>10</month><year>2000</year></pub-date><volume>83</volume><issue>8</issue><fpage>980</fpage><lpage>985</lpage><history><date date-type="received"><day>01</day><month>12</month><year>1999</year></date><date date-type="rev-recd"><day>13</day><month>06</month><year>2000</year></date><date date-type="accepted"><day>27</day><month>06</month><year>2000</year></date></history><copyright-statement>Copyright 2000, Cancer Research Campaign</copyright-statement><copyright-year>2000</copyright-year><permissions><copyright-holder>Cancer Research Campaign</copyright-holder></permissions><abstract><p>Our purpose was to assess the activity of alpha-interferon (IFN-α), interleukin-2 (IL-2) and 5 fluorouracil (5FU) administered by protracted venous infusion (PVI) as opposed to bolus injection. 55 patients with advanced renal cell cancer were treated as follows: IL-2 and IFN-α according to the schedule originally described by Atzpodien, with PVI 5FU 200 mg m<sup>–2</sup> day<sup>–1</sup> during weeks 5–9. 42 patients (76%) were of moderate or poor prognosis as defined by previous studies. The response rate by intention to treat was 31% (17 of 55, three complete response, 14 partial response; 95% CI = 19–45%) and in evaluable patients (completed one cycle, <italic>n</italic> = 42), it was 40% (95% CI = 26–57%). In addition, 24% (13 of 55) patients achieved disease stabilization. The overall median survival was 11 months with a 1-year survival of 45%. The median survival for evaluable patients was 18 months with 1- and 2-year survivals of 60% and 40% respectively. The median survival of responding patients was 31 months and the three patients achieving complete response remain progression-free at 14+, 18+ and 23+ months. Evaluable patients with poor prognostic features achieved a response rate of 54% and median survival of 18 months. Toxicity was significant yet manageable with 12 patients unable to complete one cycle due to side-effects and 36% experiencing grade 3–4 toxicities. The three on-treatment deaths were considered unlikely to be due to toxicity. The schedule of IFN-α, IL-2 and PVI 5FU has significant activity in advanced renal cell cancer with manageable toxicity. It is of particular interest that this regimen appears to have high activity in fit patients with poor prognostic features. © 2000 Cancer Research Campaign</p></abstract><kwd-group><kwd>renal cell cancer</kwd><kwd>interleukin-2</kwd><kwd>interferon</kwd><kwd>5-fluorouracil</kwd><kwd>biochemotherapy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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