Genetic Heterogeneity in Algerian Human Populations.
Identifieur interne : 000003 ( PubMed/Corpus ); précédent : 000002; suivant : 000004Genetic Heterogeneity in Algerian Human Populations.
Auteurs : Asmahan Bekada ; Lara R. Arauna ; Tahria Deba ; Francesc Calafell ; Soraya Benhamamouch ; David ComasSource :
- PloS one [ 1932-6203 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical : DNA, Mitochondrial.
- geographic : Algeria.
- genetics : Ethnic Groups.
- Chromosomes, Human, Y, Female, Genetic Heterogeneity, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Haplotypes, Humans, Male, Polymorphism, Single Nucleotide.
Abstract
The demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.
DOI: 10.1371/journal.pone.0138453
PubMed: 26402429
Links to Exploration step
pubmed:26402429Le document en format XML
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Arauna</name><affiliation><nlm:affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Deba, Tahria" sort="Deba, Tahria" uniqKey="Deba T" first="Tahria" last="Deba">Tahria Deba</name><affiliation><nlm:affiliation>Centre de Transfusion Sanguine- Centre Hospitalo-Universitaire d'Oran (CTS-CHUO), Oran, Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Calafell, Francesc" sort="Calafell, Francesc" uniqKey="Calafell F" first="Francesc" last="Calafell">Francesc Calafell</name><affiliation><nlm:affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Benhamamouch, Soraya" sort="Benhamamouch, Soraya" uniqKey="Benhamamouch S" first="Soraya" last="Benhamamouch">Soraya Benhamamouch</name><affiliation><nlm:affiliation>Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 (Ahmad Ben Bella), Oran, Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Comas, David" sort="Comas, David" uniqKey="Comas D" first="David" last="Comas">David Comas</name><affiliation><nlm:affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26402429</idno><idno type="pmid">26402429</idno><idno type="doi">10.1371/journal.pone.0138453</idno><idno type="wicri:Area/PubMed/Corpus">000003</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000003</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic Heterogeneity in Algerian Human Populations.</title><author><name sortKey="Bekada, Asmahan" sort="Bekada, Asmahan" uniqKey="Bekada A" first="Asmahan" last="Bekada">Asmahan Bekada</name><affiliation><nlm:affiliation>Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 (Ahmad Ben Bella), Oran, Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Arauna, Lara R" sort="Arauna, Lara R" uniqKey="Arauna L" first="Lara R" last="Arauna">Lara R. Arauna</name><affiliation><nlm:affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Deba, Tahria" sort="Deba, Tahria" uniqKey="Deba T" first="Tahria" last="Deba">Tahria Deba</name><affiliation><nlm:affiliation>Centre de Transfusion Sanguine- Centre Hospitalo-Universitaire d'Oran (CTS-CHUO), Oran, Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Calafell, Francesc" sort="Calafell, Francesc" uniqKey="Calafell F" first="Francesc" last="Calafell">Francesc Calafell</name><affiliation><nlm:affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Benhamamouch, Soraya" sort="Benhamamouch, Soraya" uniqKey="Benhamamouch S" first="Soraya" last="Benhamamouch">Soraya Benhamamouch</name><affiliation><nlm:affiliation>Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 (Ahmad Ben Bella), Oran, Algeria.</nlm:affiliation></affiliation></author><author><name sortKey="Comas, David" sort="Comas, David" uniqKey="Comas D" first="David" last="Comas">David Comas</name><affiliation><nlm:affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algeria</term><term>Chromosomes, Human, Y</term><term>DNA, Mitochondrial</term><term>Ethnic Groups (genetics)</term><term>Female</term><term>Genetic Heterogeneity</term><term>Genetic Variation</term><term>Genetics, Population</term><term>Genome-Wide Association Study</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA, Mitochondrial</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Algeria</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ethnic Groups</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromosomes, Human, Y</term><term>Female</term><term>Genetic Heterogeneity</term><term>Genetic Variation</term><term>Genetics, Population</term><term>Genome-Wide Association Study</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26402429</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>25</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>01</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>02</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Genetic Heterogeneity in Algerian Human Populations.</ArticleTitle><Pagination><MedlinePgn>e0138453</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0138453</ELocationID><Abstract><AbstractText>The demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bekada</LastName><ForeName>Asmahan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 (Ahmad Ben Bella), Oran, Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arauna</LastName><ForeName>Lara R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deba</LastName><ForeName>Tahria</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Centre de Transfusion Sanguine- Centre Hospitalo-Universitaire d'Oran (CTS-CHUO), Oran, Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calafell</LastName><ForeName>Francesc</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benhamamouch</LastName><ForeName>Soraya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 (Ahmad Ben Bella), Oran, Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Comas</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut de Biologia Evolutiva (CSIC-UPF), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004272">DNA, 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