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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinctive genetic signatures in the Libyan Jews</title><author><name sortKey="Rosenberg, Noah A" sort="Rosenberg, Noah A" uniqKey="Rosenberg N" first="Noah A." last="Rosenberg">Noah A. Rosenberg</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Biological Sciences, Stanford University, Stanford, CA 94305;</nlm:aff></affiliation></author><author><name sortKey="Woolf, Eilon" sort="Woolf, Eilon" uniqKey="Woolf E" first="Eilon" last="Woolf">Eilon Woolf</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Genetics, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel;</nlm:aff></affiliation></author><author><name sortKey="Pritchard, Jonathan K" sort="Pritchard, Jonathan K" uniqKey="Pritchard J" first="Jonathan K." last="Pritchard">Jonathan K. Pritchard</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1–3TG, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Schaap, Tamar" sort="Schaap, Tamar" uniqKey="Schaap T" first="Tamar" last="Schaap">Tamar Schaap</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Human Genetics, Hadassah Medical Center, Jerusalem 91120, Israel;</nlm:aff></affiliation></author><author><name sortKey="Gefel, Dov" sort="Gefel, Dov" uniqKey="Gefel D" first="Dov" last="Gefel">Dov Gefel</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Medicine-C, Barzilai Medical Center, Ashkelon 78306, Israel;</nlm:aff></affiliation></author><author><name sortKey="Shpirer, Isaac" sort="Shpirer, Isaac" uniqKey="Shpirer I" first="Isaac" last="Shpirer">Isaac Shpirer</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Pulmonary Institute, Assaf Harofeh Medical Center, P. O. Beer Yaacov, Zerifin 70300, Israel;</nlm:aff></affiliation></author><author><name sortKey="Lavi, Uri" sort="Lavi, Uri" uniqKey="Lavi U" first="Uri" last="Lavi">Uri Lavi</name><affiliation><nlm:aff wicri:cut="; and" id="N0x9cbc1d0.0x9bdf820">Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel</nlm:aff></affiliation></author><author><name sortKey="Bonne Tamir, Batsheva" sort="Bonne Tamir, Batsheva" uniqKey="Bonne Tamir B" first="Batsheva" last="Bonné-Tamir">Batsheva Bonné-Tamir</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Human Genetics, Sackler School of Medicine, Ramat Aviv 69978, Israel</nlm:aff></affiliation></author><author><name sortKey="Hillel, Jossi" sort="Hillel, Jossi" uniqKey="Hillel J" first="Jossi" last="Hillel">Jossi Hillel</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Genetics, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel;</nlm:aff></affiliation></author><author><name sortKey="Feldman, Marcus W" sort="Feldman, Marcus W" uniqKey="Feldman M" first="Marcus W." last="Feldman">Marcus W. Feldman</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Biological Sciences, Stanford University, Stanford, CA 94305;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">11158561</idno><idno type="pmc">14674</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC14674</idno><idno type="RBID">PMC:14674</idno><date when="2001">2001</date><idno type="wicri:Area/Pmc/Corpus">000050</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Distinctive genetic signatures in the Libyan Jews</title><author><name sortKey="Rosenberg, Noah A" sort="Rosenberg, Noah A" uniqKey="Rosenberg N" first="Noah A." last="Rosenberg">Noah A. Rosenberg</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Biological Sciences, Stanford University, Stanford, CA 94305;</nlm:aff></affiliation></author><author><name sortKey="Woolf, Eilon" sort="Woolf, Eilon" uniqKey="Woolf E" first="Eilon" last="Woolf">Eilon Woolf</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Genetics, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel;</nlm:aff></affiliation></author><author><name sortKey="Pritchard, Jonathan K" sort="Pritchard, Jonathan K" uniqKey="Pritchard J" first="Jonathan K." last="Pritchard">Jonathan K. Pritchard</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1–3TG, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Schaap, Tamar" sort="Schaap, Tamar" uniqKey="Schaap T" first="Tamar" last="Schaap">Tamar Schaap</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Human Genetics, Hadassah Medical Center, Jerusalem 91120, Israel;</nlm:aff></affiliation></author><author><name sortKey="Gefel, Dov" sort="Gefel, Dov" uniqKey="Gefel D" first="Dov" last="Gefel">Dov Gefel</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Medicine-C, Barzilai Medical Center, Ashkelon 78306, Israel;</nlm:aff></affiliation></author><author><name sortKey="Shpirer, Isaac" sort="Shpirer, Isaac" uniqKey="Shpirer I" first="Isaac" last="Shpirer">Isaac Shpirer</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Pulmonary Institute, Assaf Harofeh Medical Center, P. O. Beer Yaacov, Zerifin 70300, Israel;</nlm:aff></affiliation></author><author><name sortKey="Lavi, Uri" sort="Lavi, Uri" uniqKey="Lavi U" first="Uri" last="Lavi">Uri Lavi</name><affiliation><nlm:aff wicri:cut="; and" id="N0x9cbc1d0.0x9bdf820">Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel</nlm:aff></affiliation></author><author><name sortKey="Bonne Tamir, Batsheva" sort="Bonne Tamir, Batsheva" uniqKey="Bonne Tamir B" first="Batsheva" last="Bonné-Tamir">Batsheva Bonné-Tamir</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Human Genetics, Sackler School of Medicine, Ramat Aviv 69978, Israel</nlm:aff></affiliation></author><author><name sortKey="Hillel, Jossi" sort="Hillel, Jossi" uniqKey="Hillel J" first="Jossi" last="Hillel">Jossi Hillel</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Genetics, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel;</nlm:aff></affiliation></author><author><name sortKey="Feldman, Marcus W" sort="Feldman, Marcus W" uniqKey="Feldman M" first="Marcus W." last="Feldman">Marcus W. Feldman</name><affiliation><nlm:aff id="N0x9cbc1d0.0x9bdf820">Department of Biological Sciences, Stanford University, Stanford, CA 94305;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Unlinked autosomal microsatellites in six Jewish and two non-Jewish
populations were genotyped, and the relationships among these
populations were explored. Based on considerations of clustering,
pairwise population differentiation, and genetic distance, we found
that the Libyan Jewish group retains genetic signatures distinguishable
from those of the other populations, in agreement with some historical
records on the relative isolation of this community. Our methods also
identified evidence of some similarity between Ethiopian and Yemenite
Jews, reflecting possible migration in the Red Sea region. We suggest
that high-resolution statistical methods that use individual multilocus
genotypes may make it practical to distinguish related populations of
extremely recent common ancestry.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>The National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">11158561</article-id><article-id pub-id-type="pmc">14674</article-id><article-id pub-id-type="publisher-id">5619</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Anthropology</subject></subj-group></subj-group></article-categories><title-group><article-title>Distinctive genetic signatures in the Libyan Jews</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rosenberg</surname><given-names>Noah A.</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">*</xref><xref ref-type="author-notes" rid="FN151">†</xref></contrib><contrib contrib-type="author"><name><surname>Woolf</surname><given-names>Eilon</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">‡</xref></contrib><contrib contrib-type="author"><name><surname>Pritchard</surname><given-names>Jonathan K.</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">§</xref></contrib><contrib contrib-type="author"><name><surname>Schaap</surname><given-names>Tamar</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">¶</xref></contrib><contrib contrib-type="author"><name><surname>Gefel</surname><given-names>Dov</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">‖</xref></contrib><contrib contrib-type="author"><name><surname>Shpirer</surname><given-names>Isaac</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">**</xref></contrib><contrib contrib-type="author"><name><surname>Lavi</surname><given-names>Uri</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Bonné-Tamir</surname><given-names>Batsheva</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">††</xref></contrib><contrib contrib-type="author"><name><surname>Hillel</surname><given-names>Jossi</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">‡</xref></contrib><contrib contrib-type="author"><name><surname>Feldman</surname><given-names>Marcus W.</given-names></name><xref ref-type="aff" rid="N0x9cbc1d0.0x9bdf820">*</xref></contrib></contrib-group><aff id="N0x9cbc1d0.0x9bdf820"><label>*</label>Department of Biological Sciences, Stanford University, Stanford, CA 94305;<label>‡</label>Department of Genetics, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel;<label>§</label>Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1–3TG, United Kingdom;<label>¶</label>Department of Human Genetics, Hadassah Medical Center, Jerusalem 91120, Israel;<label>‖</label>Department of Medicine-C, Barzilai Medical Center, Ashkelon 78306, Israel;<label>**</label>Pulmonary Institute, Assaf Harofeh Medical Center, P. O. Beer Yaacov, Zerifin 70300, Israel;<label>‡‡</label>Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel; and<label>††</label>Department of Human Genetics, Sackler School of Medicine, Ramat Aviv 69978, Israel</aff><author-notes><fn id="FN151"><label>†</label><p>To whom reprint requests should be addressed.
E-mail: <email>noah@charles.stanford.edu</email>.</p></fn><fn><p>Communicated by Paul R. Ehrlich, Stanford University, Stanford,
CA</p></fn></author-notes><pub-date pub-type="ppub"><day>30</day><month>1</month><year>2001</year></pub-date><volume>98</volume><issue>3</issue><fpage>858</fpage><lpage>863</lpage><history><date date-type="received"><day>17</day><month>8</month><year>2000</year></date><date date-type="accepted"><day>27</day><month>11</month><year>2000</year></date></history><copyright-statement>Copyright © 2001, The National Academy of Sciences</copyright-statement><copyright-year>2001</copyright-year><abstract><p>Unlinked autosomal microsatellites in six Jewish and two non-Jewish
populations were genotyped, and the relationships among these
populations were explored. Based on considerations of clustering,
pairwise population differentiation, and genetic distance, we found
that the Libyan Jewish group retains genetic signatures distinguishable
from those of the other populations, in agreement with some historical
records on the relative isolation of this community. Our methods also
identified evidence of some similarity between Ethiopian and Yemenite
Jews, reflecting possible migration in the Red Sea region. We suggest
that high-resolution statistical methods that use individual multilocus
genotypes may make it practical to distinguish related populations of
extremely recent common ancestry.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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