Using mitochondrial DNA to test the hypothesis of a European post-glacial human recolonization from the Franco-Cantabrian refuge
Identifieur interne : 000080 ( Ncbi/Merge ); précédent : 000079; suivant : 000081Using mitochondrial DNA to test the hypothesis of a European post-glacial human recolonization from the Franco-Cantabrian refuge
Auteurs : O. García [Espagne] ; R. Fregel [Espagne] ; J M Larruga [Espagne] ; V. Álvarez [Espagne] ; I. Yurrebaso [Espagne] ; V M Cabrera [Espagne] ; A M González [Espagne]Source :
- Heredity [ 0018-067X ] ; 2010.
Abstract
It has been proposed that the distribution patterns and coalescence ages found in Europeans for mitochondrial DNA (mtDNA) haplogroups V, H1 and H3 are the result of a post-glacial expansion from a Franco-Cantabrian refuge that recolonized central and northern areas. In contrast, in this refined mtDNA study of the Cantabrian Cornice that contributes 413 partial and 9 complete new mtDNA sequences, including a large Basque sample and a sample of Asturians, no experimental evidence was found to support the human refuge-expansion theory. In fact, all measures of gene diversity point to the Cantabrian Cornice in general and the Basques in particular, as less polymorphic for V, H1 and H3 than other southern regions in Iberia or in Central Europe. Genetic distances show the Cantabrian Cornice is a very heterogeneous region with significant local differences. The analysis of several minor subhaplogroups, based on complete sequences, also suggests different focal expansions over a local and peninsular range that did not affect continental Europe. Furthermore, all detected clinal trends show stronger longitudinal than latitudinal profiles. In Northern Iberia, it seems that the highest diversity values for some haplogroups with Mesolithic coalescence ages are centred on the Mediterranean side, including Catalonia and South-eastern France.
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DOI: 10.1038/hdy.2010.47
PubMed: 20407470
PubMed Central: 3183843
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García</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Basque Country Forensic Genetics Laboratory</institution>, Erandio, Bizkaia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fregel, R" sort="Fregel, R" uniqKey="Fregel R" first="R" last="Fregel">R. Fregel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Área de Genética, Departamento de Parasitología, Ecología y Genética, Facultad de Biología, Universidad de La Laguna (ULL)</institution>, La Laguna, Tenerife,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Larruga, J M" sort="Larruga, J M" uniqKey="Larruga J" first="J M" last="Larruga">J M Larruga</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Área de Genética, Departamento de Parasitología, Ecología y Genética, Facultad de Biología, Universidad de La Laguna (ULL)</institution>, La Laguna, Tenerife,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alvarez, V" sort="Alvarez, V" uniqKey="Alvarez V" first="V" last="Álvarez">V. Álvarez</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Unidad de Genética, Hospital Universitario Central de Asturias</institution>, Oviedo, Asturias,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yurrebaso, I" sort="Yurrebaso, I" uniqKey="Yurrebaso I" first="I" last="Yurrebaso">I. Yurrebaso</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Basque Country Forensic Genetics Laboratory</institution>, Erandio, Bizkaia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cabrera, V M" sort="Cabrera, V M" uniqKey="Cabrera V" first="V M" last="Cabrera">V M Cabrera</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Área de Genética, Departamento de Parasitología, Ecología y Genética, Facultad de Biología, Universidad de La Laguna (ULL)</institution>, La Laguna, Tenerife,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, A M" sort="Gonzalez, A M" uniqKey="Gonzalez A" first="A M" last="González">A M González</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Área de Genética, Departamento de Parasitología, Ecología y Genética, Facultad de Biología, Universidad de La Laguna (ULL)</institution>, La Laguna, Tenerife,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Heredity</title><idno type="ISSN">0018-067X</idno><idno type="eISSN">1365-2540</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>It has been proposed that the distribution patterns and coalescence ages found in Europeans for mitochondrial DNA (mtDNA) haplogroups V, H1 and H3 are the result of a post-glacial expansion from a Franco-Cantabrian refuge that recolonized central and northern areas. In contrast, in this refined mtDNA study of the Cantabrian Cornice that contributes 413 partial and 9 complete new mtDNA sequences, including a large Basque sample and a sample of Asturians, no experimental evidence was found to support the human refuge-expansion theory. In fact, all measures of gene diversity point to the Cantabrian Cornice in general and the Basques in particular, as less polymorphic for V, H1 and H3 than other southern regions in Iberia or in Central Europe. Genetic distances show the Cantabrian Cornice is a very heterogeneous region with significant local differences. The analysis of several minor subhaplogroups, based on complete sequences, also suggests different focal expansions over a local and peninsular range that did not affect continental Europe. Furthermore, all detected clinal trends show stronger longitudinal than latitudinal profiles. In Northern Iberia, it seems that the highest diversity values for some haplogroups with Mesolithic coalescence ages are centred on the Mediterranean side, including Catalonia and South-eastern France.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Heredity</journal-id><journal-title-group><journal-title>Heredity</journal-title></journal-title-group><issn pub-type="ppub">0018-067X</issn><issn pub-type="epub">1365-2540</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20407470</article-id><article-id pub-id-type="pmc">3183843</article-id><article-id pub-id-type="pii">hdy201047</article-id><article-id pub-id-type="doi">10.1038/hdy.2010.47</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Using mitochondrial DNA to test the hypothesis of a European post-glacial human recolonization from the Franco-Cantabrian refuge</article-title><alt-title alt-title-type="running">mtDNA in the Cantabrian Cornice</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>García</surname><given-names>O</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="author-notes" rid="note1"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fregel</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="author-notes" rid="note1"><sup>4</sup></xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><contrib contrib-type="author"><name><surname>Larruga</surname><given-names>J M</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Álvarez</surname><given-names>V</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Yurrebaso</surname><given-names>I</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cabrera</surname><given-names>V M</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>González</surname><given-names>A M</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><aff id="aff1"><label>1</label><institution>Basque Country Forensic Genetics Laboratory</institution>, Erandio, Bizkaia,<country>Spain</country></aff><aff id="aff2"><label>2</label><institution>Área de Genética, Departamento de Parasitología, Ecología y Genética, Facultad de Biología, Universidad de La Laguna (ULL)</institution>, La Laguna, Tenerife,<country>Spain</country></aff><aff id="aff3"><label>3</label><institution>Unidad de Genética, Hospital Universitario Central de Asturias</institution>, Oviedo, Asturias,<country>Spain</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>Departamento de Genética, Facultad de Biología, Universidad de La Laguna</institution>, La Laguna, Santa Cruz de Tenerife 38270, <country>Spain</country>. E-mail: <email>rfregel@gmail.com</email></corresp><fn fn-type="present-address" id="note1"><label>4</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><month>01</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>21</day><month>04</month><year>2010</year></pub-date><volume>106</volume><issue>1</issue><fpage>37</fpage><lpage>45</lpage><history><date date-type="received"><day>01</day><month>12</month><year>2009</year></date><date date-type="rev-recd"><day>23</day><month>02</month><year>2010</year></date><date date-type="accepted"><day>18</day><month>03</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2011 The Genetics Society</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>The Genetics Society</copyright-holder></permissions><abstract><p>It has been proposed that the distribution patterns and coalescence ages found in Europeans for mitochondrial DNA (mtDNA) haplogroups V, H1 and H3 are the result of a post-glacial expansion from a Franco-Cantabrian refuge that recolonized central and northern areas. In contrast, in this refined mtDNA study of the Cantabrian Cornice that contributes 413 partial and 9 complete new mtDNA sequences, including a large Basque sample and a sample of Asturians, no experimental evidence was found to support the human refuge-expansion theory. In fact, all measures of gene diversity point to the Cantabrian Cornice in general and the Basques in particular, as less polymorphic for V, H1 and H3 than other southern regions in Iberia or in Central Europe. Genetic distances show the Cantabrian Cornice is a very heterogeneous region with significant local differences. The analysis of several minor subhaplogroups, based on complete sequences, also suggests different focal expansions over a local and peninsular range that did not affect continental Europe. Furthermore, all detected clinal trends show stronger longitudinal than latitudinal profiles. In Northern Iberia, it seems that the highest diversity values for some haplogroups with Mesolithic coalescence ages are centred on the Mediterranean side, including Catalonia and South-eastern France.</p></abstract><kwd-group><kwd>mtDNA haplogroups</kwd><kwd>humans</kwd><kwd>Franco-Cantabrian refuge theory</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Garcia, O" sort="Garcia, O" uniqKey="Garcia O" first="O" last="García">O. García</name></noRegion><name sortKey="Alvarez, V" sort="Alvarez, V" uniqKey="Alvarez V" first="V" last="Álvarez">V. Álvarez</name><name sortKey="Cabrera, V M" sort="Cabrera, V M" uniqKey="Cabrera V" first="V M" last="Cabrera">V M Cabrera</name><name sortKey="Fregel, R" sort="Fregel, R" uniqKey="Fregel R" first="R" last="Fregel">R. Fregel</name><name sortKey="Gonzalez, A M" sort="Gonzalez, A M" uniqKey="Gonzalez A" first="A M" last="González">A M González</name><name sortKey="Larruga, J M" sort="Larruga, J M" uniqKey="Larruga J" first="J M" last="Larruga">J M Larruga</name><name sortKey="Yurrebaso, I" sort="Yurrebaso, I" uniqKey="Yurrebaso I" first="I" last="Yurrebaso">I. Yurrebaso</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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