Population genetic relationships between Mediterranean populations determined by HLA allele distribution and a historic perspective.
Identifieur interne : 000016 ( Ncbi/Curation ); précédent : 000015; suivant : 000017Population genetic relationships between Mediterranean populations determined by HLA allele distribution and a historic perspective.
Auteurs : A. Arnaiz-Villena [Espagne] ; E. Gomez-Casado ; J. Martinez-LasoSource :
- Tissue antigens [ 0001-2815 ] ; 2002.
Descripteurs français
- KwdFr :
- Afrique subsaharienne, Allèles, Antigènes HLA (génétique), Antigènes HLA (histoire), Fréquence d'allèle, Groupes ethniques (génétique), Génétique des populations (histoire), Histoire ancienne, Humains, Langage, Linguistique, Modèles théoriques, Phylogénie, Phénotype, Région méditerranéenne, Variation génétique.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HLA Antigens.
- chemical , history : HLA Antigens.
- geographic : Africa South of the Sahara, Mediterranean Region.
- genetics : Ethnic Groups.
- history : Genetics, Population.
- Alleles, Gene Frequency, Genetic Variation, History, Ancient, Humans, Language, Linguistics, Models, Theoretical, Phenotype, Phylogeny.
Abstract
HLA genes allele distribution has been studied in Mediterranean and sub-Saharan populations. Their relatedness has been tested by genetic distances, neighbour-joining dendrograms and correspondence analyses. The population genetic relationships have been compared with the history of the classical populations living in the area. A revision of the historic postulates would have to be undertaken, particularly in the cases when genetics and history are overtly discordant. HLA genomics shows that: 1) Greeks share an important part of their genetic pool with sub-Saharan Africans (Ethiopians and west Africans) also supported by Chr 7 Markers. The gene flow from Black Africa to Greece may have occurred in Pharaonic times or when Saharan people emigrated after the present hyperarid conditions were established (5000 years B.C.). 2) Turks (Anatolians) do not significantly differ from other Mediterraneans, indicating that while the Asians Turks carried out an invasion with cultural significance (language), it is not genetically detectable. 3) Kurds and Armenians are genetically very close to Turks and other Middle East populations. 4) There is no HLA genetic trace of the so called Aryan invasion, which has only been defined on doubtful linguistic bases. 5) Iberians, including Basques, are related to north-African Berbers. 6) Present-day Algerian and Moroccan urban and country people show an indistinguishable Berber HLA profile.
PubMed: 12392505
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Gomez-Casado</name></author><author><name sortKey="Martinez Laso, J" sort="Martinez Laso, J" uniqKey="Martinez Laso J" first="J" last="Martinez-Laso">J. 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Arnaiz-Villena</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Molecular Biology, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology and Molecular Biology, Universidad Complutense, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Gomez Casado, E" sort="Gomez Casado, E" uniqKey="Gomez Casado E" first="E" last="Gomez-Casado">E. Gomez-Casado</name></author><author><name sortKey="Martinez Laso, J" sort="Martinez Laso, J" uniqKey="Martinez Laso J" first="J" last="Martinez-Laso">J. Martinez-Laso</name></author></analytic><series><title level="j">Tissue antigens</title><idno type="ISSN">0001-2815</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa South of the Sahara</term><term>Alleles</term><term>Ethnic Groups (genetics)</term><term>Gene Frequency</term><term>Genetic Variation</term><term>Genetics, Population (history)</term><term>HLA Antigens (genetics)</term><term>HLA Antigens (history)</term><term>History, Ancient</term><term>Humans</term><term>Language</term><term>Linguistics</term><term>Mediterranean Region</term><term>Models, Theoretical</term><term>Phenotype</term><term>Phylogeny</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique subsaharienne</term><term>Allèles</term><term>Antigènes HLA (génétique)</term><term>Antigènes HLA (histoire)</term><term>Fréquence d'allèle</term><term>Groupes ethniques (génétique)</term><term>Génétique des populations (histoire)</term><term>Histoire ancienne</term><term>Humains</term><term>Langage</term><term>Linguistique</term><term>Modèles théoriques</term><term>Phylogénie</term><term>Phénotype</term><term>Région méditerranéenne</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="history" xml:lang="en"><term>HLA Antigens</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Africa South of the Sahara</term><term>Mediterranean Region</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ethnic Groups</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Groupes ethniques</term></keywords><keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Antigènes HLA</term><term>Génétique des populations</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Genetics, Population</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Gene Frequency</term><term>Genetic Variation</term><term>History, Ancient</term><term>Humans</term><term>Language</term><term>Linguistics</term><term>Models, Theoretical</term><term>Phenotype</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Afrique subsaharienne</term><term>Allèles</term><term>Fréquence d'allèle</term><term>Histoire ancienne</term><term>Humains</term><term>Langage</term><term>Linguistique</term><term>Modèles théoriques</term><term>Phylogénie</term><term>Phénotype</term><term>Région méditerranéenne</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HLA genes allele distribution has been studied in Mediterranean and sub-Saharan populations. Their relatedness has been tested by genetic distances, neighbour-joining dendrograms and correspondence analyses. The population genetic relationships have been compared with the history of the classical populations living in the area. A revision of the historic postulates would have to be undertaken, particularly in the cases when genetics and history are overtly discordant. HLA genomics shows that: 1) Greeks share an important part of their genetic pool with sub-Saharan Africans (Ethiopians and west Africans) also supported by Chr 7 Markers. The gene flow from Black Africa to Greece may have occurred in Pharaonic times or when Saharan people emigrated after the present hyperarid conditions were established (5000 years B.C.). 2) Turks (Anatolians) do not significantly differ from other Mediterraneans, indicating that while the Asians Turks carried out an invasion with cultural significance (language), it is not genetically detectable. 3) Kurds and Armenians are genetically very close to Turks and other Middle East populations. 4) There is no HLA genetic trace of the so called Aryan invasion, which has only been defined on doubtful linguistic bases. 5) Iberians, including Basques, are related to north-African Berbers. 6) Present-day Algerian and Moroccan urban and country people show an indistinguishable Berber HLA profile.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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