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Norcoclaurine as biosynthetic precursor of thebaine and morphine

Identifieur interne : 001909 ( Main/Merge ); précédent : 001908; suivant : 001910

Norcoclaurine as biosynthetic precursor of thebaine and morphine

Auteurs : Susanne Loeffler ; Richard Stadler ; Naotaka Nagakura ; Meinhart H. Zenk

Source :

RBID : ISTEX:677B53AE1D26CFF013A852761B050C9678CD383C

Abstract

(R,S)-[1-13C]Norcoclaurine and (R,S)-[1-13C]coclaurine fed to Papaver somniferum plants afford highly enriched thebaine and morphine which are specifically labelled at position C-9; the results are interpreted as showing that the morphine skeleton is built up from the condensation product of dopamine with 4-hydroxyphenylacetaldehyde.

Url:
DOI: 10.1039/C39870001160

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Links to Exploration step

ISTEX:677B53AE1D26CFF013A852761B050C9678CD383C

Le document en format XML

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<name sortKey="Stadler, Richard" sort="Stadler, Richard" uniqKey="Stadler R" first="Richard" last="Stadler">Richard Stadler</name>
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<title level="j">Journal of the Chemical Society, Chemical Communications</title>
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<div type="abstract">(R,S)-[1-13C]Norcoclaurine and (R,S)-[1-13C]coclaurine fed to Papaver somniferum plants afford highly enriched thebaine and morphine which are specifically labelled at position C-9; the results are interpreted as showing that the morphine skeleton is built up from the condensation product of dopamine with 4-hydroxyphenylacetaldehyde.</div>
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