HLA class I polymorphism in a Moroccan population from Casablanca
Identifieur interne : 000E65 ( Main/Merge ); précédent : 000E64; suivant : 000E66HLA class I polymorphism in a Moroccan population from Casablanca
Auteurs : F. Choukri ; A. Chakib ; H. Himmich ; H. Raissi ; S. Caillat-Zucman [France]Source :
- European Journal of Immunogenetics [ 0960-7420 ] ; 2002-06.
Abstract
We have studied the distribution of HLA‐A and ‐B alleles and haplotypes by sequence‐specific primer amplification in a sample of 100 unrelated healthy individuals belonging to both Berber and Arabic‐speaking groups from the region of Casablanca in Morocco. Among the 17 HLA‐A and 23 HLA‐B alleles observed, the most frequent were HLA‐A2 (21%), ‐A1 (11%), ‐A3 (10%), ‐B44 (11.4%), ‐B50 (9.9%), ‐B5(8.5%) and ‐B35 (6.5%). Six two‐locus haplotypes were observed with a frequency above 5%: A2‐B50 (9.6%), A23‐B44 (7.4%), A2‐B15 (6.4%), A68‐B39 (5.3%), A1‐B51 (5.3%) and A68‐B44 (4.3%). Our data confirm that, on the basis of genetic distances, the majority of present‐day North Africans from Morocco are closely related to Berbers and also to Iberians. They cluster apart from Middle‐Eastern Mediterranean populations, and show greater genetic distances to Eastern and other Mediterranean populations. This study will serve as a reference for further anthropological studies, as well as studies of HLA and disease associations.
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DOI: 10.1046/j.1365-2370.2002.00289.x
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