Cost-effectiveness of bone densitometry among Caucasian women and men without a prior fracture according to age and body weight.
Identifieur interne : 000062 ( Main/Merge ); précédent : 000061; suivant : 000063Cost-effectiveness of bone densitometry among Caucasian women and men without a prior fracture according to age and body weight.
Auteurs : J T Schousboe [États-Unis] ; M. Gourlay ; H A Fink ; B C Taylor ; E S Orwoll ; E. Barrett-Connor ; L J Melton ; S R Cummings ; K E EnsrudSource :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [ 1433-2965 ] ; 2013.
Descripteurs français
- KwdFr :
- Absorptiométrie photonique (économie), Adulte d'âge moyen (MeSH), Analyse coût-bénéfice (MeSH), Années de vie ajustées sur la qualité (MeSH), Appréciation des risques (méthodes), Coûts des soins de santé (statistiques et données numériques), Densité osseuse (physiologie), Facteurs âges (MeSH), Femelle (MeSH), Fractures ostéoporotiques (physiopathologie), Fractures ostéoporotiques (prévention et contrôle), Fractures ostéoporotiques (économie), Humains (MeSH), Modèles économétriques (MeSH), Mâle (MeSH), Ostéoporose (diagnostic), Ostéoporose (physiopathologie), Ostéoporose (économie), Poids (physiologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Sélection de patients (MeSH).
- MESH :
- diagnostic : Ostéoporose.
- méthodes : Appréciation des risques.
- physiologie : Densité osseuse, Poids.
- physiopathologie : Fractures ostéoporotiques, Ostéoporose.
- prévention et contrôle : Fractures ostéoporotiques.
- statistiques et données numériques : Coûts des soins de santé.
- économie : Absorptiométrie photonique, Fractures ostéoporotiques, Ostéoporose.
- Adulte d'âge moyen, Analyse coût-bénéfice, Années de vie ajustées sur la qualité, Facteurs âges, Femelle, Humains, Modèles économétriques, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Sélection de patients.
English descriptors
- KwdEn :
- Absorptiometry, Photon (economics), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Body Weight (physiology), Bone Density (physiology), Cost-Benefit Analysis (MeSH), Female (MeSH), Health Care Costs (statistics & numerical data), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Models, Econometric (MeSH), Osteoporosis (diagnosis), Osteoporosis (economics), Osteoporosis (physiopathology), Osteoporotic Fractures (economics), Osteoporotic Fractures (physiopathology), Osteoporotic Fractures (prevention & control), Patient Selection (MeSH), Quality-Adjusted Life Years (MeSH), Risk Assessment (methods).
- MESH :
- diagnosis : Osteoporosis.
- economics : Absorptiometry, Photon, Osteoporosis, Osteoporotic Fractures.
- methods : Risk Assessment.
- physiology : Body Weight, Bone Density.
- physiopathology : Osteoporosis, Osteoporotic Fractures.
- prevention & control : Osteoporotic Fractures.
- statistics & numerical data : Health Care Costs.
- Age Factors, Aged, Aged, 80 and over, Cost-Benefit Analysis, Female, Humans, Male, Middle Aged, Models, Econometric, Patient Selection, Quality-Adjusted Life Years.
Abstract
UNLABELLED
We used a microsimulation model to estimate the threshold body weights at which screening bone densitometry is cost-effective. Among women aged 55-65 years and men aged 55-75 years without a prior fracture, body weight can be used to identify those for whom bone densitometry is cost-effective.
INTRODUCTION
Bone densitometry may be more cost-effective for those with lower body weight since the prevalence of osteoporosis is higher for those with low body weight. Our purpose was to estimate weight thresholds below which bone densitometry is cost-effective for women and men without a prior clinical fracture at ages 55, 60, 65, 75, and 80 years.
METHODS
We used a microsimulation model to estimate the costs and health benefits of bone densitometry and 5 years of fracture prevention therapy for those without prior fracture but with femoral neck osteoporosis (T-score ≤ -2.5) and a 10-year hip fracture risk of ≥3%. Threshold pre-test probabilities of low BMD warranting drug therapy at which bone densitometry is cost-effective were calculated. Corresponding body weight thresholds were estimated using data from the Study of Osteoporotic Fractures (SOF), the Osteoporotic Fractures in Men (MrOS) study, and the National Health and Nutrition Examination Survey (NHANES) for 2005-2006.
RESULTS
Assuming a willingness to pay of $75,000 per quality adjusted life year (QALY) and drug cost of $500/year, body weight thresholds below which bone densitometry is cost-effective for those without a prior fracture were 74, 90, and 100 kg, respectively, for women aged 55, 65, and 80 years; and were 67, 101, and 108 kg, respectively, for men aged 55, 75, and 80 years.
CONCLUSIONS
For women aged 55-65 years and men aged 55-75 years without a prior fracture, body weight can be used to select those for whom bone densitometry is cost-effective.
DOI: 10.1007/s00198-012-1936-7
PubMed: 22349916
PubMed Central: PMC3739718
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000102
- to stream PubMed, to step Curation: 000102
- to stream PubMed, to step Checkpoint: 000060
Links to Exploration step
pubmed:22349916Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cost-effectiveness of bone densitometry among Caucasian women and men without a prior fracture according to age and body weight.</title><author><name sortKey="Schousboe, J T" sort="Schousboe, J T" uniqKey="Schousboe J" first="J T" last="Schousboe">J T Schousboe</name><affiliation wicri:level="2"><nlm:affiliation>Park Nicollet Institute, Minneapolis, MN, USA. john.schousboe@parknicollet.com</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Park Nicollet Institute, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gourlay, M" sort="Gourlay, M" uniqKey="Gourlay M" first="M" last="Gourlay">M. Gourlay</name></author><author><name sortKey="Fink, H A" sort="Fink, H A" uniqKey="Fink H" first="H A" last="Fink">H A Fink</name></author><author><name sortKey="Taylor, B C" sort="Taylor, B C" uniqKey="Taylor B" first="B C" last="Taylor">B C Taylor</name></author><author><name sortKey="Orwoll, E S" sort="Orwoll, E S" uniqKey="Orwoll E" first="E S" last="Orwoll">E S Orwoll</name></author><author><name sortKey="Barrett Connor, E" sort="Barrett Connor, E" uniqKey="Barrett Connor E" first="E" last="Barrett-Connor">E. Barrett-Connor</name></author><author><name sortKey="Melton, L J" sort="Melton, L J" uniqKey="Melton L" first="L J" last="Melton">L J Melton</name></author><author><name sortKey="Cummings, S R" sort="Cummings, S R" uniqKey="Cummings S" first="S R" last="Cummings">S R Cummings</name></author><author><name sortKey="Ensrud, K E" sort="Ensrud, K E" uniqKey="Ensrud K" first="K E" last="Ensrud">K E Ensrud</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1007/s00198-012-1936-7</idno><idno type="RBID">pubmed:22349916</idno><idno type="pmid">22349916</idno><idno type="pmc">PMC3739718</idno><idno type="wicri:Area/PubMed/Corpus">000102</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000102</idno><idno type="wicri:Area/PubMed/Curation">000102</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000102</idno><idno type="wicri:Area/PubMed/Checkpoint">000060</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000060</idno><idno type="wicri:Area/Main/Merge">000062</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cost-effectiveness of bone densitometry among Caucasian women and men without a prior fracture according to age and body weight.</title><author><name sortKey="Schousboe, J T" sort="Schousboe, J T" uniqKey="Schousboe J" first="J T" last="Schousboe">J T Schousboe</name><affiliation wicri:level="2"><nlm:affiliation>Park Nicollet Institute, Minneapolis, MN, USA. john.schousboe@parknicollet.com</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Park Nicollet Institute, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Gourlay, M" sort="Gourlay, M" uniqKey="Gourlay M" first="M" last="Gourlay">M. Gourlay</name></author><author><name sortKey="Fink, H A" sort="Fink, H A" uniqKey="Fink H" first="H A" last="Fink">H A Fink</name></author><author><name sortKey="Taylor, B C" sort="Taylor, B C" uniqKey="Taylor B" first="B C" last="Taylor">B C Taylor</name></author><author><name sortKey="Orwoll, E S" sort="Orwoll, E S" uniqKey="Orwoll E" first="E S" last="Orwoll">E S Orwoll</name></author><author><name sortKey="Barrett Connor, E" sort="Barrett Connor, E" uniqKey="Barrett Connor E" first="E" last="Barrett-Connor">E. Barrett-Connor</name></author><author><name sortKey="Melton, L J" sort="Melton, L J" uniqKey="Melton L" first="L J" last="Melton">L J Melton</name></author><author><name sortKey="Cummings, S R" sort="Cummings, S R" uniqKey="Cummings S" first="S R" last="Cummings">S R Cummings</name></author><author><name sortKey="Ensrud, K E" sort="Ensrud, K E" uniqKey="Ensrud K" first="K E" last="Ensrud">K E Ensrud</name></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="eISSN">1433-2965</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorptiometry, Photon (economics)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Body Weight (physiology)</term><term>Bone Density (physiology)</term><term>Cost-Benefit Analysis (MeSH)</term><term>Female (MeSH)</term><term>Health Care Costs (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Models, Econometric (MeSH)</term><term>Osteoporosis (diagnosis)</term><term>Osteoporosis (economics)</term><term>Osteoporosis (physiopathology)</term><term>Osteoporotic Fractures (economics)</term><term>Osteoporotic Fractures (physiopathology)</term><term>Osteoporotic Fractures (prevention & control)</term><term>Patient Selection (MeSH)</term><term>Quality-Adjusted Life Years (MeSH)</term><term>Risk Assessment (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Absorptiométrie photonique (économie)</term><term>Adulte d'âge moyen (MeSH)</term><term>Analyse coût-bénéfice (MeSH)</term><term>Années de vie ajustées sur la qualité (MeSH)</term><term>Appréciation des risques (méthodes)</term><term>Coûts des soins de santé (statistiques et données numériques)</term><term>Densité osseuse (physiologie)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Fractures ostéoporotiques (physiopathologie)</term><term>Fractures ostéoporotiques (prévention et contrôle)</term><term>Fractures ostéoporotiques (économie)</term><term>Humains (MeSH)</term><term>Modèles économétriques (MeSH)</term><term>Mâle (MeSH)</term><term>Ostéoporose (diagnostic)</term><term>Ostéoporose (physiopathologie)</term><term>Ostéoporose (économie)</term><term>Poids (physiologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Sélection de patients (MeSH)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Osteoporosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Ostéoporose</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Absorptiometry, Photon</term><term>Osteoporosis</term><term>Osteoporotic Fractures</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Appréciation des risques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Densité osseuse</term><term>Poids</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Body Weight</term><term>Bone Density</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Fractures ostéoporotiques</term><term>Ostéoporose</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Osteoporosis</term><term>Osteoporotic Fractures</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Osteoporotic Fractures</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Fractures ostéoporotiques</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Health Care Costs</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Coûts des soins de santé</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Absorptiométrie photonique</term><term>Fractures ostéoporotiques</term><term>Ostéoporose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Cost-Benefit Analysis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Econometric</term><term>Patient Selection</term><term>Quality-Adjusted Life Years</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse coût-bénéfice</term><term>Années de vie ajustées sur la qualité</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Modèles économétriques</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sélection de patients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>UNLABELLED</b></p><p>We used a microsimulation model to estimate the threshold body weights at which screening bone densitometry is cost-effective. Among women aged 55-65 years and men aged 55-75 years without a prior fracture, body weight can be used to identify those for whom bone densitometry is cost-effective.</p></div><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Bone densitometry may be more cost-effective for those with lower body weight since the prevalence of osteoporosis is higher for those with low body weight. Our purpose was to estimate weight thresholds below which bone densitometry is cost-effective for women and men without a prior clinical fracture at ages 55, 60, 65, 75, and 80 years.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We used a microsimulation model to estimate the costs and health benefits of bone densitometry and 5 years of fracture prevention therapy for those without prior fracture but with femoral neck osteoporosis (T-score ≤ -2.5) and a 10-year hip fracture risk of ≥3%. Threshold pre-test probabilities of low BMD warranting drug therapy at which bone densitometry is cost-effective were calculated. Corresponding body weight thresholds were estimated using data from the Study of Osteoporotic Fractures (SOF), the Osteoporotic Fractures in Men (MrOS) study, and the National Health and Nutrition Examination Survey (NHANES) for 2005-2006.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Assuming a willingness to pay of $75,000 per quality adjusted life year (QALY) and drug cost of $500/year, body weight thresholds below which bone densitometry is cost-effective for those without a prior fracture were 74, 90, and 100 kg, respectively, for women aged 55, 65, and 80 years; and were 67, 101, and 108 kg, respectively, for men aged 55, 75, and 80 years.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>For women aged 55-65 years and men aged 55-75 years without a prior fracture, body weight can be used to select those for whom bone densitometry is cost-effective.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=MicroSimulV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000062 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000062 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= MicroSimulV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:22349916
|texte= Cost-effectiveness of bone densitometry among Caucasian women and men without a prior fracture according to age and body weight.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:22349916" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MicroSimulV1
| This area was generated with Dilib version V0.6.38. |  |