Childhood cancer and agricultural pesticide use: an ecologic study in California.
Identifieur interne : 000485 ( PubMed/Curation ); précédent : 000484; suivant : 000486Childhood cancer and agricultural pesticide use: an ecologic study in California.
Auteurs : Peggy Reynolds [États-Unis] ; Julie Von Behren ; Robert B. Gunier ; Debbie E. Goldberg ; Andrew Hertz ; Martha E. HarnlySource :
- Environmental health perspectives [ 0091-6765 ] ; 2002.
English descriptors
- KwdEn :
- Adolescent, Agriculture, California (epidemiology), Child, Child, Preschool, Environmental Exposure, Epidemiologic Studies, Female, Humans, Incidence, Infant, Infant, Newborn, Leukemia (epidemiology), Leukemia (etiology), Male, Neoplasms (epidemiology), Neoplasms (etiology), Pesticides (adverse effects).
- MESH :
- chemical , adverse effects : Pesticides.
- geographic , epidemiology : California.
- epidemiology : Leukemia, Neoplasms.
- etiology : Leukemia, Neoplasms.
- Adolescent, Agriculture, Child, Child, Preschool, Environmental Exposure, Epidemiologic Studies, Female, Humans, Incidence, Infant, Infant, Newborn, Male.
Abstract
We analyzed population-based childhood cancer incidence rates throughout California in relation to agricultural pesticide use. During 1988-1994, a total of 7,143 cases of invasive cancer were diagnosed among children under 15 years of age in California. Building on the availability of high-quality population-based cancer incidence information from the California Cancer Registry, population data from the U.S. Census, and uniquely comprehensive agricultural pesticide use information from California's Department of Pesticide Regulation, we used a geographic information system to assign summary population, exposure, and outcome attributes at the block group level. We used Poisson regression to estimate rate ratios (RRs) by pesticide use density adjusted for race/ethnicity, age, and sex for all types of childhood cancer combined and separately for the leukemias and central nervous system cancers. We generally found no association between pesticide use density and childhood cancer incidence rates. The RR for all cancers was 0.95 [95% confidence interval (CI), 0.80-1.13] for block groups in the 90th percentile and above for use of pesticides classified as probable carcinogens, compared to the block groups with use of < 1 lb/mi(2). The RRs were similar for leukemia and central nervous system cancers. Childhood leukemia rates were significantly elevated (RR = 1.48; 95% CI, 1.03-2.13) in block groups with the highest use of propargite, although we saw no dose-response trend with increasing exposure categories. Results were unchanged by further adjustment for socioeconomic status and urbanization.
PubMed: 11882484
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Gunier</name></author><author><name sortKey="Goldberg, Debbie E" sort="Goldberg, Debbie E" uniqKey="Goldberg D" first="Debbie E" last="Goldberg">Debbie E. Goldberg</name></author><author><name sortKey="Hertz, Andrew" sort="Hertz, Andrew" uniqKey="Hertz A" first="Andrew" last="Hertz">Andrew Hertz</name></author><author><name sortKey="Harnly, Martha E" sort="Harnly, Martha E" uniqKey="Harnly M" first="Martha E" last="Harnly">Martha E. 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Gunier</name></author><author><name sortKey="Goldberg, Debbie E" sort="Goldberg, Debbie E" uniqKey="Goldberg D" first="Debbie E" last="Goldberg">Debbie E. Goldberg</name></author><author><name sortKey="Hertz, Andrew" sort="Hertz, Andrew" uniqKey="Hertz A" first="Andrew" last="Hertz">Andrew Hertz</name></author><author><name sortKey="Harnly, Martha E" sort="Harnly, Martha E" uniqKey="Harnly M" first="Martha E" last="Harnly">Martha E. Harnly</name></author></analytic><series><title level="j">Environmental health perspectives</title><idno type="ISSN">0091-6765</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Agriculture</term><term>California (epidemiology)</term><term>Child</term><term>Child, Preschool</term><term>Environmental Exposure</term><term>Epidemiologic Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Infant, Newborn</term><term>Leukemia (epidemiology)</term><term>Leukemia (etiology)</term><term>Male</term><term>Neoplasms (epidemiology)</term><term>Neoplasms (etiology)</term><term>Pesticides (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>California</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Leukemia</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Leukemia</term><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Agriculture</term><term>Child</term><term>Child, Preschool</term><term>Environmental Exposure</term><term>Epidemiologic Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We analyzed population-based childhood cancer incidence rates throughout California in relation to agricultural pesticide use. During 1988-1994, a total of 7,143 cases of invasive cancer were diagnosed among children under 15 years of age in California. Building on the availability of high-quality population-based cancer incidence information from the California Cancer Registry, population data from the U.S. Census, and uniquely comprehensive agricultural pesticide use information from California's Department of Pesticide Regulation, we used a geographic information system to assign summary population, exposure, and outcome attributes at the block group level. We used Poisson regression to estimate rate ratios (RRs) by pesticide use density adjusted for race/ethnicity, age, and sex for all types of childhood cancer combined and separately for the leukemias and central nervous system cancers. We generally found no association between pesticide use density and childhood cancer incidence rates. The RR for all cancers was 0.95 [95% confidence interval (CI), 0.80-1.13] for block groups in the 90th percentile and above for use of pesticides classified as probable carcinogens, compared to the block groups with use of < 1 lb/mi(2). The RRs were similar for leukemia and central nervous system cancers. Childhood leukemia rates were significantly elevated (RR = 1.48; 95% CI, 1.03-2.13) in block groups with the highest use of propargite, although we saw no dose-response trend with increasing exposure categories. Results were unchanged by further adjustment for socioeconomic status and urbanization.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11882484</PMID><DateCreated><Year>2002</Year><Month>03</Month><Day>07</Day></DateCreated><DateCompleted><Year>2002</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0091-6765</ISSN><JournalIssue CitedMedium="Print"><Volume>110</Volume><Issue>3</Issue><PubDate><Year>2002</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Environmental health perspectives</Title><ISOAbbreviation>Environ. Health Perspect.</ISOAbbreviation></Journal><ArticleTitle>Childhood cancer and agricultural pesticide use: an ecologic study in California.</ArticleTitle><Pagination><MedlinePgn>319-24</MedlinePgn></Pagination><Abstract><AbstractText>We analyzed population-based childhood cancer incidence rates throughout California in relation to agricultural pesticide use. During 1988-1994, a total of 7,143 cases of invasive cancer were diagnosed among children under 15 years of age in California. Building on the availability of high-quality population-based cancer incidence information from the California Cancer Registry, population data from the U.S. Census, and uniquely comprehensive agricultural pesticide use information from California's Department of Pesticide Regulation, we used a geographic information system to assign summary population, exposure, and outcome attributes at the block group level. We used Poisson regression to estimate rate ratios (RRs) by pesticide use density adjusted for race/ethnicity, age, and sex for all types of childhood cancer combined and separately for the leukemias and central nervous system cancers. We generally found no association between pesticide use density and childhood cancer incidence rates. The RR for all cancers was 0.95 [95% confidence interval (CI), 0.80-1.13] for block groups in the 90th percentile and above for use of pesticides classified as probable carcinogens, compared to the block groups with use of < 1 lb/mi(2). The RRs were similar for leukemia and central nervous system cancers. Childhood leukemia rates were significantly elevated (RR = 1.48; 95% CI, 1.03-2.13) in block groups with the highest use of propargite, although we saw no dose-response trend with increasing exposure categories. Results were unchanged by further adjustment for socioeconomic status and urbanization.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>Peggy</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Environmental Health Investigations Branch, California Department of Health Services, 1515 Clay Street, Oakland, CA 94612, USA. preynold@dhs.ca.gov</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Von Behren</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gunier</LastName><ForeName>Robert B</ForeName><Initials>RB</Initials></Author><Author ValidYN="Y"><LastName>Goldberg</LastName><ForeName>Debbie E</ForeName><Initials>DE</Initials></Author><Author ValidYN="Y"><LastName>Hertz</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Harnly</LastName><ForeName>Martha E</ForeName><Initials>ME</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA 71745</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Environ Health Perspect</MedlineTA><NlmUniqueID>0330411</NlmUniqueID><ISSNLinking>0091-6765</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010575">Pesticides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 1998 Jun;106 Suppl 3:893-908</RefSource><PMID 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Version="1">9132896</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 1988 Sep 15;48(18):5358-62</RefSource><PMID Version="1">3409256</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000383" MajorTopicYN="Y">Agriculture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002140" MajorTopicYN="N" Type="Geographic">California</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004781" MajorTopicYN="Y">Environmental Exposure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016021" MajorTopicYN="N">Epidemiologic Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007938" MajorTopicYN="N">Leukemia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName 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