Dopamine transporter genetic variants and pesticides in Parkinson's disease.
Identifieur interne : 000285 ( PubMed/Corpus ); précédent : 000284; suivant : 000286Dopamine transporter genetic variants and pesticides in Parkinson's disease.
Auteurs : Beate R. Ritz ; Angelika D. Manthripragada ; Sadie Costello ; Sarah J. Lincoln ; Matthew J. Farrer ; Myles Cockburn ; Jeff BronsteinSource :
- Environmental health perspectives [ 1552-9924 ] ; 2009.
English descriptors
- KwdEn :
- Case-Control Studies, Dopamine Plasma Membrane Transport Proteins (genetics), Environmental Exposure, Environmental Pollutants (toxicity), Female, Genetic Variation, Genotype, Humans, Male, Maneb (toxicity), Middle Aged, Paraquat (toxicity), Parkinson Disease (genetics), Pesticides (toxicity), Polymorphism, Single Nucleotide (genetics), Risk Factors.
- MESH :
- chemical , genetics : Dopamine Plasma Membrane Transport Proteins.
- chemical , toxicity : Environmental Pollutants, Maneb, Paraquat, Pesticides.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Case-Control Studies, Environmental Exposure, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Risk Factors.
Abstract
Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk.
DOI: 10.1289/ehp.0800277
PubMed: 19590691
Links to Exploration step
pubmed:19590691Le document en format XML
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Manthripragada</name></author><author><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J" last="Lincoln">Sarah J. Lincoln</name></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name></author><author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19590691</idno><idno type="pmid">19590691</idno><idno type="doi">10.1289/ehp.0800277</idno><idno type="wicri:Area/PubMed/Corpus">000285</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000285</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopamine transporter genetic variants and pesticides in Parkinson's disease.</title><author><name sortKey="Ritz, Beate R" sort="Ritz, Beate R" uniqKey="Ritz B" first="Beate R" last="Ritz">Beate R. Ritz</name><affiliation><nlm:affiliation>Department of Epidemiology, Center for Occupational and Environmental Health, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California 90095-1772, USA. britz@ucla.edu</nlm:affiliation></affiliation></author><author><name sortKey="Manthripragada, Angelika D" sort="Manthripragada, Angelika D" uniqKey="Manthripragada A" first="Angelika D" last="Manthripragada">Angelika D. Manthripragada</name></author><author><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J" last="Lincoln">Sarah J. Lincoln</name></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name></author><author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name></author></analytic><series><title level="j">Environmental health perspectives</title><idno type="eISSN">1552-9924</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term><term>Dopamine Plasma Membrane Transport Proteins (genetics)</term><term>Environmental Exposure</term><term>Environmental Pollutants (toxicity)</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Maneb (toxicity)</term><term>Middle Aged</term><term>Paraquat (toxicity)</term><term>Parkinson Disease (genetics)</term><term>Pesticides (toxicity)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Environmental Pollutants</term><term>Maneb</term><term>Paraquat</term><term>Pesticides</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Environmental Exposure</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19590691</PMID><DateCreated><Year>2009</Year><Month>07</Month><Day>10</Day></DateCreated><DateCompleted><Year>2009</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-9924</ISSN><JournalIssue CitedMedium="Internet"><Volume>117</Volume><Issue>6</Issue><PubDate><Year>2009</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Environmental health perspectives</Title><ISOAbbreviation>Environ. Health Perspect.</ISOAbbreviation></Journal><ArticleTitle>Dopamine transporter genetic variants and pesticides in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>964-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1289/ehp.0800277</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk.</AbstractText><AbstractText Label="MATERIALS" NlmCategory="METHODS"></AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In 324 incident PD patients and 334 population controls from our rural California case-control study, we genotyped rs2652510, rs2550956 (for the DAT 5' clades), and the 3' variable number of tandem repeats (VNTR). Using geographic information system methods, we determined residential exposure to agricultural maneb and paraquat applications. We also collected occupational pesticide use data. Employing logistic regression, we calculated odds ratios (ORs) for clade diplotypes, VNTR genotype, and number of susceptibility (A clade and 9-repeat) alleles and assessed susceptibility allele-pesticide interactions.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">PD risk was increased separately in DAT A clade diplotype carriers [AA vs. BB: OR = 1.66; 95% confidence interval (CI), 1.08-2.57] and 3' VNTR 9/9 carriers (9/9 vs. 10/10: OR = 1.8; 95% CI, 0.96-3.57), and our data suggest a gene dosing effect. Importantly, high exposure to paraquat and maneb in carriers of one susceptibility allele increased PD risk 3-fold (OR = 2.99; 95% CI, 0.88-10.2), and in carriers of two or more alleles more than 4-fold (OR = 4.53; 95% CI, 1.70-12.1). We obtained similar results for occupational pesticide measures.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Using two independent pesticide measures, we a) replicated previously reported gene-environment interactions between DAT genetic variants and occupational pesticide exposure in men and b) overcame previous limitations of nonspecific pesticide measures and potential recall bias by employing state records and computer models to estimate residential pesticide exposure.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results suggest that DAT genetic variability and pesticide exposure interact to increase PD risk.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Beate R</ForeName><Initials>BR</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Center for Occupational and Environmental Health, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California 90095-1772, USA. britz@ucla.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manthripragada</LastName><ForeName>Angelika D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Costello</LastName><ForeName>Sadie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lincoln</LastName><ForeName>Sarah J</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Farrer</LastName><ForeName>Matthew J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Cockburn</LastName><ForeName>Myles</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bronstein</LastName><ForeName>Jeff</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>ES10544</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 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MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008344" MajorTopicYN="N">Maneb</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010269" MajorTopicYN="N">Paraquat</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" 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