Parkinson's disease risk from ambient exposure to pesticides.
Identifieur interne : 000231 ( PubMed/Corpus ); précédent : 000230; suivant : 000232Parkinson's disease risk from ambient exposure to pesticides.
Auteurs : Anthony Wang ; Sadie Costello ; Myles Cockburn ; Xinbo Zhang ; Jeff Bronstein ; Beate RitzSource :
- European journal of epidemiology [ 1573-7284 ] ; 2011.
English descriptors
- KwdEn :
- Age Factors, California, Environmental Exposure (adverse effects), Female, Geographic Information Systems, Humans, Male, Maneb (toxicity), Middle Aged, Occupational Exposure (adverse effects), Paraquat (toxicity), Parkinson Disease, Secondary (chemically induced), Pesticides (toxicity), Risk Factors, Smoking, Socioeconomic Factors, Ziram (toxicity).
- MESH :
- chemical , toxicity : Maneb, Paraquat, Pesticides, Ziram.
- geographic : California.
- adverse effects : Environmental Exposure, Occupational Exposure.
- chemically induced : Parkinson Disease, Secondary.
- Age Factors, Female, Geographic Information Systems, Humans, Male, Middle Aged, Risk Factors, Smoking, Socioeconomic Factors.
Abstract
Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson's disease (PD). We focus our investigation on pesticide use in California's heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.
DOI: 10.1007/s10654-011-9574-5
PubMed: 21505849
Links to Exploration step
pubmed:21505849Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease risk from ambient exposure to pesticides.</title>
<author><name sortKey="Wang, Anthony" sort="Wang, Anthony" uniqKey="Wang A" first="Anthony" last="Wang">Anthony Wang</name>
<affiliation><nlm:affiliation>Epidemiology, UCLA School of Public Health, BOX 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA. Anthony.epi@gmail.com</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name>
</author>
<author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name>
</author>
<author><name sortKey="Zhang, Xinbo" sort="Zhang, Xinbo" uniqKey="Zhang X" first="Xinbo" last="Zhang">Xinbo Zhang</name>
</author>
<author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21505849</idno>
<idno type="pmid">21505849</idno>
<idno type="doi">10.1007/s10654-011-9574-5</idno>
<idno type="wicri:Area/PubMed/Corpus">000231</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000231</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson's disease risk from ambient exposure to pesticides.</title>
<author><name sortKey="Wang, Anthony" sort="Wang, Anthony" uniqKey="Wang A" first="Anthony" last="Wang">Anthony Wang</name>
<affiliation><nlm:affiliation>Epidemiology, UCLA School of Public Health, BOX 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA. Anthony.epi@gmail.com</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name>
</author>
<author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name>
</author>
<author><name sortKey="Zhang, Xinbo" sort="Zhang, Xinbo" uniqKey="Zhang X" first="Xinbo" last="Zhang">Xinbo Zhang</name>
</author>
<author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</author>
</analytic>
<series><title level="j">European journal of epidemiology</title>
<idno type="eISSN">1573-7284</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>California</term>
<term>Environmental Exposure (adverse effects)</term>
<term>Female</term>
<term>Geographic Information Systems</term>
<term>Humans</term>
<term>Male</term>
<term>Maneb (toxicity)</term>
<term>Middle Aged</term>
<term>Occupational Exposure (adverse effects)</term>
<term>Paraquat (toxicity)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Pesticides (toxicity)</term>
<term>Risk Factors</term>
<term>Smoking</term>
<term>Socioeconomic Factors</term>
<term>Ziram (toxicity)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Maneb</term>
<term>Paraquat</term>
<term>Pesticides</term>
<term>Ziram</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>California</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term>
<term>Occupational Exposure</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Female</term>
<term>Geographic Information Systems</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk Factors</term>
<term>Smoking</term>
<term>Socioeconomic Factors</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson's disease (PD). We focus our investigation on pesticide use in California's heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21505849</PMID>
<DateCreated><Year>2011</Year>
<Month>07</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>11</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7284</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>7</Issue>
<PubDate><Year>2011</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>European journal of epidemiology</Title>
<ISOAbbreviation>Eur. J. Epidemiol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Parkinson's disease risk from ambient exposure to pesticides.</ArticleTitle>
<Pagination><MedlinePgn>547-55</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s10654-011-9574-5</ELocationID>
<Abstract><AbstractText>Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson's disease (PD). We focus our investigation on pesticide use in California's heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Anthony</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Epidemiology, UCLA School of Public Health, BOX 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA. Anthony.epi@gmail.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Costello</LastName>
<ForeName>Sadie</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cockburn</LastName>
<ForeName>Myles</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xinbo</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bronstein</LastName>
<ForeName>Jeff</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ritz</LastName>
<ForeName>Beate</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>ES10544</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078-03</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 ES007048</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-02</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-07</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 ES016732-03</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-06A1</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 ES016732-02S1</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078-02</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 ES016732-01S1</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-04</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-03</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-01A1</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>NS 038367</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES010544-05</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 ES016732-01</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54ES12078</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50 NS038367</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078-01</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078-05</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078-04</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U54 ES012078-02S1</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 ES016732-02</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>5P30 ES07048</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>04</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Eur J Epidemiol</MedlineTA>
<NlmUniqueID>8508062</NlmUniqueID>
<ISSNLinking>0393-2990</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010575">Pesticides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>12427-38-2</RegistryNumber>
<NameOfSubstance UI="D008344">Maneb</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>73D8UA974J</RegistryNumber>
<NameOfSubstance UI="D015039">Ziram</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>PLG39H7695</RegistryNumber>
<NameOfSubstance UI="D010269">Paraquat</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Toxicology. 2001 Mar 7;160(1-3):27-33</RefSource>
<PMID Version="1">11246121</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2009 Oct;66(4):494-504</RefSource>
<PMID Version="1">19847896</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2002 Jul;10(2):119-27</RefSource>
<PMID Version="1">12127150</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2002 Nov;59(11):1787-92</RefSource>
<PMID Version="1">12433267</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2003 Jan;18(1):19-31</RefSource>
<PMID Version="1">12518297</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2003 Jan;84(2):336-46</RefSource>
<PMID Version="1">12558996</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2003 May;85(4):1075-86</RefSource>
<PMID Version="1">12716439</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2003 Jun 27;976(2):243-52</RefSource>
<PMID Version="1">12763259</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Epidemiology. 2003 Jul;14(4):399-407</RefSource>
<PMID Version="1">12843762</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuroepidemiology. 2003 Sep-Oct;22(5):305-10</RefSource>
<PMID Version="1">12902626</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2003 Oct;111(13):1582-9</RefSource>
<PMID Version="1">14527836</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2004;128(2):281-91</RefSource>
<PMID Version="1">15350641</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Environ Contam Toxicol. 1984 Sep;13(5):551-63</RefSource>
<PMID Version="1">6486883</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1996 May;46(5):1275-84</RefSource>
<PMID Version="1">8628466</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurol Clin. 1996 May;14(2):317-35</RefSource>
<PMID Version="1">8827174</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1997 Jun;48(6):1583-8</RefSource>
<PMID Version="1">9191770</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2004 Dec;10(8):481-5</RefSource>
<PMID Version="1">15542008</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2005 Jan;62(1):91-5</RefSource>
<PMID Version="1">15642854</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 Jun 10;280(23):22530-9</RefSource>
<PMID Version="1">15824117</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2005 Sep;20(9):1133-42</RefSource>
<PMID Version="1">15954133</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2005 Sep;113(9):1263-70</RefSource>
<PMID Version="1">16140639</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2006 Jun;114(6):893-7</RefSource>
<PMID Version="1">16759991</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2006 Sep 15;141(4):2155-65</RefSource>
<PMID Version="1">16797138</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2006 Aug;60(2):197-203</RefSource>
<PMID Version="1">16802290</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Oct;21(10):1688-92</RefSource>
<PMID Version="1">16773614</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropharmacology. 2006 Dec;51(7-8):1109-19</RefSource>
<PMID Version="1">16984802</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2006 Sep;1076:378-87</RefSource>
<PMID Version="1">17119217</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2007 Feb;25(2):392-400</RefSource>
<PMID Version="1">17166727</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2007 Feb 15;165(4):364-74</RefSource>
<PMID Version="1">17116648</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2007 Apr;204(2):619-30</RefSource>
<PMID Version="1">17291500</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Occup Environ Med. 2007 Oct;64(10):666-72</RefSource>
<PMID Version="1">17332139</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Neurol. 2008;8:6</RefSource>
<PMID Version="1">18373838</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Agromedicine. 2008;13(1):37-48</RefSource>
<PMID Version="1">19042691</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2008 Dec 12;283(50):34696-703</RefSource>
<PMID Version="1">18818210</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2009 Apr 15;169(8):919-26</RefSource>
<PMID Version="1">19270050</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Environ Res. 2001 Jun;86(2):122-7</RefSource>
<PMID Version="1">11437458</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002140" MajorTopicYN="N" Type="Geographic">California</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004781" MajorTopicYN="N">Environmental Exposure</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040362" MajorTopicYN="N">Geographic Information Systems</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008344" MajorTopicYN="N">Maneb</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016273" MajorTopicYN="N">Occupational Exposure</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010269" MajorTopicYN="N">Paraquat</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015039" MajorTopicYN="N">Ziram</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS305016</OtherID>
<OtherID Source="NLM">PMC3643971</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year>
<Month>12</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>03</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>4</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>4</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>12</Month>
<Day>13</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">21505849</ArticleId>
<ArticleId IdType="doi">10.1007/s10654-011-9574-5</ArticleId>
<ArticleId IdType="pmc">PMC3643971</ArticleId>
<ArticleId IdType="mid">NIHMS305016</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Agronomie/explor/SisAgriV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000231 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000231 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Agronomie |area= SisAgriV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:21505849 |texte= Parkinson's disease risk from ambient exposure to pesticides. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:21505849" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a SisAgriV1
![]() | This area was generated with Dilib version V0.6.28. | ![]() |