Parkinson's disease risk from ambient exposure to pesticides.
Identifieur interne : 000231 ( PubMed/Corpus ); précédent : 000230; suivant : 000232Parkinson's disease risk from ambient exposure to pesticides.
Auteurs : Anthony Wang ; Sadie Costello ; Myles Cockburn ; Xinbo Zhang ; Jeff Bronstein ; Beate RitzSource :
- European journal of epidemiology [ 1573-7284 ] ; 2011.
English descriptors
- KwdEn :
- Age Factors, California, Environmental Exposure (adverse effects), Female, Geographic Information Systems, Humans, Male, Maneb (toxicity), Middle Aged, Occupational Exposure (adverse effects), Paraquat (toxicity), Parkinson Disease, Secondary (chemically induced), Pesticides (toxicity), Risk Factors, Smoking, Socioeconomic Factors, Ziram (toxicity).
- MESH :
- chemical , toxicity : Maneb, Paraquat, Pesticides, Ziram.
- geographic : California.
- adverse effects : Environmental Exposure, Occupational Exposure.
- chemically induced : Parkinson Disease, Secondary.
- Age Factors, Female, Geographic Information Systems, Humans, Male, Middle Aged, Risk Factors, Smoking, Socioeconomic Factors.
Abstract
Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson's disease (PD). We focus our investigation on pesticide use in California's heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.
DOI: 10.1007/s10654-011-9574-5
PubMed: 21505849
Links to Exploration step
pubmed:21505849Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease risk from ambient exposure to pesticides.</title><author><name sortKey="Wang, Anthony" sort="Wang, Anthony" uniqKey="Wang A" first="Anthony" last="Wang">Anthony Wang</name><affiliation><nlm:affiliation>Epidemiology, UCLA School of Public Health, BOX 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA. Anthony.epi@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name></author><author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name></author><author><name sortKey="Zhang, Xinbo" sort="Zhang, Xinbo" uniqKey="Zhang X" first="Xinbo" last="Zhang">Xinbo Zhang</name></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21505849</idno><idno type="pmid">21505849</idno><idno type="doi">10.1007/s10654-011-9574-5</idno><idno type="wicri:Area/PubMed/Corpus">000231</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000231</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson's disease risk from ambient exposure to pesticides.</title><author><name sortKey="Wang, Anthony" sort="Wang, Anthony" uniqKey="Wang A" first="Anthony" last="Wang">Anthony Wang</name><affiliation><nlm:affiliation>Epidemiology, UCLA School of Public Health, BOX 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA. Anthony.epi@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Costello, Sadie" sort="Costello, Sadie" uniqKey="Costello S" first="Sadie" last="Costello">Sadie Costello</name></author><author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name></author><author><name sortKey="Zhang, Xinbo" sort="Zhang, Xinbo" uniqKey="Zhang X" first="Xinbo" last="Zhang">Xinbo Zhang</name></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name></author></analytic><series><title level="j">European journal of epidemiology</title><idno type="eISSN">1573-7284</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>California</term><term>Environmental Exposure (adverse effects)</term><term>Female</term><term>Geographic Information Systems</term><term>Humans</term><term>Male</term><term>Maneb (toxicity)</term><term>Middle Aged</term><term>Occupational Exposure (adverse effects)</term><term>Paraquat (toxicity)</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Pesticides (toxicity)</term><term>Risk Factors</term><term>Smoking</term><term>Socioeconomic Factors</term><term>Ziram (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Maneb</term><term>Paraquat</term><term>Pesticides</term><term>Ziram</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>California</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Female</term><term>Geographic Information Systems</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Smoking</term><term>Socioeconomic Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson's disease (PD). We focus our investigation on pesticide use in California's heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21505849</PMID><DateCreated><Year>2011</Year><Month>07</Month><Day>26</Day></DateCreated><DateCompleted><Year>2011</Year><Month>11</Month><Day>29</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7284</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>7</Issue><PubDate><Year>2011</Year><Month>Jul</Month></PubDate></JournalIssue><Title>European journal of epidemiology</Title><ISOAbbreviation>Eur. J. Epidemiol.</ISOAbbreviation></Journal><ArticleTitle>Parkinson's disease risk from ambient exposure to pesticides.</ArticleTitle><Pagination><MedlinePgn>547-55</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10654-011-9574-5</ELocationID><Abstract><AbstractText>Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson's disease (PD). We focus our investigation on pesticide use in California's heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Epidemiology, UCLA School of Public Health, BOX 951772, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA. 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HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54ES12078</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS038367</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 ES012078-01</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 ES012078-05</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 ES012078-04</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 ES012078-02S1</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 ES016732-02</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>5P30 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UI="D015039">Ziram</NameOfSubstance></Chemical><Chemical><RegistryNumber>PLG39H7695</RegistryNumber><NameOfSubstance UI="D010269">Paraquat</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Toxicology. 2001 Mar 7;160(1-3):27-33</RefSource><PMID Version="1">11246121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2009 Oct;66(4):494-504</RefSource><PMID Version="1">19847896</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2002 Jul;10(2):119-27</RefSource><PMID Version="1">12127150</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2002 Nov;59(11):1787-92</RefSource><PMID Version="1">12433267</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2003 Jan;18(1):19-31</RefSource><PMID 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Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002140" MajorTopicYN="N" Type="Geographic">California</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004781" MajorTopicYN="N">Environmental Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040362" MajorTopicYN="N">Geographic Information Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008344" MajorTopicYN="N">Maneb</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016273" MajorTopicYN="N">Occupational Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010269" MajorTopicYN="N">Paraquat</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012959" 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