Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.
Identifieur interne : 000199 ( PubMed/Corpus ); précédent : 000198; suivant : 000200Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.
Auteurs : Pei-Chen Lee ; Yvette Bordelon ; Jeff Bronstein ; Beate RitzSource :
- Neurology [ 1526-632X ] ; 2012.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Injuries (epidemiology), Case-Control Studies, Chi-Square Distribution, Environmental Exposure (adverse effects), Female, Humans, Male, Middle Aged, Paraquat (adverse effects), Parkinson Disease (epidemiology), Parkinson Disease (etiology), Pesticides (adverse effects), Risk Factors.
- MESH :
- chemical , adverse effects : Paraquat, Pesticides.
- adverse effects : Environmental Exposure.
- epidemiology : Brain Injuries, Parkinson Disease.
- etiology : Parkinson Disease.
- Aged, Aged, 80 and over, Case-Control Studies, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Risk Factors.
Abstract
Traumatic brain injury (TBI) increased risk of Parkinson disease (PD) in many but not all epidemiologic studies, giving rise to speculations about modifying factors. A recent animal study suggested that the combination of TBI with subthreshold paraquat exposure increases dopaminergic neurodegeneration. The objective of our study was to investigate PD risk due to both TBI and paraquat exposure in humans.
DOI: 10.1212/WNL.0b013e3182749f28
PubMed: 23150532
Links to Exploration step
pubmed:23150532Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.</title><author><name sortKey="Lee, Pei Chen" sort="Lee, Pei Chen" uniqKey="Lee P" first="Pei-Chen" last="Lee">Pei-Chen Lee</name><affiliation><nlm:affiliation>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, CA, USA. pel27@ucla.edu</nlm:affiliation></affiliation></author><author><name sortKey="Bordelon, Yvette" sort="Bordelon, Yvette" uniqKey="Bordelon Y" first="Yvette" last="Bordelon">Yvette Bordelon</name></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23150532</idno><idno type="pmid">23150532</idno><idno type="doi">10.1212/WNL.0b013e3182749f28</idno><idno type="wicri:Area/PubMed/Corpus">000199</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000199</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.</title><author><name sortKey="Lee, Pei Chen" sort="Lee, Pei Chen" uniqKey="Lee P" first="Pei-Chen" last="Lee">Pei-Chen Lee</name><affiliation><nlm:affiliation>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, CA, USA. pel27@ucla.edu</nlm:affiliation></affiliation></author><author><name sortKey="Bordelon, Yvette" sort="Bordelon, Yvette" uniqKey="Bordelon Y" first="Yvette" last="Bordelon">Yvette Bordelon</name></author><author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Injuries (epidemiology)</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Environmental Exposure (adverse effects)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Paraquat (adverse effects)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (etiology)</term><term>Pesticides (adverse effects)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Paraquat</term><term>Pesticides</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Brain Injuries</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Traumatic brain injury (TBI) increased risk of Parkinson disease (PD) in many but not all epidemiologic studies, giving rise to speculations about modifying factors. A recent animal study suggested that the combination of TBI with subthreshold paraquat exposure increases dopaminergic neurodegeneration. The objective of our study was to investigate PD risk due to both TBI and paraquat exposure in humans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23150532</PMID><DateCreated><Year>2012</Year><Month>11</Month><Day>15</Day></DateCreated><DateCompleted><Year>2013</Year><Month>01</Month><Day>16</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><Issue>20</Issue><PubDate><Year>2012</Year><Month>Nov</Month><Day>13</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>2061-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0b013e3182749f28</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Traumatic brain injury (TBI) increased risk of Parkinson disease (PD) in many but not all epidemiologic studies, giving rise to speculations about modifying factors. A recent animal study suggested that the combination of TBI with subthreshold paraquat exposure increases dopaminergic neurodegeneration. The objective of our study was to investigate PD risk due to both TBI and paraquat exposure in humans.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">From 2001 to 2011, we enrolled 357 incident idiopathic PD cases and 754 population controls in central California. Study participants were asked to report all head injuries with loss of consciousness for >5 minutes. Paraquat exposure was assessed via a validated geographic information system (GIS) based on records of pesticide applications to agricultural crops in California since 1974. This GIS tool assesses ambient pesticide exposure within 500 m of residences and workplaces.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In logistic regression analyses, we observed a 2-fold increase in risk of PD for subjects who reported a TBI (adjusted odds ratio [AOR] 2.00, 95% confidence interval [CI] 1.28-3.14) and a weaker association for paraquat exposures (AOR 1.36, 95% CI 1.02-1.81). However, the risk of developing PD was 3-fold higher (AOR 3.01, 95% CI 1.51-6.01) in study participants with a TBI and exposure to paraquat than those exposed to neither risk factor.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">While TBI and paraquat exposure each increase the risk of PD moderately, exposure to both factors almost tripled PD risk. These environmental factors seem to act together to increase PD risk in a more than additive manner.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Pei-Chen</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles, Los Angeles, CA, USA. pel27@ucla.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bordelon</LastName><ForeName>Yvette</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Bronstein</LastName><ForeName>Jeff</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Beate</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 ES007048</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01ES010544</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010544</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50NS038367</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30ES007048</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54ES012078</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010575">Pesticides</NameOfSubstance></Chemical><Chemical><RegistryNumber>PLG39H7695</RegistryNumber><NameOfSubstance UI="D010269">Paraquat</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Brain Res Brain Res Rev. 2005 Apr;48(2):388-99</RefSource><PMID Version="1">15850678</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2006 Sep;1076:378-87</RefSource><PMID Version="1">17119217</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 1999 Dec;58(12):1263-8</RefSource><PMID Version="1">10604751</PMID></CommentsCorrections><CommentsCorrections 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MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004781" MajorTopicYN="N">Environmental Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010269" MajorTopicYN="N">Paraquat</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson 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