Proximity to pollution sources and risk of amphibian limb malformation.
Identifieur interne : 000387 ( PubMed/Checkpoint ); précédent : 000386; suivant : 000388Proximity to pollution sources and risk of amphibian limb malformation.
Auteurs : Brynn Taylor [États-Unis] ; David Skelly ; Livia K. Demarchis ; Martin D. Slade ; Deron Galusha ; Peter M. RabinowitzSource :
- Environmental health perspectives [ 0091-6765 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- geographic : Vermont.
- abnormalities : Anura, Ranidae.
- adverse effects : Water Pollution.
- veterinary : Limb Deformities, Congenital.
- Agriculture, Animals, Environmental Monitoring, Fresh Water, Geographic Information Systems, Regression Analysis.
Abstract
The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.
PubMed: 16263502
Affiliations:
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pubmed:16263502Le document en format XML
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<front><div type="abstract" xml:lang="en">The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.</div>
</front>
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<Abstract><AbstractText>The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.</AbstractText>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2000 Jan;108(1):83-90</RefSource>
<PMID Version="1">10620528</PMID>
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<CommentsCorrections RefType="Cites"><RefSource>Aquat Toxicol. 2005 Jan 26;71(2):109-20</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Teratology. 2000 Sep;62(3):151-71</RefSource>
<PMID Version="1">10935979</PMID>
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<CommentsCorrections RefType="Cites"><RefSource>Toxicol Sci. 2000 Oct;57(2):264-74</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>J Appl Toxicol. 2001 May-Jun;21(3):199-209</RefSource>
<PMID Version="1">11404831</PMID>
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<CommentsCorrections RefType="Cites"><RefSource>Environ Toxicol Chem. 2002 Feb;21(2):353-60</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Environ Sci Technol. 2002 Jul 1;36(13):2853-8</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Sci Am. 2003 Feb;288(2):60-5</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Environ Toxicol Chem. 2003 May;22(5):1127-33</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>J Wildl Dis. 2003 Jul;39(3):522-8</RefSource>
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</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Wildl Dis. 1997 Jan;33(1):95-104</RefSource>
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<name sortKey="Rabinowitz, Peter M" sort="Rabinowitz, Peter M" uniqKey="Rabinowitz P" first="Peter M" last="Rabinowitz">Peter M. Rabinowitz</name>
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