Proximity to pollution sources and risk of amphibian limb malformation.
Identifieur interne : 000387 ( PubMed/Checkpoint ); précédent : 000386; suivant : 000388Proximity to pollution sources and risk of amphibian limb malformation.
Auteurs : Brynn Taylor [États-Unis] ; David Skelly ; Livia K. Demarchis ; Martin D. Slade ; Deron Galusha ; Peter M. RabinowitzSource :
- Environmental health perspectives [ 0091-6765 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- geographic : Vermont.
- abnormalities : Anura, Ranidae.
- adverse effects : Water Pollution.
- veterinary : Limb Deformities, Congenital.
- Agriculture, Animals, Environmental Monitoring, Fresh Water, Geographic Information Systems, Regression Analysis.
Abstract
The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.
PubMed: 16263502
Affiliations:
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Demarchis</name></author><author><name sortKey="Slade, Martin D" sort="Slade, Martin D" uniqKey="Slade M" first="Martin D" last="Slade">Martin D. Slade</name></author><author><name sortKey="Galusha, Deron" sort="Galusha, Deron" uniqKey="Galusha D" first="Deron" last="Galusha">Deron Galusha</name></author><author><name sortKey="Rabinowitz, Peter M" sort="Rabinowitz, Peter M" uniqKey="Rabinowitz P" first="Peter M" last="Rabinowitz">Peter M. 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Demarchis</name></author><author><name sortKey="Slade, Martin D" sort="Slade, Martin D" uniqKey="Slade M" first="Martin D" last="Slade">Martin D. Slade</name></author><author><name sortKey="Galusha, Deron" sort="Galusha, Deron" uniqKey="Galusha D" first="Deron" last="Galusha">Deron Galusha</name></author><author><name sortKey="Rabinowitz, Peter M" sort="Rabinowitz, Peter M" uniqKey="Rabinowitz P" first="Peter M" last="Rabinowitz">Peter M. Rabinowitz</name></author></analytic><series><title level="j">Environmental health perspectives</title><idno type="ISSN">0091-6765</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agriculture</term><term>Animals</term><term>Anura (abnormalities)</term><term>Environmental Monitoring</term><term>Fresh Water</term><term>Geographic Information Systems</term><term>Limb Deformities, Congenital (veterinary)</term><term>Ranidae (abnormalities)</term><term>Regression Analysis</term><term>Vermont</term><term>Water Pollution (adverse effects)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Vermont</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Anura</term><term>Ranidae</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Water Pollution</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Limb Deformities, Congenital</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Agriculture</term><term>Animals</term><term>Environmental Monitoring</term><term>Fresh Water</term><term>Geographic Information Systems</term><term>Regression Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16263502</PMID><DateCreated><Year>2005</Year><Month>11</Month><Day>02</Day></DateCreated><DateCompleted><Year>2006</Year><Month>01</Month><Day>26</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0091-6765</ISSN><JournalIssue CitedMedium="Print"><Volume>113</Volume><Issue>11</Issue><PubDate><Year>2005</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Environmental health perspectives</Title><ISOAbbreviation>Environ. Health Perspect.</ISOAbbreviation></Journal><ArticleTitle>Proximity to pollution sources and risk of amphibian limb malformation.</ArticleTitle><Pagination><MedlinePgn>1497-501</MedlinePgn></Pagination><Abstract><AbstractText>The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Brynn</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skelly</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Demarchis</LastName><ForeName>Livia K</ForeName><Initials>LK</Initials></Author><Author ValidYN="Y"><LastName>Slade</LastName><ForeName>Martin D</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Galusha</LastName><ForeName>Deron</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Rabinowitz</LastName><ForeName>Peter M</ForeName><Initials>PM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 ES011067</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>5R01ES011067</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Environ Health Perspect</MedlineTA><NlmUniqueID>0330411</NlmUniqueID><ISSNLinking>0091-6765</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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RefType="Cites"><RefSource>Teratology. 2000 Sep;62(3):147-50</RefSource><PMID Version="1">10935978</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000383" MajorTopicYN="N">Agriculture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001001" MajorTopicYN="N">Anura</DescriptorName><QualifierName UI="Q000002" MajorTopicYN="Y">abnormalities</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004784" MajorTopicYN="N">Environmental Monitoring</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005618" MajorTopicYN="N">Fresh Water</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040362" MajorTopicYN="N">Geographic Information Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017880" MajorTopicYN="N">Limb Deformities, Congenital</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011898" MajorTopicYN="N">Ranidae</DescriptorName><QualifierName UI="Q000002" MajorTopicYN="Y">abnormalities</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014707" MajorTopicYN="N" Type="Geographic">Vermont</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014876" MajorTopicYN="N">Water Pollution</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1310909</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>11</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>1</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>11</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16263502</ArticleId><ArticleId IdType="pmc">PMC1310909</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><noCountry><name sortKey="Demarchis, Livia K" sort="Demarchis, Livia K" uniqKey="Demarchis L" first="Livia K" last="Demarchis">Livia K. Demarchis</name><name sortKey="Galusha, Deron" sort="Galusha, Deron" uniqKey="Galusha D" first="Deron" last="Galusha">Deron Galusha</name><name sortKey="Rabinowitz, Peter M" sort="Rabinowitz, Peter M" uniqKey="Rabinowitz P" first="Peter M" last="Rabinowitz">Peter M. Rabinowitz</name><name sortKey="Skelly, David" sort="Skelly, David" uniqKey="Skelly D" first="David" last="Skelly">David Skelly</name><name sortKey="Slade, Martin D" sort="Slade, Martin D" uniqKey="Slade M" first="Martin D" last="Slade">Martin D. Slade</name></noCountry><country name="États-Unis"><region name="Connecticut"><name sortKey="Taylor, Brynn" sort="Taylor, Brynn" uniqKey="Taylor B" first="Brynn" last="Taylor">Brynn Taylor</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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