Neural Tube Defects and Maternal Residential Proximity to Agricultural Pesticide Applications
Identifieur interne : 001380 ( Istex/Corpus ); précédent : 001379; suivant : 001381Neural Tube Defects and Maternal Residential Proximity to Agricultural Pesticide Applications
Auteurs : Rudolph P. Rull ; Beate Ritz ; Gary M. ShawSource :
- American Journal of Epidemiology [ 0002-9262 ] ; 2006-04-15.
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- KwdEn :
Abstract
Residential proximity to applications of agricultural pesticides may be an important source of exposure to agents that have been classified as developmental toxins. Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. Maternal residential proximity within 1,000 m of pesticide applications was ascertained by linking mothers' addresses with agricultural pesticide use reports and crop maps. Odds ratios were computed by using conventional single- and multiple-pesticide and hierarchical multiple-pesticide logistic regression. In single-pesticide models, several pesticides were associated with NTDs after adjustment for study population, maternal ethnicity, educational level, cigarette smoking, and vitamin use. In a hierarchical multiple-pesticide model, effect estimates for only benomyl and methomyl suggested a possible association. Elevated risks of NTDs and anencephaly or spina bifida subtypes were also associated with exposures to chemicals classified as amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers of pesticides. These results suggest that ambient exposure to certain categories of agricultural pesticides may increase the risk of NTDs.
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DOI: 10.1093/aje/kwj101
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ISTEX:1A4048FDBC9D759942C6CFBAF613DB6BAB7A30FBLe document en format XML
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Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. Maternal residential proximity within 1,000 m of pesticide applications was ascertained by linking mothers' addresses with agricultural pesticide use reports and crop maps. Odds ratios were computed by using conventional single- and multiple-pesticide and hierarchical multiple-pesticide logistic regression. In single-pesticide models, several pesticides were associated with NTDs after adjustment for study population, maternal ethnicity, educational level, cigarette smoking, and vitamin use. In a hierarchical multiple-pesticide model, effect estimates for only benomyl and methomyl suggested a possible association. Elevated risks of NTDs and anencephaly or spina bifida subtypes were also associated with exposures to chemicals classified as amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers of pesticides. These results suggest that ambient exposure to certain categories of agricultural pesticides may increase the risk of NTDs.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Rudolph P. 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Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. Maternal residential proximity within 1,000 m of pesticide applications was ascertained by linking mothers' addresses with agricultural pesticide use reports and crop maps. Odds ratios were computed by using conventional single- and multiple-pesticide and hierarchical multiple-pesticide logistic regression. In single-pesticide models, several pesticides were associated with NTDs after adjustment for study population, maternal ethnicity, educational level, cigarette smoking, and vitamin use. In a hierarchical multiple-pesticide model, effect estimates for only benomyl and methomyl suggested a possible association. Elevated risks of NTDs and anencephaly or spina bifida subtypes were also associated with exposures to chemicals classified as amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers of pesticides. 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J. Epidemiol.</title><idno type="pISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-04-15"></date><biblScope unit="volume">163</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="743">743</biblScope><biblScope unit="page" to="753">753</biblScope></imprint></monogr><idno type="istex">1A4048FDBC9D759942C6CFBAF613DB6BAB7A30FB</idno><idno type="DOI">10.1093/aje/kwj101</idno><idno type="local">kwj101</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006-02-22</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Residential proximity to applications of agricultural pesticides may be an important source of exposure to agents that have been classified as developmental toxins. Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. Maternal residential proximity within 1,000 m of pesticide applications was ascertained by linking mothers' addresses with agricultural pesticide use reports and crop maps. Odds ratios were computed by using conventional single- and multiple-pesticide and hierarchical multiple-pesticide logistic regression. In single-pesticide models, several pesticides were associated with NTDs after adjustment for study population, maternal ethnicity, educational level, cigarette smoking, and vitamin use. In a hierarchical multiple-pesticide model, effect estimates for only benomyl and methomyl suggested a possible association. Elevated risks of NTDs and anencephaly or spina bifida subtypes were also associated with exposures to chemicals classified as amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers of pesticides. These results suggest that ambient exposure to certain categories of agricultural pesticides may increase the risk of NTDs.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>KWD</head><item><term>anencephaly</term></item><item><term>crops, agricultural</term></item><item><term>environmental exposure</term></item><item><term>geographic information systems</term></item><item><term>neural tube defects</term></item><item><term>maternal exposure</term></item><item><term>pesticides</term></item><item><term>spina dysraphism</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>ABR</head><item><term>CI, confidence interval</term></item><item><term>NTD, neural tube defect</term></item><item><term>OR, odds ratio</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-02-22">Created</change><change when="2006-04-15">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/1A4048FDBC9D759942C6CFBAF613DB6BAB7A30FB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="other"><front><journal-meta><journal-id journal-id-type="hwp">amjepid</journal-id><journal-id journal-id-type="nlm-ta">Am J Epidemiol</journal-id><journal-id journal-id-type="publisher-id">aje</journal-id><journal-title>American Journal of Epidemiology</journal-title><abbrev-journal-title abbrev-type="publisher">Am. J. Epidemiol.</abbrev-journal-title><issn pub-type="ppub">0002-9262</issn><issn pub-type="epub">1476-6256</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">kwj101</article-id><article-id pub-id-type="doi">10.1093/aje/kwj101</article-id><article-categories><subj-group subj-group-type="heading"><subject>ORIGINAL CONTRIBUTIONS</subject></subj-group></article-categories><title-group><article-title>Neural Tube Defects and Maternal Residential Proximity to Agricultural Pesticide Applications</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rull</surname><given-names>Rudolph P.</given-names></name><xref rid="AFF1"><sup>1</sup></xref><xref rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ritz</surname><given-names>Beate</given-names></name><xref rid="AFF2"><sup>2</sup></xref><xref rid="AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shaw</surname><given-names>Gary M.</given-names></name><xref rid="AFF4"><sup>4</sup></xref></contrib><aff id="AFF1"><label>1</label>Northern California Cancer Center, Berkeley, CA</aff><aff id="AFF2"><label>2</label>Department of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, CA</aff><aff id="AFF3"><label>3</label>Department of Environmental Health Sciences, School of Public Health, University of California at Los Angeles, Los Angeles, CA</aff><aff id="AFF4"><label>4</label>California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Berkeley, CA</aff></contrib-group><author-notes><corresp>Correspondence to Dr. Rudolph P. Rull, Northern California Cancer Center, 2001 Center Street, 7th Floor, Berkeley, CA 94704-1204 (e-mail: <ext-link xlink:href="rrull@nccc.org" ext-link-type="email">rrull@nccc.org</ext-link>).</corresp></author-notes><pub-date pub-type="epub"><day>22</day><month>2</month><year>2006</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>April</month><year>2006</year></pub-date><volume>163</volume><issue>8</issue><fpage>743</fpage><lpage>753</lpage><history><date date-type="accepted"><day>8</day><month>12</month><year>2005</year></date><date date-type="received"><day>27</day><month>8</month><year>2005</year></date></history><permissions><copyright-statement>American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.</copyright-statement><copyright-year>2006</copyright-year></permissions><abstract xml:lang="en"><p>Residential proximity to applications of agricultural pesticides may be an important source of exposure to agents that have been classified as developmental toxins. Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. Maternal residential proximity within 1,000 m of pesticide applications was ascertained by linking mothers' addresses with agricultural pesticide use reports and crop maps. Odds ratios were computed by using conventional single- and multiple-pesticide and hierarchical multiple-pesticide logistic regression. In single-pesticide models, several pesticides were associated with NTDs after adjustment for study population, maternal ethnicity, educational level, cigarette smoking, and vitamin use. In a hierarchical multiple-pesticide model, effect estimates for only benomyl and methomyl suggested a possible association. Elevated risks of NTDs and anencephaly or spina bifida subtypes were also associated with exposures to chemicals classified as amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers of pesticides. These results suggest that ambient exposure to certain categories of agricultural pesticides may increase the risk of NTDs.</p></abstract><kwd-group kwd-group-type="KWD" xml:lang="en"><kwd>anencephaly</kwd><kwd>crops, agricultural</kwd><kwd>environmental exposure</kwd><kwd>geographic information systems</kwd><kwd>neural tube defects</kwd><kwd>maternal exposure</kwd><kwd>pesticides</kwd><kwd>spina dysraphism</kwd></kwd-group><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>CI, confidence interval</kwd><kwd>NTD, neural tube defect</kwd><kwd>OR, odds ratio</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>743</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>15 April 2006</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Original Contribution</meta-value></custom-meta></custom-meta-wrap></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Neural Tube Defects and Maternal Residential Proximity to Agricultural Pesticide Applications</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Neural Tube Defects and Maternal Residential Proximity to Agricultural Pesticide Applications</title></titleInfo><name type="personal"><namePart type="given">Rudolph P.</namePart><namePart type="family">Rull</namePart><affiliation>Northern California Cancer Center, Berkeley, CA</affiliation><affiliation>Department of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, CA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Beate</namePart><namePart type="family">Ritz</namePart><affiliation>Department of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, CA</affiliation><affiliation>Department of Environmental Health Sciences, School of Public Health, University of California at Los Angeles, Los Angeles, CA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gary M.</namePart><namePart type="family">Shaw</namePart><affiliation>California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Berkeley, CA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="other" displayLabel="other"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2006-04-15</dateIssued><dateCreated encoding="w3cdtf">2006-02-22</dateCreated><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Residential proximity to applications of agricultural pesticides may be an important source of exposure to agents that have been classified as developmental toxins. Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. Maternal residential proximity within 1,000 m of pesticide applications was ascertained by linking mothers' addresses with agricultural pesticide use reports and crop maps. Odds ratios were computed by using conventional single- and multiple-pesticide and hierarchical multiple-pesticide logistic regression. In single-pesticide models, several pesticides were associated with NTDs after adjustment for study population, maternal ethnicity, educational level, cigarette smoking, and vitamin use. In a hierarchical multiple-pesticide model, effect estimates for only benomyl and methomyl suggested a possible association. Elevated risks of NTDs and anencephaly or spina bifida subtypes were also associated with exposures to chemicals classified as amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers of pesticides. These results suggest that ambient exposure to certain categories of agricultural pesticides may increase the risk of NTDs.</abstract><note type="author-notes">Correspondence to Dr. Rudolph P. Rull, Northern California Cancer Center, 2001 Center Street, 7th Floor, Berkeley, CA 94704-1204 (e-mail: rrull@nccc.org).</note><subject lang="en"><genre>KWD</genre><topic>anencephaly</topic><topic>crops, agricultural</topic><topic>environmental exposure</topic><topic>geographic information systems</topic><topic>neural tube defects</topic><topic>maternal exposure</topic><topic>pesticides</topic><topic>spina dysraphism</topic></subject><subject lang="en"><genre>ABR</genre><topic>CI, confidence interval</topic><topic>NTD, neural tube defect</topic><topic>OR, odds ratio</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Epidemiology</title></titleInfo><titleInfo type="abbreviated"><title>Am. J. Epidemiol.</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0002-9262</identifier><identifier type="eISSN">1476-6256</identifier><identifier type="PublisherID">aje</identifier><identifier type="PublisherID-hwp">amjepid</identifier><identifier type="PublisherID-nlm-ta">Am J Epidemiol</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>743</start><end>753</end></extent></part></relatedItem><identifier type="istex">1A4048FDBC9D759942C6CFBAF613DB6BAB7A30FB</identifier><identifier type="DOI">10.1093/aje/kwj101</identifier><identifier type="local">kwj101</identifier><accessCondition type="use and reproduction" contentType="copyright">American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/1A4048FDBC9D759942C6CFBAF613DB6BAB7A30FB/covers/tiff</uri></json:item></covers><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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