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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.</title><author><name sortKey="Saiki, I" sort="Saiki, I" uniqKey="Saiki I" first="I." last="Saiki">I. Saiki</name></author><author><name sortKey="Murata, J" sort="Murata, J" uniqKey="Murata J" first="J." last="Murata">J. Murata</name></author><author><name sortKey="Iida, J" sort="Iida, J" uniqKey="Iida J" first="J." last="Iida">J. Iida</name></author><author><name sortKey="Sakurai, T" sort="Sakurai, T" uniqKey="Sakurai T" first="T." last="Sakurai">T. Sakurai</name></author><author><name sortKey="Nishi, N" sort="Nishi, N" uniqKey="Nishi N" first="N." last="Nishi">N. Nishi</name></author><author><name sortKey="Matsuno, K" sort="Matsuno, K" uniqKey="Matsuno K" first="K." last="Matsuno">K. Matsuno</name></author><author><name sortKey="Azuma, I" sort="Azuma, I" uniqKey="Azuma I" first="I." last="Azuma">I. Azuma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2803948</idno><idno type="pmc">2247318</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247318</idno><idno type="RBID">PMC:2247318</idno><date when="1989">1989</date><idno type="wicri:Area/Pmc/Corpus">000134</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.</title><author><name sortKey="Saiki, I" sort="Saiki, I" uniqKey="Saiki I" first="I." last="Saiki">I. Saiki</name></author><author><name sortKey="Murata, J" sort="Murata, J" uniqKey="Murata J" first="J." last="Murata">J. Murata</name></author><author><name sortKey="Iida, J" sort="Iida, J" uniqKey="Iida J" first="J." last="Iida">J. Iida</name></author><author><name sortKey="Sakurai, T" sort="Sakurai, T" uniqKey="Sakurai T" first="T." last="Sakurai">T. Sakurai</name></author><author><name sortKey="Nishi, N" sort="Nishi, N" uniqKey="Nishi N" first="N." last="Nishi">N. Nishi</name></author><author><name sortKey="Matsuno, K" sort="Matsuno, K" uniqKey="Matsuno K" first="K." last="Matsuno">K. Matsuno</name></author><author><name sortKey="Azuma, I" sort="Azuma, I" uniqKey="Azuma I" first="I." last="Azuma">I. Azuma</name></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have investigated the inhibitory effect on experimental or spontaneous lung metastases of polypeptides which contain repetitive structures of the Arg-Gly-Asp (RGD) or Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence derived from adhesion molecules, and studied their biological characterisation after administration. In the spontaneous metastasis model, multiple intravenous (i.v.) administrations of poly (RGD) and poly (YIGSR) resulted in a reduction of lung tumour colonies, although the monomer peptides, RGD or YIGSR, had no effect under these conditions. The treatment with poly(RGD) substantially prolonged the survival time for mice injected i.v. with B16-BL6 cells as compared to the treatment with RGD and random poly(R, G, D). Tumour cell adhesion to the fibronectin-substrates was remarkably inhibited by adding poly(RGD) freely in solution. Poly(RGD) was found to inhibit completely the ability of platelets to enhance tumour cell adhesion to fibronectin-substrate and tumour cell-elicited platelet aggregation in vitro, but poly(R, G, D) had no such effect. We also found that poly(RGD) led to a decrease in the arrest and retention of tumour cells after its co-injection with radiolabelled tumour cells and that the radiolabelled polypeptide can be at least decomposed into small fragments during circulation. Poly(RGD) was found to be still active in inhibiting experimental lung metastasis even when the contributions of NK cells or macrophages were removed from this system after pretreatment with anti-asialo GM1 serum, 2-chloroadenosine or carrageenan. The results indicate that the poly(RGD)-mediated inhibition of tumour metastasis may be due to the interference of the adhesive interaction of tumour cells with a specific site in the target organs. Derivatives of polypeptides which contain RGD and/or YIGSR sequences derived from cell adhesion proteins may thus provide a promising approach for the control and prevention of cancer metastasis.</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-id journal-id-type="pmc">brjcancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">2803948</article-id><article-id pub-id-type="pmc">2247318</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Saiki</surname><given-names>I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Murata</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Iida</surname><given-names>J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sakurai</surname><given-names>T.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nishi</surname><given-names>N.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Matsuno</surname><given-names>K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Azuma</surname><given-names>I.</given-names></name></contrib></contrib-group><aff>Institute of Immunological Science, Faculty of Science, Hokkaido University, Sapporo, Japan.</aff><pub-date pub-type="ppub"><month>11</month><year>1989</year></pub-date><volume>60</volume><issue>5</issue><fpage>722</fpage><lpage>728</lpage><abstract><p>We have investigated the inhibitory effect on experimental or spontaneous lung metastases of polypeptides which contain repetitive structures of the Arg-Gly-Asp (RGD) or Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence derived from adhesion molecules, and studied their biological characterisation after administration. In the spontaneous metastasis model, multiple intravenous (i.v.) administrations of poly (RGD) and poly (YIGSR) resulted in a reduction of lung tumour colonies, although the monomer peptides, RGD or YIGSR, had no effect under these conditions. The treatment with poly(RGD) substantially prolonged the survival time for mice injected i.v. with B16-BL6 cells as compared to the treatment with RGD and random poly(R, G, D). Tumour cell adhesion to the fibronectin-substrates was remarkably inhibited by adding poly(RGD) freely in solution. Poly(RGD) was found to inhibit completely the ability of platelets to enhance tumour cell adhesion to fibronectin-substrate and tumour cell-elicited platelet aggregation in vitro, but poly(R, G, D) had no such effect. We also found that poly(RGD) led to a decrease in the arrest and retention of tumour cells after its co-injection with radiolabelled tumour cells and that the radiolabelled polypeptide can be at least decomposed into small fragments during circulation. Poly(RGD) was found to be still active in inhibiting experimental lung metastasis even when the contributions of NK cells or macrophages were removed from this system after pretreatment with anti-asialo GM1 serum, 2-chloroadenosine or carrageenan. The results indicate that the poly(RGD)-mediated inhibition of tumour metastasis may be due to the interference of the adhesive interaction of tumour cells with a specific site in the target organs. Derivatives of polypeptides which contain RGD and/or YIGSR sequences derived from cell adhesion proteins may thus provide a promising approach for the control and prevention of cancer metastasis.</p></abstract></article-meta></front><body><supplementary-material content-type="scanned-pages"><graphic xlink:href="brjcancer00121-0076.tif" xlink:title="scanned-page" xlink:role="722" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00121-0077.tif" xlink:title="scanned-page" xlink:role="723" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00121-0078.tif" xlink:title="scanned-page" xlink:role="724" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00121-0079.tif" xlink:title="scanned-page" xlink:role="725" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00121-0080.tif" xlink:title="scanned-page" xlink:role="726" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00121-0081.tif" xlink:title="scanned-page" xlink:role="727" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00121-0082.tif" xlink:title="scanned-page" xlink:role="728" mimetype="image" mime-subtype="tiff"></graphic></supplementary-material></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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