LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
Identifieur interne : 002878 ( Main/Exploration ); précédent : 002877; suivant : 002879LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
Auteurs : C. R. W. Edwards [Royaume-Uni] ; D. Burt [Royaume-Uni] ; M. A. Mcintyre [Royaume-Uni] ; E. R. De Kloet [Pays-Bas] ; P. M. Stewart [Royaume-Uni] ; L. Brett [Royaume-Uni] ; W. S. Sutanto [Pays-Bas] ; C. Monder [États-Unis]Source :
- The Lancet [ 0140-6736 ] ; 1988.
Abstract
In vitro the mineralocorticoid receptor is non-specific and does not distinguish between aldosterone and cortisol. In vivo certain tissues with this receptor are aldosterone selective (eg, kidney and parotid) whereas others with the same receptor are not (eg, hippocampus and heart). Experiments in rats showed that 11β-hydroxysteroid dehydrogenase (which converts cortisol to cortisone in man and corticosterone to 11-dehydrocorticosterone in the rat) was much more highly concentrated in aldosterone-selective tissues than in non-selective tissues. The localisation in the selective tissues was such that the enzyme could act as a paracrine or possibly an autocrine mechanism protecting the receptor from exposure to corticosterone. Autoradiographic studies showed that protection is lost when the enzyme is inhibited; 3H-corticosterone and 3H-aldosterone were bound to similar sites. These findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11β-OHSD and those in whom the enzyme has been inhibited by liquorice.
Url:
DOI: 10.1016/S0140-6736(88)90742-8
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002812
- to stream Istex, to step Curation: 002812
- to stream Istex, to step Checkpoint: 002620
- to stream Main, to step Merge: 002915
- to stream Main, to step Curation: 002878
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR</title><author><name sortKey="Edwards, C R W" sort="Edwards, C R W" uniqKey="Edwards C" first="C. R. W." last="Edwards">C. R. W. Edwards</name></author><author><name sortKey="Burt, D" sort="Burt, D" uniqKey="Burt D" first="D." last="Burt">D. Burt</name></author><author><name sortKey="Mcintyre, M A" sort="Mcintyre, M A" uniqKey="Mcintyre M" first="M. A." last="Mcintyre">M. A. Mcintyre</name></author><author><name sortKey="De Kloet, E R" sort="De Kloet, E R" uniqKey="De Kloet E" first="E. R." last="De Kloet">E. R. De Kloet</name></author><author><name sortKey="Stewart, P M" sort="Stewart, P M" uniqKey="Stewart P" first="P. M." last="Stewart">P. M. Stewart</name></author><author><name sortKey="Brett, L" sort="Brett, L" uniqKey="Brett L" first="L." last="Brett">L. Brett</name></author><author><name sortKey="Sutanto, W S" sort="Sutanto, W S" uniqKey="Sutanto W" first="W. S." last="Sutanto">W. S. Sutanto</name></author><author><name sortKey="Monder, C" sort="Monder, C" uniqKey="Monder C" first="C." last="Monder">C. Monder</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A151C90D4994033ED57D24D6F34D76D507D33FEB</idno><date when="1988" year="1988">1988</date><idno type="doi">10.1016/S0140-6736(88)90742-8</idno><idno type="url">https://api.istex.fr/document/A151C90D4994033ED57D24D6F34D76D507D33FEB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002812</idno><idno type="wicri:Area/Istex/Curation">002812</idno><idno type="wicri:Area/Istex/Checkpoint">002620</idno><idno type="wicri:doubleKey">0140-6736:1988:Edwards C:localisation:of:hydroxysteroid</idno><idno type="wicri:Area/Main/Merge">002915</idno><idno type="wicri:Area/Main/Curation">002878</idno><idno type="wicri:Area/Main/Exploration">002878</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR</title><author><name sortKey="Edwards, C R W" sort="Edwards, C R W" uniqKey="Edwards C" first="C. R. W." last="Edwards">C. R. W. Edwards</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Medicine and Pathology, Western General Hospital, Edinburgh EH4 2XU;</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU;</wicri:noRegion></affiliation></author><author><name sortKey="Burt, D" sort="Burt, D" uniqKey="Burt D" first="D." last="Burt">D. Burt</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Medicine and Pathology, Western General Hospital, Edinburgh EH4 2XU;</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU;</wicri:noRegion></affiliation></author><author><name sortKey="Mcintyre, M A" sort="Mcintyre, M A" uniqKey="Mcintyre M" first="M. A." last="Mcintyre">M. A. Mcintyre</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Medicine and Pathology, Western General Hospital, Edinburgh EH4 2XU;</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU;</wicri:noRegion></affiliation></author><author><name sortKey="De Kloet, E R" sort="De Kloet, E R" uniqKey="De Kloet E" first="E. R." last="De Kloet">E. R. De Kloet</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Rudolf Magnus Institute, Utrecht;</wicri:regionArea><wicri:noRegion>Utrecht;</wicri:noRegion></affiliation></author><author><name sortKey="Stewart, P M" sort="Stewart, P M" uniqKey="Stewart P" first="P. M." last="Stewart">P. M. Stewart</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Medicine and Pathology, Western General Hospital, Edinburgh EH4 2XU;</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU;</wicri:noRegion></affiliation></author><author><name sortKey="Brett, L" sort="Brett, L" uniqKey="Brett L" first="L." last="Brett">L. Brett</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Medicine and Pathology, Western General Hospital, Edinburgh EH4 2XU;</wicri:regionArea><wicri:noRegion>Edinburgh EH4 2XU;</wicri:noRegion></affiliation></author><author><name sortKey="Sutanto, W S" sort="Sutanto, W S" uniqKey="Sutanto W" first="W. S." last="Sutanto">W. S. Sutanto</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Rudolf Magnus Institute, Utrecht;</wicri:regionArea><wicri:noRegion>Utrecht;</wicri:noRegion></affiliation></author><author><name sortKey="Monder, C" sort="Monder, C" uniqKey="Monder C" first="C." last="Monder">C. Monder</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Population Council, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">332</biblScope><biblScope unit="issue">8618</biblScope><biblScope unit="page" from="986">986</biblScope><biblScope unit="page" to="989">989</biblScope></imprint><idno type="ISSN">0140-6736</idno></series><idno type="istex">A151C90D4994033ED57D24D6F34D76D507D33FEB</idno><idno type="DOI">10.1016/S0140-6736(88)90742-8</idno><idno type="PII">S0140-6736(88)90742-8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vitro the mineralocorticoid receptor is non-specific and does not distinguish between aldosterone and cortisol. In vivo certain tissues with this receptor are aldosterone selective (eg, kidney and parotid) whereas others with the same receptor are not (eg, hippocampus and heart). Experiments in rats showed that 11β-hydroxysteroid dehydrogenase (which converts cortisol to cortisone in man and corticosterone to 11-dehydrocorticosterone in the rat) was much more highly concentrated in aldosterone-selective tissues than in non-selective tissues. The localisation in the selective tissues was such that the enzyme could act as a paracrine or possibly an autocrine mechanism protecting the receptor from exposure to corticosterone. Autoradiographic studies showed that protection is lost when the enzyme is inhibited; 3H-corticosterone and 3H-aldosterone were bound to similar sites. These findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11β-OHSD and those in whom the enzyme has been inhibited by liquorice.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Edwards, C R W" sort="Edwards, C R W" uniqKey="Edwards C" first="C. R. W." last="Edwards">C. R. W. Edwards</name></noRegion><name sortKey="Brett, L" sort="Brett, L" uniqKey="Brett L" first="L." last="Brett">L. Brett</name><name sortKey="Burt, D" sort="Burt, D" uniqKey="Burt D" first="D." last="Burt">D. Burt</name><name sortKey="Mcintyre, M A" sort="Mcintyre, M A" uniqKey="Mcintyre M" first="M. A." last="Mcintyre">M. A. Mcintyre</name><name sortKey="Stewart, P M" sort="Stewart, P M" uniqKey="Stewart P" first="P. M." last="Stewart">P. M. Stewart</name></country><country name="Pays-Bas"><noRegion><name sortKey="De Kloet, E R" sort="De Kloet, E R" uniqKey="De Kloet E" first="E. R." last="De Kloet">E. R. De Kloet</name></noRegion><name sortKey="Sutanto, W S" sort="Sutanto, W S" uniqKey="Sutanto W" first="W. S." last="Sutanto">W. S. Sutanto</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Monder, C" sort="Monder, C" uniqKey="Monder C" first="C." last="Monder">C. Monder</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002878 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002878 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Informatique
|area= ScrumV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A151C90D4994033ED57D24D6F34D76D507D33FEB
|texte= LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
}}
| This area was generated with Dilib version V0.6.39. |  |