Specificities of human heterophilic Hanganutziu and Deicher (H-D) antibodies and avian antisera against H-D antigen-active glycosphingolipids
Identifieur interne : 003583 ( Main/Exploration ); précédent : 003582; suivant : 003584Specificities of human heterophilic Hanganutziu and Deicher (H-D) antibodies and avian antisera against H-D antigen-active glycosphingolipids
Auteurs : Y. Fujii [Japon] ; H. Higashi [Japon] ; K. Ikuta [Japon] ; S. Kato [Japon] ; M. Naiki [Japon]Source :
- Molecular Immunology [ 0161-5890 ] ; 1981.
Abstract
The precise specificities of human H-D antibodies and newly obtained avian antisera to the H-D antigen-active glycosphingolipids, N-glycolylneuraminyl(α2–3)lactosyl ceramide (hematoside) and N-glycolylneuraminyl(α2–3)lactoneotetraosyl ceramide (sialosylparagloboside) were compared by gel precipitation and hemagglutination inhibition using other gangliosides with a related structure and chemically modified hematoside derivatives and the oligosaccharides from both the antigenic glycosphingolipids. Human H-D antibodies were found to have the same affinity for both antigenic glycosphingolipids; however, the avian anti-hematoside or anti-sialosylparaglobosides showed a higher affinity for the homologous antigen. Human H-D antibodies were directed more exactly toward the terminal sialic acid residue and more roughly to the hydrophobic portion of both compounds; however, the two avian antibodies were directed more specifically to the whole structure of the homologous antigen glycosphingolipid.
Url:
DOI: 10.1016/0161-5890(82)90250-4
Affiliations:
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Human H-D antibodies were found to have the same affinity for both antigenic glycosphingolipids; however, the avian anti-hematoside or anti-sialosylparaglobosides showed a higher affinity for the homologous antigen. Human H-D antibodies were directed more exactly toward the terminal sialic acid residue and more roughly to the hydrophobic portion of both compounds; however, the two avian antibodies were directed more specifically to the whole structure of the homologous antigen glycosphingolipid.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Fujii, Y" sort="Fujii, Y" uniqKey="Fujii Y" first="Y." last="Fujii">Y. Fujii</name></noRegion><name sortKey="Higashi, H" sort="Higashi, H" uniqKey="Higashi H" first="H." last="Higashi">H. Higashi</name><name sortKey="Ikuta, K" sort="Ikuta, K" uniqKey="Ikuta K" first="K." last="Ikuta">K. Ikuta</name><name sortKey="Kato, S" sort="Kato, S" uniqKey="Kato S" first="S." last="Kato">S. Kato</name><name sortKey="Naiki, M" sort="Naiki, M" uniqKey="Naiki M" first="M." last="Naiki">M. Naiki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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