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“Tertiary” hyperparathyroidism induced by osteomalacia resulting from phosphorus depletion

Identifieur interne : 004F99 ( Main/Exploration ); précédent : 004F98; suivant : 005000

“Tertiary” hyperparathyroidism induced by osteomalacia resulting from phosphorus depletion

Auteurs : George D. Ludwig [États-Unis] ; G. Clayton Kyle [États-Unis] ; M. De Blanco [États-Unis]

Source :

RBID : ISTEX:FCC5257E38C7CE80FA7BDF3A15CFE53C036D3B2E

Abstract

In the patient described clinical and chemical signs of osteomalacia developed as a result of phosphorus depletion caused by ingestion of excessive amounts of aluminum hydroxide. Symptoms disappeared and serum calcium and phosphorus levels were restored to normal by discontinuing these medications. Four years later hyperparathyroidism due to an autonomously functioning adenoma (“tertiary” hyperparathyroidism) developed. It is postulated that osteomalacia, with low serum calcium and phosphate concentrations, served as the stimulus for the development of secondary parathyroid hyperplasia and, in turn, to an autonomously functioning parathyroid adenoma.

Url:
DOI: 10.1016/0002-9343(67)90155-6


Affiliations:


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