Characterization of adherent T cells to human endothelial cells in patients with HTLV-I-associated myelopathy
Identifieur interne : 001929 ( Istex/Curation ); précédent : 001928; suivant : 001930Characterization of adherent T cells to human endothelial cells in patients with HTLV-I-associated myelopathy
Auteurs : Katsuhiro Ichinose [Japon] ; Tatsufumi Nakamura [Japon] ; Yoshihiro Nishiura [Japon] ; Kunihiko Nagasato [Japon] ; Kiyosumi Ohishi [Japon] ; Hiroko Watanabe [Japon] ; Akira Fujita [Japon] ; Ken-Ichi Kurouji [Japon] ; Mitsuhiro Tsujihata [Japon] ; Shigenobu Nagataki [Japon]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1993.
Abstract
To clarify the phenomenon of increased adherence of T cells to endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM), we determined the surface markers and expression of lymphocyte function antigen-1 (LFA-1) in T cells adherent or nonadherent to EC. The percentage of activated or HLA-DR+ T cells and the expression of LFA-1 in the adherent cell population were significantly higher than those in the nonadherent cell population. Moreover, the CD4 to CD8 ratio of the HLA-DR+ cells in the EC-adherent T cells was significantly higher than that in the nonadherent cells. Collectively, these results indicate that increased adherence of T cells to EC in HAM patients is based on the increase of activated T cells with high density LFA-1 expression in the peripheral blood. Moreover, CD4+ HLA-DR+ cells exhibited more adhesive activity to EC than CD8+ HLA-DR+ cells, suggesting that activated CD4+ cells, rather than activated CD8+ cells, may be important as the first trigger for T cell-infiltration to the central nervous system in the immunopathogenesis of HAM.
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DOI: 10.1016/0022-510X(94)90299-2
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Shigenobu Nagataki<affiliation><mods:affiliation>Corresponding author. Tel.: 81-958-47-2111, ext. 2800; Fax: 81-958-43-0255.</mods:affiliation><wicri:noCountry code="subField">255.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation>Le document en format XML
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Tel.: 81-958-47-2111, ext. 2800; Fax: 81-958-43-0255.</mods:affiliation><wicri:noCountry code="subField">255.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:81E6945445416C1C10BD95A60BF665B0C6756451</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0022-510X(94)90299-2</idno><idno type="url">https://api.istex.fr/document/81E6945445416C1C10BD95A60BF665B0C6756451/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001929</idno><idno 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Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author><author><name sortKey="Nishiura, Yoshihiro" sort="Nishiura, Yoshihiro" uniqKey="Nishiura Y" first="Yoshihiro" last="Nishiura">Yoshihiro Nishiura</name><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author><author><name sortKey="Nagasato, Kunihiko" sort="Nagasato, Kunihiko" uniqKey="Nagasato K" first="Kunihiko" last="Nagasato">Kunihiko Nagasato</name><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author><author><name sortKey="Ohishi, Kiyosumi" sort="Ohishi, Kiyosumi" uniqKey="Ohishi K" first="Kiyosumi" last="Ohishi">Kiyosumi Ohishi</name><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author><author><name sortKey="Watanabe, Hiroko" sort="Watanabe, Hiroko" uniqKey="Watanabe H" first="Hiroko" last="Watanabe">Hiroko Watanabe</name><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author><author><name sortKey="Fujita, Akira" sort="Fujita, Akira" uniqKey="Fujita A" first="Akira" last="Fujita">Akira Fujita</name><affiliation wicri:level="1"><mods:affiliation>Nagasaki Atomic Bomb Hospital, Japan Red Cross, Nagasaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagasaki Atomic Bomb Hospital, Japan Red Cross, Nagasaki</wicri:regionArea></affiliation></author><author><name sortKey="Kurouji, Ken Ichi" sort="Kurouji, Ken Ichi" uniqKey="Kurouji K" first="Ken-Ichi" last="Kurouji">Ken-Ichi Kurouji</name><affiliation wicri:level="1"><mods:affiliation>Nagasaki Atomic Bomb Hospital, Japan Red Cross, Nagasaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagasaki Atomic Bomb Hospital, Japan Red Cross, Nagasaki</wicri:regionArea></affiliation></author><author><name sortKey="Tsujihata, Mitsuhiro" sort="Tsujihata, Mitsuhiro" uniqKey="Tsujihata M" first="Mitsuhiro" last="Tsujihata">Mitsuhiro Tsujihata</name><affiliation wicri:level="1"><mods:affiliation>School of Allied Medicine, Nagasaki University, Nagasaki, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>School of Allied Medicine, Nagasaki University, Nagasaki</wicri:regionArea></affiliation></author><author><name sortKey="Nagataki, Shigenobu" sort="Nagataki, Shigenobu" uniqKey="Nagataki S" first="Shigenobu" last="Nagataki">Shigenobu Nagataki</name><affiliation><mods:affiliation>Corresponding author. Tel.: 81-958-47-2111, ext. 2800; Fax: 81-958-43-0255.</mods:affiliation><wicri:noCountry code="subField">255.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">122</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="204">204</biblScope><biblScope unit="page" to="209">209</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">81E6945445416C1C10BD95A60BF665B0C6756451</idno><idno type="DOI">10.1016/0022-510X(94)90299-2</idno><idno type="PII">0022-510X(94)90299-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To clarify the phenomenon of increased adherence of T cells to endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM), we determined the surface markers and expression of lymphocyte function antigen-1 (LFA-1) in T cells adherent or nonadherent to EC. The percentage of activated or HLA-DR+ T cells and the expression of LFA-1 in the adherent cell population were significantly higher than those in the nonadherent cell population. Moreover, the CD4 to CD8 ratio of the HLA-DR+ cells in the EC-adherent T cells was significantly higher than that in the nonadherent cells. Collectively, these results indicate that increased adherence of T cells to EC in HAM patients is based on the increase of activated T cells with high density LFA-1 expression in the peripheral blood. Moreover, CD4+ HLA-DR+ cells exhibited more adhesive activity to EC than CD8+ HLA-DR+ cells, suggesting that activated CD4+ cells, rather than activated CD8+ cells, may be important as the first trigger for T cell-infiltration to the central nervous system in the immunopathogenesis of HAM.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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