Renal function during cefuroxime treatment in patients with pre-existing renal impairment
Identifieur interne : 003D48 ( Istex/Corpus ); précédent : 003D47; suivant : 003D49Renal function during cefuroxime treatment in patients with pre-existing renal impairment
Auteurs : Birger Trollfors ; Madis Suurkula ; John D. Price ; Ragnar NorrbySource :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 1980-09.
Abstract
Glomerular filtration rate measured by 51Chrome-EDTA clearance, serum retention of β2-microglobulin and creatinine and, as a sign of proximal tubular function, urinary loss of β2-microglobulin, were studied in patients with pre-existing renal impairment during treatment with cefuroxime for 2 weeks. There were no signs of nephrotoxicity in 19 out of 20 patients treated with moderately high doses of cefuroxime, with or without concurrent administration of frusemide. Decreased renal function was observed in one patient who had received an overdose of the drug. Renal impairment occurring during treatment with cephaloridine or gentamicin was reversible during subsequent cefuroxime treatment.
Url:
DOI: 10.1093/jac/6.5.665
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Renal function during cefuroxime treatment in patients with pre-existing renal impairment</title><author><name sortKey="Trollfors, Birger" sort="Trollfors, Birger" uniqKey="Trollfors B" first="Birger" last="Trollfors">Birger Trollfors</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author><author><name sortKey="Suurkula, Madis" sort="Suurkula, Madis" uniqKey="Suurkula M" first="Madis" last="Suurkula">Madis Suurkula</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author><author><name sortKey="Price, John D" sort="Price, John D" uniqKey="Price J" first="John D." last="Price">John D. Price</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author><author><name sortKey="Norrby, Ragnar" sort="Norrby, Ragnar" uniqKey="Norrby R" first="Ragnar" last="Norrby">Ragnar Norrby</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0482CB37047B2BA3571F48A23A089B93A138ECD3</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1093/jac/6.5.665</idno><idno type="url">https://api.istex.fr/document/0482CB37047B2BA3571F48A23A089B93A138ECD3/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003D48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Renal function during cefuroxime treatment in patients with pre-existing renal impairment</title><author><name sortKey="Trollfors, Birger" sort="Trollfors, Birger" uniqKey="Trollfors B" first="Birger" last="Trollfors">Birger Trollfors</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author><author><name sortKey="Suurkula, Madis" sort="Suurkula, Madis" uniqKey="Suurkula M" first="Madis" last="Suurkula">Madis Suurkula</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author><author><name sortKey="Price, John D" sort="Price, John D" uniqKey="Price J" first="John D." last="Price">John D. Price</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author><author><name sortKey="Norrby, Ragnar" sort="Norrby, Ragnar" uniqKey="Norrby R" first="Ragnar" last="Norrby">Ragnar Norrby</name><affiliation><mods:affiliation>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Antimicrobial Chemotherapy</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1980-09">1980-09</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="665">665</biblScope><biblScope unit="page" to="670">670</biblScope></imprint><idno type="ISSN">0305-7453</idno></series><idno type="istex">0482CB37047B2BA3571F48A23A089B93A138ECD3</idno><idno type="DOI">10.1093/jac/6.5.665</idno><idno type="ArticleID">6.5.665</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-7453</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Glomerular filtration rate measured by 51Chrome-EDTA clearance, serum retention of β2-microglobulin and creatinine and, as a sign of proximal tubular function, urinary loss of β2-microglobulin, were studied in patients with pre-existing renal impairment during treatment with cefuroxime for 2 weeks. There were no signs of nephrotoxicity in 19 out of 20 patients treated with moderately high doses of cefuroxime, with or without concurrent administration of frusemide. Decreased renal function was observed in one patient who had received an overdose of the drug. Renal impairment occurring during treatment with cephaloridine or gentamicin was reversible during subsequent cefuroxime treatment.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Birger Trollfors</name><affiliations><json:string>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</json:string></affiliations></json:item><json:item><name>Madis Suurkula</name><affiliations><json:string>The Departments of Infectious Diseases and Clinical Physiology, University of Göteborg, S-416 85 Göteborg, Sweden, Greenford, England</json:string></affiliations></json:item><json:item><name>John D. 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There were no signs of nephrotoxicity in 19 out of 20 patients treated with moderately high doses of cefuroxime, with or without concurrent administration of frusemide. Decreased renal function was observed in one patient who had received an overdose of the drug. 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There were no signs of nephrotoxicity in 19 out of 20 patients treated with moderately high doses of cefuroxime, with or without concurrent administration of frusemide. Decreased renal function was observed in one patient who had received an overdose of the drug. 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