Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation
Identifieur interne : 003863 ( Istex/Corpus ); précédent : 003862; suivant : 003864Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation
Auteurs : Masaharu Muranaka ; Hiroshi Igarashi ; Kazuhiro Koizumi ; Hiroshi Okumura ; Koyo Takeda ; Shuji SuzukiSource :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1973.
Abstract
Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.
Url:
DOI: 10.1016/0091-6749(74)90023-2
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<author><name sortKey="Igarashi, Hiroshi" sort="Igarashi, Hiroshi" uniqKey="Igarashi H" first="Hiroshi" last="Igarashi">Hiroshi Igarashi</name>
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<author><name sortKey="Koizumi, Kazuhiro" sort="Koizumi, Kazuhiro" uniqKey="Koizumi K" first="Kazuhiro" last="Koizumi">Kazuhiro Koizumi</name>
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<author><name sortKey="Okumura, Hiroshi" sort="Okumura, Hiroshi" uniqKey="Okumura H" first="Hiroshi" last="Okumura">Hiroshi Okumura</name>
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<author><name sortKey="Takeda, Koyo" sort="Takeda, Koyo" uniqKey="Takeda K" first="Koyo" last="Takeda">Koyo Takeda</name>
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<author><name sortKey="Suzuki, Shuji" sort="Suzuki, Shuji" uniqKey="Suzuki S" first="Shuji" last="Suzuki">Shuji Suzuki</name>
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<author><name sortKey="Koizumi, Kazuhiro" sort="Koizumi, Kazuhiro" uniqKey="Koizumi K" first="Kazuhiro" last="Koizumi">Kazuhiro Koizumi</name>
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<front><div type="abstract" xml:lang="en">Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</div>
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<value>PCA : passive cutaneous anaphylaxis</value>
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<value>BPO : benzylpenicilloyl</value>
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<value>EACA : ϵ-aminoeaproic acid BSA bovine serum albumin</value>
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<value>BGG : bovine gamma globulin GP guinea pig</value>
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<abstract>Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</abstract>
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<author><persName><forename type="first">Masaharu</forename>
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</persName>
<note type="biography">Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</note>
<affiliation>Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</affiliation>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
</author>
<author><persName><forename type="first">Hiroshi</forename>
<surname>Igarashi</surname>
</persName>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
</author>
<author><persName><forename type="first">Kazuhiro</forename>
<surname>Koizumi</surname>
</persName>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
</author>
<author><persName><forename type="first">Hiroshi</forename>
<surname>Okumura</surname>
</persName>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
</author>
<author><persName><forename type="first">Koyo</forename>
<surname>Takeda</surname>
</persName>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
</author>
<author><persName><forename type="first">Shuji</forename>
<surname>Suzuki</surname>
</persName>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
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<abstract xml:lang="en"><p>Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</p>
</abstract>
<textClass><keywords scheme="keyword"><list><head>Abbreviations</head>
<item><term>PCA</term>
<term>passive cutaneous anaphylaxis</term>
</item>
<item><term>BPO</term>
<term>benzylpenicilloyl</term>
</item>
<item><term>PcG</term>
<term>benzylpenicillin preparation</term>
</item>
<item><term>BPE</term>
<term>benzylpenicillenic acid</term>
</item>
<item><term>BPOA</term>
<term>bonzylpenicilloic acid</term>
</item>
<item><term>EACA</term>
<term>ϵ-aminoeaproic acid BSA bovine serum albumin</term>
</item>
<item><term>BGG</term>
<term>bovine gamma globulin GP guinea pig</term>
</item>
<item><term>GSP</term>
<term>guinea pig serum protein</term>
</item>
</list>
</keywords>
</textClass>
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<change when="1973">Published</change>
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<head><ce:title>Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</ce:title>
<ce:author-group><ce:author><ce:given-name>Masaharu</ce:given-name>
<ce:surname>Muranaka</ce:surname>
<ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup>
</ce:cross-ref>
</ce:author>
<ce:author><ce:given-name>Hiroshi</ce:given-name>
<ce:surname>Igarashi</ce:surname>
</ce:author>
<ce:author><ce:given-name>Kazuhiro</ce:given-name>
<ce:surname>Koizumi</ce:surname>
</ce:author>
<ce:author><ce:given-name>Hiroshi</ce:given-name>
<ce:surname>Okumura</ce:surname>
</ce:author>
<ce:author><ce:given-name>Koyo</ce:given-name>
<ce:surname>Takeda</ce:surname>
</ce:author>
<ce:author><ce:given-name>Shuji</ce:given-name>
<ce:surname>Suzuki</ce:surname>
</ce:author>
<ce:affiliation><ce:textfn>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</ce:textfn>
</ce:affiliation>
<ce:correspondence id="COR1"><ce:label>∗</ce:label>
<ce:text>Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</ce:text>
</ce:correspondence>
</ce:author-group>
<ce:date-received day="13" month="12" year="1973"></ce:date-received>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO <ce:italic>γ</ce:italic>
<ce:inf>1</ce:inf>
homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive <ce:italic>γ</ce:italic>
<ce:inf>1</ce:inf>
-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of <ce:italic>γ</ce:italic>
<ce:inf>1</ce:inf>
-mediated PCA.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title>
<ce:keyword><ce:text>PCA</ce:text>
<ce:keyword><ce:text>passive cutaneous anaphylaxis</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>BPO</ce:text>
<ce:keyword><ce:text>benzylpenicilloyl</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>PcG</ce:text>
<ce:keyword><ce:text>benzylpenicillin preparation</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>BPE</ce:text>
<ce:keyword><ce:text>benzylpenicillenic acid</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>BPOA</ce:text>
<ce:keyword><ce:text>bonzylpenicilloic acid</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>EACA</ce:text>
<ce:keyword><ce:text>ϵ-aminoeaproic acid BSA bovine serum albumin</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>BGG</ce:text>
<ce:keyword><ce:text>bovine gamma globulin GP guinea pig</ce:text>
</ce:keyword>
</ce:keyword>
<ce:keyword><ce:text>GSP</ce:text>
<ce:keyword><ce:text>guinea pig serum protein</ce:text>
</ce:keyword>
</ce:keyword>
</ce:keywords>
</head>
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<name type="personal"><namePart type="given">Masaharu</namePart>
<namePart type="family">Muranaka</namePart>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
<description>Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</description>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Hiroshi</namePart>
<namePart type="family">Igarashi</namePart>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Kazuhiro</namePart>
<namePart type="family">Koizumi</namePart>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Hiroshi</namePart>
<namePart type="family">Okumura</namePart>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Koyo</namePart>
<namePart type="family">Takeda</namePart>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Shuji</namePart>
<namePart type="family">Suzuki</namePart>
<affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1973</dateIssued>
<dateCaptured encoding="w3cdtf">1973-12-13</dateCaptured>
<copyrightDate encoding="w3cdtf">1974</copyrightDate>
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<abstract lang="en">Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</abstract>
<subject><genre>Abbreviations</genre>
<topic>PCA : passive cutaneous anaphylaxis</topic>
<topic>BPO : benzylpenicilloyl</topic>
<topic>PcG : benzylpenicillin preparation</topic>
<topic>BPE : benzylpenicillenic acid</topic>
<topic>BPOA : bonzylpenicilloic acid</topic>
<topic>EACA : ϵ-aminoeaproic acid BSA bovine serum albumin</topic>
<topic>BGG : bovine gamma globulin GP guinea pig</topic>
<topic>GSP : guinea pig serum protein</topic>
</subject>
<relatedItem type="host"><titleInfo><title>The Journal of Allergy and Clinical Immunology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>YMAI</title>
</titleInfo>
<genre type="Journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">197412</dateIssued>
</originInfo>
<identifier type="ISSN">0091-6749</identifier>
<identifier type="PII">S0091-6749(00)X0119-4</identifier>
<part><date>197412</date>
<detail type="volume"><number>54</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>6</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>A39</start>
<end>A46</end>
</extent>
<extent unit="issue pages"><start>2</start>
<end>412</end>
</extent>
<extent unit="pages"><start>329</start>
<end>338</end>
</extent>
</part>
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<identifier type="istex">ADF98802F42C8AC7FE8F5AC2F95038E5BA398022</identifier>
<identifier type="DOI">10.1016/0091-6749(74)90023-2</identifier>
<identifier type="PII">0091-6749(74)90023-2</identifier>
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