Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation
Identifieur interne : 003863 ( Istex/Corpus ); précédent : 003862; suivant : 003864Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation
Auteurs : Masaharu Muranaka ; Hiroshi Igarashi ; Kazuhiro Koizumi ; Hiroshi Okumura ; Koyo Takeda ; Shuji SuzukiSource :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1973.
Abstract
Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.
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DOI: 10.1016/0091-6749(74)90023-2
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title><author><name sortKey="Muranaka, Masaharu" sort="Muranaka, Masaharu" uniqKey="Muranaka M" first="Masaharu" last="Muranaka">Masaharu Muranaka</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Igarashi, Hiroshi" sort="Igarashi, Hiroshi" uniqKey="Igarashi H" first="Hiroshi" last="Igarashi">Hiroshi Igarashi</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Koizumi, Kazuhiro" sort="Koizumi, Kazuhiro" uniqKey="Koizumi K" first="Kazuhiro" last="Koizumi">Kazuhiro Koizumi</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Okumura, Hiroshi" sort="Okumura, Hiroshi" uniqKey="Okumura H" first="Hiroshi" last="Okumura">Hiroshi Okumura</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takeda, Koyo" sort="Takeda, Koyo" uniqKey="Takeda K" first="Koyo" last="Takeda">Koyo Takeda</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Suzuki, Shuji" sort="Suzuki, Shuji" uniqKey="Suzuki S" first="Shuji" last="Suzuki">Shuji Suzuki</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ADF98802F42C8AC7FE8F5AC2F95038E5BA398022</idno><date when="1974" year="1974">1974</date><idno type="doi">10.1016/0091-6749(74)90023-2</idno><idno type="url">https://api.istex.fr/document/ADF98802F42C8AC7FE8F5AC2F95038E5BA398022/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003863</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title><author><name sortKey="Muranaka, Masaharu" sort="Muranaka, Masaharu" uniqKey="Muranaka M" first="Masaharu" last="Muranaka">Masaharu Muranaka</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Igarashi, Hiroshi" sort="Igarashi, Hiroshi" uniqKey="Igarashi H" first="Hiroshi" last="Igarashi">Hiroshi Igarashi</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Koizumi, Kazuhiro" sort="Koizumi, Kazuhiro" uniqKey="Koizumi K" first="Kazuhiro" last="Koizumi">Kazuhiro Koizumi</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Okumura, Hiroshi" sort="Okumura, Hiroshi" uniqKey="Okumura H" first="Hiroshi" last="Okumura">Hiroshi Okumura</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takeda, Koyo" sort="Takeda, Koyo" uniqKey="Takeda K" first="Koyo" last="Takeda">Koyo Takeda</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Suzuki, Shuji" sort="Suzuki, Shuji" uniqKey="Suzuki S" first="Shuji" last="Suzuki">Shuji Suzuki</name><affiliation><mods:affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="ISSN">0091-6749</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973">1973</date><biblScope unit="volume">54</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="329">329</biblScope><biblScope unit="page" to="338">338</biblScope></imprint><idno type="ISSN">0091-6749</idno></series><idno type="istex">ADF98802F42C8AC7FE8F5AC2F95038E5BA398022</idno><idno type="DOI">10.1016/0091-6749(74)90023-2</idno><idno type="PII">0091-6749(74)90023-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-6749</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Masaharu Muranaka</name><affiliations><json:string>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroshi Igarashi</name><affiliations><json:string>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Kazuhiro Koizumi</name><affiliations><json:string>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroshi Okumura</name><affiliations><json:string>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Koyo Takeda</name><affiliations><json:string>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Shuji Suzuki</name><affiliations><json:string>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>PCA : passive cutaneous anaphylaxis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>BPO : benzylpenicilloyl</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PcG : benzylpenicillin preparation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>BPE : benzylpenicillenic acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>BPOA : bonzylpenicilloic acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>EACA : ϵ-aminoeaproic acid BSA bovine serum albumin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>BGG : bovine gamma globulin GP guinea pig</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GSP : guinea pig serum protein</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</abstract><qualityIndicators><score>5.031</score><pdfVersion>1.3</pdfVersion><pdfPageSize>468 x 684 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>8</keywordCount><abstractCharCount>1135</abstractCharCount><pdfWordCount>3183</pdfWordCount><pdfCharCount>22881</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>154</abstractWordCount></qualityIndicators><title>Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title><pii><json:string>0091-6749(74)90023-2</json:string></pii><genre><json:string>research-article</json:string></genre><serie><pages><first>61</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>VIII International Congress of 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uri="https://api.istex.fr/document/ADF98802F42C8AC7FE8F5AC2F95038E5BA398022/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1974</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title><author><persName><forename type="first">Masaharu</forename><surname>Muranaka</surname></persName><note type="biography">Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</note><affiliation>Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</affiliation><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation></author><author><persName><forename type="first">Hiroshi</forename><surname>Igarashi</surname></persName><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation></author><author><persName><forename type="first">Kazuhiro</forename><surname>Koizumi</surname></persName><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation></author><author><persName><forename type="first">Hiroshi</forename><surname>Okumura</surname></persName><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation></author><author><persName><forename type="first">Koyo</forename><surname>Takeda</surname></persName><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation></author><author><persName><forename type="first">Shuji</forename><surname>Suzuki</surname></persName><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation></author></analytic><monogr><title level="j">The Journal of Allergy and Clinical Immunology</title><title level="j" type="abbrev">YMAI</title><idno type="pISSN">0091-6749</idno><idno type="PII">S0091-6749(00)X0119-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973"></date><biblScope unit="volume">54</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="329">329</biblScope><biblScope unit="page" to="338">338</biblScope></imprint></monogr><idno type="istex">ADF98802F42C8AC7FE8F5AC2F95038E5BA398022</idno><idno type="DOI">10.1016/0091-6749(74)90023-2</idno><idno type="PII">0091-6749(74)90023-2</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1974</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</p></abstract><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>PCA</term><term>passive cutaneous anaphylaxis</term></item><item><term>BPO</term><term>benzylpenicilloyl</term></item><item><term>PcG</term><term>benzylpenicillin preparation</term></item><item><term>BPE</term><term>benzylpenicillenic acid</term></item><item><term>BPOA</term><term>bonzylpenicilloic acid</term></item><item><term>EACA</term><term>ϵ-aminoeaproic acid BSA bovine serum albumin</term></item><item><term>BGG</term><term>bovine gamma globulin GP guinea pig</term></item><item><term>GSP</term><term>guinea pig serum protein</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1973-12-13">Received</change><change when="1973">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YMAI</jid><aid>74900232</aid><ce:pii>0091-6749(74)90023-2</ce:pii><ce:doi>10.1016/0091-6749(74)90023-2</ce:doi><ce:copyright type="unknown" year="1974"></ce:copyright></item-info><head><ce:title>Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</ce:title><ce:author-group><ce:author><ce:given-name>Masaharu</ce:given-name><ce:surname>Muranaka</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Hiroshi</ce:given-name><ce:surname>Igarashi</ce:surname></ce:author><ce:author><ce:given-name>Kazuhiro</ce:given-name><ce:surname>Koizumi</ce:surname></ce:author><ce:author><ce:given-name>Hiroshi</ce:given-name><ce:surname>Okumura</ce:surname></ce:author><ce:author><ce:given-name>Koyo</ce:given-name><ce:surname>Takeda</ce:surname></ce:author><ce:author><ce:given-name>Shuji</ce:given-name><ce:surname>Suzuki</ce:surname></ce:author><ce:affiliation><ce:textfn>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="13" month="12" year="1973"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO <ce:italic>γ</ce:italic><ce:inf>1</ce:inf> homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive <ce:italic>γ</ce:italic><ce:inf>1</ce:inf>-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of <ce:italic>γ</ce:italic><ce:inf>1</ce:inf>-mediated PCA.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>PCA</ce:text><ce:keyword><ce:text>passive cutaneous anaphylaxis</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>BPO</ce:text><ce:keyword><ce:text>benzylpenicilloyl</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PcG</ce:text><ce:keyword><ce:text>benzylpenicillin preparation</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>BPE</ce:text><ce:keyword><ce:text>benzylpenicillenic acid</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>BPOA</ce:text><ce:keyword><ce:text>bonzylpenicilloic acid</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>EACA</ce:text><ce:keyword><ce:text>ϵ-aminoeaproic acid BSA bovine serum albumin</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>BGG</ce:text><ce:keyword><ce:text>bovine gamma globulin GP guinea pig</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>GSP</ce:text><ce:keyword><ce:text>guinea pig serum protein</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Elicitation of homologous passive cutaneous anaphylactic reactions by a benzylpenicillin preparation</title></titleInfo><name type="personal"><namePart type="given">Masaharu</namePart><namePart type="family">Muranaka</namePart><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation><description>Reprint requests to: Dr. Masaharu Muranaka, Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroshi</namePart><namePart type="family">Igarashi</namePart><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kazuhiro</namePart><namePart type="family">Koizumi</namePart><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroshi</namePart><namePart type="family">Okumura</namePart><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Koyo</namePart><namePart type="family">Takeda</namePart><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shuji</namePart><namePart type="family">Suzuki</namePart><affiliation>From the Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1973</dateIssued><dateCaptured encoding="w3cdtf">1973-12-13</dateCaptured><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Four out of five commercially available benzylpenicillin preparations elicited homologous passive cutaneous anaphylactic (PCA) reaction in sensitized guinea pigs with anti-benzylpenicilloyl (anti-BPO) reaginic sera. The same preparations could not evoke PCA reaction in sensitized guinea pigs with anti-BPO γ1 homocytotropic antibodies. The PCA reactions were completely inhibited by a prior injection of BPO-ε-aminocaproic acid (BPO-EACA). Chromatographic analysis of one of the benzylpenicillin preparations on Sephadex G 10 revealed that the reagin-mediated PCA reaction was not evoked with the fractions from the main peak of the benzylpenicillin but with fractions eluted earlier. None of the fractions gave positive γ1-mediated PCA reactions. These results indicated that some commercial benzylpenicillin preparations contained minute amounts of the impurities that could elicit the homologous PCA reaction in guinea pigs sensitized with anti-BPO reaginic sera. It was also indicated that the PCA elicitation activity of the benzylpenicillin preparation in the system of reagin-mediated PCA differed from that of γ1-mediated PCA.</abstract><subject><genre>Abbreviations</genre><topic>PCA : passive cutaneous anaphylaxis</topic><topic>BPO : benzylpenicilloyl</topic><topic>PcG : benzylpenicillin preparation</topic><topic>BPE : benzylpenicillenic acid</topic><topic>BPOA : bonzylpenicilloic acid</topic><topic>EACA : ϵ-aminoeaproic acid BSA bovine serum albumin</topic><topic>BGG : bovine gamma globulin GP guinea pig</topic><topic>GSP : guinea pig serum protein</topic></subject><relatedItem type="host"><titleInfo><title>The Journal of Allergy and Clinical Immunology</title></titleInfo><titleInfo type="abbreviated"><title>YMAI</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197412</dateIssued></originInfo><identifier type="ISSN">0091-6749</identifier><identifier type="PII">S0091-6749(00)X0119-4</identifier><part><date>197412</date><detail type="volume"><number>54</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue pages"><start>A39</start><end>A46</end></extent><extent unit="issue pages"><start>2</start><end>412</end></extent><extent unit="pages"><start>329</start><end>338</end></extent></part></relatedItem><identifier type="istex">ADF98802F42C8AC7FE8F5AC2F95038E5BA398022</identifier><identifier type="DOI">10.1016/0091-6749(74)90023-2</identifier><identifier type="PII">0091-6749(74)90023-2</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/ADF98802F42C8AC7FE8F5AC2F95038E5BA398022/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">ALLERGY</classCode><classCode scheme="WOS">IMMUNOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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