Effect of immunization with highly purified Panton-Valentine leucocidin and delta-toxin on staphylococcal mastitis in rabbits
Identifieur interne : 003541 ( Istex/Corpus ); précédent : 003540; suivant : 003542Effect of immunization with highly purified Panton-Valentine leucocidin and delta-toxin on staphylococcal mastitis in rabbits
Auteurs : C. Adlam ; P. D. Ward ; W. H. TurnerSource :
- Journal of Comparative Pathology [ 0021-9975 ] ; 1979.
Abstract
In an attempt to protect female rabbits from the localized abscess type of staphylococcal mastitis, which we have previously shown to be unaffected by immunization with alpha and beta-toxins, animals were immunized with purified Panton-Valentine leucocidin or delta-toxin either alone or in combination with alpha-toxoid. Challenge was carried out by injecting lactating mammary tissue with low numbers of a strain of staphylococcus (CN 6708) responsible for a natural outbreak of abscess type rabbit mastitis. Not only was no protection obtained against the abscess disease produced by this organism, but several animals contracted the lethal spreading type of disease (“blue breast”), even though circulating antibodies to all three toxins were present.Since our previous work showed that “blue breast”, produced by intramammary challenge with two staphylococcal strains of bovine origin, was modified to the abscess disease by alpha-toxoid immunization, we conclude that the “blue breast” produced in a proportion of does challenged by strain CN 6708 may be caused by a different, and as yet unidentified toxin.
Url:
DOI: 10.1016/0021-9975(80)90063-8
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Challenge was carried out by injecting lactating mammary tissue with low numbers of a strain of staphylococcus (CN 6708) responsible for a natural outbreak of abscess type rabbit mastitis. Not only was no protection obtained against the abscess disease produced by this organism, but several animals contracted the lethal spreading type of disease (“blue breast”), even though circulating antibodies to all three toxins were present.Since our previous work showed that “blue breast”, produced by intramammary challenge with two staphylococcal strains of bovine origin, was modified to the abscess disease by alpha-toxoid immunization, we conclude that the “blue breast” produced in a proportion of does challenged by strain CN 6708 may be caused by a different, and as yet unidentified toxin.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C. 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an attempt to protect female rabbits from the localized abscess type of staphylococcal mastitis, which we have previously shown to be unaffected by immunization with alpha and beta-toxins, animals were immunized with purified Panton-Valentine leucocidin or delta-toxin either alone or in combination with alpha-toxoid. Challenge was carried out by injecting lactating mammary tissue with low numbers of a strain of staphylococcus (CN 6708) responsible for a natural outbreak of abscess type rabbit mastitis. Not only was no protection obtained against the abscess disease produced by this organism, but several animals contracted the lethal spreading type of disease (“blue breast”), even though circulating antibodies to all three toxins were present.Since our previous work showed that “blue breast”, produced by intramammary challenge with two staphylococcal strains of bovine origin, was modified to the abscess disease by alpha-toxoid immunization, we conclude that the “blue breast” produced in a proportion of does challenged by strain CN 6708 may be caused by a different, and as yet unidentified toxin.</p></abstract></profileDesc><revisionDesc><change when="1979-06-05">Received</change><change when="1979">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YJCPA</jid><aid>80900638</aid><ce:pii>0021-9975(80)90063-8</ce:pii><ce:doi>10.1016/0021-9975(80)90063-8</ce:doi><ce:copyright type="unknown" year="1980"></ce:copyright></item-info><head><ce:title>Effect of immunization with highly purified Panton-Valentine leucocidin and delta-toxin on staphylococcal mastitis in rabbits</ce:title><ce:author-group><ce:author><ce:given-name>C.</ce:given-name><ce:surname>Adlam</ce:surname></ce:author><ce:author><ce:given-name>P.D.</ce:given-name><ce:surname>Ward</ce:surname></ce:author><ce:author><ce:given-name>W.H.</ce:given-name><ce:surname>Turner</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Bacteriology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K.</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="5" month="6" year="1979"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>In an attempt to protect female rabbits from the localized abscess type of staphylococcal mastitis, which we have previously shown to be unaffected by immunization with alpha and beta-toxins, animals were immunized with purified Panton-Valentine leucocidin or delta-toxin either alone or in combination with alpha-toxoid. Challenge was carried out by injecting lactating mammary tissue with low numbers of a strain of staphylococcus (CN 6708) responsible for a natural outbreak of abscess type rabbit mastitis. 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Challenge was carried out by injecting lactating mammary tissue with low numbers of a strain of staphylococcus (CN 6708) responsible for a natural outbreak of abscess type rabbit mastitis. Not only was no protection obtained against the abscess disease produced by this organism, but several animals contracted the lethal spreading type of disease (“blue breast”), even though circulating antibodies to all three toxins were present.Since our previous work showed that “blue breast”, produced by intramammary challenge with two staphylococcal strains of bovine origin, was modified to the abscess disease by alpha-toxoid immunization, we conclude that the “blue breast” produced in a proportion of does challenged by strain CN 6708 may be caused by a different, and as yet unidentified toxin.</abstract><relatedItem type="host"><titleInfo><title>Journal of Comparative Pathology</title></titleInfo><titleInfo type="abbreviated"><title>YJCPA</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198004</dateIssued></originInfo><identifier type="ISSN">0021-9975</identifier><identifier type="PII">S0021-9975(00)X0162-4</identifier><part><date>198004</date><detail type="volume"><number>90</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>169</start><end>338</end></extent><extent unit="pages"><start>265</start><end>274</end></extent></part></relatedItem><identifier type="istex">F539523B11376294F325DDD8E88B8765B1E552C7</identifier><identifier type="DOI">10.1016/0021-9975(80)90063-8</identifier><identifier type="PII">0021-9975(80)90063-8</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/F539523B11376294F325DDD8E88B8765B1E552C7/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">PATHOLOGY</classCode><classCode scheme="WOS">VETERINARY SCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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