Trypanosoma lewisi: Production of exoantigens during infection in the rat
Identifieur interne : 002F70 ( Istex/Corpus ); précédent : 002F69; suivant : 002F71Trypanosoma lewisi: Production of exoantigens during infection in the rat
Auteurs : Philip A. D'AlesandroSource :
- Experimental Parasitology [ 0014-4894 ] ; 1971.
Abstract
Exoantigens are produced by Trypanosoma lewisi during infections in the rat. They were detected in rat serum and plasma by gel-diffusion techniques with hyperimmune rat sera and with rabbit antiserum to washed, living trypanosomes. Their parasite origin is indicated by their presence in trypanosome homogenates, which also contain bound antigens, the continued reactivity of rabbit antisera after absorption with normal rat serum, and the reactions of identity obtained with rat and rabbit antisera. Moreover, by immunoelectrophoresis, the exontigens are revealed as new components in infected rat serum with a mobility slightly anodal to the origin. The results also show that the exoantigens are continuously released in vivo and that the trypanosomes avidly bind non-antibody rat serum proteins to their surface. Unlike the complete qualitative changes in exoantigens that accompany antigenic variation of pathogenic species of trypanosomes, at least one exoantigen remains unchanged when antigenic variation occurs with T. lewisi although additional exoantigens may appear and disappear. The relation of the exoantigens to the known ablastic and trypanocidal antibodies is difficult to determine since these antibodies and the exoantigens occur simultaneously in the blood during and after the infection. Although it cannot yet be ruled out that the exoantigens elicit the formation of these antibodies, a review of all the available evidence suggests that the exoantigens of T. lewisi may not be immunogenic during a natural course of infection. Possibly they are hemolysins with a nutritive function.
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DOI: 10.1016/0014-4894(72)90020-3
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D'Alesandro</name><affiliation><mods:affiliation>The Rockefeller University, New York, New York 10021 USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7006268D118DC826E5CE694CC7E459CE83258DC7</idno><date when="1972" year="1972">1972</date><idno type="doi">10.1016/0014-4894(72)90020-3</idno><idno type="url">https://api.istex.fr/document/7006268D118DC826E5CE694CC7E459CE83258DC7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002F70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Trypanosoma lewisi: Production of exoantigens during infection in the rat</title><author><name sortKey="D Alesandro, Philip A" sort="D Alesandro, Philip A" uniqKey="D Alesandro P" first="Philip A." last="D'Alesandro">Philip A. D'Alesandro</name><affiliation><mods:affiliation>The Rockefeller University, New York, New York 10021 USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Parasitology</title><title level="j" type="abbrev">YEXPR</title><idno type="ISSN">0014-4894</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1971">1971</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="164">164</biblScope></imprint><idno type="ISSN">0014-4894</idno></series><idno type="istex">7006268D118DC826E5CE694CC7E459CE83258DC7</idno><idno type="DOI">10.1016/0014-4894(72)90020-3</idno><idno type="PII">0014-4894(72)90020-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4894</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exoantigens are produced by Trypanosoma lewisi during infections in the rat. They were detected in rat serum and plasma by gel-diffusion techniques with hyperimmune rat sera and with rabbit antiserum to washed, living trypanosomes. Their parasite origin is indicated by their presence in trypanosome homogenates, which also contain bound antigens, the continued reactivity of rabbit antisera after absorption with normal rat serum, and the reactions of identity obtained with rat and rabbit antisera. Moreover, by immunoelectrophoresis, the exontigens are revealed as new components in infected rat serum with a mobility slightly anodal to the origin. The results also show that the exoantigens are continuously released in vivo and that the trypanosomes avidly bind non-antibody rat serum proteins to their surface. Unlike the complete qualitative changes in exoantigens that accompany antigenic variation of pathogenic species of trypanosomes, at least one exoantigen remains unchanged when antigenic variation occurs with T. lewisi although additional exoantigens may appear and disappear. The relation of the exoantigens to the known ablastic and trypanocidal antibodies is difficult to determine since these antibodies and the exoantigens occur simultaneously in the blood during and after the infection. Although it cannot yet be ruled out that the exoantigens elicit the formation of these antibodies, a review of all the available evidence suggests that the exoantigens of T. lewisi may not be immunogenic during a natural course of infection. Possibly they are hemolysins with a nutritive function.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Philip A. D'alesandro</name><affiliations><json:string>The Rockefeller University, New York, New York 10021 USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Trypanosoma lewisi</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Exoantigens</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Gel diffusion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Antigenic variation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Surface coat</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Immunoelectrophoresis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Bound antigens</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rats</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Exoantigens are produced by Trypanosoma lewisi during infections in the rat. They were detected in rat serum and plasma by gel-diffusion techniques with hyperimmune rat sera and with rabbit antiserum to washed, living trypanosomes. Their parasite origin is indicated by their presence in trypanosome homogenates, which also contain bound antigens, the continued reactivity of rabbit antisera after absorption with normal rat serum, and the reactions of identity obtained with rat and rabbit antisera. Moreover, by immunoelectrophoresis, the exontigens are revealed as new components in infected rat serum with a mobility slightly anodal to the origin. The results also show that the exoantigens are continuously released in vivo and that the trypanosomes avidly bind non-antibody rat serum proteins to their surface. Unlike the complete qualitative changes in exoantigens that accompany antigenic variation of pathogenic species of trypanosomes, at least one exoantigen remains unchanged when antigenic variation occurs with T. lewisi although additional exoantigens may appear and disappear. The relation of the exoantigens to the known ablastic and trypanocidal antibodies is difficult to determine since these antibodies and the exoantigens occur simultaneously in the blood during and after the infection. Although it cannot yet be ruled out that the exoantigens elicit the formation of these antibodies, a review of all the available evidence suggests that the exoantigens of T. lewisi may not be immunogenic during a natural course of infection. 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They were detected in rat serum and plasma by gel-diffusion techniques with hyperimmune rat sera and with rabbit antiserum to washed, living trypanosomes. Their parasite origin is indicated by their presence in trypanosome homogenates, which also contain bound antigens, the continued reactivity of rabbit antisera after absorption with normal rat serum, and the reactions of identity obtained with rat and rabbit antisera. Moreover, by immunoelectrophoresis, the exontigens are revealed as new components in infected rat serum with a mobility slightly anodal to the origin. The results also show that the exoantigens are continuously released in vivo and that the trypanosomes avidly bind non-antibody rat serum proteins to their surface. Unlike the complete qualitative changes in exoantigens that accompany antigenic variation of pathogenic species of trypanosomes, at least one exoantigen remains unchanged when antigenic variation occurs with T. lewisi although additional exoantigens may appear and disappear. The relation of the exoantigens to the known ablastic and trypanocidal antibodies is difficult to determine since these antibodies and the exoantigens occur simultaneously in the blood during and after the infection. Although it cannot yet be ruled out that the exoantigens elicit the formation of these antibodies, a review of all the available evidence suggests that the exoantigens of T. lewisi may not be immunogenic during a natural course of infection. Possibly they are hemolysins with a nutritive function.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Trypanosoma lewisi</term></item><item><term>Exoantigens</term></item><item><term>Immunity</term></item><item><term>Gel diffusion</term></item><item><term>Antigenic variation</term></item><item><term>Surface coat</term></item><item><term>Immunoelectrophoresis</term></item><item><term>Bound antigens</term></item><item><term>Rats</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1971-12-15">Received</change><change when="1971">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YEXPR</jid><aid>72900203</aid><ce:pii>0014-4894(72)90020-3</ce:pii><ce:doi>10.1016/0014-4894(72)90020-3</ce:doi><ce:copyright type="unknown" year="1972"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was supported by Grant 5 T1 AI 00192 from the National Institute of Allergy and Infectious Diseases U.S. Public Health Service.</ce:note-para></ce:article-footnote><ce:title><ce:italic>Trypanosoma lewisi:</ce:italic> Production of exoantigens during infection in the rat</ce:title><ce:author-group><ce:author><ce:given-name>Philip A.</ce:given-name><ce:surname>D'alesandro</ce:surname></ce:author><ce:affiliation><ce:textfn>The Rockefeller University, New York, New York 10021 USA</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="15" month="12" year="1971"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Exoantigens are produced by <ce:italic>Trypanosoma lewisi</ce:italic> during infections in the rat. They were detected in rat serum and plasma by gel-diffusion techniques with hyperimmune rat sera and with rabbit antiserum to washed, living trypanosomes. Their parasite origin is indicated by their presence in trypanosome homogenates, which also contain bound antigens, the continued reactivity of rabbit antisera after absorption with normal rat serum, and the reactions of identity obtained with rat and rabbit antisera. Moreover, by immunoelectrophoresis, the exontigens are revealed as new components in infected rat serum with a mobility slightly anodal to the origin. The results also show that the exoantigens are continuously released <ce:italic>in vivo</ce:italic> and that the trypanosomes avidly bind non-antibody rat serum proteins to their surface. Unlike the complete qualitative changes in exoantigens that accompany antigenic variation of pathogenic species of trypanosomes, at least one exoantigen remains unchanged when antigenic variation occurs with <ce:italic>T. lewisi</ce:italic> although additional exoantigens may appear and disappear. The relation of the exoantigens to the known ablastic and trypanocidal antibodies is difficult to determine since these antibodies and the exoantigens occur simultaneously in the blood during and after the infection. Although it cannot yet be ruled out that the exoantigens elicit the formation of these antibodies, a review of all the available evidence suggests that the exoantigens of <ce:italic>T. lewisi</ce:italic> may not be immunogenic during a natural course of infection. Possibly they are hemolysins with a nutritive function.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text><ce:italic>Trypanosoma lewisi</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>Exoantigens</ce:text></ce:keyword><ce:keyword><ce:text>Immunity</ce:text></ce:keyword><ce:keyword><ce:text>Gel diffusion</ce:text></ce:keyword><ce:keyword><ce:text>Antigenic variation</ce:text></ce:keyword><ce:keyword><ce:text>Surface coat</ce:text></ce:keyword><ce:keyword><ce:text>Immunoelectrophoresis</ce:text></ce:keyword><ce:keyword><ce:text>Bound antigens</ce:text></ce:keyword><ce:keyword><ce:text>Rats</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Trypanosoma lewisi: Production of exoantigens during infection in the rat</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Production of exoantigens during infection in the rat</title></titleInfo><name type="personal"><namePart type="given">Philip A.</namePart><namePart type="family">D'alesandro</namePart><affiliation>The Rockefeller University, New York, New York 10021 USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1971</dateIssued><dateCaptured encoding="w3cdtf">1971-12-15</dateCaptured><copyrightDate encoding="w3cdtf">1972</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Exoantigens are produced by Trypanosoma lewisi during infections in the rat. They were detected in rat serum and plasma by gel-diffusion techniques with hyperimmune rat sera and with rabbit antiserum to washed, living trypanosomes. Their parasite origin is indicated by their presence in trypanosome homogenates, which also contain bound antigens, the continued reactivity of rabbit antisera after absorption with normal rat serum, and the reactions of identity obtained with rat and rabbit antisera. Moreover, by immunoelectrophoresis, the exontigens are revealed as new components in infected rat serum with a mobility slightly anodal to the origin. The results also show that the exoantigens are continuously released in vivo and that the trypanosomes avidly bind non-antibody rat serum proteins to their surface. Unlike the complete qualitative changes in exoantigens that accompany antigenic variation of pathogenic species of trypanosomes, at least one exoantigen remains unchanged when antigenic variation occurs with T. lewisi although additional exoantigens may appear and disappear. The relation of the exoantigens to the known ablastic and trypanocidal antibodies is difficult to determine since these antibodies and the exoantigens occur simultaneously in the blood during and after the infection. Although it cannot yet be ruled out that the exoantigens elicit the formation of these antibodies, a review of all the available evidence suggests that the exoantigens of T. lewisi may not be immunogenic during a natural course of infection. Possibly they are hemolysins with a nutritive function.</abstract><note>This work was supported by Grant 5 T1 AI 00192 from the National Institute of Allergy and Infectious Diseases U.S. Public Health Service.</note><subject><genre>Keywords</genre><topic>Trypanosoma lewisi</topic><topic>Exoantigens</topic><topic>Immunity</topic><topic>Gel diffusion</topic><topic>Antigenic variation</topic><topic>Surface coat</topic><topic>Immunoelectrophoresis</topic><topic>Bound antigens</topic><topic>Rats</topic></subject><relatedItem type="host"><titleInfo><title>Experimental Parasitology</title></titleInfo><titleInfo type="abbreviated"><title>YEXPR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197208</dateIssued></originInfo><identifier type="ISSN">0014-4894</identifier><identifier type="PII">S0014-4894(00)X0132-4</identifier><part><date>197208</date><detail type="volume"><number>32</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>173</end></extent><extent unit="pages"><start>149</start><end>164</end></extent></part></relatedItem><identifier type="istex">7006268D118DC826E5CE694CC7E459CE83258DC7</identifier><identifier type="DOI">10.1016/0014-4894(72)90020-3</identifier><identifier type="PII">0014-4894(72)90020-3</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/7006268D118DC826E5CE694CC7E459CE83258DC7/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">PARASITOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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