Identification and differentiation of surgically correctable hypertension due to primary aldosteronism
Identifieur interne : 002F68 ( Istex/Corpus ); précédent : 002F67; suivant : 002F69Identification and differentiation of surgically correctable hypertension due to primary aldosteronism
Auteurs : Steven M. Herf ; David C. Teates ; Charles J. Tegtmeyer ; E. Darrocott Vaughan Jr. ; Carlos R. Ayers ; Robert M. CareySource :
- The American Journal of Medicine [ 0002-9343 ] ; 1979.
Abstract
During a protocol study for the evaluation of patients with primary aldosteronism, a variety of diagnostic studies were employed in an attempt to identify patients with primary aldosteronism and to differentiate patients with adrenal adenoma from patients with idiopathic adrenal hyperplasia. In this study, we are able to demonstrate the utility of (1) absent postural increase in plasma aldosterone concentration, (2) adrenal scanning and (3) normalization of blood pressure with spironolactone therapy in identifying patients with primary aldosterone excess who have an adrenal adenoma, surgical removal of which results in eliminating their hypertension.
Url:
DOI: 10.1016/0002-9343(79)90785-X
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In this study, we are able to demonstrate the utility of (1) absent postural increase in plasma aldosterone concentration, (2) adrenal scanning and (3) normalization of blood pressure with spironolactone therapy in identifying patients with primary aldosterone excess who have an adrenal adenoma, surgical removal of which results in eliminating their hypertension.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Steven M. Herf M.D.</name><affiliations><json:string>Charlottesville, Virginia, USA</json:string></affiliations></json:item><json:item><name>David C. Teates M.D.</name><affiliations><json:string>Charlottesville, Virginia, USA</json:string></affiliations></json:item><json:item><name>Charles J. 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In this study, we are able to demonstrate the utility of (1) absent postural increase in plasma aldosterone concentration, (2) adrenal scanning and (3) normalization of blood pressure with spironolactone therapy in identifying patients with primary aldosterone excess who have an adrenal adenoma, surgical removal of which results in eliminating their hypertension.</abstract><qualityIndicators><score>4.768</score><pdfVersion>1.4</pdfVersion><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>658</abstractCharCount><pdfWordCount>3152</pdfWordCount><pdfCharCount>22847</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>93</abstractWordCount></qualityIndicators><title>Identification and differentiation of surgically correctable hypertension due to primary 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address: 52 Springhaven Drive, Evansville, Indiana 47710.</note><affiliation>Present address: 52 Springhaven Drive, Evansville, Indiana 47710.</affiliation><affiliation>Charlottesville, Virginia, USA</affiliation></author><author><persName><forename type="first">David C.</forename><surname>Teates</surname></persName><roleName type="degree">M.D.</roleName><note type="biography">From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</note><affiliation>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</affiliation><affiliation>Charlottesville, Virginia, USA</affiliation></author><author><persName><forename type="first">Charles J.</forename><surname>Tegtmeyer</surname></persName><roleName type="degree">M.D.</roleName><note type="biography">From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</note><affiliation>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</affiliation><affiliation>Charlottesville, Virginia, USA</affiliation></author><author><persName><forename type="first">E.Darrocott</forename><surname>Vaughan, Jr.</surname></persName><roleName type="degree">M.D.</roleName><note type="biography">From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</note><affiliation>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</affiliation><affiliation>Charlottesville, Virginia, USA</affiliation></author><author><persName><forename type="first">Carlos R.</forename><surname>Ayers</surname></persName><roleName type="degree">M.D.</roleName><note type="biography">From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</note><affiliation>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</affiliation><affiliation>Charlottesville, Virginia, USA</affiliation></author><author><persName><forename type="first">Robert M.</forename><surname>Carey</surname></persName><roleName type="degree">M.D.</roleName><note type="biography">Requests for reprints should be addressed to Dr. Robert M. Carey, Box 146, University of Virginia School of Medicine, Charlottesville, Virginia 22908.</note><note type="biography">From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</note><affiliation>Requests for reprints should be addressed to Dr. Robert M. Carey, Box 146, University of Virginia School of Medicine, Charlottesville, Virginia 22908.</affiliation><affiliation>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</affiliation><affiliation>Established Investigator of the American Heart Association Charlottesville, Virginia, USA</affiliation></author></analytic><monogr><title level="j">The American Journal of Medicine</title><title level="j" type="abbrev">AJM</title><idno type="pISSN">0002-9343</idno><idno type="PII">S0002-9343(00)X0537-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1979"></date><biblScope unit="volume">67</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="397">397</biblScope><biblScope unit="page" to="402">402</biblScope></imprint></monogr><idno type="istex">7803185CDC82615FCF5382C5EFB2297A257AD662</idno><idno type="DOI">10.1016/0002-9343(79)90785-X</idno><idno type="PII">0002-9343(79)90785-X</idno><idno type="ArticleID">7990785X</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1979</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>During a protocol study for the evaluation of patients with primary aldosteronism, a variety of diagnostic studies were employed in an attempt to identify patients with primary aldosteronism and to differentiate patients with adrenal adenoma from patients with idiopathic adrenal hyperplasia. In this study, we are able to demonstrate the utility of (1) absent postural increase in plasma aldosterone concentration, (2) adrenal scanning and (3) normalization of blood pressure with spironolactone therapy in identifying patients with primary aldosterone excess who have an adrenal adenoma, surgical removal of which results in eliminating their hypertension.</p></abstract></profileDesc><revisionDesc><change when="1979-05-02">Registration</change><change when="1979">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>AJM</jid><aid>7990785X</aid><ce:pii>0002-9343(79)90785-X</ce:pii><ce:doi>10.1016/0002-9343(79)90785-X</ce:doi><ce:copyright type="unknown" year="1979"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This paper was supported by U.S. Public Health Service General Clinical Research Grant RR-847.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Clinical study</ce:textfn></ce:dochead><ce:title>Identification and differentiation of surgically correctable hypertension due to primary aldosteronism</ce:title><ce:author-group><ce:author><ce:given-name>Steven M.</ce:given-name><ce:surname>Herf</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN2"><ce:sup loc="post">★</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David C.</ce:given-name><ce:surname>Teates</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Charles J.</ce:given-name><ce:surname>Tegtmeyer</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>E.Darrocott</ce:given-name><ce:surname>Vaughan</ce:surname><ce:suffix>Jr.</ce:suffix><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN3"><ce:sup loc="post">†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Carlos R.</ce:given-name><ce:surname>Ayers</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Robert M.</ce:given-name><ce:surname>Carey</ce:surname><ce:degrees>M.D.</ce:degrees><ce:cross-ref refid="COR1"><ce:sup loc="post">∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">‡</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Charlottesville, Virginia, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Established Investigator of the American Heart Association Charlottesville, Virginia, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Requests for reprints should be addressed to Dr. Robert M. Carey, Box 146, University of Virginia School of Medicine, Charlottesville, Virginia 22908.</ce:text></ce:correspondence><ce:footnote id="FN2"><ce:label>★</ce:label><ce:note-para>Present address: 52 Springhaven Drive, Evansville, Indiana 47710.</ce:note-para></ce:footnote><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</ce:note-para></ce:footnote><ce:footnote id="FN3"><ce:label>†</ce:label><ce:note-para>Present address: Division of Urology, The New York Hospital-Cornell Medical Center, 525 East 68th Street, New York, New York 10021.</ce:note-para></ce:footnote></ce:author-group><ce:date-accepted day="2" month="5" year="1979"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">During a protocol study for the evaluation of patients with primary aldosteronism, a variety of diagnostic studies were employed in an attempt to identify patients with primary aldosteronism and to differentiate patients with adrenal adenoma from patients with idiopathic adrenal hyperplasia. In this study, we are able to demonstrate the utility of (1) absent postural increase in plasma aldosterone concentration, (2) adrenal scanning and (3) normalization of blood pressure with spironolactone therapy in identifying patients with primary aldosterone excess who have an adrenal adenoma, surgical removal of which results in eliminating their hypertension.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Identification and differentiation of surgically correctable hypertension due to primary aldosteronism</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Identification and differentiation of surgically correctable hypertension due to primary aldosteronism</title></titleInfo><name type="personal"><namePart type="given">Steven M.</namePart><namePart type="family">Herf</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Charlottesville, Virginia, USA</affiliation><description>Present address: 52 Springhaven Drive, Evansville, Indiana 47710.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David C.</namePart><namePart type="family">Teates</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Charlottesville, Virginia, USA</affiliation><description>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles J.</namePart><namePart type="family">Tegtmeyer</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Charlottesville, Virginia, USA</affiliation><description>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.Darrocott</namePart><namePart type="family">Vaughan, Jr.</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Charlottesville, Virginia, USA</affiliation><description>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlos R.</namePart><namePart type="family">Ayers</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Charlottesville, Virginia, USA</affiliation><description>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert M.</namePart><namePart type="family">Carey</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Established Investigator of the American Heart Association Charlottesville, Virginia, USA</affiliation><description>Requests for reprints should be addressed to Dr. Robert M. Carey, Box 146, University of Virginia School of Medicine, Charlottesville, Virginia 22908.</description><description>From the Departments of Internal Medicine, Radiology and Urology, University of Virginia School of Medicine, Charlottesville, Virginia.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1979</dateIssued><dateValid encoding="w3cdtf">1979-05-02</dateValid><copyrightDate encoding="w3cdtf">1979</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">During a protocol study for the evaluation of patients with primary aldosteronism, a variety of diagnostic studies were employed in an attempt to identify patients with primary aldosteronism and to differentiate patients with adrenal adenoma from patients with idiopathic adrenal hyperplasia. In this study, we are able to demonstrate the utility of (1) absent postural increase in plasma aldosterone concentration, (2) adrenal scanning and (3) normalization of blood pressure with spironolactone therapy in identifying patients with primary aldosterone excess who have an adrenal adenoma, surgical removal of which results in eliminating their hypertension.</abstract><note>This paper was supported by U.S. Public Health Service General Clinical Research Grant RR-847.</note><note type="content">Section title: Clinical study</note><relatedItem type="host"><titleInfo><title>The American Journal of Medicine</title></titleInfo><titleInfo type="abbreviated"><title>AJM</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">197909</dateIssued></originInfo><identifier type="ISSN">0002-9343</identifier><identifier type="PII">S0002-9343(00)X0537-2</identifier><part><date>197909</date><detail type="volume"><number>67</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>A3</start><end>A36</end></extent><extent unit="issue pages"><start>A44</start></extent><extent unit="issue pages"><start>A49</start><end>A53</end></extent><extent unit="issue pages"><start>A54</start><end>A56</end></extent><extent unit="issue pages"><start>A63</start></extent><extent unit="issue pages"><start>A67</start></extent><extent unit="issue pages"><start>A72</start><end>A79</end></extent><extent unit="issue pages"><start>A83</start><end>A86</end></extent><extent unit="issue pages"><start>363</start><end>546</end></extent><extent unit="pages"><start>397</start><end>402</end></extent></part></relatedItem><identifier type="istex">7803185CDC82615FCF5382C5EFB2297A257AD662</identifier><identifier type="DOI">10.1016/0002-9343(79)90785-X</identifier><identifier type="PII">0002-9343(79)90785-X</identifier><identifier type="ArticleID">7990785X</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/7803185CDC82615FCF5382C5EFB2297A257AD662/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct><analytic><title level="a" type="main">Conn jW: Primary aldosteronism. a new clinical syndrome Biglieri EG. 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I. %Hydrox-ylation and T&Hydroxydehydrogcnation Idem: II.~ll-&Hydroxylation</title><author><persName><forename type="first">Freitas</forename><forename type="middle">Je</forename><surname>Thrall</surname></persName></author><author><persName><forename type="first">Jh</forename><surname>Swanson</surname></persName></author><author><persName><forename type="first">Dp</forename></persName></author></analytic><monogr><title level="j">J Nucl Mcd Ann Intern Med Acta Endocrinol (Kbh) Acta Endocrinol (Kbh] The American Journal of Medicine</title><imprint><biblScope unit="volume">19</biblScope><biblScope unit="issue">67</biblScope><biblScope unit="page" from="149" to="1079"></biblScope><date type="published" when="1067"></date></imprint></monogr></biblStruct></listBibl></back></text></istex:refBibTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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