Atopic allergy in Japanese subjects: Studies primarily with radioallergosorbent test
Identifieur interne : 001E87 ( Istex/Corpus ); précédent : 001E86; suivant : 001E88Atopic allergy in Japanese subjects: Studies primarily with radioallergosorbent test
Auteurs : Terumasa Miyamoto ; S. G. O. Johansson ; Koji Ito ; Yoshihiko HoriuchiSource :
- The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 1973.
Abstract
The radioallergosorbent test (RAST) was performed on the sera of 65 Japanese patients with bronchial asthma to show the allergic similarities between extracts of house dust originating in Japan and in the United States, and between an extract of the mite Dermatophagoides farinae. Patients whose sera were shown to be positive by RAST to house dust or mite extract reacted positively to inhalation provocation tests with these substances. In general, when the RAST was negative, the inhalation provocation test was also negative. The end point of intracutaneous test titration with the mite extract correlated well with the level of specific IgE to mite as determined by RAST, thereby indicating that the end point of intracutaneous testing provides a good indication of the serum level of allergen-specific IgE. The lowest concentration of anti-IgE producing a positive skin reaction did not, however, correlate well with the IgE level in the serum.
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DOI: 10.1016/0091-6749(74)90094-3
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<front><div type="abstract" xml:lang="en">The radioallergosorbent test (RAST) was performed on the sera of 65 Japanese patients with bronchial asthma to show the allergic similarities between extracts of house dust originating in Japan and in the United States, and between an extract of the mite Dermatophagoides farinae. Patients whose sera were shown to be positive by RAST to house dust or mite extract reacted positively to inhalation provocation tests with these substances. In general, when the RAST was negative, the inhalation provocation test was also negative. The end point of intracutaneous test titration with the mite extract correlated well with the level of specific IgE to mite as determined by RAST, thereby indicating that the end point of intracutaneous testing provides a good indication of the serum level of allergen-specific IgE. The lowest concentration of anti-IgE producing a positive skin reaction did not, however, correlate well with the IgE level in the serum.</div>
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<abstract xml:lang="en"><p>The radioallergosorbent test (RAST) was performed on the sera of 65 Japanese patients with bronchial asthma to show the allergic similarities between extracts of house dust originating in Japan and in the United States, and between an extract of the mite Dermatophagoides farinae. Patients whose sera were shown to be positive by RAST to house dust or mite extract reacted positively to inhalation provocation tests with these substances. In general, when the RAST was negative, the inhalation provocation test was also negative. The end point of intracutaneous test titration with the mite extract correlated well with the level of specific IgE to mite as determined by RAST, thereby indicating that the end point of intracutaneous testing provides a good indication of the serum level of allergen-specific IgE. The lowest concentration of anti-IgE producing a positive skin reaction did not, however, correlate well with the IgE level in the serum.</p>
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<ce:abstract-sec><ce:simple-para>The radioallergosorbent test (RAST) was performed on the sera of 65 Japanese patients with bronchial asthma to show the allergic similarities between extracts of house dust originating in Japan and in the United States, and between an extract of the mite <ce:italic>Dermatophagoides farinae</ce:italic>
. Patients whose sera were shown to be positive by RAST to house dust or mite extract reacted positively to inhalation provocation tests with these substances. In general, when the RAST was negative, the inhalation provocation test was also negative. The end point of intracutaneous test titration with the mite extract correlated well with the level of specific IgE to mite as determined by RAST, thereby indicating that the end point of intracutaneous testing provides a good indication of the serum level of allergen-specific IgE. The lowest concentration of anti-IgE producing a positive skin reaction did not, however, correlate well with the IgE level in the serum.</ce:simple-para>
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