Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart
Identifieur interne : 001D00 ( Istex/Corpus ); précédent : 001C99; suivant : 001D01Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart
Auteurs : Naoya Nakai ; Yuzo Sato ; Yoshiharu Oshida ; Atsushi Yoshimura ; Noriaki Fujitsuka ; Satoru Sugiyama ; Yoshiharu ShimomuraSource :
- Life Sciences [ 0024-3205 ] ; 1997.
Abstract
Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.
Url:
DOI: 10.1016/S0024-3205(97)00286-5
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<front><div type="abstract" xml:lang="en">Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</div>
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<abstract xml:lang="en"><p>Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</p>
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<head><ce:title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</ce:title>
<ce:author-group><ce:author><ce:given-name>Naoya</ce:given-name>
<ce:surname>Nakai</ce:surname>
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<ce:author><ce:given-name>Yuzo</ce:given-name>
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<ce:text>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</ce:text>
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<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</ce:simple-para>
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</ce:abstract>
<ce:keywords><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>pyruvate dehydrogenase complex</ce:text>
</ce:keyword>
<ce:keyword><ce:text>pyruvate dehydrogenase kinase</ce:text>
</ce:keyword>
<ce:keyword><ce:text>aging</ce:text>
</ce:keyword>
<ce:keyword><ce:text>starvation</ce:text>
</ce:keyword>
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<mods version="3.6"><titleInfo><title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</title>
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<titleInfo type="alternative" contentType="CDATA"><title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</title>
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<name type="personal"><namePart type="given">Naoya</namePart>
<namePart type="family">Nakai</namePart>
<affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Yuzo</namePart>
<namePart type="family">Sato</namePart>
<affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Yoshiharu</namePart>
<namePart type="family">Oshida</namePart>
<affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Atsushi</namePart>
<namePart type="family">Yoshimura</namePart>
<affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Noriaki</namePart>
<namePart type="family">Fujitsuka</namePart>
<affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">satoru</namePart>
<namePart type="family">Sugiyama</namePart>
<affiliation>Institute of Applied Biochemistry, Gifu 505-01, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Yoshiharu</namePart>
<namePart type="family">Shimomura</namePart>
<affiliation>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</affiliation>
<affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation>
<affiliation>E-mail: SHIMO@ks.kyy.nitech.ac.jp</affiliation>
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<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1997</dateIssued>
<dateModified encoding="w3cdtf">1997-03-17</dateModified>
<copyrightDate encoding="w3cdtf">1997</copyrightDate>
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<abstract lang="en">Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</abstract>
<subject><genre>Keywords</genre>
<topic>pyruvate dehydrogenase complex</topic>
<topic>pyruvate dehydrogenase kinase</topic>
<topic>aging</topic>
<topic>starvation</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Life Sciences</title>
</titleInfo>
<titleInfo type="abbreviated"><title>LFS</title>
</titleInfo>
<genre type="Journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">19970516</dateIssued>
</originInfo>
<identifier type="ISSN">0024-3205</identifier>
<identifier type="PII">S0024-3205(00)X0118-X</identifier>
<part><date>19970516</date>
<detail type="volume"><number>60</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>25</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>PL371</start>
<end>PL394</end>
</extent>
<extent unit="issue pages"><start>2255</start>
<end>2359</end>
</extent>
<extent unit="pages"><start>2309</start>
<end>2314</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">3DA80D27C65F7F414E65C4D95AC419900F133886</identifier>
<identifier type="DOI">10.1016/S0024-3205(97)00286-5</identifier>
<identifier type="PII">S0024-3205(97)00286-5</identifier>
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