Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart
Identifieur interne : 001D00 ( Istex/Corpus ); précédent : 001C99; suivant : 001D01Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart
Auteurs : Naoya Nakai ; Yuzo Sato ; Yoshiharu Oshida ; Atsushi Yoshimura ; Noriaki Fujitsuka ; Satoru Sugiyama ; Yoshiharu ShimomuraSource :
- Life Sciences [ 0024-3205 ] ; 1997.
Abstract
Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.
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DOI: 10.1016/S0024-3205(97)00286-5
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</title><author><name sortKey="Nakai, Naoya" sort="Nakai, Naoya" uniqKey="Nakai N" first="Naoya" last="Nakai">Naoya Nakai</name><affiliation><mods:affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sato, Yuzo" sort="Sato, Yuzo" uniqKey="Sato Y" first="Yuzo" last="Sato">Yuzo Sato</name><affiliation><mods:affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</mods:affiliation></affiliation></author><author><name sortKey="Oshida, Yoshiharu" sort="Oshida, Yoshiharu" uniqKey="Oshida Y" first="Yoshiharu" last="Oshida">Yoshiharu Oshida</name><affiliation><mods:affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</mods:affiliation></affiliation></author><author><name sortKey="Yoshimura, Atsushi" sort="Yoshimura, Atsushi" uniqKey="Yoshimura A" first="Atsushi" last="Yoshimura">Atsushi Yoshimura</name><affiliation><mods:affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</mods:affiliation></affiliation></author><author><name sortKey="Fujitsuka, Noriaki" sort="Fujitsuka, Noriaki" uniqKey="Fujitsuka N" first="Noriaki" last="Fujitsuka">Noriaki Fujitsuka</name><affiliation><mods:affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sugiyama, Satoru" sort="Sugiyama, Satoru" uniqKey="Sugiyama S" first="Satoru" last="Sugiyama">Satoru Sugiyama</name><affiliation><mods:affiliation>Institute of Applied Biochemistry, Gifu 505-01, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shimomura, Yoshiharu" sort="Shimomura, Yoshiharu" uniqKey="Shimomura Y" first="Yoshiharu" last="Shimomura">Yoshiharu Shimomura</name><affiliation><mods:affiliation>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: SHIMO@ks.kyy.nitech.ac.jp</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3DA80D27C65F7F414E65C4D95AC419900F133886</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0024-3205(97)00286-5</idno><idno type="url">https://api.istex.fr/document/3DA80D27C65F7F414E65C4D95AC419900F133886/fulltext/pdf</idno><idno 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and Sports, Nagoya University, Nagoya 464-01, Japan</mods:affiliation></affiliation></author><author><name sortKey="Yoshimura, Atsushi" sort="Yoshimura, Atsushi" uniqKey="Yoshimura A" first="Atsushi" last="Yoshimura">Atsushi Yoshimura</name><affiliation><mods:affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</mods:affiliation></affiliation></author><author><name sortKey="Fujitsuka, Noriaki" sort="Fujitsuka, Noriaki" uniqKey="Fujitsuka N" first="Noriaki" last="Fujitsuka">Noriaki Fujitsuka</name><affiliation><mods:affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sugiyama, Satoru" sort="Sugiyama, Satoru" uniqKey="Sugiyama S" first="Satoru" last="Sugiyama">Satoru Sugiyama</name><affiliation><mods:affiliation>Institute of Applied Biochemistry, Gifu 505-01, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shimomura, Yoshiharu" sort="Shimomura, Yoshiharu" uniqKey="Shimomura Y" first="Yoshiharu" last="Shimomura">Yoshiharu Shimomura</name><affiliation><mods:affiliation>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: SHIMO@ks.kyy.nitech.ac.jp</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">60</biblScope><biblScope unit="issue">25</biblScope><biblScope unit="page" from="2309">2309</biblScope><biblScope unit="page" 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Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Naoya Nakai</name><affiliations><json:string>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</json:string></affiliations></json:item><json:item><name>Yuzo Sato</name><affiliations><json:string>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</json:string></affiliations></json:item><json:item><name>Yoshiharu Oshida</name><affiliations><json:string>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</json:string></affiliations></json:item><json:item><name>Atsushi Yoshimura</name><affiliations><json:string>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</json:string></affiliations></json:item><json:item><name>Noriaki Fujitsuka</name><affiliations><json:string>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</json:string></affiliations></json:item><json:item><name>satoru Sugiyama</name><affiliations><json:string>Institute of Applied Biochemistry, Gifu 505-01, Japan</json:string></affiliations></json:item><json:item><name>Yoshiharu Shimomura</name><affiliations><json:string>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</json:string><json:string>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</json:string><json:string>E-mail: SHIMO@ks.kyy.nitech.ac.jp</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>pyruvate dehydrogenase complex</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pyruvate dehydrogenase kinase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>aging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>starvation</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</abstract><qualityIndicators><score>5.064</score><pdfVersion>1.2</pdfVersion><pdfPageSize>468 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1123</abstractCharCount><pdfWordCount>2796</pdfWordCount><pdfCharCount>16085</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>189</abstractWordCount></qualityIndicators><title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat 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Japan</affiliation></author><author><persName><forename type="first">Yoshiharu</forename><surname>Oshida</surname></persName><affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation></author><author><persName><forename type="first">Atsushi</forename><surname>Yoshimura</surname></persName><affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation></author><author><persName><forename type="first">Noriaki</forename><surname>Fujitsuka</surname></persName><affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation></author><author><persName><forename type="first">satoru</forename><surname>Sugiyama</surname></persName><affiliation>Institute of Applied Biochemistry, Gifu 505-01, Japan</affiliation></author><author><persName><forename type="first">Yoshiharu</forename><surname>Shimomura</surname></persName><email>SHIMO@ks.kyy.nitech.ac.jp</email><affiliation>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</affiliation><affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation></author></analytic><monogr><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="pISSN">0024-3205</idno><idno type="PII">S0024-3205(00)X0118-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">60</biblScope><biblScope unit="issue">25</biblScope><biblScope unit="page" from="2309">2309</biblScope><biblScope unit="page" to="2314">2314</biblScope></imprint></monogr><idno type="istex">3DA80D27C65F7F414E65C4D95AC419900F133886</idno><idno 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Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>pyruvate dehydrogenase complex</term></item><item><term>pyruvate dehydrogenase kinase</term></item><item><term>aging</term></item><item><term>starvation</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-03-17">Modified</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>LFS</jid><aid>97002865</aid><ce:pii>S0024-3205(97)00286-5</ce:pii><ce:doi>10.1016/S0024-3205(97)00286-5</ce:doi><ce:copyright type="unknown" year="1997"></ce:copyright></item-info><head><ce:title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</ce:title><ce:author-group><ce:author><ce:given-name>Naoya</ce:given-name><ce:surname>Nakai</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yuzo</ce:given-name><ce:surname>Sato</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yoshiharu</ce:given-name><ce:surname>Oshida</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Atsushi</ce:given-name><ce:surname>Yoshimura</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>#</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Noriaki</ce:given-name><ce:surname>Fujitsuka</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>#</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>satoru</ce:given-name><ce:surname>Sugiyama</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yoshiharu</ce:given-name><ce:surname>Shimomura</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>#</ce:sup></ce:cross-ref><ce:e-address>SHIMO@ks.kyy.nitech.ac.jp</ce:e-address></ce:author><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Institute of Applied Biochemistry, Gifu 505-01, Japan</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</ce:text></ce:correspondence></ce:author-group><ce:date-revised day="17" month="3" year="1997"></ce:date-revised><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>pyruvate dehydrogenase complex</ce:text></ce:keyword><ce:keyword><ce:text>pyruvate dehydrogenase kinase</ce:text></ce:keyword><ce:keyword><ce:text>aging</ce:text></ce:keyword><ce:keyword><ce:text>starvation</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart</title></titleInfo><name type="personal"><namePart type="given">Naoya</namePart><namePart type="family">Nakai</namePart><affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yuzo</namePart><namePart type="family">Sato</namePart><affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshiharu</namePart><namePart type="family">Oshida</namePart><affiliation>Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464-01, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Atsushi</namePart><namePart type="family">Yoshimura</namePart><affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Noriaki</namePart><namePart type="family">Fujitsuka</namePart><affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">satoru</namePart><namePart type="family">Sugiyama</namePart><affiliation>Institute of Applied Biochemistry, Gifu 505-01, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshiharu</namePart><namePart type="family">Shimomura</namePart><affiliation>Corresponding author: Yoshiharu Shimomura, Ph.D., Department of Bioscience, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466, Japan. +81-52-735-5198 (TEL), +81-52-735-5201 (FAX).</affiliation><affiliation>Department of Bioscience, Nagoya Institute of Technology, Nagoya 466, Japan</affiliation><affiliation>E-mail: SHIMO@ks.kyy.nitech.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateModified encoding="w3cdtf">1997-03-17</dateModified><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Effects of aging on the activities of heart pyruvate dehydrogenase complex and pyruvate dehydrogenase kinase were examined using 7, 35 and 60 wk old rats. Aging did not affect the total activity of pyruvate dehydrogenase complex but decreased the activity state (percentage of active form) of the complex in rats under the fed condition (52%, 36% and 26% for 7, 35 and 60 wk old rats, respectively). This decrease in the complex activity with aging was suggested to be associated with an age-related decrease in the blood glucose disposal. Starvation for 24 h decreased the activity state to less than 3% in all of the age groups. The activity of pyruvate dehydrogcnase kinase associated with the complex was not related to the alteration in the activity state of the complex; the kinase activity was slightly lower in 60 wk old rats than in the younger rats under the fed condition and activation of the kinase by starvation was greater in the younger rats. The mechanism for the decrease in activity of pyruvate dehydrogenase complex was discussed on the basis of glucose and fatty acid utilization of heart muscle cells.</abstract><subject><genre>Keywords</genre><topic>pyruvate dehydrogenase complex</topic><topic>pyruvate dehydrogenase kinase</topic><topic>aging</topic><topic>starvation</topic></subject><relatedItem type="host"><titleInfo><title>Life Sciences</title></titleInfo><titleInfo type="abbreviated"><title>LFS</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19970516</dateIssued></originInfo><identifier type="ISSN">0024-3205</identifier><identifier type="PII">S0024-3205(00)X0118-X</identifier><part><date>19970516</date><detail type="volume"><number>60</number><caption>vol.</caption></detail><detail type="issue"><number>25</number><caption>no.</caption></detail><extent unit="issue pages"><start>PL371</start><end>PL394</end></extent><extent unit="issue pages"><start>2255</start><end>2359</end></extent><extent unit="pages"><start>2309</start><end>2314</end></extent></part></relatedItem><identifier type="istex">3DA80D27C65F7F414E65C4D95AC419900F133886</identifier><identifier type="DOI">10.1016/S0024-3205(97)00286-5</identifier><identifier type="PII">S0024-3205(97)00286-5</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/3DA80D27C65F7F414E65C4D95AC419900F133886/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">MEDICINE, RESEARCH & EXPERIMENTAL</classCode><classCode scheme="WOS">PHARMACOLOGY & PHARMACY</classCode><classCode scheme="WOS">BIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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