Steroid response pattern in Indian children with nephrotic syndrome
Identifieur interne : 001A22 ( Istex/Corpus ); précédent : 001A21; suivant : 001A23Steroid response pattern in Indian children with nephrotic syndrome
Auteurs : Sanjeev Gulati ; Vijay Kher ; Rk Sharma ; Amit GuptaSource :
- Acta Pædiatrica [ 0803-5253 ] ; 1994-05.
English descriptors
Abstract
Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253 The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow‐up. Of the 116 children with follow‐up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid‐dependent (18.1%), initial non‐responders (17.3%) and subsequent non‐responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non‐minimal change nephrotic syndrome lesions on histopathology
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DOI: 10.1111/j.1651-2227.1994.tb13074.x
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Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253 The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow‐up. Of the 116 children with follow‐up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid‐dependent (18.1%), initial non‐responders (17.3%) and subsequent non‐responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non‐minimal change nephrotic syndrome lesions on histopathology</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sanjeev Gulati</name><affiliations><json:string>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</json:string></affiliations></json:item><json:item><name>Vijay Kher</name><affiliations><json:string>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</json:string></affiliations></json:item><json:item><name>RK Sharma</name><affiliations><json:string>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</json:string></affiliations></json:item><json:item><name>Amit Gupta</name><affiliations><json:string>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Children</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nephrotic syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>steroid response patteern</value></json:item></subject><articleId><json:string>APA530</json:string></articleId><language><json:string>eng</json:string></language><abstract>Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253 The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow‐up. Of the 116 children with follow‐up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid‐dependent (18.1%), initial non‐responders (17.3%) and subsequent non‐responders (5.1%). 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Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253 The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow‐up. Of the 116 children with follow‐up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid‐dependent (18.1%), initial non‐responders (17.3%) and subsequent non‐responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non‐minimal change nephrotic syndrome lesions on histopathology</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Children</term></item><item><term>nephrotic syndrome</term></item><item><term>steroid response patteern</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/61F0732DDD36BE57EE4FC3515FB303EA0D851677/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1651-2227</doi><issn type="print">0803-5253</issn><issn type="electronic">1651-2227</issn><idGroup><id type="product" value="APA"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA PAEDIATRICA">Acta Pædiatrica</title></titleGroup></publicationMeta><publicationMeta level="part" position="05005"><doi origin="wiley">10.1111/apa.1994.83.issue-5</doi><numberingGroup><numbering type="journalVolume" number="83">83</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="1994-05">May 1994</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0053000" status="forIssue"><doi origin="wiley">10.1111/j.1651-2227.1994.tb13074.x</doi><idGroup><id type="unit" value="APA530"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLE</title></titleGroup><eventGroup><event type="firstOnline" date="2008-01-21"></event><event type="publishedOnlineFinalForm" date="2008-01-21"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:HeaderRef result:HeaderRef" date="2010-04-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="530">530</numbering><numbering type="pageLast" number="533">533</numbering></numberingGroup><correspondenceTo>V Kher, Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, UP India</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:APA.APA530.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received May 28, 1993. 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Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253</p><p>The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow‐up. Of the 116 children with follow‐up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid‐dependent (18.1%), initial non‐responders (17.3%) and subsequent non‐responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non‐minimal change nephrotic syndrome lesions on histopathology</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Steroid response pattern in Indian children with nephrotic syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Steroid response pattern in Indian children with nephrotic syndrome</title></titleInfo><name type="personal"><namePart type="given">Sanjeev</namePart><namePart type="family">Gulati</namePart><affiliation>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vijay</namePart><namePart type="family">Kher</namePart><affiliation>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</affiliation><description>Correspondence: V Kher, Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, UP India</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RK</namePart><namePart type="family">Sharma</namePart><affiliation>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amit</namePart><namePart type="family">Gupta</namePart><affiliation>Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1994-05</dateIssued><edition>Received May 28, 1993. Accepted Sep. 2. 1993</edition><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">12</extent></physicalDescription><abstract lang="en">Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253 The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow‐up. Of the 116 children with follow‐up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid‐dependent (18.1%), initial non‐responders (17.3%) and subsequent non‐responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non‐minimal change nephrotic syndrome lesions on histopathology</abstract><subject lang="en"><genre>Keywords</genre><topic>Children</topic><topic>nephrotic syndrome</topic><topic>steroid response patteern</topic></subject><relatedItem type="host"><titleInfo><title>Acta Pædiatrica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0803-5253</identifier><identifier type="eISSN">1651-2227</identifier><identifier type="DOI">10.1111/(ISSN)1651-2227</identifier><identifier type="PublisherID">APA</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>530</start><end>533</end><total>4</total></extent></part></relatedItem><identifier type="istex">61F0732DDD36BE57EE4FC3515FB303EA0D851677</identifier><identifier type="DOI">10.1111/j.1651-2227.1994.tb13074.x</identifier><identifier type="ArticleID">APA530</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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