Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat
Identifieur interne : 001930 ( Istex/Corpus ); précédent : 001929; suivant : 001931Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat
Auteurs : Albert J. Siemens ; Harold Kalant ; Jatinder M. Khanna ; Joan Marshman ; Gregory HoSource :
- Biochemical Pharmacology [ 0006-2952 ] ; 1973.
Abstract
The effects of two cannabis extracts with different cannabinoid compositions, as well of as pure Δ1-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on pentobarbital metabolism were studied in the rat. Extract I, with high proportions of CBN and CBD relative to THC, when given by gavage 21·5, 40 or 63 hr before pentobarbital (30 mg/kg, i.p.), prolonged the sleeping time by 53, 42 and 21 per cent respectively. This effect was paralleled by decreases in the rate of disappearance of [14C]pentobarbital from the blood, and of pentobarbital metabolism by liver microsomal preparations in vitro. Extract II, with low relative proportions of CBN and CBD, did not have any significant effect on penobarbital metabolism or sleeping time. CBD alone, in the same dose as that given in Extract I, had very similar effects, while a dose of CBD equivalent to that given in Extract II had no effect. THC, CBN and CBD added to normal rat liver microsomes in vitro inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN. The CBD content may, therefore, be a significant factor in interactions between marijuana and other drugs.
Url:
DOI: 10.1016/0006-2952(74)90612-1
Links to Exploration step
ISTEX:FC201FBA58195462D0A95C217D1D37C1A37C9828Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title><author><name sortKey="Siemens, Albert J" sort="Siemens, Albert J" uniqKey="Siemens A" first="Albert J." last="Siemens">Albert J. Siemens</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Kalant, Harold" sort="Kalant, Harold" uniqKey="Kalant H" first="Harold" last="Kalant">Harold Kalant</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Khanna, Jatinder M" sort="Khanna, Jatinder M" uniqKey="Khanna J" first="Jatinder M." last="Khanna">Jatinder M. Khanna</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Marshman, Joan" sort="Marshman, Joan" uniqKey="Marshman J" first="Joan" last="Marshman">Joan Marshman</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ho, Gregory" sort="Ho, Gregory" uniqKey="Ho G" first="Gregory" last="Ho">Gregory Ho</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FC201FBA58195462D0A95C217D1D37C1A37C9828</idno><date when="1974" year="1974">1974</date><idno type="doi">10.1016/0006-2952(74)90612-1</idno><idno type="url">https://api.istex.fr/document/FC201FBA58195462D0A95C217D1D37C1A37C9828/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001930</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title><author><name sortKey="Siemens, Albert J" sort="Siemens, Albert J" uniqKey="Siemens A" first="Albert J." last="Siemens">Albert J. Siemens</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Kalant, Harold" sort="Kalant, Harold" uniqKey="Kalant H" first="Harold" last="Kalant">Harold Kalant</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Khanna, Jatinder M" sort="Khanna, Jatinder M" uniqKey="Khanna J" first="Jatinder M." last="Khanna">Jatinder M. Khanna</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Marshman, Joan" sort="Marshman, Joan" uniqKey="Marshman J" first="Joan" last="Marshman">Joan Marshman</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ho, Gregory" sort="Ho, Gregory" uniqKey="Ho G" first="Gregory" last="Ho">Gregory Ho</name><affiliation><mods:affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical Pharmacology</title><title level="j" type="abbrev">BCP</title><idno type="ISSN">0006-2952</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973">1973</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="477">477</biblScope><biblScope unit="page" to="488">488</biblScope></imprint><idno type="ISSN">0006-2952</idno></series><idno type="istex">FC201FBA58195462D0A95C217D1D37C1A37C9828</idno><idno type="DOI">10.1016/0006-2952(74)90612-1</idno><idno type="PII">0006-2952(74)90612-1</idno><idno type="ArticleID">74906121</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-2952</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of two cannabis extracts with different cannabinoid compositions, as well of as pure Δ1-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on pentobarbital metabolism were studied in the rat. Extract I, with high proportions of CBN and CBD relative to THC, when given by gavage 21·5, 40 or 63 hr before pentobarbital (30 mg/kg, i.p.), prolonged the sleeping time by 53, 42 and 21 per cent respectively. This effect was paralleled by decreases in the rate of disappearance of [14C]pentobarbital from the blood, and of pentobarbital metabolism by liver microsomal preparations in vitro. Extract II, with low relative proportions of CBN and CBD, did not have any significant effect on penobarbital metabolism or sleeping time. CBD alone, in the same dose as that given in Extract I, had very similar effects, while a dose of CBD equivalent to that given in Extract II had no effect. THC, CBN and CBD added to normal rat liver microsomes in vitro inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN. The CBD content may, therefore, be a significant factor in interactions between marijuana and other drugs.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Albert J. Siemens</name><affiliations><json:string>Department of Pharmacology, University of Toronto, Toronto, Canada</json:string><json:string>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Harold Kalant</name><affiliations><json:string>Department of Pharmacology, University of Toronto, Toronto, Canada</json:string><json:string>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Jatinder M. Khanna</name><affiliations><json:string>Department of Pharmacology, University of Toronto, Toronto, Canada</json:string><json:string>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Joan Marshman</name><affiliations><json:string>Department of Pharmacology, University of Toronto, Toronto, Canada</json:string><json:string>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Gregory Ho</name><affiliations><json:string>Department of Pharmacology, University of Toronto, Toronto, Canada</json:string><json:string>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</json:string></affiliations></json:item></author><articleId><json:string>74906121</json:string></articleId><language><json:string>eng</json:string></language><abstract>The effects of two cannabis extracts with different cannabinoid compositions, as well of as pure Δ1-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on pentobarbital metabolism were studied in the rat. Extract I, with high proportions of CBN and CBD relative to THC, when given by gavage 21·5, 40 or 63 hr before pentobarbital (30 mg/kg, i.p.), prolonged the sleeping time by 53, 42 and 21 per cent respectively. This effect was paralleled by decreases in the rate of disappearance of [14C]pentobarbital from the blood, and of pentobarbital metabolism by liver microsomal preparations in vitro. Extract II, with low relative proportions of CBN and CBD, did not have any significant effect on penobarbital metabolism or sleeping time. CBD alone, in the same dose as that given in Extract I, had very similar effects, while a dose of CBD equivalent to that given in Extract II had no effect. THC, CBN and CBD added to normal rat liver microsomes in vitro inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN. The CBD content may, therefore, be a significant factor in interactions between marijuana and other drugs.</abstract><qualityIndicators><score>7.069</score><pdfVersion>1.2</pdfVersion><pdfPageSize>461 x 706 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1185</abstractCharCount><pdfWordCount>4789</pdfWordCount><pdfCharCount>27171</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>190</abstractWordCount></qualityIndicators><title>Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title><pii><json:string>0006-2952(74)90612-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>23</volume><pii><json:string>S0006-2952(00)X0882-9</json:string></pii><pages><last>488</last><first>477</first></pages><issn><json:string>0006-2952</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Biochemical Pharmacology</title><publicationDate>1974</publicationDate></host><publicationDate>1973</publicationDate><copyrightDate>1974</copyrightDate><doi><json:string>10.1016/0006-2952(74)90612-1</json:string></doi><id>FC201FBA58195462D0A95C217D1D37C1A37C9828</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/FC201FBA58195462D0A95C217D1D37C1A37C9828/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FC201FBA58195462D0A95C217D1D37C1A37C9828/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/FC201FBA58195462D0A95C217D1D37C1A37C9828/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FC201FBA58195462D0A95C217D1D37C1A37C9828/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1974</date></publicationStmt><notesStmt><note>Supported in part by Grant NHG-606-25-2, National Health and Welfare, Canada</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title><author><persName><forename type="first">Albert J.</forename><surname>Siemens</surname></persName><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation></author><author><persName><forename type="first">Harold</forename><surname>Kalant</surname></persName><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation></author><author><persName><forename type="first">Jatinder M.</forename><surname>Khanna</surname></persName><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation></author><author><persName><forename type="first">Joan</forename><surname>Marshman</surname></persName><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation></author><author><persName><forename type="first">Gregory</forename><surname>Ho</surname></persName><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation></author></analytic><monogr><title level="j">Biochemical Pharmacology</title><title level="j" type="abbrev">BCP</title><idno type="pISSN">0006-2952</idno><idno type="PII">S0006-2952(00)X0882-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="477">477</biblScope><biblScope unit="page" to="488">488</biblScope></imprint></monogr><idno type="istex">FC201FBA58195462D0A95C217D1D37C1A37C9828</idno><idno type="DOI">10.1016/0006-2952(74)90612-1</idno><idno type="PII">0006-2952(74)90612-1</idno><idno type="ArticleID">74906121</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1974</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The effects of two cannabis extracts with different cannabinoid compositions, as well of as pure Δ1-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on pentobarbital metabolism were studied in the rat. Extract I, with high proportions of CBN and CBD relative to THC, when given by gavage 21·5, 40 or 63 hr before pentobarbital (30 mg/kg, i.p.), prolonged the sleeping time by 53, 42 and 21 per cent respectively. This effect was paralleled by decreases in the rate of disappearance of [14C]pentobarbital from the blood, and of pentobarbital metabolism by liver microsomal preparations in vitro. Extract II, with low relative proportions of CBN and CBD, did not have any significant effect on penobarbital metabolism or sleeping time. CBD alone, in the same dose as that given in Extract I, had very similar effects, while a dose of CBD equivalent to that given in Extract II had no effect. THC, CBN and CBD added to normal rat liver microsomes in vitro inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN. The CBD content may, therefore, be a significant factor in interactions between marijuana and other drugs.</p></abstract></profileDesc><revisionDesc><change when="1973-07-27">Registration</change><change when="1973">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>BCP</jid><aid>74906121</aid><ce:pii>0006-2952(74)90612-1</ce:pii><ce:doi>10.1016/0006-2952(74)90612-1</ce:doi><ce:copyright type="unknown" year="1974"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Supported in part by Grant NHG-606-25-2, National Health and Welfare, Canada</ce:note-para></ce:article-footnote><ce:title>Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</ce:title><ce:author-group><ce:author><ce:given-name>Albert J.</ce:given-name><ce:surname>Siemens</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Harold</ce:given-name><ce:surname>Kalant</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jatinder M.</ce:given-name><ce:surname>Khanna</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Joan</ce:given-name><ce:surname>Marshman</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Gregory</ce:given-name><ce:surname>Ho</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Pharmacology, University of Toronto, Toronto, Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="28" month="2" year="1973"></ce:date-received><ce:date-accepted day="27" month="7" year="1973"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">The effects of two cannabis extracts with different cannabinoid compositions, as well of as pure Δ<ce:sup loc="post">1</ce:sup>-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on pentobarbital metabolism were studied in the rat. Extract I, with high proportions of CBN and CBD relative to THC, when given by gavage 21·5, 40 or 63 hr before pentobarbital (30 mg/kg, i.p.), prolonged the sleeping time by 53, 42 and 21 per cent respectively. This effect was paralleled by decreases in the rate of disappearance of [<ce:sup loc="pre">14</ce:sup>C]pentobarbital from the blood, and of pentobarbital metabolism by liver microsomal preparations <ce:italic>in vitro</ce:italic>. Extract II, with low relative proportions of CBN and CBD, did not have any significant effect on penobarbital metabolism or sleeping time. CBD alone, in the same dose as that given in Extract I, had very similar effects, while a dose of CBD equivalent to that given in Extract II had no effect. THC, CBN and CBD added to normal rat liver microsomes <ce:italic>in vitro</ce:italic> inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN. The CBD content may, therefore, be a significant factor in interactions between marijuana and other drugs.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat</title></titleInfo><name type="personal"><namePart type="given">Albert J.</namePart><namePart type="family">Siemens</namePart><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Harold</namePart><namePart type="family">Kalant</namePart><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jatinder M.</namePart><namePart type="family">Khanna</namePart><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joan</namePart><namePart type="family">Marshman</namePart><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregory</namePart><namePart type="family">Ho</namePart><affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada</affiliation><affiliation>The Alcoholism and Drug Addiction Research Foundation, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1973</dateIssued><dateValid encoding="w3cdtf">1973-07-27</dateValid><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The effects of two cannabis extracts with different cannabinoid compositions, as well of as pure Δ1-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on pentobarbital metabolism were studied in the rat. Extract I, with high proportions of CBN and CBD relative to THC, when given by gavage 21·5, 40 or 63 hr before pentobarbital (30 mg/kg, i.p.), prolonged the sleeping time by 53, 42 and 21 per cent respectively. This effect was paralleled by decreases in the rate of disappearance of [14C]pentobarbital from the blood, and of pentobarbital metabolism by liver microsomal preparations in vitro. Extract II, with low relative proportions of CBN and CBD, did not have any significant effect on penobarbital metabolism or sleeping time. CBD alone, in the same dose as that given in Extract I, had very similar effects, while a dose of CBD equivalent to that given in Extract II had no effect. THC, CBN and CBD added to normal rat liver microsomes in vitro inhibited pentobarbital metabolism competitively, CBD being a much more potent inhibitor than THC and CBN. The CBD content may, therefore, be a significant factor in interactions between marijuana and other drugs.</abstract><note>Supported in part by Grant NHG-606-25-2, National Health and Welfare, Canada</note><relatedItem type="host"><titleInfo><title>Biochemical Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>BCP</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19740201</dateIssued></originInfo><identifier type="ISSN">0006-2952</identifier><identifier type="PII">S0006-2952(00)X0882-9</identifier><part><date>19740201</date><detail type="volume"><number>23</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>477</start><end>761</end></extent><extent unit="pages"><start>477</start><end>488</end></extent></part></relatedItem><identifier type="istex">FC201FBA58195462D0A95C217D1D37C1A37C9828</identifier><identifier type="DOI">10.1016/0006-2952(74)90612-1</identifier><identifier type="PII">0006-2952(74)90612-1</identifier><identifier type="ArticleID">74906121</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:refBibTEI uri="https://api.istex.fr/document/FC201FBA58195462D0A95C217D1D37C1A37C9828/enrichments/refBib"><teiHeader></teiHeader><text><front></front><body></body><back><listBibl><biblStruct><analytic><author><persName><forename type="first">I</forename><forename type="middle">R C</forename><surname>Pillard</surname></persName></author><author><persName><surname>Eng</surname></persName></author></analytic><monogr><title level="j">J. Med</title><imprint><biblScope unit="volume">283</biblScope><biblScope unit="issue">294</biblScope><biblScope unit="page">0970</biblScope></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">W</forename><surname>Mcglothlin</surname></persName></author><author><persName><forename type="first">K</forename><surname>Jamison</surname></persName></author><author><persName><forename type="first">S. Rosi-;</forename><surname>Si~la</surname></persName></author><author><persName><surname>Rr</surname></persName></author><author><persName><surname>Nature</surname></persName></author><author><persName><surname>Lond</surname></persName></author><imprint><date type="published" when="1970"></date><biblScope unit="page">1227</biblScope></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">L</forename><forename type="middle">E</forename><surname>Hollister</surname></persName></author><author><persName><forename type="first">N</forename><forename type="middle">Y</forename><surname>Science</surname></persName></author><imprint><date type="published" when="1971"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">A</forename><forename type="middle">S</forename><surname>Carlin</surname></persName></author><author><persName><forename type="first">R</forename><forename type="middle">D</forename><surname>Post</surname></persName></author><author><persName><forename type="first">J</forename></persName></author></analytic><monogr><title level="j">Am. reed. Ass</title><imprint><biblScope unit="volume">218</biblScope><biblScope unit="page">867</biblScope><date type="published" when="1971"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">B</forename><forename type="middle">C</forename><surname>Bose</surname></persName></author><author><persName><forename type="first">A</forename><forename type="middle">Q</forename><surname>Satlq</surname></persName></author><author><persName><forename type="first">A</forename><forename type="middle">W</forename><surname>Bhagwa</surname></persName></author></analytic><monogr><title level="j">Archs. int. Pharmacodyn. ThOr</title><imprint><biblScope unit="volume">141</biblScope><biblScope unit="page">520</biblScope><date type="published" when="1963"></date></imprint></monogr></biblStruct><biblStruct><monogr><title level="m" type="main">~h: Its Chemistry and</title><author><persName><forename type="first">S</forename><surname>Gara</surname></persName></author><author><persName><surname>Itini</surname></persName></author><editor>Pharmacolo.qy G. E. W. WOLSTI-NHOLME and J. KYIGHr</editor><imprint><date type="published" when="1965"></date><biblScope unit="page">70</biblScope><pubPlace>Little, Brown, Boston</pubPlace></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">R</forename><forename type="middle">K</forename><surname>Keat</surname></persName></author><author><persName><forename type="first">H</forename><surname>~a</surname></persName></author><author><persName><surname>Barry</surname></persName></author><author><persName><forename type="first">J</forename><surname>Ill</surname></persName></author><imprint><date type="published" when="1970"></date><biblScope unit="page">94</biblScope></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">R</forename><forename type="middle">D</forename><surname>Soha</surname></persName></author><author><persName><forename type="first">H</forename><surname>Barry</surname></persName></author></analytic><monogr><title level="j">IIl. Eur. J. Pharmac</title><imprint><biblScope unit="volume">13</biblScope><biblScope unit="page">134</biblScope><date type="published" when="1970"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">J</forename><forename type="middle">C L J</forename><surname>Garriott</surname></persName></author><author><persName><forename type="first">R</forename><forename type="middle">B</forename><surname>King</surname></persName></author><author><persName><forename type="first">F</forename><forename type="middle">W</forename><surname>Eorney</surname></persName></author><author><persName><surname>Ht</surname></persName></author></analytic><monogr><title level="j">Life Sci., Pt. l</title><imprint><publisher>GH~S</publisher><publisher>GH~S</publisher><biblScope unit="volume">6</biblScope><biblScope unit="page">2119</biblScope><date type="published" when="1967"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">W</forename><forename type="middle">D M</forename><surname>Paton</surname></persName></author><author><persName><forename type="first">R</forename><forename type="middle">G</forename></persName></author></analytic><monogr><title level="j">Br. J. Pharmac. Chemother</title><imprint><biblScope unit="volume">44</biblScope><biblScope unit="page">250</biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">G</forename><surname>Jon~s</surname></persName></author><author><persName><forename type="first">R</forename><forename type="middle">G</forename><surname>Pertwi 'e</surname></persName></author><author><persName><surname>Br</surname></persName></author></analytic><monogr><title level="j">Pharmac. Chemother</title><imprint><biblScope unit="volume">45</biblScope><biblScope unit="page">375</biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">W</forename><forename type="middle">D M</forename><surname>Pa</surname></persName></author><author><persName><forename type="first">D</forename><forename type="middle">M</forename><surname>Temple</surname></persName></author><author><persName><surname>Br</surname></persName></author></analytic><monogr><title level="j">J. Pharmac. Chemother</title><imprint><biblScope unit="volume">44</biblScope><biblScope unit="page">346</biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">S</forename><forename type="middle">M</forename><surname>Agt 'rell</surname></persName></author><author><persName><forename type="first">C,, ~ ) N</forename><surname>Nil</surname></persName></author><author><persName><forename type="first">A</forename><surname>Ohly~</surname></persName></author><author><persName><forename type="first">F</forename><surname>Sa</surname></persName></author><author><persName><surname>~dberc</surname></persName></author></analytic><monogr><title level="j">Biochem. Pharmac</title><imprint><biblScope unit="volume">19</biblScope><biblScope unit="page">1333</biblScope><date type="published" when="1970"></date></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">M</forename><forename type="middle">D</forename><surname>Williyskv</surname></persName></author><imprint><date type="published" when="1971"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">H</forename><forename type="middle">Kala</forename></persName></author><author><persName><forename type="first">J</forename><forename type="middle">M</forename><surname>Kiianna</surname></persName></author><author><persName><forename type="first">J</forename><surname>Marshma~</surname></persName></author></analytic><monogr><title level="j">J. Pharmac. exp. Ther</title><imprint><biblScope unit="volume">175</biblScope><biblScope unit="page">318</biblScope><date type="published" when="1970"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">E</forename><surname>Rubii</surname></persName></author><author><persName><forename type="first">:</forename><forename type="middle">H</forename><surname>Gang</surname></persName></author><author><persName><forename type="first">P</forename><forename type="middle">S</forename><surname>Misra</surname></persName></author><author><persName><forename type="first">C</forename><forename type="middle">S</forename><surname>Liei3er</surname></persName></author></analytic><monogr><title level="j">Am. J. Med</title><imprint><biblScope unit="volume">49</biblScope><biblScope unit="page">801</biblScope><date type="published" when="1970"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">A</forename><forename type="middle">G</forename><surname>Gornat</surname></persName></author><author><persName><forename type="first">L</forename></persName></author><author><persName><forename type="first">C</forename><forename type="middle">J</forename><surname>Bardawlll</surname></persName></author><author><persName><forename type="first">M</forename><forename type="middle">M</forename><surname>David</surname></persName></author></analytic><monogr><title level="j">J. biol. Chem</title><imprint><biblScope unit="volume">177</biblScope><biblScope unit="page">751</biblScope><date type="published" when="1949"></date></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">B</forename><forename type="middle">B J J</forename><surname>Brodie</surname></persName></author><author><persName><forename type="first">L</forename><forename type="middle">C</forename><surname>Burns</surname></persName></author><author><persName><forename type="first">P</forename><forename type="middle">A</forename><surname>Mark</surname></persName></author><author><persName><forename type="middle">E</forename><surname>Lief</surname></persName></author><author><persName><forename type="first">E</forename><forename type="middle">M</forename><surname>Ber~qs~irq</surname></persName></author><author><persName><forename type="first">J</forename><surname>Papper</surname></persName></author><imprint><biblScope unit="page">0953</biblScope></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">H</forename><surname>Lineweaver</surname></persName></author><author><persName><forename type="first">D</forename><surname>Bl 'rk</surname></persName></author><author><persName><forename type="first">J</forename></persName></author></analytic><monogr><title level="j">Am. chem. Soc</title><imprint><biblScope unit="volume">56</biblScope><biblScope unit="page">658</biblScope><date type="published" when="1934"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">L</forename><surname>M1chaelis</surname></persName></author><author><persName><forename type="first">M</forename><forename type="middle">L</forename><surname>Menyi~n</surname></persName></author></analytic><monogr><title level="j">Biochem. Z</title><imprint><biblScope unit="volume">49</biblScope><biblScope unit="page">333</biblScope><date type="published" when="1913"></date></imprint></monogr></biblStruct><biblStruct><monogr><title level="m" type="main">Enzymes</title><author><persName><forename type="first">M</forename><surname>Dixon</surname></persName></author><author><persName><forename type="first">E</forename><forename type="middle">C</forename><surname>Weab</surname></persName></author><imprint><date type="published" when="1964"></date><publisher>Academic Press</publisher><biblScope unit="page">327</biblScope><pubPlace>New York</pubPlace></imprint></monogr><note>2nd. Ed</note></biblStruct><biblStruct><analytic><author><persName><forename type="first">H</forename><forename type="middle">P</forename><surname>Witschi</surname></persName></author><author><persName><forename type="first">B</forename><surname>Saint-Francois</surname></persName></author></analytic><monogr><title level="j">Toxic. appl. Pharmac</title><imprint><biblScope unit="volume">23</biblScope><biblScope unit="page">165</biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">J</forename><surname>Marcotte</surname></persName></author><author><persName><forename type="first">H</forename><forename type="middle">P</forename><surname>W1tscm</surname></persName></author></analytic><monogr><title level="j">Res. Commun. Chem. Path. Pharmac</title><imprint><biblScope unit="volume">4</biblScope><biblScope unit="page">561</biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct><analytic></analytic><monogr><title level="j">A. H. CO>;NEY, Pharmac. Rev</title><imprint><biblScope unit="volume">19</biblScope><biblScope unit="page">317</biblScope><date type="published" when="1967"></date></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">J</forename><forename type="middle">V</forename><surname>Dingell</surname></persName></author><author><persName><forename type="first">H</forename><forename type="middle">G</forename><surname>Wilcox</surname></persName></author><author><persName><forename type="first">H</forename><forename type="middle">A</forename><surname>Klat</surname></persName></author><editor>$NER</editor><imprint><date type="published" when="1971"></date><biblScope unit="page">296</biblScope></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">G</forename><forename type="middle">M</forename><surname>Cohen</surname></persName></author><author><persName><forename type="first">D</forename><forename type="middle">W</forename><surname>Peterson</surname></persName></author><author><persName><forename type="first">G</forename><forename type="middle">J</forename><surname>Mannering</surname></persName></author><author><persName><forename type="first">Life</forename><surname>Sci</surname></persName></author><imprint><date type="published" when="1971"></date><biblScope unit="page">1207</biblScope></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">O</forename><forename type="middle">H</forename><surname>S~</surname></persName></author><author><persName><forename type="first">A</forename><surname>Aus</surname></persName></author><author><persName><forename type="first">J</forename><surname>Goldstein</surname></persName></author></analytic><monogr><title level="j">gen. Physiol</title><imprint><biblScope unit="volume">26</biblScope><biblScope unit="page">559</biblScope><date type="published" when="1943"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">J</forename><forename type="middle">V</forename><surname>Dingell</surname></persName></author><author><persName><forename type="first">K</forename><forename type="middle">W</forename><surname>Miller</surname></persName></author><author><persName><forename type="first">E</forename><forename type="middle">C</forename><surname>Heath</surname></persName></author><author><persName><forename type="first">H</forename><forename type="middle">A</forename><surname>Klausner</surname></persName></author></analytic><monogr><title level="j">Biochem. Pharmac</title><imprint><biblScope unit="volume">22</biblScope><biblScope unit="page" from="949" to="0973"></biblScope></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">E</forename><forename type="middle">W</forename><surname>Maynert</surname></persName></author><author><persName><forename type="first">G</forename><forename type="middle">I</forename><surname>Keingman</surname></persName></author><author><persName><forename type="first">J</forename></persName></author><imprint><date type="published" when="1960"></date><biblScope unit="page">192</biblScope></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">H</forename><surname>Kalant</surname></persName></author><author><persName><forename type="first">A</forename></persName></author><author><persName><forename type="first">E</forename><surname>Leblanc</surname></persName></author><author><persName><forename type="first">R</forename><forename type="middle">J</forename><surname>Gm~ins</surname></persName></author></analytic><monogr><title level="j">Pharmac. Rev</title><imprint><biblScope unit="volume">23</biblScope><biblScope unit="page">135</biblScope><date type="published" when="1971"></date></imprint></monogr></biblStruct><biblStruct><analytic><author><persName><forename type="first">R</forename><forename type="middle">J</forename><surname>Freudenthal</surname></persName></author><author><persName><forename type="first">J</forename><surname>Mar</surname></persName></author><author><persName><forename type="first">M</forename><forename type="middle">E</forename><surname>Wall</surname></persName></author><author><persName><surname>Br</surname></persName></author></analytic><monogr><title level="j">J. Pharmac. Chemother</title><imprint><biblScope unit="volume">44</biblScope><biblScope unit="page">244</biblScope><date type="published" when="1972"></date></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">R</forename><forename type="middle">B</forename><surname>Forney</surname></persName></author><author><persName><surname>Pharmac</surname></persName></author><author><persName><surname>Re~</surname></persName></author><imprint><date type="published" when="1971"></date><biblScope unit="page">279</biblScope></imprint></monogr></biblStruct><biblStruct><monogr><author><persName><forename type="first">L</forename><forename type="middle">J</forename><surname>Lemaerger</surname></persName></author><author><persName><forename type="first">I</forename><forename type="middle">J</forename><surname>Axelrod</surname></persName></author><author><persName><surname>Kopin</surname></persName></author><author><persName><surname>Pharmac</surname></persName></author><author><persName><surname>Ret</surname></persName></author><imprint><date type="published" when="1971"></date><biblScope unit="page">371</biblScope></imprint></monogr></biblStruct></listBibl></back></text></istex:refBibTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001930 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001930 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Informatique
|area= ScrumV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:FC201FBA58195462D0A95C217D1D37C1A37C9828
|texte= Effect of cannabis on pentobarbital-induced sleeping time and pentobarbital metabolism in the rat
}}
| This area was generated with Dilib version V0.6.39. |  |