Immunological studies on aphthous ulcer and erythema nodosum‐like eruptions in Behcet's disease
Identifieur interne : 001875 ( Istex/Corpus ); précédent : 001874; suivant : 001876Immunological studies on aphthous ulcer and erythema nodosum‐like eruptions in Behcet's disease
Auteurs : F. Kaneko ; Y. Takahashi ; Y. Muramatsu ; Y. MiuraSource :
- British Journal of Dermatology [ 0007-0963 ] ; 1985-09.
Abstract
Patients with Behcet's disease show an intense delayed hypersensitivity (DH) reaction to a group of streptococcal bacteria. We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)‐like eruptions. Deposits of IgM and positive fluorescence of anti‐streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T‐cells and macrophages in association with natural killer cells. These results suggest that DH reactions with antigen‐antibody mediated cytotoxicity may play an important role in causing the lesions of Behcet's disease.
Url:
DOI: 10.1111/j.1365-2133.1985.tb02082.x
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Miura</name><affiliation><mods:affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6D0A5EA815C3A5992B958EDCA056C77D34C5F276</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1111/j.1365-2133.1985.tb02082.x</idno><idno type="url">https://api.istex.fr/document/6D0A5EA815C3A5992B958EDCA056C77D34C5F276/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001875</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Immunological studies on aphthous ulcer and erythema nodosum‐like eruptions in Behcet's disease</title><author><name sortKey="Kaneko, F" sort="Kaneko, F" uniqKey="Kaneko F" first="F." last="Kaneko">F. 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We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)‐like eruptions. Deposits of IgM and positive fluorescence of anti‐streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T‐cells and macrophages in association with natural killer cells. These results suggest that DH reactions with antigen‐antibody mediated cytotoxicity may play an important role in causing the lesions of Behcet's disease.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>F. KANEKO</name><affiliations><json:string>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</json:string></affiliations></json:item><json:item><name>Y. TAKAHASHI</name><affiliations><json:string>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</json:string></affiliations></json:item><json:item><name>Y. MURAMATSU</name><affiliations><json:string>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</json:string></affiliations></json:item><json:item><name>Y. MIURA</name><affiliations><json:string>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</json:string></affiliations></json:item></author><articleId><json:string>BJD303</json:string></articleId><language><json:string>eng</json:string></language><abstract>Patients with Behcet's disease show an intense delayed hypersensitivity (DH) reaction to a group of streptococcal bacteria. We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)‐like eruptions. 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We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)‐like eruptions. Deposits of IgM and positive fluorescence of anti‐streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T‐cells and macrophages in association with natural killer cells. 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We have attempted to detect deposits of immune complexes and to analyse cytological reactions in the aphthous ulcers and erythema nodosum (EN)‐like eruptions. Deposits of IgM and positive fluorescence of anti‐streptococcal group D serum were found in vessel walls and sites infiltrated by inflammatory cells. Cytological analysis has revealed that the inflammatory infiltrating cells are mainly composed of activated T‐cells and macrophages in association with natural killer cells. These results suggest that DH reactions with antigen‐antibody mediated cytotoxicity may play an important role in causing the lesions of Behcet's disease.</abstract><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0007-0963</identifier><identifier type="eISSN">1365-2133</identifier><identifier type="DOI">10.1111/(ISSN)1365-2133</identifier><identifier type="PublisherID">BJD</identifier><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>303</start><end>312</end><total>10</total></extent></part></relatedItem><identifier type="istex">6D0A5EA815C3A5992B958EDCA056C77D34C5F276</identifier><identifier type="DOI">10.1111/j.1365-2133.1985.tb02082.x</identifier><identifier type="ArticleID">BJD303</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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