HORMONAL RESPONSES TO CARDIAC SURGERY: EFFECTS OF SUFENTANIL, SOMATOSTATIN AND GANGLION BLOCK
Identifieur interne : 001192 ( Istex/Corpus ); précédent : 001191; suivant : 001193HORMONAL RESPONSES TO CARDIAC SURGERY: EFFECTS OF SUFENTANIL, SOMATOSTATIN AND GANGLION BLOCK
Auteurs : J. P. Desborough ; G. M. Hall ; G. R. Hart ; J. M. Burrin ; S. R. BloomSource :
- BJA: British Journal of Anaesthesia [ 0007-0912 ] ; 1990-06.
Abstract
We have investigated the effect of the addition of somatostatin and trimetaphan to sufentanil 20 μg kg−1 on the hormonal responses to cardiac surgery and compared the changes with a control group receiving sufentanil and sodium nitro-prusside. Eighteen patients undergoing elective valve replacement surgery were studied. Patients who received somatostatin and trimetaphan in addition to sufentanil had significantly smaller serum growth hormone and plasma glucagon concentrations compared with those who received sufentanil and sodium nitroprusside. The cortisol response to surgery was inhibited in both groups. There were no significant differences in catecholamine concentrations between the two groups. There was no effect of the additional inhibition of glucagon and growth hormone on circulating concentrations of glucose and lactate, but plasma concentrations of non-esterified fatty acids increased significantly. Thus the addition of somatostatin increased the suppression of the hormonal response to cardiac surgery by sufentanil.
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DOI: 10.1093/bja/64.6.688
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Burrin</name><affiliation><mods:affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</mods:affiliation></affiliation></author><author><name sortKey="Bloom, S R" sort="Bloom, S R" uniqKey="Bloom S" first="S. R." last="Bloom">S. R. Bloom</name><affiliation><mods:affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">BJA: British Journal of Anaesthesia</title><idno type="ISSN">0007-0912</idno><idno type="eISSN">1471-6771</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-06">1990-06</date><biblScope unit="volume">64</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="688">688</biblScope><biblScope unit="page" to="695">695</biblScope></imprint><idno type="ISSN">0007-0912</idno></series><idno type="istex">C6C5ACB0E2167AAB52BBA503D208056D64558DB7</idno><idno type="DOI">10.1093/bja/64.6.688</idno><idno type="ArticleID">64.6.688</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0912</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">We have investigated the effect of the addition of somatostatin and trimetaphan to sufentanil 20 μg kg−1 on the hormonal responses to cardiac surgery and compared the changes with a control group receiving sufentanil and sodium nitro-prusside. Eighteen patients undergoing elective valve replacement surgery were studied. Patients who received somatostatin and trimetaphan in addition to sufentanil had significantly smaller serum growth hormone and plasma glucagon concentrations compared with those who received sufentanil and sodium nitroprusside. The cortisol response to surgery was inhibited in both groups. There were no significant differences in catecholamine concentrations between the two groups. There was no effect of the additional inhibition of glucagon and growth hormone on circulating concentrations of glucose and lactate, but plasma concentrations of non-esterified fatty acids increased significantly. Thus the addition of somatostatin increased the suppression of the hormonal response to cardiac surgery by sufentanil.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>J. P. DESBOROUGH</name><affiliations><json:string>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</json:string></affiliations></json:item><json:item><name>G. M. HALL</name><affiliations><json:string>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</json:string></affiliations></json:item><json:item><name>G. R. HART</name><affiliations><json:string>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</json:string></affiliations></json:item><json:item><name>J. M. BURRIN</name><affiliations><json:string>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</json:string></affiliations></json:item><json:item><name>S. R. BLOOM</name><affiliations><json:string>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ORIGINAL ARTICLES</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Analgesics: sufentanil</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hormones: catecholamines, cortisol, growth hormone, somatostatin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Surgery: cardiac, hormonal response</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sympathetic nervous system: ganglion block</value></json:item></subject><articleId><json:string>64.6.688</json:string></articleId><language><json:string>eng</json:string></language><abstract>We have investigated the effect of the addition of somatostatin and trimetaphan to sufentanil 20 μg kg−1 on the hormonal responses to cardiac surgery and compared the changes with a control group receiving sufentanil and sodium nitro-prusside. 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P.</forename><surname>DESBOROUGH</surname></persName><affiliation>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation></author><author><persName><forename type="first">G. M.</forename><surname>HALL</surname></persName><affiliation>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation></author><author><persName><forename type="first">G. R.</forename><surname>HART</surname></persName><affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation></author><author><persName><forename type="first">J. M.</forename><surname>BURRIN</surname></persName><affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation></author><author><persName><forename type="first">S. R.</forename><surname>BLOOM</surname></persName><affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation></author></analytic><monogr><title level="j">BJA: British Journal of Anaesthesia</title><idno type="pISSN">0007-0912</idno><idno type="eISSN">1471-6771</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-06"></date><biblScope unit="volume">64</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="688">688</biblScope><biblScope unit="page" to="695">695</biblScope></imprint></monogr><idno type="istex">C6C5ACB0E2167AAB52BBA503D208056D64558DB7</idno><idno type="DOI">10.1093/bja/64.6.688</idno><idno type="ArticleID">64.6.688</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>We have investigated the effect of the addition of somatostatin and trimetaphan to sufentanil 20 μg kg−1 on the hormonal responses to cardiac surgery and compared the changes with a control group receiving sufentanil and sodium nitro-prusside. 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Thus the addition of somatostatin increased the suppression of the hormonal response to cardiac surgery by sufentanil.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>ORIGINAL ARTICLES</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Analgesics: sufentanil</term></item><item><term>Hormones: catecholamines, cortisol, growth hormone, somatostatin</term></item><item><term>Surgery: cardiac, hormonal response</term></item><item><term>Sympathetic nervous system: ganglion block</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-06">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-15">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C6C5ACB0E2167AAB52BBA503D208056D64558DB7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">brjana</journal-id><journal-id journal-id-type="publisher-id">bjaint</journal-id><journal-id journal-id-type="pmc">brjana</journal-id><journal-title>BJA: British Journal of Anaesthesia</journal-title><issn pub-type="epub">1471-6771</issn><issn pub-type="ppub">0007-0912</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">64.6.688</article-id><article-id pub-id-type="doi">10.1093/bja/64.6.688</article-id><article-categories><subj-group><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>HORMONAL RESPONSES TO CARDIAC SURGERY: EFFECTS OF SUFENTANIL, SOMATOSTATIN AND GANGLION BLOCK</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>DESBOROUGH</surname><given-names>J. P.</given-names></name><degrees>M.B., CH.B., F.F.A.R.C.S.</degrees><xref ref-type="aff" rid="au1"></xref></contrib><contrib contrib-type="author"><name><surname>HALL</surname><given-names>G. M.</given-names></name><degrees>M.B., B.S., PH.D., F.I.BIOL., F.F.A.R.C.S.</degrees><xref ref-type="aff" rid="au1"></xref></contrib><contrib contrib-type="author"><name><surname>HART</surname><given-names>G. R.</given-names></name><degrees>B.SC., PH.D.</degrees><xref ref-type="aff" rid="au2"></xref></contrib><contrib contrib-type="author"><name><surname>BURRIN</surname><given-names>J. M.</given-names></name><degrees>B.SC., PH.D.</degrees><xref ref-type="aff" rid="au2"></xref></contrib><contrib contrib-type="author"><name><surname>BLOOM</surname><given-names>S. R.</given-names></name><degrees>M.D., D.SC., F.R.C.P.</degrees><xref ref-type="aff" rid="au2"></xref></contrib><aff id="au1"><institution>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School</institution> <addr-line>Du Cane Road, London W12 0HS</addr-line></aff><aff id="au2"><institution>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School</institution> <addr-line>Du Cane Road, London W12 0HS</addr-line></aff></contrib-group><pub-date pub-type="ppub"><month>6</month><year>1990</year></pub-date><volume>64</volume><issue>6</issue><fpage>688</fpage><lpage>695</lpage><history><date date-type="accepted"><day>21</day><month>12</month><year>1989</year></date></history><copyright-statement>© 1990 British Journal of Anaesthesia</copyright-statement><copyright-year>1990</copyright-year><abstract><p>We have investigated the effect of the addition of somatostatin and trimetaphan to sufentanil 20 μg kg<sup>−1</sup> on the hormonal responses to cardiac surgery and compared the changes with a control group receiving sufentanil and sodium nitro-prusside. Eighteen patients undergoing elective valve replacement surgery were studied. Patients who received somatostatin and trimetaphan in addition to sufentanil had significantly smaller serum growth hormone and plasma glucagon concentrations compared with those who received sufentanil and sodium nitroprusside. The cortisol response to surgery was inhibited in both groups. There were no significant differences in catecholamine concentrations between the two groups. There was no effect of the additional inhibition of glucagon and growth hormone on circulating concentrations of glucose and lactate, but plasma concentrations of non-esterified fatty acids increased significantly. Thus the addition of somatostatin increased the suppression of the hormonal response to cardiac surgery by sufentanil.</p></abstract><kwd-group><kwd>Analgesics: sufentanil</kwd><kwd>Hormones: catecholamines, cortisol, growth hormone, somatostatin</kwd><kwd>Surgery: cardiac, hormonal response</kwd><kwd>Sympathetic nervous system: ganglion block</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>HORMONAL RESPONSES TO CARDIAC SURGERY: EFFECTS OF SUFENTANIL, SOMATOSTATIN AND GANGLION BLOCK</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>HORMONAL RESPONSES TO CARDIAC SURGERY: EFFECTS OF SUFENTANIL, SOMATOSTATIN AND GANGLION BLOCK</title></titleInfo><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">DESBOROUGH</namePart><affiliation>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. M.</namePart><namePart type="family">HALL</namePart><affiliation>Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. R.</namePart><namePart type="family">HART</namePart><affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">BURRIN</namePart><affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. R.</namePart><namePart type="family">BLOOM</namePart><affiliation>Department of Endocrinology, Hammersmith Hospital, Royal Postgraduate Medical School Du Cane Road, London W12 0HS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>ORIGINAL ARTICLES</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1990-06</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>We have investigated the effect of the addition of somatostatin and trimetaphan to sufentanil 20 μg kg−1 on the hormonal responses to cardiac surgery and compared the changes with a control group receiving sufentanil and sodium nitro-prusside. 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Thus the addition of somatostatin increased the suppression of the hormonal response to cardiac surgery by sufentanil.</abstract><subject><genre>Keywords</genre><topic>Analgesics: sufentanil</topic><topic>Hormones: catecholamines, cortisol, growth hormone, somatostatin</topic><topic>Surgery: cardiac, hormonal response</topic><topic>Sympathetic nervous system: ganglion block</topic></subject><relatedItem type="host"><titleInfo><title>BJA: British Journal of Anaesthesia</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0007-0912</identifier><identifier type="eISSN">1471-6771</identifier><identifier type="PublisherID">bjaint</identifier><identifier type="PublisherID-hwp">brjana</identifier><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>64</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>688</start><end>695</end></extent></part></relatedItem><identifier type="istex">C6C5ACB0E2167AAB52BBA503D208056D64558DB7</identifier><identifier type="DOI">10.1093/bja/64.6.688</identifier><identifier type="ArticleID">64.6.688</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1990 British Journal of Anaesthesia</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C6C5ACB0E2167AAB52BBA503D208056D64558DB7/annexes/pdf</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/C6C5ACB0E2167AAB52BBA503D208056D64558DB7/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">ANESTHESIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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