IgE, IgG and IgA antibodies in serum and nasal secretion during parenteral hyposensitization
Identifieur interne : 001190 ( Istex/Corpus ); précédent : 001189; suivant : 001191IgE, IgG and IgA antibodies in serum and nasal secretion during parenteral hyposensitization
Auteurs : H. Deuschl ; S. G. O. Johansson ; F. FagerbergSource :
- Clinical & Experimental Allergy [ 0954-7894 ] ; 1977-07.
Abstract
Eighteen adult patients with allergic rhinitis due to Timothy pollen were observed for 36 weeks before, during and after the grass pollen season. Eight patients were treated by parenteral hyposensitization with grass pollen extract, and ten patients who were given no immunotherapy served as controls. Timothy‐specific IgE, IgG and IgA antibodies in samples of serum and nasal secretion were quantified by radioimmunological technique. In comparison with the control group, the serum concentration of Timothy‐specific IgE antibodies increased significantly (P <0.05) during the preseasonal hyposensitization treatment and then decreased significantly (P <0.05) during and after the pollen season while this therapy was being continued. In the hyposensitized patients the serum concentration of both IgG and IgA antibodies increased highly significantly (P <0.01 and P <0.001, respectively) during immunotherapy. In nasal secretion quantitative changes of the three types of antibodies were usually less pronounced or not detectable at all. The concentration of IgG antibodies, however, showed some increase in the nasal secretion during hyposensitization. These minor increases in allergen‐specific IgG and IgA antibodies in nasal secretion might explain why parenteral hyposensitization in allergic rhinitis often does not give complete relief from symptoms.
Url:
DOI: 10.1111/j.1365-2222.1977.tb01459.x
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Fagerberg</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DAA116853919F557E5D37DBA1CE8A6F626F04201</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1111/j.1365-2222.1977.tb01459.x</idno><idno type="url">https://api.istex.fr/document/DAA116853919F557E5D37DBA1CE8A6F626F04201/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001190</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">IgE, IgG and IgA antibodies in serum and nasal secretion during parenteral hyposensitization</title><author><name sortKey="Deuschl, H" sort="Deuschl, H" uniqKey="Deuschl H" first="H." last="Deuschl">H. Deuschl</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Johansson, S G O" sort="Johansson, S G O" uniqKey="Johansson S" first="S. G. O." last="Johansson">S. G. O. Johansson</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Fagerberg, F" sort="Fagerberg, F" uniqKey="Fagerberg F" first="F." last="Fagerberg">F. 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Eight patients were treated by parenteral hyposensitization with grass pollen extract, and ten patients who were given no immunotherapy served as controls. Timothy‐specific IgE, IgG and IgA antibodies in samples of serum and nasal secretion were quantified by radioimmunological technique. In comparison with the control group, the serum concentration of Timothy‐specific IgE antibodies increased significantly (P <0.05) during the preseasonal hyposensitization treatment and then decreased significantly (P <0.05) during and after the pollen season while this therapy was being continued. In the hyposensitized patients the serum concentration of both IgG and IgA antibodies increased highly significantly (P <0.01 and P <0.001, respectively) during immunotherapy. In nasal secretion quantitative changes of the three types of antibodies were usually less pronounced or not detectable at all. The concentration of IgG antibodies, however, showed some increase in the nasal secretion during hyposensitization. These minor increases in allergen‐specific IgG and IgA antibodies in nasal secretion might explain why parenteral hyposensitization in allergic rhinitis often does not give complete relief from symptoms.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>H. DEUSCHL</name><affiliations><json:string>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</json:string></affiliations></json:item><json:item><name>S. G. O. JOHANSSON</name><affiliations><json:string>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</json:string></affiliations></json:item><json:item><name>F. 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In comparison with the control group, the serum concentration of Timothy‐specific IgE antibodies increased significantly (P >0.05) during the preseasonal hyposensitization treatment and then decreased significantly (P >0.05) during and after the pollen season while this therapy was being continued. In the hyposensitized patients the serum concentration of both IgG and IgA antibodies increased highly significantly (P >0.01 and P >0.001, respectively) during immunotherapy. In nasal secretion quantitative changes of the three types of antibodies were usually less pronounced or not detectable at all. The concentration of IgG antibodies, however, showed some increase in the nasal secretion during hyposensitization. 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Eight patients were treated by parenteral hyposensitization with grass pollen extract, and ten patients who were given no immunotherapy served as controls. Timothy‐specific IgE, IgG and IgA antibodies in samples of serum and nasal secretion were quantified by radioimmunological technique. In comparison with the control group, the serum concentration of Timothy‐specific IgE antibodies increased significantly (P <0.05) during the preseasonal hyposensitization treatment and then decreased significantly (P <0.05) during and after the pollen season while this therapy was being continued. In the hyposensitized patients the serum concentration of both IgG and IgA antibodies increased highly significantly (P <0.01 and P <0.001, respectively) during immunotherapy. In nasal secretion quantitative changes of the three types of antibodies were usually less pronounced or not detectable at all. The concentration of IgG antibodies, however, showed some increase in the nasal secretion during hyposensitization. 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Deuschl, Department of Otorhinolaryngology, University Hospital, S‐750 14 Uppsala, Sweden.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CEA.CEA315.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="33"></count><count type="linksCrossRef" number="4"></count></countGroup><titleGroup><title type="main">IgE, IgG and IgA antibodies in serum and nasal secretion during parenteral hyposensitization</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>H.</givenNames><familyName>DEUSCHL</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>S. G. O.</givenNames><familyName>JOHANSSON</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>F.</givenNames><familyName>FAGERBERG</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="SE"><unparsedAffiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>Eighteen adult patients with allergic rhinitis due to Timothy pollen were observed for 36 weeks before, during and after the grass pollen season. Eight patients were treated by parenteral hyposensitization with grass pollen extract, and ten patients who were given no immunotherapy served as controls. Timothy‐specific IgE, IgG and IgA antibodies in samples of serum and nasal secretion were quantified by radioimmunological technique.</p><p>In comparison with the control group, the serum concentration of Timothy‐specific IgE antibodies increased significantly (<i>P</i> <0.05) during the preseasonal hyposensitization treatment and then decreased significantly (<i>P</i> <0.05) during and after the pollen season while this therapy was being continued. In the hyposensitized patients the serum concentration of both IgG and IgA antibodies increased highly significantly (<i>P</i> <0.01 and <i>P</i> <0.001, respectively) during immunotherapy.</p><p>In nasal secretion quantitative changes of the three types of antibodies were usually less pronounced or not detectable at all. The concentration of IgG antibodies, however, showed some increase in the nasal secretion during hyposensitization. These minor increases in allergen‐specific IgG and IgA antibodies in nasal secretion might explain why parenteral hyposensitization in allergic rhinitis often does not give complete relief from symptoms.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>IgE, IgG and IgA antibodies in serum and nasal secretion during parenteral hyposensitization</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>IgE, IgG and IgA antibodies in serum and nasal secretion during parenteral hyposensitization</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">DEUSCHL</namePart><affiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</affiliation><description>Correspondence: Dr H. Deuschl, Department of Otorhinolaryngology, University Hospital, S‐750 14 Uppsala, Sweden.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. G. O.</namePart><namePart type="family">JOHANSSON</namePart><affiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">FAGERBERG</namePart><affiliation>Department of Otorhinolaryngology, the Blood Centre and Department of Lung Medicine, University Hospital, Uppsala, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1977-07</dateIssued><copyrightDate encoding="w3cdtf">1977</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">33</extent></physicalDescription><abstract lang="en">Eighteen adult patients with allergic rhinitis due to Timothy pollen were observed for 36 weeks before, during and after the grass pollen season. Eight patients were treated by parenteral hyposensitization with grass pollen extract, and ten patients who were given no immunotherapy served as controls. Timothy‐specific IgE, IgG and IgA antibodies in samples of serum and nasal secretion were quantified by radioimmunological technique. In comparison with the control group, the serum concentration of Timothy‐specific IgE antibodies increased significantly (P <0.05) during the preseasonal hyposensitization treatment and then decreased significantly (P <0.05) during and after the pollen season while this therapy was being continued. In the hyposensitized patients the serum concentration of both IgG and IgA antibodies increased highly significantly (P <0.01 and P <0.001, respectively) during immunotherapy. In nasal secretion quantitative changes of the three types of antibodies were usually less pronounced or not detectable at all. The concentration of IgG antibodies, however, showed some increase in the nasal secretion during hyposensitization. These minor increases in allergen‐specific IgG and IgA antibodies in nasal secretion might explain why parenteral hyposensitization in allergic rhinitis often does not give complete relief from symptoms.</abstract><relatedItem type="host"><titleInfo><title>Clinical & Experimental Allergy</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0954-7894</identifier><identifier type="eISSN">1365-2222</identifier><identifier type="DOI">10.1111/(ISSN)1365-2222</identifier><identifier type="PublisherID">CEA</identifier><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>315</start><end>324</end><total>10</total></extent></part></relatedItem><identifier type="istex">DAA116853919F557E5D37DBA1CE8A6F626F04201</identifier><identifier type="DOI">10.1111/j.1365-2222.1977.tb01459.x</identifier><identifier type="ArticleID">CEA315</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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