SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS
Identifieur interne : 000E30 ( Istex/Corpus ); précédent : 000E29; suivant : 000E31SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS
Auteurs : A. Pakarinen ; G. L. Hammond ; R. VihkoSource :
- Clinical Endocrinology [ 0300-0664 ] ; 1979-11.
Abstract
We have determined the concentrations of pregnenolone, progesterone, 17α‐hydroxyprogesterone, androstenedione, testosterone, 5α‐dihydrotestosler‐one and androsterone in serum samples collected from a total of seventy‐nine boys who were 8–18 years of age at the time the first blood samples were drawn. Additional samples were drawn from sixty‐six and forty‐four of these boys after 1 and 2 year intervals, respectively. The first increases in serum steroid concentrations were those of androstenedione and androsterone, thus supporting the hypothesis that an early activation of the adrenal cortex is the first hormonal change in puberty. This increase in serum androstenedione occurred 2 years earlier than the first significant increase in serum testosterone, which took place by 13 5 years, after the first signs of external genital development, but in concert with the onset of pubic hair growth. The serum concentrations of 5α‐dihydrotestosterone were closely related to those of testosterone, but the relative increases were smaller, the consequence of which is a decrease in the ratio of 5α‐dihydrotestosterone: testosterone throughout puberty. The main increase in serum androsterone tends to take place after that of 5α‐dihydrotestosterone and testosterone. In comparison with the four androgens, the serum concentrations of their C21 precursors correlated rather poorly with the physical signs of advancing puberty. As in the case of androstenedione, the concentrations of pregnenolone and 17α‐hydroxyprogesterone were relatively high in the youngest age groups, which probably also reflects an early adrenal activation. In contrast to testosterone, the major increases in precursor steroids occur at a relatively late stage of puberty. It seems likely therefore that a major qualitative shift in the testicular secretion of steroids occurs during puberty in boys.
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DOI: 10.1111/j.1365-2265.1979.tb03098.x
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ISTEX:012D17595F29409C46787080D8E9AD9D6CBDD47BLe document en format XML
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University of Oulu, SF‐90220 Oulu 22, Finland</mods:affiliation></affiliation></author><author><name sortKey="Hammond, G L" sort="Hammond, G L" uniqKey="Hammond G" first="G. L." last="Hammond">G. L. Hammond</name><affiliation><mods:affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</mods:affiliation></affiliation></author><author><name sortKey="Vihko, R" sort="Vihko, R" uniqKey="Vihko R" first="R." last="Vihko">R. Vihko</name><affiliation><mods:affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Endocrinology</title><idno type="ISSN">0300-0664</idno><idno type="eISSN">1365-2265</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1979-11">1979-11</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="465">465</biblScope><biblScope unit="page" to="474">474</biblScope></imprint><idno type="ISSN">0300-0664</idno></series><idno type="istex">012D17595F29409C46787080D8E9AD9D6CBDD47B</idno><idno type="DOI">10.1111/j.1365-2265.1979.tb03098.x</idno><idno type="ArticleID">CEN465</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-0664</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have determined the concentrations of pregnenolone, progesterone, 17α‐hydroxyprogesterone, androstenedione, testosterone, 5α‐dihydrotestosler‐one and androsterone in serum samples collected from a total of seventy‐nine boys who were 8–18 years of age at the time the first blood samples were drawn. Additional samples were drawn from sixty‐six and forty‐four of these boys after 1 and 2 year intervals, respectively. The first increases in serum steroid concentrations were those of androstenedione and androsterone, thus supporting the hypothesis that an early activation of the adrenal cortex is the first hormonal change in puberty. This increase in serum androstenedione occurred 2 years earlier than the first significant increase in serum testosterone, which took place by 13 5 years, after the first signs of external genital development, but in concert with the onset of pubic hair growth. The serum concentrations of 5α‐dihydrotestosterone were closely related to those of testosterone, but the relative increases were smaller, the consequence of which is a decrease in the ratio of 5α‐dihydrotestosterone: testosterone throughout puberty. The main increase in serum androsterone tends to take place after that of 5α‐dihydrotestosterone and testosterone. In comparison with the four androgens, the serum concentrations of their C21 precursors correlated rather poorly with the physical signs of advancing puberty. As in the case of androstenedione, the concentrations of pregnenolone and 17α‐hydroxyprogesterone were relatively high in the youngest age groups, which probably also reflects an early adrenal activation. In contrast to testosterone, the major increases in precursor steroids occur at a relatively late stage of puberty. It seems likely therefore that a major qualitative shift in the testicular secretion of steroids occurs during puberty in boys.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>A. PAKARINEN</name><affiliations><json:string>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</json:string></affiliations></json:item><json:item><name>G. L. HAMMOND</name><affiliations><json:string>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</json:string></affiliations></json:item><json:item><name>R. VIHKO</name><affiliations><json:string>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</json:string></affiliations></json:item></author><articleId><json:string>CEN465</json:string></articleId><language><json:string>eng</json:string></language><abstract>We have determined the concentrations of pregnenolone, progesterone, 17α‐hydroxyprogesterone, androstenedione, testosterone, 5α‐dihydrotestosler‐one and androsterone in serum samples collected from a total of seventy‐nine boys who were 8–18 years of age at the time the first blood samples were drawn. Additional samples were drawn from sixty‐six and forty‐four of these boys after 1 and 2 year intervals, respectively. The first increases in serum steroid concentrations were those of androstenedione and androsterone, thus supporting the hypothesis that an early activation of the adrenal cortex is the first hormonal change in puberty. This increase in serum androstenedione occurred 2 years earlier than the first significant increase in serum testosterone, which took place by 13 5 years, after the first signs of external genital development, but in concert with the onset of pubic hair growth. The serum concentrations of 5α‐dihydrotestosterone were closely related to those of testosterone, but the relative increases were smaller, the consequence of which is a decrease in the ratio of 5α‐dihydrotestosterone: testosterone throughout puberty. The main increase in serum androsterone tends to take place after that of 5α‐dihydrotestosterone and testosterone. In comparison with the four androgens, the serum concentrations of their C21 precursors correlated rather poorly with the physical signs of advancing puberty. As in the case of androstenedione, the concentrations of pregnenolone and 17α‐hydroxyprogesterone were relatively high in the youngest age groups, which probably also reflects an early adrenal activation. In contrast to testosterone, the major increases in precursor steroids occur at a relatively late stage of puberty. It seems likely therefore that a major qualitative shift in the testicular secretion of steroids occurs during puberty in boys.</abstract><qualityIndicators><score>7.011</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1874</abstractCharCount><pdfWordCount>3511</pdfWordCount><pdfCharCount>23030</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>269</abstractWordCount></qualityIndicators><title>SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS</title><genre><json:string>article</json:string></genre><host><volume>11</volume><publisherId><json:string>CEN</json:string></publisherId><pages><total>10</total><last>474</last><first>465</first></pages><issn><json:string>0300-0664</json:string></issn><issue>5</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1365-2265</json:string></eissn><title>Clinical Endocrinology</title><doi><json:string>10.1111/(ISSN)1365-2265</json:string></doi></host><publicationDate>1979</publicationDate><copyrightDate>1979</copyrightDate><doi><json:string>10.1111/j.1365-2265.1979.tb03098.x</json:string></doi><id>012D17595F29409C46787080D8E9AD9D6CBDD47B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/012D17595F29409C46787080D8E9AD9D6CBDD47B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/012D17595F29409C46787080D8E9AD9D6CBDD47B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/012D17595F29409C46787080D8E9AD9D6CBDD47B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1979</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS</title><author><persName><forename type="first">A.</forename><surname>PAKARINEN</surname></persName><note type="correspondence"><p>Correspondence: Dr Arto Pakarinen, Department of Clinical Chemistry, University of Oulu, SF‐90220 Oulu 22, Finland</p></note><affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</affiliation></author><author><persName><forename type="first">G. L.</forename><surname>HAMMOND</surname></persName><affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</affiliation></author><author><persName><forename type="first">R.</forename><surname>VIHKO</surname></persName><affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</affiliation></author></analytic><monogr><title level="j">Clinical Endocrinology</title><idno type="pISSN">0300-0664</idno><idno type="eISSN">1365-2265</idno><idno type="DOI">10.1111/(ISSN)1365-2265</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1979-11"></date><biblScope unit="volume">11</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="465">465</biblScope><biblScope unit="page" to="474">474</biblScope></imprint></monogr><idno type="istex">012D17595F29409C46787080D8E9AD9D6CBDD47B</idno><idno type="DOI">10.1111/j.1365-2265.1979.tb03098.x</idno><idno type="ArticleID">CEN465</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1979</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We have determined the concentrations of pregnenolone, progesterone, 17α‐hydroxyprogesterone, androstenedione, testosterone, 5α‐dihydrotestosler‐one and androsterone in serum samples collected from a total of seventy‐nine boys who were 8–18 years of age at the time the first blood samples were drawn. Additional samples were drawn from sixty‐six and forty‐four of these boys after 1 and 2 year intervals, respectively. The first increases in serum steroid concentrations were those of androstenedione and androsterone, thus supporting the hypothesis that an early activation of the adrenal cortex is the first hormonal change in puberty. This increase in serum androstenedione occurred 2 years earlier than the first significant increase in serum testosterone, which took place by 13 5 years, after the first signs of external genital development, but in concert with the onset of pubic hair growth. The serum concentrations of 5α‐dihydrotestosterone were closely related to those of testosterone, but the relative increases were smaller, the consequence of which is a decrease in the ratio of 5α‐dihydrotestosterone: testosterone throughout puberty. The main increase in serum androsterone tends to take place after that of 5α‐dihydrotestosterone and testosterone. In comparison with the four androgens, the serum concentrations of their C21 precursors correlated rather poorly with the physical signs of advancing puberty. As in the case of androstenedione, the concentrations of pregnenolone and 17α‐hydroxyprogesterone were relatively high in the youngest age groups, which probably also reflects an early adrenal activation. In contrast to testosterone, the major increases in precursor steroids occur at a relatively late stage of puberty. 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L.</givenNames><familyName>HAMMOND</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>R.</givenNames><familyName>VIHKO</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FI"><unparsedAffiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">SUMMARY</title><p>We have determined the concentrations of pregnenolone, progesterone, 17α‐hydroxyprogesterone, androstenedione, testosterone, 5α‐dihydrotestosler‐one and androsterone in serum samples collected from a total of seventy‐nine boys who were 8–18 years of age at the time the first blood samples were drawn. Additional samples were drawn from sixty‐six and forty‐four of these boys after 1 and 2 year intervals, respectively. The first increases in serum steroid concentrations were those of androstenedione and androsterone, thus supporting the hypothesis that an early activation of the adrenal cortex is the first hormonal change in puberty. This increase in serum androstenedione occurred 2 years earlier than the first significant increase in serum testosterone, which took place by 13 5 years, after the first signs of external genital development, but in concert with the onset of pubic hair growth. The serum concentrations of 5α‐dihydrotestosterone were closely related to those of testosterone, but the relative increases were smaller, the consequence of which is a decrease in the ratio of 5α‐dihydrotestosterone: testosterone throughout puberty. The main increase in serum androsterone tends to take place after that of 5α‐dihydrotestosterone and testosterone. In comparison with the four androgens, the serum concentrations of their C<sub>21</sub> precursors correlated rather poorly with the physical signs of advancing puberty. As in the case of androstenedione, the concentrations of pregnenolone and 17α‐hydroxyprogesterone were relatively high in the youngest age groups, which probably also reflects an early adrenal activation. In contrast to testosterone, the major increases in precursor steroids occur at a relatively late stage of puberty. It seems likely therefore that a major qualitative shift in the testicular secretion of steroids occurs during puberty in boys.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>SERUM PREGNENOLONE, PROGESTERONE, 17α‐HYDROXYPROGESTERONE, ANDROSTENEDIONE, TESTOSTERONE, 5α‐DIHYDROTESTOSTERONE AND ANDROSTERONE DURING PUBERTY IN BOYS</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">PAKARINEN</namePart><affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</affiliation><description>Correspondence: Dr Arto Pakarinen, Department of Clinical Chemistry, University of Oulu, SF‐90220 Oulu 22, Finland</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. L.</namePart><namePart type="family">HAMMOND</namePart><affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">VIHKO</namePart><affiliation>Department of Clinical Chemistry. University of Oulu, SF‐90220 Oulu 22, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1979-11</dateIssued><edition>(Received 12 January 1979; revised 8 May 1979; accepted 10 May 1979)</edition><copyrightDate encoding="w3cdtf">1979</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">19</extent></physicalDescription><abstract lang="en">We have determined the concentrations of pregnenolone, progesterone, 17α‐hydroxyprogesterone, androstenedione, testosterone, 5α‐dihydrotestosler‐one and androsterone in serum samples collected from a total of seventy‐nine boys who were 8–18 years of age at the time the first blood samples were drawn. Additional samples were drawn from sixty‐six and forty‐four of these boys after 1 and 2 year intervals, respectively. The first increases in serum steroid concentrations were those of androstenedione and androsterone, thus supporting the hypothesis that an early activation of the adrenal cortex is the first hormonal change in puberty. This increase in serum androstenedione occurred 2 years earlier than the first significant increase in serum testosterone, which took place by 13 5 years, after the first signs of external genital development, but in concert with the onset of pubic hair growth. The serum concentrations of 5α‐dihydrotestosterone were closely related to those of testosterone, but the relative increases were smaller, the consequence of which is a decrease in the ratio of 5α‐dihydrotestosterone: testosterone throughout puberty. The main increase in serum androsterone tends to take place after that of 5α‐dihydrotestosterone and testosterone. In comparison with the four androgens, the serum concentrations of their C21 precursors correlated rather poorly with the physical signs of advancing puberty. As in the case of androstenedione, the concentrations of pregnenolone and 17α‐hydroxyprogesterone were relatively high in the youngest age groups, which probably also reflects an early adrenal activation. In contrast to testosterone, the major increases in precursor steroids occur at a relatively late stage of puberty. It seems likely therefore that a major qualitative shift in the testicular secretion of steroids occurs during puberty in boys.</abstract><relatedItem type="host"><titleInfo><title>Clinical Endocrinology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0300-0664</identifier><identifier type="eISSN">1365-2265</identifier><identifier type="DOI">10.1111/(ISSN)1365-2265</identifier><identifier type="PublisherID">CEN</identifier><part><date>1979</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>465</start><end>474</end><total>10</total></extent></part></relatedItem><identifier type="istex">012D17595F29409C46787080D8E9AD9D6CBDD47B</identifier><identifier type="DOI">10.1111/j.1365-2265.1979.tb03098.x</identifier><identifier type="ArticleID">CEN465</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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