Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature
Identifieur interne : 000D65 ( Istex/Corpus ); précédent : 000D64; suivant : 000D66Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature
Auteurs : K. Tadokoro ; N. Niimi ; T. Ohtoshi ; K. Nakajima ; S. Takafuji ; K. Onodera ; S. Suzuki ; M. MuranakaSource :
- Clinical & Experimental Allergy [ 0954-7894 ] ; 1994-02.
Abstract
Cefotiam (CTM) is one of the most popular cephem antibiotics in Japan. Recently we experienced two cases of nurses with CTM‐induced contact anaphylaxis. When they were preparing drip infusions of antibiotics or working around other nurses doing so, they suddenly fell into shock with other symptoms such as flushing, urtiearia, abdominal distress, vomiting, dyspnoea and or loss of consciousness. The symptoms never occurred after they avoided exposure to CTM. Passive cutaneous or open patch tests were positive for CTM. Histamine release was induced by CTM from washed leucocytes. RAST analysis using CTM‐human serum albumin‐coupled dises showed high % RAST count, suggesting that these reactions were mediated by IgE antibodies. A RAST inhibition test suggested that the methyl‐thiotetrazol side‐chain was the main antigenic determinant. Both patients had hand dermatitis that had appeared preceding the episodes of anaphylaxis. Although the dermatitis had been resistant to treatments, it also disappeared after they avoided exposure to CTM, It seemed likely that it was also induced or exacerbated by CTM and facilitated the penetration of CTM to cause anaphylaxis. The literature is also reviewed.
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DOI: 10.1111/j.1365-2222.1994.tb00208.x
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Ohtoshi</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K." last="Nakajima">K. Nakajima</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takafuji, S" sort="Takafuji, S" uniqKey="Takafuji S" first="S." last="Takafuji">S. Takafuji</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Onodera, K" sort="Onodera, K" uniqKey="Onodera K" first="K." last="Onodera">K. 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Tadokoro</name><affiliation><mods:affiliation>Department of Research, The Japanese Red Cross Central Blood Centre, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Niimi, N" sort="Niimi, N" uniqKey="Niimi N" first="N." last="Niimi">N. Niimi</name><affiliation><mods:affiliation>Yuaikinen Hospital, Ibaraki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ohtoshi, T" sort="Ohtoshi, T" uniqKey="Ohtoshi T" first="T." last="Ohtoshi">T. Ohtoshi</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K." last="Nakajima">K. Nakajima</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Takafuji, S" sort="Takafuji, S" uniqKey="Takafuji S" first="S." last="Takafuji">S. Takafuji</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Onodera, K" sort="Onodera, K" uniqKey="Onodera K" first="K." last="Onodera">K. Onodera</name><affiliation><mods:affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Suzuki, S" sort="Suzuki, S" uniqKey="Suzuki S" first="S." last="Suzuki">S. Suzuki</name><affiliation><mods:affiliation>Health Care Center, University of Shijuoka, Shizuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Muranaka, M" sort="Muranaka, M" uniqKey="Muranaka M" first="M." last="Muranaka">M. Muranaka</name><affiliation><mods:affiliation>Yugawara Kosei‐nenkin Hospital, Kanagawa, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical & Experimental Allergy</title><idno type="ISSN">0954-7894</idno><idno type="eISSN">1365-2222</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-02">1994-02</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="127">127</biblScope><biblScope unit="page" to="133">133</biblScope></imprint><idno type="ISSN">0954-7894</idno></series><idno type="istex">3E6265996318BF571F2FD7250C716CEC7E101F34</idno><idno type="DOI">10.1111/j.1365-2222.1994.tb00208.x</idno><idno type="ArticleID">CEA127</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0954-7894</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cefotiam (CTM) is one of the most popular cephem antibiotics in Japan. Recently we experienced two cases of nurses with CTM‐induced contact anaphylaxis. When they were preparing drip infusions of antibiotics or working around other nurses doing so, they suddenly fell into shock with other symptoms such as flushing, urtiearia, abdominal distress, vomiting, dyspnoea and or loss of consciousness. The symptoms never occurred after they avoided exposure to CTM. Passive cutaneous or open patch tests were positive for CTM. Histamine release was induced by CTM from washed leucocytes. RAST analysis using CTM‐human serum albumin‐coupled dises showed high % RAST count, suggesting that these reactions were mediated by IgE antibodies. A RAST inhibition test suggested that the methyl‐thiotetrazol side‐chain was the main antigenic determinant. Both patients had hand dermatitis that had appeared preceding the episodes of anaphylaxis. Although the dermatitis had been resistant to treatments, it also disappeared after they avoided exposure to CTM, It seemed likely that it was also induced or exacerbated by CTM and facilitated the penetration of CTM to cause anaphylaxis. The literature is also reviewed.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>K. TADOKORO</name><affiliations><json:string>Department of Research, The Japanese Red Cross Central Blood Centre, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>N. NIIMI</name><affiliations><json:string>Yuaikinen Hospital, Ibaraki, Japan</json:string></affiliations></json:item><json:item><name>T. OHTOSHI</name><affiliations><json:string>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>K. NAKAJIMA</name><affiliations><json:string>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>S. TAKAFUJI</name><affiliations><json:string>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>K. ONODERA</name><affiliations><json:string>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>S. SUZUKI</name><affiliations><json:string>Health Care Center, University of Shijuoka, Shizuoka, Japan</json:string></affiliations></json:item><json:item><name>M. MURANAKA</name><affiliations><json:string>Yugawara Kosei‐nenkin Hospital, Kanagawa, Japan</json:string></affiliations></json:item></author><articleId><json:string>CEA127</json:string></articleId><language><json:string>eng</json:string></language><abstract>Cefotiam (CTM) is one of the most popular cephem antibiotics in Japan. Recently we experienced two cases of nurses with CTM‐induced contact anaphylaxis. When they were preparing drip infusions of antibiotics or working around other nurses doing so, they suddenly fell into shock with other symptoms such as flushing, urtiearia, abdominal distress, vomiting, dyspnoea and or loss of consciousness. The symptoms never occurred after they avoided exposure to CTM. Passive cutaneous or open patch tests were positive for CTM. Histamine release was induced by CTM from washed leucocytes. RAST analysis using CTM‐human serum albumin‐coupled dises showed high % RAST count, suggesting that these reactions were mediated by IgE antibodies. A RAST inhibition test suggested that the methyl‐thiotetrazol side‐chain was the main antigenic determinant. Both patients had hand dermatitis that had appeared preceding the episodes of anaphylaxis. Although the dermatitis had been resistant to treatments, it also disappeared after they avoided exposure to CTM, It seemed likely that it was also induced or exacerbated by CTM and facilitated the penetration of CTM to cause anaphylaxis. The literature is also reviewed.</abstract><qualityIndicators><score>7.132</score><pdfVersion>1.6</pdfVersion><pdfPageSize>546 x 744 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1203</abstractCharCount><pdfWordCount>3484</pdfWordCount><pdfCharCount>20496</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>179</abstractWordCount></qualityIndicators><title>Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>CEA</json:string></publisherId><pages><total>7</total><last>133</last><first>127</first></pages><issn><json:string>0954-7894</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1365-2222</json:string></eissn><title>Clinical & Experimental Allergy</title><doi><json:string>10.1111/(ISSN)1365-2222</json:string></doi></host><publicationDate>1994</publicationDate><copyrightDate>1994</copyrightDate><doi><json:string>10.1111/j.1365-2222.1994.tb00208.x</json:string></doi><id>3E6265996318BF571F2FD7250C716CEC7E101F34</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3E6265996318BF571F2FD7250C716CEC7E101F34/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3E6265996318BF571F2FD7250C716CEC7E101F34/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3E6265996318BF571F2FD7250C716CEC7E101F34/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1994</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature</title><author><persName><forename type="first">K.</forename><surname>TADOKORO</surname></persName><note type="correspondence"><p>Correspondence: Dr K. Tadokoro, Department of Research, The Japanese Red Cross Central Blood Center, 4‐1‐31, Hiro‐o. Shibuya‐ku, Tokyo, 150 Japan</p></note><affiliation>Department of Research, The Japanese Red Cross Central Blood Centre, Tokyo, Japan</affiliation></author><author><persName><forename type="first">N.</forename><surname>NIIMI</surname></persName><affiliation>Yuaikinen Hospital, Ibaraki, Japan</affiliation></author><author><persName><forename type="first">T.</forename><surname>OHTOSHI</surname></persName><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation></author><author><persName><forename type="first">K.</forename><surname>NAKAJIMA</surname></persName><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation></author><author><persName><forename type="first">S.</forename><surname>TAKAFUJI</surname></persName><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation></author><author><persName><forename type="first">K.</forename><surname>ONODERA</surname></persName><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation></author><author><persName><forename type="first">S.</forename><surname>SUZUKI</surname></persName><affiliation>Health Care Center, University of Shijuoka, Shizuoka, Japan</affiliation></author><author><persName><forename type="first">M.</forename><surname>MURANAKA</surname></persName><affiliation>Yugawara Kosei‐nenkin Hospital, Kanagawa, Japan</affiliation></author></analytic><monogr><title level="j">Clinical & Experimental Allergy</title><idno type="pISSN">0954-7894</idno><idno type="eISSN">1365-2222</idno><idno type="DOI">10.1111/(ISSN)1365-2222</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-02"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="127">127</biblScope><biblScope unit="page" to="133">133</biblScope></imprint></monogr><idno type="istex">3E6265996318BF571F2FD7250C716CEC7E101F34</idno><idno type="DOI">10.1111/j.1365-2222.1994.tb00208.x</idno><idno type="ArticleID">CEA127</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Cefotiam (CTM) is one of the most popular cephem antibiotics in Japan. Recently we experienced two cases of nurses with CTM‐induced contact anaphylaxis. When they were preparing drip infusions of antibiotics or working around other nurses doing so, they suddenly fell into shock with other symptoms such as flushing, urtiearia, abdominal distress, vomiting, dyspnoea and or loss of consciousness. The symptoms never occurred after they avoided exposure to CTM. Passive cutaneous or open patch tests were positive for CTM. Histamine release was induced by CTM from washed leucocytes. RAST analysis using CTM‐human serum albumin‐coupled dises showed high % RAST count, suggesting that these reactions were mediated by IgE antibodies. A RAST inhibition test suggested that the methyl‐thiotetrazol side‐chain was the main antigenic determinant. Both patients had hand dermatitis that had appeared preceding the episodes of anaphylaxis. Although the dermatitis had been resistant to treatments, it also disappeared after they avoided exposure to CTM, It seemed likely that it was also induced or exacerbated by CTM and facilitated the penetration of CTM to cause anaphylaxis. The literature is also reviewed.</p></abstract></profileDesc><revisionDesc><change when="1994-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3E6265996318BF571F2FD7250C716CEC7E101F34/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2222</doi><issn type="print">0954-7894</issn><issn type="electronic">1365-2222</issn><idGroup><id type="product" value="CEA"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CLINICAL EXPERIMENTAL ALLERGY">Clinical & Experimental Allergy</title></titleGroup></publicationMeta><publicationMeta level="part" position="02002"><doi origin="wiley">10.1111/cea.1994.24.issue-2</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="1994-02">February 1994</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0012700" status="forIssue"><doi origin="wiley">10.1111/j.1365-2222.1994.tb00208.x</doi><idGroup><id type="unit" value="CEA127"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original article</title></titleGroup><eventGroup><event type="firstOnline" date="2006-04-27"></event><event type="publishedOnlineFinalForm" date="2006-04-27"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-09"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="127">127</numbering><numbering type="pageLast" number="133">133</numbering></numberingGroup><correspondenceTo>Dr K. Tadokoro, Department of Research, The Japanese Red Cross Central Blood Center, 4‐1‐31, Hiro‐o. Shibuya‐ku, Tokyo, 150 Japan</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CEA.CEA127.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Submitted 26 January 1993; revised 20 August 1993: accepted 13 September 1993.</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="21"></count><count type="linksCrossRef" number="9"></count></countGroup><titleGroup><title type="main">Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a2" corresponding="yes"><personName><givenNames>K.</givenNames><familyName>TADOKORO</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>N.</givenNames><familyName>NIIMI</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>T.</givenNames><familyName>OHTOSHI</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>K.</givenNames><familyName>NAKAJIMA</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>S.</givenNames><familyName>TAKAFUJI</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>K.</givenNames><familyName>ONODERA</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a4"><personName><givenNames>S.</givenNames><familyName>SUZUKI</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a5"><personName><givenNames>M.</givenNames><familyName>MURANAKA</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="JP"><unparsedAffiliation>Department of Research, The Japanese Red Cross Central Blood Centre, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="JP"><unparsedAffiliation>Yuaikinen Hospital, Ibaraki, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="JP"><unparsedAffiliation>Health Care Center, University of Shijuoka, Shizuoka, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="JP"><unparsedAffiliation>Yugawara Kosei‐nenkin Hospital, Kanagawa, Japan</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>Cefotiam (CTM) is one of the most popular cephem antibiotics in Japan. Recently we experienced two cases of nurses with CTM‐induced contact anaphylaxis. When they were preparing drip infusions of antibiotics or working around other nurses doing so, they suddenly fell into shock with other symptoms such as flushing, urtiearia, abdominal distress, vomiting, dyspnoea and or loss of consciousness. The symptoms never occurred after they avoided exposure to CTM. Passive cutaneous or open patch tests were positive for CTM. Histamine release was induced by CTM from washed leucocytes. RAST analysis using CTM‐human serum albumin‐coupled dises showed high % RAST count, suggesting that these reactions were mediated by IgE antibodies. A RAST inhibition test suggested that the methyl‐thiotetrazol side‐chain was the main antigenic determinant. Both patients had hand dermatitis that had appeared preceding the episodes of anaphylaxis. Although the dermatitis had been resistant to treatments, it also disappeared after they avoided exposure to CTM, It seemed likely that it was also induced or exacerbated by CTM and facilitated the penetration of CTM to cause anaphylaxis. The literature is also reviewed.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cefotiam‐induced IgE‐mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">TADOKORO</namePart><affiliation>Department of Research, The Japanese Red Cross Central Blood Centre, Tokyo, Japan</affiliation><description>Correspondence: Dr K. Tadokoro, Department of Research, The Japanese Red Cross Central Blood Center, 4‐1‐31, Hiro‐o. Shibuya‐ku, Tokyo, 150 Japan</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">NIIMI</namePart><affiliation>Yuaikinen Hospital, Ibaraki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">OHTOSHI</namePart><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">NAKAJIMA</namePart><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">TAKAFUJI</namePart><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">ONODERA</namePart><affiliation>Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">SUZUKI</namePart><affiliation>Health Care Center, University of Shijuoka, Shizuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">MURANAKA</namePart><affiliation>Yugawara Kosei‐nenkin Hospital, Kanagawa, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1994-02</dateIssued><edition>Submitted 26 January 1993; revised 20 August 1993: accepted 13 September 1993.</edition><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">21</extent></physicalDescription><abstract lang="en">Cefotiam (CTM) is one of the most popular cephem antibiotics in Japan. Recently we experienced two cases of nurses with CTM‐induced contact anaphylaxis. When they were preparing drip infusions of antibiotics or working around other nurses doing so, they suddenly fell into shock with other symptoms such as flushing, urtiearia, abdominal distress, vomiting, dyspnoea and or loss of consciousness. The symptoms never occurred after they avoided exposure to CTM. Passive cutaneous or open patch tests were positive for CTM. Histamine release was induced by CTM from washed leucocytes. RAST analysis using CTM‐human serum albumin‐coupled dises showed high % RAST count, suggesting that these reactions were mediated by IgE antibodies. A RAST inhibition test suggested that the methyl‐thiotetrazol side‐chain was the main antigenic determinant. Both patients had hand dermatitis that had appeared preceding the episodes of anaphylaxis. Although the dermatitis had been resistant to treatments, it also disappeared after they avoided exposure to CTM, It seemed likely that it was also induced or exacerbated by CTM and facilitated the penetration of CTM to cause anaphylaxis. The literature is also reviewed.</abstract><relatedItem type="host"><titleInfo><title>Clinical & Experimental Allergy</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0954-7894</identifier><identifier type="eISSN">1365-2222</identifier><identifier type="DOI">10.1111/(ISSN)1365-2222</identifier><identifier type="PublisherID">CEA</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>127</start><end>133</end><total>7</total></extent></part></relatedItem><identifier type="istex">3E6265996318BF571F2FD7250C716CEC7E101F34</identifier><identifier type="DOI">10.1111/j.1365-2222.1994.tb00208.x</identifier><identifier type="ArticleID">CEA127</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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