Drug Therapy in Alcoholic Liver Disease
Identifieur interne : 000B69 ( Istex/Corpus ); précédent : 000B68; suivant : 000B70Drug Therapy in Alcoholic Liver Disease
Auteurs : J B Saunders ; Roger WilliamsSource :
- Alcohol and Alcoholism [ 0735-0414 ] ; 1981.
Abstract
Drug therapy in patients with alcoholic liver disease may be directed towards preventing the disease progessing, treating complications such as ascites and hepatic encephalopathy, and treating associated clinical problems such as the alcohol-withdrawal syndrome. No drugs, with the possible exception of cortiscosteroids, modify the disease process significantly. Treatment of ascites has improved in recent years with the use of aldosterone antagonists such as spironolactone, and lactulose has proved to be a useful drug in the management of hepatic encephalopathy. Sedatives and other drugs that depress central nervous system fuction must be used with great caution, particularly in patients who have decompensated liver disease or who continue to drink heavily. The possibility of toxic side-effects must be considered before any drug is prescribed for a patient with alcoholic liver disease.
Url:
DOI: 10.1093/oxfordjournals.alcalc.a044275
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No drugs, with the possible exception of cortiscosteroids, modify the disease process significantly. Treatment of ascites has improved in recent years with the use of aldosterone antagonists such as spironolactone, and lactulose has proved to be a useful drug in the management of hepatic encephalopathy. Sedatives and other drugs that depress central nervous system fuction must be used with great caution, particularly in patients who have decompensated liver disease or who continue to drink heavily. 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