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Macrocryoglobulinemia and sarcoidosis

Identifieur interne : 000845 ( Istex/Corpus ); précédent : 000844; suivant : 000846

Macrocryoglobulinemia and sarcoidosis

Auteurs : Roger W. Turkington ; C. Edward Buckley Iii

Source :

RBID : ISTEX:2BFCF2541B32CED6F3AAC5FFA753AC033AC5A57B

Abstract

Macrocryoglobulinemia as the initial and predominant manifestation of systemic illness in a patient who had sarcoidosis is described and related to specific alterations in the serum immunoglobulins during the development of the disease. Ultracentrifugation of serum revealed an increase in intermediate molecular weight macroglobulin in addition to the IgM and IgG cryoglobulin complex. Immunoserologic studies demonstrated significant increases in IgA immunoglobulin and beta1C and beta1A globulins occurring coincident with the development of increased serum complement activity and anergy to tuberculoprotein. These changes are formulated as indicating that an unusual response to sensitization may be pathogenetically important in sarcoidosis. Alterations in serum protein fractions in sarcoidosis may be a manifestation of this immune response.

Url:
DOI: 10.1016/0002-9343(66)90197-5

Links to Exploration step

ISTEX:2BFCF2541B32CED6F3AAC5FFA753AC033AC5A57B

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