Effect of low dose cyproterone acetate on the response of acne to isotretinoin
Identifieur interne : 000612 ( Istex/Corpus ); précédent : 000611; suivant : 000613Effect of low dose cyproterone acetate on the response of acne to isotretinoin
Auteurs : J. R. Marsden ; M. F. Laker ; G. P. Ford ; Sam ShusterSource :
- British Journal of Dermatology [ 0007-0963 ] ; 1984-06.
Abstract
Twenty‐seven males with severe acne were treated for 12 weeks with 0·05 mg/kg/day isotretinoin (ten patients) or 5 mg daily cyproterone acetate (eight patients) or both drugs together in these doses (nine patients). With isotretinoin, the sebum excretion rate (SER) fell by 45%± 9% s.e.m. (P < 0·0025), lesion count fell by 65%± 10% (P < 0·0005) and median clinical severity fell from 8 to 2·5 (P= 0·01). With cyproterone acetate there was a 17%± 12% (NS) fall in SER, a 15%± 10% (NS) fall in lesion count and the median severity was unchanged. Patients treated with both drugs showed a 42%± 13% reduction in SER (P < 0·005), a 68%± 11% decrease in lesion count (P < 0.0005) and a decrease in median severity from 8 to 4 (P < 0·01) which was no different from the response to isotretionoin alone. Isotretinoin increased serum cholesterol from 4·4 mmol/1 ± 0.3 s.e.m. to 4.7 mmol/1 ± 0·3 s.e.m.(P < 0.01), serum triglyceride from 0·73 mmol/1 ± 0·07 s.e.m. to 0·96 mmol/1 ± 0·14 s.e.m. (P < 0·05) and γ‐glutamyltransferase (GGT) from 15·9 i.u./1 ± 2·1 s.e.m. to 19·0 i.u./1 ± 2·4 s.e.m. (P < 0·01). Comparison of the area under the concentration‐time curve for triglyceride and high density lipoprotein (HDL)‐cholesterol showed that the changes were smaller when isotretinoin was combined with cyproterone acetate. We conclude that the effect of isotretinoin in acne was not enhanced by the antiandrogen, but the increase in serum triglyceride and decrease in HDL‐cholesterol produced by the retinoid were reduced by combination with the antiandrogen.
Url:
DOI: 10.1111/j.1365-2133.1984.tb04707.x
Links to Exploration step
ISTEX:EFD92C48A37E2905BAB6459AA7C0A106B956FE37Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title><author><name sortKey="Marsden, J R" sort="Marsden, J R" uniqKey="Marsden J" first="J. R." last="Marsden">J. R. Marsden</name><affiliation><mods:affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</mods:affiliation></affiliation></author><author><name sortKey="Laker, M F" sort="Laker, M F" uniqKey="Laker M" first="M. F." last="Laker">M. F. Laker</name><affiliation><mods:affiliation>Department of Clinical Biochemistry, University of Newcastle upon Tyne, NE1 4LP, U. K.</mods:affiliation></affiliation></author><author><name sortKey="Ford, G P" sort="Ford, G P" uniqKey="Ford G" first="G. P." last="Ford">G. P. Ford</name><affiliation><mods:affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</mods:affiliation></affiliation></author><author><name sortKey="Shuster, Sam" sort="Shuster, Sam" uniqKey="Shuster S" first="Sam" last="Shuster">Sam Shuster</name><affiliation><mods:affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EFD92C48A37E2905BAB6459AA7C0A106B956FE37</idno><date when="1984" year="1984">1984</date><idno type="doi">10.1111/j.1365-2133.1984.tb04707.x</idno><idno type="url">https://api.istex.fr/document/EFD92C48A37E2905BAB6459AA7C0A106B956FE37/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000612</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title><author><name sortKey="Marsden, J R" sort="Marsden, J R" uniqKey="Marsden J" first="J. R." last="Marsden">J. R. Marsden</name><affiliation><mods:affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</mods:affiliation></affiliation></author><author><name sortKey="Laker, M F" sort="Laker, M F" uniqKey="Laker M" first="M. F." last="Laker">M. F. Laker</name><affiliation><mods:affiliation>Department of Clinical Biochemistry, University of Newcastle upon Tyne, NE1 4LP, U. K.</mods:affiliation></affiliation></author><author><name sortKey="Ford, G P" sort="Ford, G P" uniqKey="Ford G" first="G. P." last="Ford">G. P. Ford</name><affiliation><mods:affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</mods:affiliation></affiliation></author><author><name sortKey="Shuster, Sam" sort="Shuster, Sam" uniqKey="Shuster S" first="Sam" last="Shuster">Sam Shuster</name><affiliation><mods:affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Dermatology</title><idno type="ISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1984-06">1984-06</date><biblScope unit="volume">110</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="697">697</biblScope><biblScope unit="page" to="702">702</biblScope></imprint><idno type="ISSN">0007-0963</idno></series><idno type="istex">EFD92C48A37E2905BAB6459AA7C0A106B956FE37</idno><idno type="DOI">10.1111/j.1365-2133.1984.tb04707.x</idno><idno type="ArticleID">BJD697</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Twenty‐seven males with severe acne were treated for 12 weeks with 0·05 mg/kg/day isotretinoin (ten patients) or 5 mg daily cyproterone acetate (eight patients) or both drugs together in these doses (nine patients). With isotretinoin, the sebum excretion rate (SER) fell by 45%± 9% s.e.m. (P < 0·0025), lesion count fell by 65%± 10% (P < 0·0005) and median clinical severity fell from 8 to 2·5 (P= 0·01). With cyproterone acetate there was a 17%± 12% (NS) fall in SER, a 15%± 10% (NS) fall in lesion count and the median severity was unchanged. Patients treated with both drugs showed a 42%± 13% reduction in SER (P < 0·005), a 68%± 11% decrease in lesion count (P < 0.0005) and a decrease in median severity from 8 to 4 (P < 0·01) which was no different from the response to isotretionoin alone. Isotretinoin increased serum cholesterol from 4·4 mmol/1 ± 0.3 s.e.m. to 4.7 mmol/1 ± 0·3 s.e.m.(P < 0.01), serum triglyceride from 0·73 mmol/1 ± 0·07 s.e.m. to 0·96 mmol/1 ± 0·14 s.e.m. (P < 0·05) and γ‐glutamyltransferase (GGT) from 15·9 i.u./1 ± 2·1 s.e.m. to 19·0 i.u./1 ± 2·4 s.e.m. (P < 0·01). Comparison of the area under the concentration‐time curve for triglyceride and high density lipoprotein (HDL)‐cholesterol showed that the changes were smaller when isotretinoin was combined with cyproterone acetate. We conclude that the effect of isotretinoin in acne was not enhanced by the antiandrogen, but the increase in serum triglyceride and decrease in HDL‐cholesterol produced by the retinoid were reduced by combination with the antiandrogen.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J.R. MARSDEN</name><affiliations><json:string>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</json:string></affiliations></json:item><json:item><name>M. F. LAKER</name><affiliations><json:string>Department of Clinical Biochemistry, University of Newcastle upon Tyne, NE1 4LP, U. K.</json:string></affiliations></json:item><json:item><name>G.P. FORD</name><affiliations><json:string>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</json:string></affiliations></json:item><json:item><name>SAM SHUSTER</name><affiliations><json:string>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</json:string></affiliations></json:item></author><articleId><json:string>BJD697</json:string></articleId><language><json:string>eng</json:string></language><abstract>Twenty‐seven males with severe acne were treated for 12 weeks with 0·05 mg/kg/day isotretinoin (ten patients) or 5 mg daily cyproterone acetate (eight patients) or both drugs together in these doses (nine patients). With isotretinoin, the sebum excretion rate (SER) fell by 45%± 9% s.e.m. (P > 0·0025), lesion count fell by 65%± 10% (P > 0·0005) and median clinical severity fell from 8 to 2·5 (P= 0·01). With cyproterone acetate there was a 17%± 12% (NS) fall in SER, a 15%± 10% (NS) fall in lesion count and the median severity was unchanged. Patients treated with both drugs showed a 42%± 13% reduction in SER (P > 0·005), a 68%± 11% decrease in lesion count (P > 0.0005) and a decrease in median severity from 8 to 4 (P > 0·01) which was no different from the response to isotretionoin alone. Isotretinoin increased serum cholesterol from 4·4 mmol/1 ± 0.3 s.e.m. to 4.7 mmol/1 ± 0·3 s.e.m.(P > 0.01), serum triglyceride from 0·73 mmol/1 ± 0·07 s.e.m. to 0·96 mmol/1 ± 0·14 s.e.m. (P > 0·05) and γ‐glutamyltransferase (GGT) from 15·9 i.u./1 ± 2·1 s.e.m. to 19·0 i.u./1 ± 2·4 s.e.m. (P > 0·01). Comparison of the area under the concentration‐time curve for triglyceride and high density lipoprotein (HDL)‐cholesterol showed that the changes were smaller when isotretinoin was combined with cyproterone acetate. We conclude that the effect of isotretinoin in acne was not enhanced by the antiandrogen, but the increase in serum triglyceride and decrease in HDL‐cholesterol produced by the retinoid were reduced by combination with the antiandrogen.</abstract><qualityIndicators><score>5.637</score><pdfVersion>1.4</pdfVersion><pdfPageSize>516 x 709 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1549</abstractCharCount><pdfWordCount>2137</pdfWordCount><pdfCharCount>11747</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>259</abstractWordCount></qualityIndicators><title>Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title><genre><json:string>article</json:string></genre><host><volume>110</volume><publisherId><json:string>BJD</json:string></publisherId><pages><total>6</total><last>702</last><first>697</first></pages><issn><json:string>0007-0963</json:string></issn><issue>6</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1365-2133</json:string></eissn><title>British Journal of Dermatology</title><doi><json:string>10.1111/(ISSN)1365-2133</json:string></doi></host><publicationDate>1984</publicationDate><copyrightDate>1984</copyrightDate><doi><json:string>10.1111/j.1365-2133.1984.tb04707.x</json:string></doi><id>EFD92C48A37E2905BAB6459AA7C0A106B956FE37</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/EFD92C48A37E2905BAB6459AA7C0A106B956FE37/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/EFD92C48A37E2905BAB6459AA7C0A106B956FE37/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/EFD92C48A37E2905BAB6459AA7C0A106B956FE37/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1984</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title><author><persName><forename type="first">J.R.</forename><surname>MARSDEN</surname></persName><affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</affiliation></author><author><persName><forename type="first">M. F.</forename><surname>LAKER</surname></persName><affiliation>Department of Clinical Biochemistry, University of Newcastle upon Tyne, NE1 4LP, U. K.</affiliation></author><author><persName><forename type="first">G.P.</forename><surname>FORD</surname></persName><affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</affiliation></author><author><persName><forename type="first">SAM</forename><surname>SHUSTER</surname></persName><affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</affiliation></author></analytic><monogr><title level="j">British Journal of Dermatology</title><idno type="pISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><idno type="DOI">10.1111/(ISSN)1365-2133</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1984-06"></date><biblScope unit="volume">110</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="697">697</biblScope><biblScope unit="page" to="702">702</biblScope></imprint></monogr><idno type="istex">EFD92C48A37E2905BAB6459AA7C0A106B956FE37</idno><idno type="DOI">10.1111/j.1365-2133.1984.tb04707.x</idno><idno type="ArticleID">BJD697</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1984</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Twenty‐seven males with severe acne were treated for 12 weeks with 0·05 mg/kg/day isotretinoin (ten patients) or 5 mg daily cyproterone acetate (eight patients) or both drugs together in these doses (nine patients). With isotretinoin, the sebum excretion rate (SER) fell by 45%± 9% s.e.m. (P < 0·0025), lesion count fell by 65%± 10% (P < 0·0005) and median clinical severity fell from 8 to 2·5 (P= 0·01). With cyproterone acetate there was a 17%± 12% (NS) fall in SER, a 15%± 10% (NS) fall in lesion count and the median severity was unchanged. Patients treated with both drugs showed a 42%± 13% reduction in SER (P < 0·005), a 68%± 11% decrease in lesion count (P < 0.0005) and a decrease in median severity from 8 to 4 (P < 0·01) which was no different from the response to isotretionoin alone. Isotretinoin increased serum cholesterol from 4·4 mmol/1 ± 0.3 s.e.m. to 4.7 mmol/1 ± 0·3 s.e.m.(P < 0.01), serum triglyceride from 0·73 mmol/1 ± 0·07 s.e.m. to 0·96 mmol/1 ± 0·14 s.e.m. (P < 0·05) and γ‐glutamyltransferase (GGT) from 15·9 i.u./1 ± 2·1 s.e.m. to 19·0 i.u./1 ± 2·4 s.e.m. (P < 0·01). Comparison of the area under the concentration‐time curve for triglyceride and high density lipoprotein (HDL)‐cholesterol showed that the changes were smaller when isotretinoin was combined with cyproterone acetate. We conclude that the effect of isotretinoin in acne was not enhanced by the antiandrogen, but the increase in serum triglyceride and decrease in HDL‐cholesterol produced by the retinoid were reduced by combination with the antiandrogen.</p></abstract></profileDesc><revisionDesc><change when="1984-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/EFD92C48A37E2905BAB6459AA7C0A106B956FE37/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2133</doi><issn type="print">0007-0963</issn><issn type="electronic">1365-2133</issn><idGroup><id type="product" value="BJD"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="BRITISH JOURNAL OF DERMATOLOGY">British Journal of Dermatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="06006"><doi origin="wiley">10.1111/bjd.1984.110.issue-6</doi><numberingGroup><numbering type="journalVolume" number="110">110</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="1984-06">June 1984</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0069700" status="forIssue"><doi origin="wiley">10.1111/j.1365-2133.1984.tb04707.x</doi><idGroup><id type="unit" value="BJD697"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Pharmacology and Treatment</title></titleGroup><eventGroup><event type="firstOnline" date="2006-07-29"></event><event type="publishedOnlineFinalForm" date="2006-07-29"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-08"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="697">697</numbering><numbering type="pageLast" number="702">702</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:BJD.BJD697.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 1 November 1983</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="8"></count><count type="linksCrossRef" number="4"></count></countGroup><titleGroup><title type="main">Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>J.R.</givenNames><familyName>MARSDEN</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>M. F.</givenNames><familyName>LAKER</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>G.P.</givenNames><familyName>FORD</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>SAM</givenNames><familyName>SHUSTER</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Department of Clinical Biochemistry, University of Newcastle upon Tyne, NE1 4LP, U. K.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">SUMMARY</title><p>Twenty‐seven males with severe acne were treated for 12 weeks with 0·05 mg/kg/day isotretinoin (ten patients) or 5 mg daily cyproterone acetate (eight patients) or both drugs together in these doses (nine patients). With isotretinoin, the sebum excretion rate (SER) fell by 45%± 9% s.e.m. (<i>P</i> < 0·0025), lesion count fell by 65%± 10% (<i>P</i> < 0·0005) and median clinical severity fell from 8 to 2·5 (<i>P</i>= 0·01). With cyproterone acetate there was a 17%± 12% (NS) fall in SER, a 15%± 10% (NS) fall in lesion count and the median severity was unchanged. Patients treated with both drugs showed a 42%± 13% reduction in SER (<i>P</i> < 0·005), a 68%± 11% decrease in lesion count (<i>P</i> < 0.0005) and a decrease in median severity from 8 to 4 (<i>P</i> < 0·01) which was no different from the response to isotretionoin alone. Isotretinoin increased serum cholesterol from 4·4 mmol/1 ± 0.3 s.e.m. to 4.7 mmol/1 ± 0·3 s.e.m.(<i>P</i> < 0.01), serum triglyceride from 0·73 mmol/1 ± 0·07 s.e.m. to 0·96 mmol/1 ± 0·14 s.e.m. (<i>P</i> < 0·05) and γ‐glutamyltransferase (GGT) from 15·9 i.u./1 ± 2·1 s.e.m. to 19·0 i.u./1 ± 2·4 s.e.m. (<i>P</i> < 0·01). Comparison of the area under the concentration‐time curve for triglyceride and high density lipoprotein (HDL)‐cholesterol showed that the changes were smaller when isotretinoin was combined with cyproterone acetate. We conclude that the effect of isotretinoin in acne was not enhanced by the antiandrogen, but the increase in serum triglyceride and decrease in HDL‐cholesterol produced by the retinoid were reduced by combination with the antiandrogen.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of low dose cyproterone acetate on the response of acne to isotretinoin</title></titleInfo><name type="personal"><namePart type="given">J.R.</namePart><namePart type="family">MARSDEN</namePart><affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">LAKER</namePart><affiliation>Department of Clinical Biochemistry, University of Newcastle upon Tyne, NE1 4LP, U. K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.P.</namePart><namePart type="family">FORD</namePart><affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SAM</namePart><namePart type="family">SHUSTER</namePart><affiliation>Department of Dermatology Newcastle upon Tyne NE1 4LP, U. K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1984-06</dateIssued><edition>Accepted for publication 1 November 1983</edition><copyrightDate encoding="w3cdtf">1984</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">8</extent></physicalDescription><abstract lang="en">Twenty‐seven males with severe acne were treated for 12 weeks with 0·05 mg/kg/day isotretinoin (ten patients) or 5 mg daily cyproterone acetate (eight patients) or both drugs together in these doses (nine patients). With isotretinoin, the sebum excretion rate (SER) fell by 45%± 9% s.e.m. (P < 0·0025), lesion count fell by 65%± 10% (P < 0·0005) and median clinical severity fell from 8 to 2·5 (P= 0·01). With cyproterone acetate there was a 17%± 12% (NS) fall in SER, a 15%± 10% (NS) fall in lesion count and the median severity was unchanged. Patients treated with both drugs showed a 42%± 13% reduction in SER (P < 0·005), a 68%± 11% decrease in lesion count (P < 0.0005) and a decrease in median severity from 8 to 4 (P < 0·01) which was no different from the response to isotretionoin alone. Isotretinoin increased serum cholesterol from 4·4 mmol/1 ± 0.3 s.e.m. to 4.7 mmol/1 ± 0·3 s.e.m.(P < 0.01), serum triglyceride from 0·73 mmol/1 ± 0·07 s.e.m. to 0·96 mmol/1 ± 0·14 s.e.m. (P < 0·05) and γ‐glutamyltransferase (GGT) from 15·9 i.u./1 ± 2·1 s.e.m. to 19·0 i.u./1 ± 2·4 s.e.m. (P < 0·01). Comparison of the area under the concentration‐time curve for triglyceride and high density lipoprotein (HDL)‐cholesterol showed that the changes were smaller when isotretinoin was combined with cyproterone acetate. We conclude that the effect of isotretinoin in acne was not enhanced by the antiandrogen, but the increase in serum triglyceride and decrease in HDL‐cholesterol produced by the retinoid were reduced by combination with the antiandrogen.</abstract><relatedItem type="host"><titleInfo><title>British Journal of Dermatology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0007-0963</identifier><identifier type="eISSN">1365-2133</identifier><identifier type="DOI">10.1111/(ISSN)1365-2133</identifier><identifier type="PublisherID">BJD</identifier><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>697</start><end>702</end><total>6</total></extent></part></relatedItem><identifier type="istex">EFD92C48A37E2905BAB6459AA7C0A106B956FE37</identifier><identifier type="DOI">10.1111/j.1365-2133.1984.tb04707.x</identifier><identifier type="ArticleID">BJD697</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000612 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000612 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Informatique
|area= ScrumV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:EFD92C48A37E2905BAB6459AA7C0A106B956FE37
|texte= Effect of low dose cyproterone acetate on the response of acne to isotretinoin
}}
| This area was generated with Dilib version V0.6.39. |  |