Male sex hormone status in dermatitis herpetiformis
Identifieur interne : 000359 ( Istex/Corpus ); précédent : 000358; suivant : 000360Male sex hormone status in dermatitis herpetiformis
Auteurs : D. J. Gawkrodger ; V. M. Sweeting ; C. R. W. Edwards ; R. Stc. BarnetsonSource :
- British Journal of Dermatology [ 0007-0963 ] ; 1985-01.
Abstract
In twenty‐eight men with dermatitis herpetiformis (DH) the mean serum testosterone levels were within normal limits, but high levels were found in three patients with partial villous atrophy and two who had normal jejunal biopsies. The introduction of a gluten‐free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle‐stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. Thus, raised levels of testosterone and gonadotrophin were found in only a minority of men with DH, in contrast to the more marked changes previously reported in males with coeliac disease.
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DOI: 10.1111/j.1365-2133.1985.tb02291.x
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Barnetson</name><affiliation><mods:affiliation>Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh EH3 9YW U.K.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9792F9F0D462B01EC657E1F62234217CB6EBA7BC</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1111/j.1365-2133.1985.tb02291.x</idno><idno type="url">https://api.istex.fr/document/9792F9F0D462B01EC657E1F62234217CB6EBA7BC/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000359</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Male sex hormone status in dermatitis herpetiformis</title><author><name sortKey="Gawkrodger, D J" sort="Gawkrodger, D J" uniqKey="Gawkrodger D" first="D. J." last="Gawkrodger">D. J. Gawkrodger</name><affiliation><mods:affiliation>Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh EH3 9YW U.K.</mods:affiliation></affiliation></author><author><name sortKey="Sweeting, V M" sort="Sweeting, V M" uniqKey="Sweeting V" first="V. M." last="Sweeting">V. M. Sweeting</name><affiliation><mods:affiliation>Department of Clinical Chemistry, University of Edinburgh, Royal Infirmary, Edinburgh EH3 9YW U.K.</mods:affiliation></affiliation></author><author><name sortKey="Edwards, C R W" sort="Edwards, C R W" uniqKey="Edwards C" first="C. R. W." last="Edwards">C. R. W. Edwards</name><affiliation><mods:affiliation>Department of Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU U.K.</mods:affiliation></affiliation></author><author><name sortKey="Barnetson, R Stc" sort="Barnetson, R Stc" uniqKey="Barnetson R" first="R. Stc." last="Barnetson">R. Stc. 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The introduction of a gluten‐free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle‐stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. Thus, raised levels of testosterone and gonadotrophin were found in only a minority of men with DH, in contrast to the more marked changes previously reported in males with coeliac disease.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>D.J. 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Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. 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The introduction of a gluten‐free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle‐stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. 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The introduction of a gluten‐free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle‐stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. 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The introduction of a gluten‐free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle‐stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. 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