Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate
Identifieur interne : 002007 ( Istex/Checkpoint ); précédent : 002006; suivant : 002008Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate
Auteurs : Francesco Scaglione [Italie] ; Mauro Raichi [Italie] ; Franco Fraschini [Italie]Source :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 1990.
Abstract
A new approach to the study of the distribution pharmacokinetics of variably bound β-lactams is to plot the concentration time course of their free (dialysable) and total (free and bound) forms. In the present study, the 6-h concentration time course was plotted of the total and free concentrations of cefotaxime and ceftriaxone in scrum and pleural exudate in 12 patients per group, after iv dosing with 1 g of either cefotaxime or ceftriaxone. Samples were taken at 0.5, 1, 1.5, 2, 3, 4 and 6 h after dosing. The results of a study of similar design, but conducted over 24 h in ten patients per group, following iv dosing with either cefotaxime 1 g 12-hourly or ceftriaxone 1 g daily are also reported. Samples were taken at 0.5, 1, 1.5, 2, 4, 6, 8, 12, 14, 16 and 24 h after dosing. Areas under the curve of free cefotaxime in pleural fluid were greater than those of free ceftriaxone, in both the 6 h (+ 54.6%) and 24 h studies (+ 29.8% after 12 h and +71.0% after 24 h). The free cefotaxime/free ceftriaxone Cmax ratio was 1.75 in the 6 h study. Cefotaxime was superior to ceftriaxone in terms of the diffusion of the free (antibacterially active) fraction into a typical inflammatory exudate. Assessment of the effects of protein binding must be taken into account in antibiotic pharmacokinetic profiles.
Url:
DOI: 10.1093/jac/26.suppl_A.1
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:D097F41A64098ABD5F8EA8347F7984583801F924Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate</title>
<author><name sortKey="Scaglione, Francesco" sort="Scaglione, Francesco" uniqKey="Scaglione F" first="Francesco" last="Scaglione">Francesco Scaglione</name>
</author>
<author><name sortKey="Raichi, Mauro" sort="Raichi, Mauro" uniqKey="Raichi M" first="Mauro" last="Raichi">Mauro Raichi</name>
</author>
<author><name sortKey="Fraschini, Franco" sort="Fraschini, Franco" uniqKey="Fraschini F" first="Franco" last="Fraschini">Franco Fraschini</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D097F41A64098ABD5F8EA8347F7984583801F924</idno>
<date when="1990" year="1990">1990</date>
<idno type="doi">10.1093/jac/26.suppl_A.1</idno>
<idno type="url">https://api.istex.fr/document/D097F41A64098ABD5F8EA8347F7984583801F924/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000460</idno>
<idno type="wicri:Area/Istex/Curation">000460</idno>
<idno type="wicri:Area/Istex/Checkpoint">002007</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate</title>
<author><name sortKey="Scaglione, Francesco" sort="Scaglione, Francesco" uniqKey="Scaglione F" first="Francesco" last="Scaglione">Francesco Scaglione</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Chemotherapy, University of Milan, Milan</wicri:regionArea>
<wicri:noRegion>Milan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Raichi, Mauro" sort="Raichi, Mauro" uniqKey="Raichi M" first="Mauro" last="Raichi">Mauro Raichi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Chemotherapy, University of Milan, Milan</wicri:regionArea>
<wicri:noRegion>Milan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fraschini, Franco" sort="Fraschini, Franco" uniqKey="Fraschini F" first="Franco" last="Fraschini">Franco Fraschini</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Chemotherapy, University of Milan, Milan</wicri:regionArea>
<wicri:noRegion>Milan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Antimicrobial Chemotherapy</title>
<idno type="ISSN">0305-7453</idno>
<idno type="eISSN">1460-2091</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="1990">1990</date>
<biblScope unit="volume">26</biblScope>
<biblScope unit="supplement">suppl_A</biblScope>
<biblScope unit="page" from="1">1</biblScope>
<biblScope unit="page" to="10">10</biblScope>
</imprint>
<idno type="ISSN">0305-7453</idno>
</series>
<idno type="istex">D097F41A64098ABD5F8EA8347F7984583801F924</idno>
<idno type="DOI">10.1093/jac/26.suppl_A.1</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0305-7453</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">A new approach to the study of the distribution pharmacokinetics of variably bound β-lactams is to plot the concentration time course of their free (dialysable) and total (free and bound) forms. In the present study, the 6-h concentration time course was plotted of the total and free concentrations of cefotaxime and ceftriaxone in scrum and pleural exudate in 12 patients per group, after iv dosing with 1 g of either cefotaxime or ceftriaxone. Samples were taken at 0.5, 1, 1.5, 2, 3, 4 and 6 h after dosing. The results of a study of similar design, but conducted over 24 h in ten patients per group, following iv dosing with either cefotaxime 1 g 12-hourly or ceftriaxone 1 g daily are also reported. Samples were taken at 0.5, 1, 1.5, 2, 4, 6, 8, 12, 14, 16 and 24 h after dosing. Areas under the curve of free cefotaxime in pleural fluid were greater than those of free ceftriaxone, in both the 6 h (+ 54.6%) and 24 h studies (+ 29.8% after 12 h and +71.0% after 24 h). The free cefotaxime/free ceftriaxone Cmax ratio was 1.75 in the 6 h study. Cefotaxime was superior to ceftriaxone in terms of the diffusion of the free (antibacterially active) fraction into a typical inflammatory exudate. Assessment of the effects of protein binding must be taken into account in antibiotic pharmacokinetic profiles.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Scaglione, Francesco" sort="Scaglione, Francesco" uniqKey="Scaglione F" first="Francesco" last="Scaglione">Francesco Scaglione</name>
</noRegion>
<name sortKey="Fraschini, Franco" sort="Fraschini, Franco" uniqKey="Fraschini F" first="Franco" last="Fraschini">Franco Fraschini</name>
<name sortKey="Raichi, Mauro" sort="Raichi, Mauro" uniqKey="Raichi M" first="Mauro" last="Raichi">Mauro Raichi</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002007 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 002007 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Informatique |area= ScrumV1 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:D097F41A64098ABD5F8EA8347F7984583801F924 |texte= Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate }}
![]() | This area was generated with Dilib version V0.6.39. | ![]() |