Relationship between IgG1 and IgG4 antibodies to foods and the development of IgE antibodies to inhalant allergens. I. Establishment of a scoring system for the overall food responsiveness and its application to 213 unselected children
Identifieur interne : 001E58 ( Istex/Checkpoint ); précédent : 001E57; suivant : 001E59Relationship between IgG1 and IgG4 antibodies to foods and the development of IgE antibodies to inhalant allergens. I. Establishment of a scoring system for the overall food responsiveness and its application to 213 unselected children
Auteurs : P. G. Calkhoven [Pays-Bas] ; Marja Aalbers [Pays-Bas] ; V. L. Koshte [Pays-Bas] ; R. W. Griffioen [Pays-Bas] ; J. C. Van Nierop [Pays-Bas] ; D. Van Der Heide [Pays-Bas] ; R. C. Aalberse [Pays-Bas]Source :
- Clinical & Experimental Allergy [ 0954-7894 ] ; 1991-01.
Abstract
To obtain reference levels for subsequent investigations, we analysed the IgG1 and IgG4 antibody levels to common foods in the sera of 213 unselected children (age 3 months to 14 years). The children were clustered into five age groups and tested on a broad screening panel of common foods. We used the IgG1 and IgG4 RAST with Sepharose‐coupled antigens: cows’ milk, hens’ egg white, banana, legumes (a mixture of soybean and peanut), grains (a mixture of wheat and rice), potato, orange and pork. In all age groups and all antigens, a considerable variability in the antibody response was found. As for some assays more than half of the sera were negative or borderline, statistics based on interval or ordinal scaling were considered inappropriate and we resorted to nominal classification. We decided to use, for each of the assays, the 75‐percentile of the age group as a cut‐off level. Each antibody titrc was thus converted into positive (more than the 75‐percentile of that age group) or negative; the number of positive tests was used as the score. This resulted in a ΣG1score and a ΣG4 score (summed scores for IgG1 and IgG4 antibodies, respectively). The results of the present study indicate that children with a high response to one food tend to have elevated responses to other non‐related foods, possibly explained by a defective mucosal barrier and/or a hyperactive immune system. This suggests that a high‐food responder phenotype may exist.
Url:
DOI: 10.1111/j.1365-2222.1991.tb00809.x
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:4824B5BCAFB4E0174015CDE1BDBDC9C20DB9E2C6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship between IgG1 and IgG4 antibodies to foods and the development of IgE antibodies to inhalant allergens. I. Establishment of a scoring system for the overall food responsiveness and its application to 213 unselected children</title>
<author><name sortKey="Calkhoven, P G" sort="Calkhoven, P G" uniqKey="Calkhoven P" first="P. G." last="Calkhoven">P. G. Calkhoven</name>
</author>
<author><name sortKey="Aalbers, Marja" sort="Aalbers, Marja" uniqKey="Aalbers M" first="Marja" last="Aalbers">Marja Aalbers</name>
</author>
<author><name sortKey="Koshte, V L" sort="Koshte, V L" uniqKey="Koshte V" first="V. L." last="Koshte">V. L. Koshte</name>
</author>
<author><name sortKey="Griffioen, R W" sort="Griffioen, R W" uniqKey="Griffioen R" first="R. W." last="Griffioen">R. W. Griffioen</name>
</author>
<author><name sortKey="Van Nierop, J C" sort="Van Nierop, J C" uniqKey="Van Nierop J" first="J. C." last="Van Nierop">J. C. Van Nierop</name>
</author>
<author><name sortKey="Van Der Heide, D" sort="Van Der Heide, D" uniqKey="Van Der Heide D" first="D." last="Van Der Heide">D. Van Der Heide</name>
</author>
<author><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R. C." last="Aalberse">R. C. Aalberse</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4824B5BCAFB4E0174015CDE1BDBDC9C20DB9E2C6</idno>
<date when="1991" year="1991">1991</date>
<idno type="doi">10.1111/j.1365-2222.1991.tb00809.x</idno>
<idno type="url">https://api.istex.fr/document/4824B5BCAFB4E0174015CDE1BDBDC9C20DB9E2C6/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000499</idno>
<idno type="wicri:Area/Istex/Curation">000499</idno>
<idno type="wicri:Area/Istex/Checkpoint">001E58</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Relationship between IgG1 and IgG4 antibodies to foods and the development of IgE antibodies to inhalant allergens. I. Establishment of a scoring system for the overall food responsiveness and its application to 213 unselected children</title>
<author><name sortKey="Calkhoven, P G" sort="Calkhoven, P G" uniqKey="Calkhoven P" first="P. G." last="Calkhoven">P. G. Calkhoven</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aalbers, Marja" sort="Aalbers, Marja" uniqKey="Aalbers M" first="Marja" last="Aalbers">Marja Aalbers</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koshte, V L" sort="Koshte, V L" uniqKey="Koshte V" first="V. L." last="Koshte">V. L. Koshte</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Griffioen, R W" sort="Griffioen, R W" uniqKey="Griffioen R" first="R. W." last="Griffioen">R. W. Griffioen</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Emma Children's Hospital, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Nierop, J C" sort="Van Nierop, J C" uniqKey="Van Nierop J" first="J. C." last="Van Nierop">J. C. Van Nierop</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Emma Children's Hospital, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Heide, D" sort="Van Der Heide, D" uniqKey="Van Der Heide D" first="D." last="Van Der Heide">D. Van Der Heide</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Endocrinology, Unirersity of Leiden, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R. C." last="Aalberse">R. C. Aalberse</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Clinical & Experimental Allergy</title>
<idno type="ISSN">0954-7894</idno>
<idno type="eISSN">1365-2222</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="1991-01">1991-01</date>
<biblScope unit="volume">21</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="91">91</biblScope>
<biblScope unit="page" to="98">98</biblScope>
</imprint>
<idno type="ISSN">0954-7894</idno>
</series>
<idno type="istex">4824B5BCAFB4E0174015CDE1BDBDC9C20DB9E2C6</idno>
<idno type="DOI">10.1111/j.1365-2222.1991.tb00809.x</idno>
<idno type="ArticleID">CEA91</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0954-7894</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To obtain reference levels for subsequent investigations, we analysed the IgG1 and IgG4 antibody levels to common foods in the sera of 213 unselected children (age 3 months to 14 years). The children were clustered into five age groups and tested on a broad screening panel of common foods. We used the IgG1 and IgG4 RAST with Sepharose‐coupled antigens: cows’ milk, hens’ egg white, banana, legumes (a mixture of soybean and peanut), grains (a mixture of wheat and rice), potato, orange and pork. In all age groups and all antigens, a considerable variability in the antibody response was found. As for some assays more than half of the sera were negative or borderline, statistics based on interval or ordinal scaling were considered inappropriate and we resorted to nominal classification. We decided to use, for each of the assays, the 75‐percentile of the age group as a cut‐off level. Each antibody titrc was thus converted into positive (more than the 75‐percentile of that age group) or negative; the number of positive tests was used as the score. This resulted in a ΣG1score and a ΣG4 score (summed scores for IgG1 and IgG4 antibodies, respectively). The results of the present study indicate that children with a high response to one food tend to have elevated responses to other non‐related foods, possibly explained by a defective mucosal barrier and/or a hyperactive immune system. This suggests that a high‐food responder phenotype may exist.</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
</country>
<region><li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
</region>
<settlement><li>Amsterdam</li>
<li>Leyde</li>
</settlement>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Calkhoven, P G" sort="Calkhoven, P G" uniqKey="Calkhoven P" first="P. G." last="Calkhoven">P. G. Calkhoven</name>
</region>
<name sortKey="Aalbers, Marja" sort="Aalbers, Marja" uniqKey="Aalbers M" first="Marja" last="Aalbers">Marja Aalbers</name>
<name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R. C." last="Aalberse">R. C. Aalberse</name>
<name sortKey="Griffioen, R W" sort="Griffioen, R W" uniqKey="Griffioen R" first="R. W." last="Griffioen">R. W. Griffioen</name>
<name sortKey="Koshte, V L" sort="Koshte, V L" uniqKey="Koshte V" first="V. L." last="Koshte">V. L. Koshte</name>
<name sortKey="Van Der Heide, D" sort="Van Der Heide, D" uniqKey="Van Der Heide D" first="D." last="Van Der Heide">D. Van Der Heide</name>
<name sortKey="Van Nierop, J C" sort="Van Nierop, J C" uniqKey="Van Nierop J" first="J. C." last="Van Nierop">J. C. Van Nierop</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Informatique/explor/ScrumV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E58 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 001E58 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Informatique |area= ScrumV1 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:4824B5BCAFB4E0174015CDE1BDBDC9C20DB9E2C6 |texte= Relationship between IgG1 and IgG4 antibodies to foods and the development of IgE antibodies to inhalant allergens. I. Establishment of a scoring system for the overall food responsiveness and its application to 213 unselected children }}
![]() | This area was generated with Dilib version V0.6.39. | ![]() |