Collectins: collagenous C-type lectins of the innate immune defense system
Identifieur interne : 001300 ( Istex/Checkpoint ); précédent : 001299; suivant : 001301Collectins: collagenous C-type lectins of the innate immune defense system
Auteurs : Uffe Holmskov [Danemark] ; Rajneesh Malhotra [Royaume-Uni] ; Robert B. Sim [Royaume-Uni] ; Jens C. Jensenius [Danemark]Source :
- Immunology Today [ 0167-5699 ] ; 1994.
Abstract
Collectins are humoral lectins found in mammals and birds. They are oligomers whose subunits comprise three polypeptide chains each containing a collagenous section and a C-terminal lectin domain. They are related structurally and functionally to the first component of the classical complement pathway, Clq, and seem to serve important roles in innate immunity through opsonization and complement activation. The lectin domains bind carbohydrates on microorganisms, while the collagenous regions are ligands for the collectin receptor on phagocytes and also mediate Clq-independent activation of the classical complement pathway.
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DOI: 10.1016/0167-5699(94)90136-8
Affiliations:
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Jensenius</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D1A891275B8EEBDECF94780DECF3DAC39903CE4E</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0167-5699(94)90136-8</idno><idno type="url">https://api.istex.fr/document/D1A891275B8EEBDECF94780DECF3DAC39903CE4E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003854</idno><idno type="wicri:Area/Istex/Curation">003854</idno><idno type="wicri:Area/Istex/Checkpoint">001300</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Collectins: collagenous C-type lectins of the innate immune defense system</title><author><name sortKey="Holmskov, Uffe" sort="Holmskov, Uffe" uniqKey="Holmskov U" first="Uffe" last="Holmskov">Uffe Holmskov</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Dept of Medical Microbiology, University of Odense</wicri:regionArea><wicri:noRegion>University of Odense</wicri:noRegion></affiliation></author><author><name sortKey="Malhotra, Rajneesh" sort="Malhotra, Rajneesh" uniqKey="Malhotra R" first="Rajneesh" last="Malhotra">Rajneesh Malhotra</name><affiliation wicri:level="4"><country>Royaume-Uni</country><wicri:regionArea>Medical Research Council Immunochemistry Unit, Dept of Biochemistry, University of Oxford, South Parks Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Sim, Robert B" sort="Sim, Robert B" uniqKey="Sim R" first="Robert B." last="Sim">Robert B. Sim</name><affiliation wicri:level="4"><country>Royaume-Uni</country><wicri:regionArea>Medical Research Council Immunochemistry Unit, Dept of Biochemistry, University of Oxford, South Parks Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Jensenius, Jens C" sort="Jensenius, Jens C" uniqKey="Jensenius J" first="Jens C." last="Jensenius">Jens C. Jensenius</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Dept of Immunology, Institute of Medical Microbiology, University of Aarhus, DK-8000 Aarhus</wicri:regionArea><wicri:noRegion>DK-8000 Aarhus</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunology Today</title><title level="j" type="abbrev">IMTO</title><idno type="ISSN">0167-5699</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="74">74</biblScope></imprint><idno type="ISSN">0167-5699</idno></series><idno type="istex">D1A891275B8EEBDECF94780DECF3DAC39903CE4E</idno><idno type="DOI">10.1016/0167-5699(94)90136-8</idno><idno type="PII">0167-5699(94)90136-8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-5699</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Collectins are humoral lectins found in mammals and birds. They are oligomers whose subunits comprise three polypeptide chains each containing a collagenous section and a C-terminal lectin domain. They are related structurally and functionally to the first component of the classical complement pathway, Clq, and seem to serve important roles in innate immunity through opsonization and complement activation. The lectin domains bind carbohydrates on microorganisms, while the collagenous regions are ligands for the collectin receptor on phagocytes and also mediate Clq-independent activation of the classical complement pathway.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Danemark"><noRegion><name sortKey="Holmskov, Uffe" sort="Holmskov, Uffe" uniqKey="Holmskov U" first="Uffe" last="Holmskov">Uffe Holmskov</name></noRegion><name sortKey="Jensenius, Jens C" sort="Jensenius, Jens C" uniqKey="Jensenius J" first="Jens C." last="Jensenius">Jens C. Jensenius</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Malhotra, Rajneesh" sort="Malhotra, Rajneesh" uniqKey="Malhotra R" first="Rajneesh" last="Malhotra">Rajneesh Malhotra</name></region><name sortKey="Sim, Robert B" sort="Sim, Robert B" uniqKey="Sim R" first="Robert B." last="Sim">Robert B. Sim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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