Lateral entorhinal cortex is critical for novel object-context recognition.
Identifieur interne : 000024 ( PubMed/Corpus ); précédent : 000023; suivant : 000025Lateral entorhinal cortex is critical for novel object-context recognition.
Auteurs : David I G. Wilson ; Rosamund F. Langston ; Magdalene I. Schlesiger ; Monica Wagner ; Sakurako Watanabe ; James A. AingeSource :
- Hippocampus [ 1098-1063 ] ; 2013.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Discrimination (Psychology), Entorhinal Cortex (injuries), Entorhinal Cortex (physiology), Exploratory Behavior (physiology), Functional Laterality (physiology), Male, Proto-Oncogene Proteins c-fos (metabolism), Rats, Recognition (Psychology) (physiology), Spatial Behavior (physiology), Time Factors.
- MESH :
- chemical , metabolism : Proto-Oncogene Proteins c-fos.
- injuries : Entorhinal Cortex.
- physiology : Entorhinal Cortex, Exploratory Behavior, Functional Laterality, Recognition (Psychology), Spatial Behavior.
- Analysis of Variance, Animals, Discrimination (Psychology), Male, Rats, Time Factors.
Abstract
Episodic memory incorporates information about specific events or occasions including spatial locations and the contextual features of the environment in which the event took place. It has been modeled in rats using spontaneous exploration of novel configurations of objects, their locations, and the contexts in which they are presented. While we have a detailed understanding of how spatial location is processed in the brain relatively little is known about where the nonspatial contextual components of episodic memory are processed. Initial experiments measured c-fos expression during an object-context recognition (OCR) task to examine which networks within the brain process contextual features of an event. Increased c-fos expression was found in the lateral entorhinal cortex (LEC; a major hippocampal afferent) during OCR relative to control conditions. In a subsequent experiment it was demonstrated that rats with lesions of LEC were unable to recognize object-context associations yet showed normal object recognition and normal context recognition. These data suggest that contextual features of the environment are integrated with object identity in LEC and demonstrate that recognition of such object-context associations requires the LEC. This is consistent with the suggestion that contextual features of an event are processed in LEC and that this information is combined with spatial information from medial entorhinal cortex to form episodic memory in the hippocampus.
DOI: 10.1002/hipo.22095
PubMed: 23389958
Links to Exploration step
pubmed:23389958Le document en format XML
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Schlesiger</name></author><author><name sortKey="Wagner, Monica" sort="Wagner, Monica" uniqKey="Wagner M" first="Monica" last="Wagner">Monica Wagner</name></author><author><name sortKey="Watanabe, Sakurako" sort="Watanabe, Sakurako" uniqKey="Watanabe S" first="Sakurako" last="Watanabe">Sakurako Watanabe</name></author><author><name sortKey="Ainge, James A" sort="Ainge, James A" uniqKey="Ainge J" first="James A" last="Ainge">James A. Ainge</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/hipo.22095</idno><idno type="RBID">pubmed:23389958</idno><idno type="pmid">23389958</idno><idno type="wicri:Area/PubMed/Corpus">000024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lateral entorhinal cortex is critical for novel object-context recognition.</title><author><name sortKey="Wilson, David I G" sort="Wilson, David I G" uniqKey="Wilson D" first="David I G" last="Wilson">David I G. Wilson</name><affiliation><nlm:affiliation>School of Psychology, University of St Andrews, St Mary's Quad, St Andrews, Fife, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Langston, Rosamund F" sort="Langston, Rosamund F" uniqKey="Langston R" first="Rosamund F" last="Langston">Rosamund F. Langston</name></author><author><name sortKey="Schlesiger, Magdalene I" sort="Schlesiger, Magdalene I" uniqKey="Schlesiger M" first="Magdalene I" last="Schlesiger">Magdalene I. Schlesiger</name></author><author><name sortKey="Wagner, Monica" sort="Wagner, Monica" uniqKey="Wagner M" first="Monica" last="Wagner">Monica Wagner</name></author><author><name sortKey="Watanabe, Sakurako" sort="Watanabe, Sakurako" uniqKey="Watanabe S" first="Sakurako" last="Watanabe">Sakurako Watanabe</name></author><author><name sortKey="Ainge, James A" sort="Ainge, James A" uniqKey="Ainge J" first="James A" last="Ainge">James A. Ainge</name></author></analytic><series><title level="j">Hippocampus</title><idno type="eISSN">1098-1063</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Discrimination (Psychology)</term><term>Entorhinal Cortex (injuries)</term><term>Entorhinal Cortex (physiology)</term><term>Exploratory Behavior (physiology)</term><term>Functional Laterality (physiology)</term><term>Male</term><term>Proto-Oncogene Proteins c-fos (metabolism)</term><term>Rats</term><term>Recognition (Psychology) (physiology)</term><term>Spatial Behavior (physiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proto-Oncogene Proteins c-fos</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Entorhinal Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Entorhinal Cortex</term><term>Exploratory Behavior</term><term>Functional Laterality</term><term>Recognition (Psychology)</term><term>Spatial Behavior</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Discrimination (Psychology)</term><term>Male</term><term>Rats</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Episodic memory incorporates information about specific events or occasions including spatial locations and the contextual features of the environment in which the event took place. It has been modeled in rats using spontaneous exploration of novel configurations of objects, their locations, and the contexts in which they are presented. While we have a detailed understanding of how spatial location is processed in the brain relatively little is known about where the nonspatial contextual components of episodic memory are processed. Initial experiments measured c-fos expression during an object-context recognition (OCR) task to examine which networks within the brain process contextual features of an event. Increased c-fos expression was found in the lateral entorhinal cortex (LEC; a major hippocampal afferent) during OCR relative to control conditions. In a subsequent experiment it was demonstrated that rats with lesions of LEC were unable to recognize object-context associations yet showed normal object recognition and normal context recognition. These data suggest that contextual features of the environment are integrated with object identity in LEC and demonstrate that recognition of such object-context associations requires the LEC. This is consistent with the suggestion that contextual features of an event are processed in LEC and that this information is combined with spatial information from medial entorhinal cortex to form episodic memory in the hippocampus.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23389958</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2013</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>07</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-1063</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>5</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>Hippocampus</Title><ISOAbbreviation>Hippocampus</ISOAbbreviation></Journal><ArticleTitle>Lateral entorhinal cortex is critical for novel object-context recognition.</ArticleTitle><Pagination><MedlinePgn>352-66</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/hipo.22095</ELocationID><Abstract><AbstractText>Episodic memory incorporates information about specific events or occasions including spatial locations and the contextual features of the environment in which the event took place. It has been modeled in rats using spontaneous exploration of novel configurations of objects, their locations, and the contexts in which they are presented. While we have a detailed understanding of how spatial location is processed in the brain relatively little is known about where the nonspatial contextual components of episodic memory are processed. Initial experiments measured c-fos expression during an object-context recognition (OCR) task to examine which networks within the brain process contextual features of an event. Increased c-fos expression was found in the lateral entorhinal cortex (LEC; a major hippocampal afferent) during OCR relative to control conditions. In a subsequent experiment it was demonstrated that rats with lesions of LEC were unable to recognize object-context associations yet showed normal object recognition and normal context recognition. These data suggest that contextual features of the environment are integrated with object identity in LEC and demonstrate that recognition of such object-context associations requires the LEC. This is consistent with the suggestion that contextual features of an event are processed in LEC and that this information is combined with spatial information from medial entorhinal cortex to form episodic memory in the hippocampus.</AbstractText><CopyrightInformation>Copyright © 2013 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>David I G</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>School of Psychology, University of St Andrews, St Mary's Quad, St Andrews, Fife, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langston</LastName><ForeName>Rosamund F</ForeName><Initials>RF</Initials></Author><Author ValidYN="Y"><LastName>Schlesiger</LastName><ForeName>Magdalene I</ForeName><Initials>MI</Initials></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Monica</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>Sakurako</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ainge</LastName><ForeName>James A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>BB/I019367/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>02</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hippocampus</MedlineTA><NlmUniqueID>9108167</NlmUniqueID><ISSNLinking>1050-9631</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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