Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.
Identifieur interne : 000010 ( PubMed/Corpus ); précédent : 000009; suivant : 000011Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.
Auteurs : Hun Kim ; Sungwook Song ; Jinyeong Yim ; Hyun Ok Kim ; Chulmin JooSource :
- Clinica chimica acta; international journal of clinical chemistry [ 1873-3492 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Hemoglobins.
- blood : Anemia.
- Humans, Thermography, Tomography, Optical Coherence.
Abstract
We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients.
DOI: 10.1016/j.cca.2014.10.001
PubMed: 25312865
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pubmed:25312865Le document en format XML
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<author><name sortKey="Kim, Hun" sort="Kim, Hun" uniqKey="Kim H" first="Hun" last="Kim">Hun Kim</name>
<affiliation><nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Song, Sungwook" sort="Song, Sungwook" uniqKey="Song S" first="Sungwook" last="Song">Sungwook Song</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Konyang University College of Medicine, Daejeon 302-718, Republic of Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yim, Jinyeong" sort="Yim, Jinyeong" uniqKey="Yim J" first="Jinyeong" last="Yim">Jinyeong Yim</name>
<affiliation><nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Kim, Hyun Ok" sort="Kim, Hyun Ok" uniqKey="Kim H" first="Hyun Ok" last="Kim">Hyun Ok Kim</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Joo, Chulmin" sort="Joo, Chulmin" uniqKey="Joo C" first="Chulmin" last="Joo">Chulmin Joo</name>
<affiliation><nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address: cjoo@yonsei.ac.kr.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.</title>
<author><name sortKey="Kim, Hun" sort="Kim, Hun" uniqKey="Kim H" first="Hun" last="Kim">Hun Kim</name>
<affiliation><nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Song, Sungwook" sort="Song, Sungwook" uniqKey="Song S" first="Sungwook" last="Song">Sungwook Song</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Konyang University College of Medicine, Daejeon 302-718, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Yim, Jinyeong" sort="Yim, Jinyeong" uniqKey="Yim J" first="Jinyeong" last="Yim">Jinyeong Yim</name>
<affiliation><nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Kim, Hyun Ok" sort="Kim, Hyun Ok" uniqKey="Kim H" first="Hyun Ok" last="Kim">Hyun Ok Kim</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Joo, Chulmin" sort="Joo, Chulmin" uniqKey="Joo C" first="Chulmin" last="Joo">Chulmin Joo</name>
<affiliation><nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address: cjoo@yonsei.ac.kr.</nlm:affiliation>
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<series><title level="j">Clinica chimica acta; international journal of clinical chemistry</title>
<idno type="eISSN">1873-3492</idno>
<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (blood)</term>
<term>Hemoglobins (analysis)</term>
<term>Humans</term>
<term>Thermography</term>
<term>Tomography, Optical Coherence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hemoglobins</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Anemia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Thermography</term>
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<front><div type="abstract" xml:lang="en">We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>12</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>08</Month>
<Day>26</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3492</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>439</Volume>
<PubDate><Year>2015</Year>
<Month>Jan</Month>
<Day>15</Day>
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<Title>Clinica chimica acta; international journal of clinical chemistry</Title>
<ISOAbbreviation>Clin. Chim. Acta</ISOAbbreviation>
</Journal>
<ArticleTitle>Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.</ArticleTitle>
<Pagination><MedlinePgn>71-6</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cca.2014.10.001</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0009-8981(14)00432-X</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used PT SD-OCR to measure [Hb] in 50 anemic patients, and examined its accuracy against a hematology analyzer (ADVIA 2120i, Siemens AG). Its precision was assessed by examining the SD and CV based on 20 repeated measurements on 3 blood samples. Its performance was also compared with a hemoglobinometer (HemoCue 201+, HemoCue).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The PT SD-OCR demonstrated good correspondence with the hematology analyzer with a Pearson's correlation coefficient of 0.992 and a bias of -0.055 g/dl. Standard deviation and CV were measured to be <0.25 g/dl and <2.05%.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Simple and chemical-free operation of PT SD-OCR enabled rapid and accurate measurement of [Hb] in anemic patients. The sensor is expected to facilitate clinical procedures related to blood-related disorders in patient care.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Hun</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</Affiliation>
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<Author ValidYN="Y"><LastName>Song</LastName>
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<AffiliationInfo><Affiliation>Department of Laboratory Medicine, Konyang University College of Medicine, Daejeon 302-718, Republic of Korea.</Affiliation>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>Netherlands</Country>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000740">Anemia</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anemia</Keyword>
<Keyword MajorTopicYN="N">Hemoglobin concentration</Keyword>
<Keyword MajorTopicYN="N">Optical interferometer</Keyword>
<Keyword MajorTopicYN="N">Optical sensor</Keyword>
<Keyword MajorTopicYN="N">Photothermal effect</Keyword>
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