[A new concept for keratoprosthesis].
Identifieur interne : 002227 ( PubMed/Corpus ); précédent : 002226; suivant : 002228[A new concept for keratoprosthesis].
Auteurs : H L KainSource :
- Klinische Monatsblätter für Augenheilkunde [ 0023-2165 ] ; 1990.
English descriptors
- KwdEn :
- Animals, Carbon, Cells, Cultured (pathology), Cornea (blood supply), Cornea (surgery), Corneal Stroma (pathology), Fibroblasts (pathology), Foreign-Body Reaction (pathology), HeLa Cells (pathology), Humans, Microscopy, Electron, Scanning, Neovascularization, Pathologic (pathology), Optics and Photonics, Prostheses and Implants, Prosthesis Design, Rabbits, Silicone Elastomers.
- MESH :
- chemical : Carbon, Silicone Elastomers.
- blood supply : Cornea.
- pathology : Cells, Cultured, Corneal Stroma, Fibroblasts, Foreign-Body Reaction, HeLa Cells, Neovascularization, Pathologic.
- surgery : Cornea.
- Animals, Humans, Microscopy, Electron, Scanning, Optics and Photonics, Prostheses and Implants, Prosthesis Design, Rabbits.
Abstract
Although keratoprosthesis (after Strampelli and Cardona) is successful in selected cases, it remains doubtful whether the apparent problems of these procedures can be solved. The Cardona-Strampelli concept was therefore abandoned; a new design was evolved and new alloplastic materials were used--silicone for the optical zone and carbon fibers for the haptic part of the prosthesis. The interaction of living tissue with these alloplastic materials was investigated in tissue-culture experiments and in vivo, and indicated that the materials had excellent properties for prosthetic purposes. Stable anchorage of the implants was assured by the strong adhesion of the fibroplasts to the carbon fibers. In more than a year of observation no granulomatous reaction was observed. In animal experiments, the special design of the prosthesis-tissue interface prevented epithelial downgrowth, one of the major problems in keratoprosthesis. Moreover, a fluid-tight interaction of the alloplastic material and the tissue was achieved.
DOI: 10.1055/s-2008-1046298
PubMed: 1705299
Links to Exploration step
pubmed:1705299Le document en format XML
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<author><name sortKey="Kain, H L" sort="Kain, H L" uniqKey="Kain H" first="H L" last="Kain">H L Kain</name>
<affiliation><nlm:affiliation>Universitäts-Augenklinik Basel.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[A new concept for keratoprosthesis].</title>
<author><name sortKey="Kain, H L" sort="Kain, H L" uniqKey="Kain H" first="H L" last="Kain">H L Kain</name>
<affiliation><nlm:affiliation>Universitäts-Augenklinik Basel.</nlm:affiliation>
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<series><title level="j">Klinische Monatsblätter für Augenheilkunde</title>
<idno type="ISSN">0023-2165</idno>
<imprint><date when="1990" type="published">1990</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Carbon</term>
<term>Cells, Cultured (pathology)</term>
<term>Cornea (blood supply)</term>
<term>Cornea (surgery)</term>
<term>Corneal Stroma (pathology)</term>
<term>Fibroblasts (pathology)</term>
<term>Foreign-Body Reaction (pathology)</term>
<term>HeLa Cells (pathology)</term>
<term>Humans</term>
<term>Microscopy, Electron, Scanning</term>
<term>Neovascularization, Pathologic (pathology)</term>
<term>Optics and Photonics</term>
<term>Prostheses and Implants</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
<term>Silicone Elastomers</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carbon</term>
<term>Silicone Elastomers</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Cornea</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cells, Cultured</term>
<term>Corneal Stroma</term>
<term>Fibroblasts</term>
<term>Foreign-Body Reaction</term>
<term>HeLa Cells</term>
<term>Neovascularization, Pathologic</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Cornea</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Microscopy, Electron, Scanning</term>
<term>Optics and Photonics</term>
<term>Prostheses and Implants</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
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<front><div type="abstract" xml:lang="en">Although keratoprosthesis (after Strampelli and Cardona) is successful in selected cases, it remains doubtful whether the apparent problems of these procedures can be solved. The Cardona-Strampelli concept was therefore abandoned; a new design was evolved and new alloplastic materials were used--silicone for the optical zone and carbon fibers for the haptic part of the prosthesis. The interaction of living tissue with these alloplastic materials was investigated in tissue-culture experiments and in vivo, and indicated that the materials had excellent properties for prosthetic purposes. Stable anchorage of the implants was assured by the strong adhesion of the fibroplasts to the carbon fibers. In more than a year of observation no granulomatous reaction was observed. In animal experiments, the special design of the prosthesis-tissue interface prevented epithelial downgrowth, one of the major problems in keratoprosthesis. Moreover, a fluid-tight interaction of the alloplastic material and the tissue was achieved.</div>
</front>
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<DateRevised><Year>2009</Year>
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<JournalIssue CitedMedium="Print"><Volume>197</Volume>
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<PubDate><Year>1990</Year>
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<Title>Klinische Monatsblätter für Augenheilkunde</Title>
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<ArticleTitle>[A new concept for keratoprosthesis].</ArticleTitle>
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<Abstract><AbstractText>Although keratoprosthesis (after Strampelli and Cardona) is successful in selected cases, it remains doubtful whether the apparent problems of these procedures can be solved. The Cardona-Strampelli concept was therefore abandoned; a new design was evolved and new alloplastic materials were used--silicone for the optical zone and carbon fibers for the haptic part of the prosthesis. The interaction of living tissue with these alloplastic materials was investigated in tissue-culture experiments and in vivo, and indicated that the materials had excellent properties for prosthetic purposes. Stable anchorage of the implants was assured by the strong adhesion of the fibroplasts to the carbon fibers. In more than a year of observation no granulomatous reaction was observed. In animal experiments, the special design of the prosthesis-tissue interface prevented epithelial downgrowth, one of the major problems in keratoprosthesis. Moreover, a fluid-tight interaction of the alloplastic material and the tissue was achieved.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kain</LastName>
<ForeName>H L</ForeName>
<Initials>HL</Initials>
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<VernacularTitle>Ein neues Konzept zur Keratoprothese.</VernacularTitle>
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<MedlineJournalInfo><Country>GERMANY</Country>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003315">Cornea</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000098">blood supply</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003319">Corneal Stroma</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005347">Fibroblasts</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005549">Foreign-Body Reaction</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006367">HeLa Cells</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008855">Microscopy, Electron, Scanning</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009389">Neovascularization, Pathologic</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D055095">Optics and Photonics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D019736">Prostheses and Implants</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011474">Prosthesis Design</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011817">Rabbits</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D012826">Silicone Elastomers</DescriptorName>
</MeshHeading>
</MeshHeadingList>
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