Prism adaptation does not alter configural processing of faces
Identifieur interne : 001C87 ( Pmc/Curation ); précédent : 001C86; suivant : 001C88Prism adaptation does not alter configural processing of faces
Auteurs : Janet H. Bultitude [Royaume-Uni] ; Paul E. Downing [Royaume-Uni] ; Robert D. Rafal [Royaume-Uni]Source :
- F1000Research [ 2046-1402 ] ; 2013.
Abstract
Patients with hemispatial neglect (‘neglect’) following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training technique called prism adaptation as a treatment for neglect. Reaching for visual targets viewed through prismatic lenses that induce a rightward shift in the visual image results in a leftward recalibration of reaching movements that is accompanied by a reduction of symptoms in patients with neglect. The understanding of prism adaptation has also been advanced through studies of healthy participants, in whom adaptation to leftward prismatic shifts results in temporary neglect-like performance. Interestingly, prism adaptation can also alter aspects of non-lateralised spatial attention. We previously demonstrated that prism adaptation alters the extent to which neglect patients and healthy participants process local features versus global configurations of visual stimuli. Since deficits in non-lateralised spatial attention are thought to contribute to the severity of neglect symptoms, it is possible that the effect of prism adaptation on these deficits contributes to its efficacy. This study examines the pervasiveness of the effects of prism adaptation on perception by examining the effect of prism adaptation on configural face processing using a composite face task. The composite face task is a persuasive demonstration of the automatic global-level processing of faces: the top and bottom halves of two familiar faces form a seemingly new, unknown face when viewed together. Participants identified the top or bottom halves of composite faces before and after prism adaptation. Sensorimotor adaptation was confirmed by significant pointing aftereffect, however there was no significant change in the extent to which the irrelevant face half interfered with processing. The results support the proposal that the therapeutic effects of prism adaptation are limited to dorsal stream processing.
Url:
DOI: 10.12688/f1000research.2-215.v1
PubMed: 25110574
PubMed Central: 4111122
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prism adaptation does not alter configural processing of faces</title><author><name sortKey="Bultitude, Janet H" sort="Bultitude, Janet H" uniqKey="Bultitude J" first="Janet H." last="Bultitude">Janet H. Bultitude</name><affiliation wicri:level="1"><nlm:aff id="a1">Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU</wicri:regionArea></affiliation></author><author><name sortKey="Downing, Paul E" sort="Downing, Paul E" uniqKey="Downing P" first="Paul E." last="Downing">Paul E. Downing</name><affiliation wicri:level="1"><nlm:aff id="a2">Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS</wicri:regionArea></affiliation></author><author><name sortKey="Rafal, Robert D" sort="Rafal, Robert D" uniqKey="Rafal R" first="Robert D." last="Rafal">Robert D. Rafal</name><affiliation wicri:level="1"><nlm:aff id="a2">Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25110574</idno><idno type="pmc">4111122</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111122</idno><idno type="RBID">PMC:4111122</idno><idno type="doi">10.12688/f1000research.2-215.v1</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001C87</idno><idno type="wicri:Area/Pmc/Curation">001C87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prism adaptation does not alter configural processing of faces</title><author><name sortKey="Bultitude, Janet H" sort="Bultitude, Janet H" uniqKey="Bultitude J" first="Janet H." last="Bultitude">Janet H. Bultitude</name><affiliation wicri:level="1"><nlm:aff id="a1">Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU</wicri:regionArea></affiliation></author><author><name sortKey="Downing, Paul E" sort="Downing, Paul E" uniqKey="Downing P" first="Paul E." last="Downing">Paul E. Downing</name><affiliation wicri:level="1"><nlm:aff id="a2">Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS</wicri:regionArea></affiliation></author><author><name sortKey="Rafal, Robert D" sort="Rafal, Robert D" uniqKey="Rafal R" first="Robert D." last="Rafal">Robert D. Rafal</name><affiliation wicri:level="1"><nlm:aff id="a2">Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS</wicri:regionArea></affiliation></author></analytic><series><title level="j">F1000Research</title><idno type="eISSN">2046-1402</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Patients with hemispatial neglect (‘neglect’) following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training technique called prism adaptation as a treatment for neglect. Reaching for visual targets viewed through prismatic lenses that induce a rightward shift in the visual image results in a leftward recalibration of reaching movements that is accompanied by a reduction of symptoms in patients with neglect. The understanding of prism adaptation has also been advanced through studies of healthy participants, in whom adaptation to leftward prismatic shifts results in temporary neglect-like performance. Interestingly, prism adaptation can also alter aspects of non-lateralised spatial attention. We previously demonstrated that prism adaptation alters the extent to which neglect patients and healthy participants process local features versus global configurations of visual stimuli. Since deficits in non-lateralised spatial attention are thought to contribute to the severity of neglect symptoms, it is possible that the effect of prism adaptation on these deficits contributes to its efficacy. This study examines the pervasiveness of the effects of prism adaptation on perception by examining the effect of prism adaptation on configural face processing using a composite face task. The composite face task is a persuasive demonstration of the automatic global-level processing of faces: the top and bottom halves of two familiar faces form a seemingly new, unknown face when viewed together. Participants identified the top or bottom halves of composite faces before and after prism adaptation. Sensorimotor adaptation was confirmed by significant pointing aftereffect, however there was no significant change in the extent to which the irrelevant face half interfered with processing. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">F1000Res</journal-id><journal-id journal-id-type="iso-abbrev">F1000Res</journal-id><journal-id journal-id-type="pmc">F1000Research</journal-id><journal-title-group><journal-title>F1000Research</journal-title></journal-title-group><issn pub-type="epub">2046-1402</issn><publisher><publisher-name>F1000Research</publisher-name><publisher-loc>London, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25110574</article-id><article-id pub-id-type="pmc">4111122</article-id><article-id pub-id-type="doi">10.12688/f1000research.2-215.v1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group><subject>Articles</subject><subj-group><subject>Cognitive Neuroscience</subject></subj-group><subj-group><subject>Sensory Systems</subject></subj-group></subj-group></article-categories><title-group><article-title>Prism adaptation does not alter configural processing of faces</article-title><fn-group content-type="pub-status"><fn><p>v1; ref status: indexed</p></fn></fn-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bultitude</surname><given-names>Janet H.</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Downing</surname><given-names>Paul E.</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rafal</surname><given-names>Robert D.</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><aff id="a1"><label>1</label>Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK</aff><aff id="a2"><label>2</label>Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University, Gwynedd, LL57 2AS, UK</aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email xlink:href="mailto:jbultitude@fmrib.ox.ac.uk">jbultitude@fmrib.ox.ac.uk</email></corresp><fn fn-type="con"><p>JB conceived of the study, collected data for the study, analysed the data and prepared the draft manuscript. PD provided expertise on face processing and aided in interpreting the data. RR aided in the design of the study and aided in interpreting the data. All authors were involved in the revision of the draft manuscript and have agreed to the final content.</p></fn><fn fn-type="conflict"><p><bold>Competing interests: </bold>No relevant competing interests disclosed.</p></fn></author-notes><pub-date pub-type="epub"><day>14</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="collection"><year>2013</year></pub-date><volume>2</volume><elocation-id>215</elocation-id><history><date date-type="accepted"><day>7</day><month>10</month><year>2013</year></date></history><permissions><copyright-statement>Copyright: © 2013 Bultitude JH et al.</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license><license license-type="open-access" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/"><license-p>Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="f1000research-2-2468.pdf"></self-uri><abstract><p>Patients with hemispatial neglect (‘neglect’) following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training technique called prism adaptation as a treatment for neglect. Reaching for visual targets viewed through prismatic lenses that induce a rightward shift in the visual image results in a leftward recalibration of reaching movements that is accompanied by a reduction of symptoms in patients with neglect. The understanding of prism adaptation has also been advanced through studies of healthy participants, in whom adaptation to leftward prismatic shifts results in temporary neglect-like performance. Interestingly, prism adaptation can also alter aspects of non-lateralised spatial attention. We previously demonstrated that prism adaptation alters the extent to which neglect patients and healthy participants process local features versus global configurations of visual stimuli. Since deficits in non-lateralised spatial attention are thought to contribute to the severity of neglect symptoms, it is possible that the effect of prism adaptation on these deficits contributes to its efficacy. This study examines the pervasiveness of the effects of prism adaptation on perception by examining the effect of prism adaptation on configural face processing using a composite face task. The composite face task is a persuasive demonstration of the automatic global-level processing of faces: the top and bottom halves of two familiar faces form a seemingly new, unknown face when viewed together. Participants identified the top or bottom halves of composite faces before and after prism adaptation. Sensorimotor adaptation was confirmed by significant pointing aftereffect, however there was no significant change in the extent to which the irrelevant face half interfered with processing. The results support the proposal that the therapeutic effects of prism adaptation are limited to dorsal stream processing.</p></abstract><funding-group><award-group id="fund-1"><funding-source>British Federation of Women Graduates</funding-source></award-group><funding-statement>Funding for this work was provided by the British Federation of Women Graduates (to JB).</funding-statement><funding-statement><italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic></funding-statement></funding-group></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Patients with hemispatial neglect (‘neglect’) following a brain lesion show difficulty responding or orienting to objects and events that appear on the left side of space
<sup><xref rid="ref-1" ref-type="bibr">1</xref></sup>. A diagnosis of neglect is a strong predictor of poor functional outcome and low independence following stroke
<sup><xref rid="ref-2" ref-type="bibr">2</xref></sup>. This may be partly because the disorder impairs perception in a broad range of sensory modalities ranging from vision, touch, proprioception, and motor control to more abstract aspects of cognition such as a patient’s awareness of their own body
<sup><xref rid="ref-3" ref-type="bibr">3</xref></sup> and their imagined images of familiar locations
<sup><xref rid="ref-4" ref-type="bibr">4</xref></sup>. Furthermore, although the rightward spatial bias is the defining symptom of neglect, several other processing disturbances are associated with the disorder. These include low general arousal
<sup><xref rid="ref-5" ref-type="bibr">5</xref></sup>, poor sustained attention
<sup><xref rid="ref-6" ref-type="bibr">6</xref></sup>, and difficulties in keeping track of spatial locations as they move about their environment
<sup><xref rid="ref-7" ref-type="bibr">7</xref></sup>. These non-lateralised spatial biases are thought to increase neglect severity and reduce the potential for recovery
<sup><xref rid="ref-8" ref-type="bibr">8</xref></sup>.</p><p>Over the last fifteen years a promising behavioural intervention for neglect has emerged in the form of a sensorimotor training technique called prism adaptation
<sup><xref rid="ref-9" ref-type="bibr">9</xref></sup>. During prism adaptation, patients reach for objects viewed through rightward-deflecting prisms, leading to a leftward recalibration of reaching movements that can be measured as leftward errors once the prisms are removed. In patients with neglect this leftward recalibration of reaching is accompanied by a reduction in their symptoms. A single five-minute session of prism adaptation is sufficient to improve the performance of neglect patients on tests of visuo-motor function such as copying, cancellation and reading
<sup><xref rid="ref-9" ref-type="bibr">9</xref>,
<xref rid="ref-10" ref-type="bibr">10</xref></sup>. These effects extend to non-visual spatial processing, such as tactile perception
<sup><xref rid="ref-11" ref-type="bibr">11</xref></sup> and manual exploration of space while blindfolded
<sup><xref rid="ref-12" ref-type="bibr">12</xref></sup>, and to complex mental operations such as the exploration of an internally generated map of France
<sup><xref rid="ref-13" ref-type="bibr">13</xref></sup>; and 'bisection' of numbers
<sup><xref rid="ref-14" ref-type="bibr">14</xref></sup>. Evidence amassed over a number of studies suggests that this simple behavioural intervention can have broadly generalised effects, and prism adaptation is considered to be a highly promising potential treatment for neglect
<sup><xref rid="ref-15" ref-type="bibr">15</xref></sup>.</p><p>Whereas adaptation to rightward-shifting prisms can reduce neglect symptoms in brain-lesioned patients, adaptation to leftward-shifting prisms, involving a rightward recalibration of reaching, leads to neglect-like changes in the spatial performance of healthy participants. These perceptual changes have been demonstrated on a similar range of visual, non-visual and mental tasks (albeit to a lesser extent than those changes observed in patients)
<sup><xref rid="ref-17" ref-type="bibr">17</xref>–
<xref rid="ref-19" ref-type="bibr">19</xref></sup>. Since prism adaptation can be used to induce similar, but opposite, changes in the performance of healthy participants as in neglect patients, it is possible to gain insights into the potential therapeutic effects of the technique by testing healthy volunteers.</p><p>One example of research from healthy participants that has complemented the understanding gained from studies in patients is in research examining the effects of prism adaptation on non-lateralised deficits. There are now several pieces of evidence from brain-lesioned patients that prism adaptation alters spatial processing deficits that cannot be described in terms of orienting to the left versus the right, including reductions in spatial dysgraphia
<sup><xref rid="ref-20" ref-type="bibr">20</xref></sup> and shifts
<sup><xref rid="ref-21" ref-type="bibr">21</xref></sup> and reductions in perseveration
<sup><xref rid="ref-22" ref-type="bibr">22</xref></sup>. We previously demonstrated that adaptation to rightward-shifting prisms reverses the tendency of patients with right hemisphere lesions to become fixated on local details of a scene in preference to the global configuration (the ‘local processing bias’)
<sup><xref rid="ref-23" ref-type="bibr">23</xref></sup>. Patients identified the local or global level of large letters that were built from smaller letters (‘Navon’ figures). Reaction times to the local level increased after prism adaptation, demonstrating that there was a reduction in patients’ ability to identify the local level without interference from conflicting information at the global level. Conversely, RTs to the global level decreased following prism adaptation, demonstrating that patients were better able to ignore irrelevant conflicting information from the local level. In a similar experiment with healthy participants we demonstrated that adaptation to leftward-shifting prisms temporarily increased local processing
<sup><xref rid="ref-24" ref-type="bibr">24</xref></sup>, and led to neglect-like errors in the way in which a spatial representation or ‘map’ of the environment is updated as we move our gaze around it
<sup><xref rid="ref-25" ref-type="bibr">25</xref></sup>. Together these results demonstrate that prism adaptation has a more pervasive influence on visual perception than merely shifting attention to one side.</p><p>To further test the extent of this influence, the present study examines the effect of prism adaptation on the perception of composite faces in healthy participants. Faces, perhaps more than any other object, undergo automatic global-level processing in which individual components are highly integrated and less available to independent evaluation. This is powerfully illustrated in the composite face illusion (
<xref ref-type="fig" rid="f1">Figure 1</xref>): when the upper and lower halves of two faces are recombined, the virtually unavoidable illusion is that one is viewing the face of a third, different person. When participants are asked to identify the top or bottom halves of composites that are formed from faces of well-known celebrities, they are slower compared to when performing the same task when the two face halves are offset
<sup><xref rid="ref-26" ref-type="bibr">26</xref></sup>. This reaction time cost demonstrates that even when processing a face as an integrated Gestalt would impair our ability to perform the task at hand, we are unable to suppress such configural processing.</p><fig fig-type="figure" id="f1" orientation="portrait" position="float"><label>Figure 1. </label><caption><title>Examples of the four stimulus types (adapted from Weston and Perfect
<sup><xref rid="ref-30" ref-type="bibr">30</xref></sup>).</title><p>Stimuli for the task used in the present study took the same form as these examples, but were created from black-and-white publicity photographs of two well-known movie stars (Brad Pitt and George Clooney).</p></caption><graphic xlink:href="f1000research-2-2468-g0000"></graphic></fig><p>We had two main reasons for testing the influence of prism adaptation on configural face perception. First, by using a stimulus type for which normal processing is known to be strongly biased towards global processing, we reasoned that we could gain insight into the pervasiveness of the influence of prism adaptation on perceptual processes. Second, this experiment explores the possibility that prism adaptation could be used to improve face processing in individuals with prosopagnosia and autism, who have been shown to have reduced or absent configural face processing
<sup><xref rid="ref-27" ref-type="bibr">27</xref>,
<xref rid="ref-28" ref-type="bibr">28</xref></sup>. We predicted that adaptation to leftward-shifting prisms, which induced neglect-like processing in healthy participants, would reduce the RT cost associated with identifying composite faces. We further predicted that there would be no change in composite face processing following adaptation to rightward-shifting prisms, which does not induce perceptual changes in healthy participants.</p></sec><sec sec-type="materials|methods"><title>Material and methods</title><p>Sixty-four right-handed undergraduate women (mean age=19.8 years,
<italic>SEM</italic>=0.32; mean handedness=-0.83,
<italic>SEM</italic>=0.026 where a score of -1 denotes complete right-handedness;
<sup><xref rid="ref-29" ref-type="bibr">29</xref></sup>) completed a composite face task before and after a brief (five-minute) session of prism adaptation (see below for a full description of the task). Only female participants were selected for the study as it was felt that the stimuli - images of Brad Pitt and George Clooney - might have, on average, higher saliency for women than men. To be included in the study participants were also required to have normal or corrected-to-normal vision, and full use of their right arm. Informed consent was obtained in accordance with guidelines approved by the Bangor University ethics committee and the 2008 Declaration of Helsinki. Participants received course credits for the 45-minute session.</p><p>In a repeated-measures design, participants completed one set of configural face processing tasks before prism adaptation, and one set of configural face processing tasks after prism adaptation.</p><sec><title>Prism adaptation and open-loop pointing</title><p>Prism adaptation and confirmation of sensorimotor realignment were performed using a similar procedure as that used for prism adaptation treatment of hemispatial neglect
<sup><xref rid="ref-24" ref-type="bibr">24</xref></sup>. For prism adaptation, participants made 150 visually-guided pointing movements while wearing goggles fitted with prismatic lenses that shifted the visual field 15° to the left or right. In order to confirm adaptation, a participant pointed under target lines while vision of their pointing arm was occluded by a panel ('open-loop pointing'). Twelve open-loop pointing trials were performed immediately before and after prism adaptation (‘pre-' and ‘post-test’). In order to confirm that the sensorimotor realignment was retained throughout the entire post-adaptation configural face processing task, a third set of open-loop pointing errors were recorded at the end of the experiment (‘late-test’). Open-loop pointing error was measured by the experimenter to the nearest 0.5°, with negative numbers indicating leftward errors and positive numbers indicating rightward errors.</p><p>Participants performed a composite face task using stimuli similar to those used by Weston and Perfect
<sup><xref rid="ref-30" ref-type="bibr">30</xref></sup>.
<xref ref-type="fig" rid="f1">Figure 1</xref> (adapted from Weston and Perfect
<sup><xref rid="ref-30" ref-type="bibr">30</xref></sup>) provides examples of the four stimulus types used in the present experiment. Stimuli for the composite faces task had the same form as these examples, but were created from black-and-white publicity photographs of two well-known movie stars (Brad Pitt and George Clooney). All stimuli were constructed from the same two images and were presented on a black background. All participants correctly named the celebrities when shown these photographs at the beginning of the experimental session. Congruent stimuli were the unaltered pictures: that is the top and bottom face-halves were from the same celebrity. Incongruent stimuli were constructed by combining top and bottom face-halves from the two different celebrities. Faces were presented with the top and bottom halves aligned, or with the top half of the face offset to the left or right with reference to the bottom half, by approximately one-third of the face half. Participants identified the top or bottom half of each face in separate, identical blocks. For each trial, a fixation cross appeared for 500 ms, followed by the face stimulus for 200 ms, then a blank screen. Responses were made by pressing one of two buttons on a keyboard with the index or middle finger of their right hand. The participant’s response ended the trial. Each block consisted of 32 repetitions of each of the four stimulus types (congruent-aligned, congruent-misaligned, incongruent-aligned and incongruent-misaligned) in pseudorandom order, resulting in a total of 128 trials per block. Block order (top first or bottom first) and key allocation (Brad-left-George-right or George-left-Brad-right) were counterbalanced between participants.</p><p>Statistical analyses were performed using SPSS software
<sup><xref rid="ref-31" ref-type="bibr">31</xref></sup>. Pointing errors and reaction time (RT) data were subjected to repeated-measures ANOVAs. Follow-up paired-t-tests were performed using Bonferroni correction for multiple comparisons.</p></sec></sec><sec sec-type="results"><title>Results</title><sec><title>Open-loop pointing</title><p><xref ref-type="supplementary-material" rid="B1">Data File 1</xref> contains the full pointing data for each participant. A mixed ANOVA of pointing errors with the factors Prism Group (leftward, rightward) and Session (pre, post, late) revealed a significant two-way interaction [
<italic>F</italic>(2,124)=213.2,
<italic>p</italic><0.001]. This reflected a significant rightward shift in pointing error for the leftward-shifting prism group between the pre-test (
<italic>M</italic>=-0.2,
<italic>SEM</italic>=0.33) and the post-test [
<italic>M</italic>=4.9,
<italic>SEM</italic>=0.28;
<italic>t</italic>(31)=15.0,
<italic>p</italic><0.001], which was still significant in the late-test [
<italic>M</italic>=3.6,
<italic>SEM</italic>=0.27;
<italic>t</italic>(31)=10.4,
<italic>p</italic><0.001]. Similarly, there was a significant leftward shift in for the rightward-shifting prism group between the pre-test (
<italic>M</italic>=0.7,
<italic>SEM</italic>=0.35) and the post-test [
<italic>M</italic>=-3.3,
<italic>SEM</italic>=0.40;
<italic>t</italic>(31)=12.1,
<italic>p</italic><0.001], and this was sustained to the late-test [
<italic>M</italic>=-2.7,
<italic>SEM</italic>=0.39;
<italic>t</italic>(32)=8.7,
<italic>p</italic><0.001]. Comparison of 95% Confidence Intervals around the pre- to post-test pointing shifts indicated that there were no significant differences in the absolute magnitude of the after-effect for the two groups. Similarly, there were no significant differences in the pre- to late-test pointing shifts. Therefore prism adaptation resulted in significant shifts in open-loop pointing error in both groups, which were maintained for the entire duration of the post-adaptation composite face task.</p><p><supplementary-material content-type="local-data" id="B1"><caption><title>Data File 1 (spreadsheet 1): Mean pre-, post- and late-test pointing errors for all participants.</title><p>Values are in degrees of visual angle, with negative numbers indicating a leftward error, and positive values indicating a rightward error.</p></caption><media xlink:href="f1000research-2-2468-s0000.tgz"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></p></sec><sec><title>Composite face task</title><p>Mean accuracy was at ceiling (93%), precluding meaningful analysis. For each participant, responses that were faster than 200 ms or more than 3 SD above their mean RTs were excluded from analysis. Four participants demonstrated low accuracy for incongruent trials (>3 SD from mean error rate) during one or more block of the experiment, suggesting a failure to comprehend or comply with task instructions (i.e., their responses suggested that these participants were identifying, for example, the top half of the faces in a block in which they had been instructed to identify the bottom half of the faces). These participants were excluded from the analyses. Data for one of the experimental blocks was missing for two participants due to an error made by the experimenter. Since the responses of these individuals were otherwise similar to the remaining participants (suggesting that they were able to understand the instructions) these participants were retained and their missing data was replaced by the mean for that group.</p><p>For each prism group (leftward- or rightward-prisms), repeated-measures ANOVAs were conducted on the RT cost of alignment; that is, the difference between RTs for aligned and misaligned faces. By this index, a larger RT cost indicates greater interference due to configural processing, and a small RT cost indicates that participants were able to focus on the face halves with little or no interference from configural processing. The key factors of interest for the analyses were Prism (pre, post) and Congruency (congruent, incongruent). Previous studies have demonstrated temporal limitations to the effects of Navon figure processing on changes in the recognition of pre-learned faces
<sup><xref rid="ref-32" ref-type="bibr">32</xref></sup> and composite halves
<sup><xref rid="ref-30" ref-type="bibr">30</xref></sup>, with the effects decaying by the second half of the post-induction test phase. In order to test for such changes over time, we therefore included two further time-based factors in our analyses: Block Number (first, second) and Block Half (first, second). Finally, since any time-based effects may also be influenced by which half of the face participants identified immediately after prism adaptation, a between-subjects factor of Block Order (top-half-first, bottom-half-first) was also included. Therefore, the ANOVAs included five factors: Prism, Congruency, Block Order, Block Number and Block Half.</p><p>The full data for the analysis are presented in
<xref ref-type="supplementary-material" rid="B2">Data File 2</xref>. The analyses revealed significant main effects of Congruency for both leftward-shifting [M=-6.5 vs M=16.1;
<italic>F</italic>(1,28)=28.6,
<italic>p</italic><0.001] and rightward-shifting [M=0.15 vs M=14.1;
<italic>F</italic>(1,29)=913.0,
<italic>p</italic><0.005] prism groups, reflecting lower RT costs of alignment for the incongruent faces than for the congruent faces. A significant main effect of Block Half for the rightward-shifting prism group indicated higher RT costs for trials in the first half of the block compared to the second half [M=12.7 vs M=-1.6;
<italic>F</italic>(1,29)=5.5,
<italic>p</italic><0.05]. A significant Block Order x Block Number interaction for the leftward-shifting prism group [
<italic>F</italic>(1,27)=4.78,
<italic>p</italic><0.05] reflected trends in the RT cost of alignment depending on which face half the participants identified. That is, there was a non-significant tendency towards a higher RT cost of alignment for block two for participants in the ‘bottom half first’ group, and for block one for the participants in the ‘top half first’ group (
<italic>p</italic>s>0.05).</p><p><supplementary-material content-type="local-data" id="B2"><caption><title>Data File 2 (spreadsheets 2-5): RT costs of alignment for each condition for the composite face task.</title><p>RT costs were calculated by subtracting the raw RT for the misaligned condition from the RT for the aligned condition. FH=First half of the experimental block; SH=Second half of the experimental block; I=incongruent, C=congruent.</p><p>Spreadsheet 2 = Pre-adaptation, First experimental block; Spreadsheet 3 = Pre-adaptation, Second experimental block; Spreadsheet 4 = Post-adaptation, First experimental block; Spreadsheet 5 = Post-adaptation, Second experimental block</p></caption><media xlink:href="f1000research-2-2468-s0001.tgz"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></p><p>There was no significant interaction of Prism and Congruency for the leftward-shifting prism group (
<italic>p</italic>s>0.05), although a trend for a Prism x Congruency interaction arose for the rightward-shifting prism group [
<italic>F</italic>(1,29)=3.4,
<italic>p</italic>=0.074]. The RT costs for this interaction are plotted in
<xref ref-type="fig" rid="f2">Figure 2</xref> for both groups, and follow-up t-tests were performed on an
<italic>a priori</italic> basis. In contradiction of the experimental hypothesis, there was no significant change in RT cost of alignment for congruent or incongruent faces following adaptation to leftward-shifting prisms. There was, however, a trend for a reduction in RT cost for incongruent faces for participants in the rightward-shifting prism (control) group [
<italic>t</italic>(30)=2.2,
<italic>p</italic>=0.04, assessed to a Bonferroni-corrected alpha-level of
<italic>p</italic>=0.0125].</p><fig fig-type="figure" id="f2" orientation="portrait" position="float"><label>Figure 2. </label><caption><title>Data for the Prism x Congruency interaction.</title><p>RT costs of alignment for congruent and incongruent trials before and after adaptation to leftward- and rightward-shifting prisms. Error bars represent ± SEM, *=significant to a Bonferroni-corrected alpha level of
<italic>p</italic>=0.0125.</p></caption><graphic xlink:href="f1000research-2-2468-g0001"></graphic></fig><p>There were no significant interactions of Prism and Congruency with any other factor with Block Number or Block Half to suggest any short-lived effect of prism adaptation on composite face processing. This is apparent in
<xref ref-type="fig" rid="f3">Figure 3</xref>, which shows incongruent trial RT costs of the two Prism groups averaged across eight time points (2 Prism x 2 Block Number x 2 Block Halves).</p><fig fig-type="figure" id="f3" orientation="portrait" position="float"><label>Figure 3. </label><caption><title>The RT costs of alignment for incongruent trials over time.</title><p>The RT costs for the leftward- and rightward-shifting prism groups are shown broken into eight different time periods across the experiment, and were no different between the two groups.</p></caption><graphic xlink:href="f1000research-2-2468-g0002"></graphic></fig><p>Overall, the results demonstrate that the RT cost of alignment became numerically smaller with time for both groups, consistent with a practice effect. Importantly, there was no significant reduction in RT cost following adaptation to leftward-shifting prisms.</p></sec></sec><sec sec-type="discussion"><title>Discussion</title><p>Our results indicate that adaptation to leftward-shifting prisms did not reduce the RT cost associated with identifying individual halves of composite faces. Our data did reflect trends for reduced RT costs of alignment for incongruent faces for both the leftward- and rightward-shifting prism groups. However, this was not significant, and was in fact numerically larger for the rightward-shifting prism (control) group. With our large sample size (N=32 per group), it is unlikely that the lack of significant change in RT costs for incongruent trials can be attributed to type II error. We conclude instead that prism adaptation does not reduce configural processing of face stimuli.</p><p>Our research is particularly comparable to studies examining the effects of prism adaptation on the processing of chimeric faces and objects (stimuli that are formed by joining together the left and right halves of different faces or objects). Ferber and colleagues demonstrated that prism adaptation shifted the extent to which a neglect patient
<sup><xref rid="ref-33" ref-type="bibr">33</xref></sup> and healthy participants
<sup><xref rid="ref-34" ref-type="bibr">34</xref></sup> passed their gaze over different halves of chimeric faces. However, these changes in the visual exploration were not accompanied by any alteration in perceptual judgements of the faces. Sarri and colleagues
<sup><xref rid="ref-35" ref-type="bibr">35</xref></sup> extended on this to demonstrate that although prism adaptation did not alter patients’ perception of chimeric faces it did dramatically improve their awareness of the identity of the left side of non-face objects. Our findings that prism adaptation alters the global versus local processing of Navon figures
<sup><xref rid="ref-23" ref-type="bibr">23</xref>,
<xref rid="ref-24" ref-type="bibr">24</xref></sup> but not composite faces is consistent with this distinction between significant effects of prism adaptation on object but not face processing.</p><p>These results have bearing on an existing debate about whether the beneficial effects of prism adaptation on hemispatial neglect are restricted to tasks that have a direct motor or attentional component, or whether the technique also directly alters perceptual awareness per se
<sup><xref rid="ref-33" ref-type="bibr">33</xref>,
<xref rid="ref-35" ref-type="bibr">35</xref>–
<xref rid="ref-39" ref-type="bibr">39</xref></sup>. Striemer and Danckert
<sup><xref rid="ref-36" ref-type="bibr">36</xref></sup> proposed that the beneficial effects of prism adaptation are limited to dorsal stream attentional and visuomotor behaviours, whereas ventral stream perceptual processes are relatively unaffected. Many of the tasks on which neglect patients have shown improvement following neglect, such as pen-and-paper tasks
<sup><xref rid="ref-9" ref-type="bibr">9</xref>,
<xref rid="ref-40" ref-type="bibr">40</xref></sup>, reading
<sup><xref rid="ref-41" ref-type="bibr">41</xref></sup>, haptic exploration
<sup><xref rid="ref-12" ref-type="bibr">12</xref></sup>, postural imbalance
<sup><xref rid="ref-42" ref-type="bibr">42</xref></sup> and wheel-chair navigation
<sup><xref rid="ref-43" ref-type="bibr">43</xref></sup>, can be explained by a leftward shift in motor behaviour (including eye movements). In contrast, several studies have shown that prism adaptation does not alter the performance of neglect patients on tasks that require direct perceptual comparison of the left and right side of the stimuli
<sup><xref rid="ref-33" ref-type="bibr">33</xref>,
<xref rid="ref-44" ref-type="bibr">44</xref>,
<xref rid="ref-45" ref-type="bibr">45</xref></sup>, or stimuli on the left or right sides of space
<sup><xref rid="ref-46" ref-type="bibr">46</xref></sup>. Strikingly, the same patients showed leftward shifts in their ocular exploration of the stimuli
<sup><xref rid="ref-33" ref-type="bibr">33</xref>,
<xref rid="ref-46" ref-type="bibr">46</xref></sup>, or in similar tasks that had an overt motor component
<sup><xref rid="ref-45" ref-type="bibr">45</xref></sup>. Overall, Striemer and Danckert argued that prism adaptation alters performance on perceptual tasks only under specific circumstances (see Nijboer and colleagues
<sup><xref rid="ref-47" ref-type="bibr">47</xref></sup> for data that directly contradicts this conclusion, and papers by Saevarsson and Streimer and their colleagues
<sup><xref rid="ref-38" ref-type="bibr">38</xref>,
<xref rid="ref-39" ref-type="bibr">39</xref></sup> for further discussions of this model).</p><p>We previously attributed the effects of prism adaptation on the processing of Navon figures to changes in the relative activity of left and right temporo-parietal areas
<sup><xref rid="ref-23" ref-type="bibr">23</xref>,
<xref rid="ref-24" ref-type="bibr">24</xref></sup>. While object recognition per se is strongly attributed to dorsal stream processing, sensitivity to global versus local features of an object has been linked to differential specialisation of the left and right temporo-parietal cortices to these two levels of processing
<sup><xref rid="ref-48" ref-type="bibr">48</xref>–
<xref rid="ref-53" ref-type="bibr">53</xref></sup>. A further model of visual processing suggests that fast global processing of visual objects dominates in the dorsal stream providing rapid activation of frontoparietal attention mechanisms, whereas more detailed local processing occurs mainly through slower ventral stream mechanisms
<sup><xref rid="ref-54" ref-type="bibr">54</xref>–
<xref rid="ref-56" ref-type="bibr">56</xref></sup>. Thus, the effects of prism adaptation on the processing of Navon figures could be attributed to changes in dorsal stream mechanisms, either by altering relative processing weights of left and right temporo-parietal areas, or by a global enhancement or suppression of dorsal stream mechanisms.</p><p>Similar to other objects, it has been suggested that there is left hemisphere specialisation for processing face features and a right hemisphere specialisation for processing the face as a whole
<sup><xref rid="ref-57" ref-type="bibr">57</xref></sup>. However these have been localised to face-selective areas of the fusiform gyrus (i.e., the dorsal stream). A mechanism of prism adaptation that operates mainly through the ventral stream would therefore explain the absence of any effect of prism adaptation on face processing.</p><p>Prism adaptation is a promising treatment for hemispatial neglect. In order to understand the cognitive and neural mechanisms that underlie this intervention, it is important to examine tasks on which this technique has no impact, as well as those for which improvements are observed. Our finding that prism adaptation does not alter configural processing of faces is consistent with the dorsal versus ventral stream processing model proposed by Striemer and Danckert
<sup><xref rid="ref-36" ref-type="bibr">36</xref></sup>. Studies that directly compare the effects of prism adaptation on classic dorsal and ventral stream tasks would further illuminate the mechanisms of the beneficial effects of this intervention on hemispatial neglect.</p></sec></body><back><ack><title>Acknowledgements</title><p>The authors are grateful to Prof. Elinor McKone for her advice on the experimental design and Ms. Jo Mason for assistance with data collection.</p></ack><ref-list><ref id="ref-1"><label>1</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Bisiach</surname><given-names>E</given-names></name><name><surname>Vallar</surname><given-names>G</given-names></name></person-group>:
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<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/16801148">2006</ext-link>,
<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/20171612">2011</ext-link>). The study results are straightforward and the discussion appropriate. With respect to theoretical implications of the results, there remains a question in my mind about whether this study supports a selective effect of prism adaptation on dorsal processing, versus a selective effect on spatial action-intentional “Aiming”, because previous studies demonstrated that face recognition with affectively-loaded, dynamic properties may be strongly linked to the dorsal visual stream (
<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/9566428">Schwartz
<italic>et al</italic>., 1998</ext-link>;
<ext-link ext-link-type="uri" xlink:href="http://www.emotion.caltech.edu/papers/AdolphsDamasio2003Dissociable.pdf"> Adolphs
<italic>et al.</italic>, 2003</ext-link>). However, the current study did not use dynamic or (explicitly) emotional stimuli, so this distinction of dorsal visual processing versus spatial action processing is academic to the results at hand and the link of these results to dorsal versus spatial ‘Aiming’ function can be explored in future experiments.</p><p>I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p></body></sub-article><sub-article id="report2070" article-type="peer-review"><front-stub><article-id pub-id-type="doi">10.5256/f1000research.2468.r2070</article-id><title-group><article-title>Referee response for version 1</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Striemer</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="r2070a1">1</xref><role>Referee</role></contrib><aff id="r2070a1"><label>1</label>Department of Psychology, Grant MacEwan University, Edmonton, Canada</aff></contrib-group><author-notes><fn fn-type="conflict"><p><bold>Competing interests: </bold>No competing interests were disclosed.</p></fn></author-notes><pub-date pub-type="epub"><day>13</day><month>11</month><year>2013</year></pub-date><related-article id="d35e3258" related-article-type="peer-reviewed-article" ext-link-type="doi" xlink:href="10.12688/f1000research.2-215.v1">Version 1</related-article><custom-meta-group><custom-meta><meta-name>recommendation</meta-name><meta-value>approve-with-reservations</meta-value></custom-meta></custom-meta-group></front-stub><body><p>In this paper the authors have examined the after-effects of directional prism adaptation on global and local visual processing using the composite face effect. Previous work by Bultitude and colleagues has demonstrated that rightward prism adaptation in patients with right brain damage helps reduce the local processing bias. Furthermore, leftward prism adaptation in healthy individuals actually
<italic>increases</italic> the local processing bias. Based on these findings, the authors predicted that, in healthy individuals, leftward prism adaptation should
<italic>increase</italic> local processing, thereby
<italic>reducing</italic> the composite face effect (i.e., the increase in reaction time observed when processing aligned vs. misaligned composite faces).</p><p>The results of the experiment indicated that there were no significant changes in the composite face effect following leftward prism adaptation. However, there was a trend towards a reduction in the composite face effect following rightward prism adaptation. Critically, the absence of any effect of leftward shifting prisms on the composite face effect cannot be attributed to de-adaptation, as participants remained significantly adapted at the conclusion of the experiment. Based on these results the authors argued that their data are consistent with the notion that prism adaptation primarily influences processing in the dorsal visual stream, and the dorsal attention network.</p><p>Overall I found the study to be very interesting and well motivated. Although I found study to be quite interesting, I do have some queries regarding the methods used, as well as the interpretation of the data.</p><p>In the Methods section it is not clear whether concurrent or terminal feedback was used during the prism adaptation session. Please clarify in the revised manuscript.</p><p>In the Results section, when discussing the results of the composite face task (page 5, 2
<sup>nd</sup> paragraph, right column) you note that, “the analyses revealed significant main effects of congruency for both leftward and rightward shifting prisms groups, reflecting lower RT costs of alignment for the incongruent faces than for the congruent faces.” Perhaps I have misinterpreted the composite face effect, but isn’t the prediction that participants should be slower (i.e., an
<italic>increased</italic> RT cost) when processing aligned (compared misaligned) incongruent compared to congruent faces? The data from Figure 2 seem to support this interpretation in that participants are slower to respond for incongruent compared to congruent faces. Please clarify this in the revised manuscript.</p><p>It is interesting to note that the authors observed a trend towards a reduction in the composite face effect following rightward prism adaptation. However, the possible reasons for this are not addressed in the discussion. Is it possible that rightward prism adaptation may have increased activity in left temporal-parietal cortex thereby increasing attention to local features, and, by extension, decreasing configural face processing?</p><p>In the Discussion section I believe there may be a typo (or perhaps some confusion) regarding your characterization of the dorsal and ventral streams. Specifically, on the bottom of the left column on page 7 you mention that “While object recognition
<italic>per se</italic> is strongly attributed to dorsal stream processing ....” I believe what you mean to say is that object recognition is strongly tied to the
<italic>ventral</italic> visual stream. While it is true that some imaging studies have observed activation in dorsal stream areas during object processing tasks, it is as of yet unclear what visual information these signals are conveying. However, it is well known that damage to the ventral stream has devastating consequences for object and face recognition.</p><p>Likewise, when you are describing hemispheric specialization for face processing (page 7, middle paragraph, right column) you refer to the processing of face features and configural processing of faces as being “localized to face-selective areas in the fusiform gyrus (i.e., the dorsal stream).” Again, what I believe you meant to say was face selective areas in the
<italic>ventral</italic> stream. </p><p>Finally, your interpretation of the results is somewhat difficult to reconcile with findings from Sarri and colleagues (
<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/20171612">Sarri, Greenwood, Kalra, & Driver, 2011</ext-link>;
<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/16801148">Sarri, Kalra, Greenwood, & Driver, 2006</ext-link>) suggesting that patients with neglect can detect chimeric non-face objects following rightward prism adaptation, as both types of patterns (i.e., chimeric objects and composite faces) require ventral stream processing. One way to interpret this is that perhaps prisms have differential effects on face vs. non-face objects. However, perhaps a simpler way of interpreting this is one of task difficulty. That is, discriminating between halves of a chimeric face, or the top and bottom halves of a composite face, require a detailed within-category discrimination. In contrast, chimeric objects typically involve a much simpler between-category discrimination.</p><p>I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p></body></sub-article></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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