Serveur d'exploration sur les dispositifs haptiques

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Rationale, design and methods for a randomised and controlled trial of the impact of virtual reality games on motor competence, physical activity, and mental health in children with developmental coordination disorder

Identifieur interne : 001B90 ( Pmc/Curation ); précédent : 001B89; suivant : 001B91

Rationale, design and methods for a randomised and controlled trial of the impact of virtual reality games on motor competence, physical activity, and mental health in children with developmental coordination disorder

Auteurs : Leon M. Straker [Australie] ; Amity C. Campbell [Australie] ; Lyn M. Jensen [Australie] ; Deborah R. Metcalf [Australie] ; Anne J. Smith [Australie] ; Rebecca A. Abbott [Australie] ; Clare M. Pollock [Australie] ; Jan P. Piek [Australie]

Source :

RBID : PMC:3166932

Abstract

Background

A healthy start to life requires adequate motor development and physical activity participation. Currently 5-15% of children have impaired motor development without any obvious disorder. These children are at greater risk of obesity, musculoskeletal disorders, low social confidence and poor mental health. Traditional electronic game use may impact on motor development and physical activity creating a vicious cycle. However new virtual reality (VR) game interfaces may provide motor experiences that enhance motor development and lead to an increase in motor coordination and better physical activity and mental health outcomes. VR games are beginning to be used for rehabilitation, however there is no reported trial of the impact of these games on motor coordination in children with developmental coordination disorder.

Methods

This cross-over randomised and controlled trial will examine whether motor coordination is enhanced by access to active electronic games and whether daily activity, attitudes to physical activity and mental health are also enhanced. Thirty children aged 10-12 years with poor motor coordination (≤ 15th percentile) will be recruited and randomised to a balanced ordering of 'no active electronic games' and 'active electronic games'. Each child will participate in both conditions for 16 weeks, and be assessed prior to participation and at the end of each condition. The primary outcome is motor coordination, assessed by kinematic and kinetic motion analysis laboratory measures. Physical activity and sedentary behaviour will be assessed by accelerometry, coordination in daily life by parent report questionnaire and attitudes to physical activity, self-confidence, anxiety and depressed mood will be assessed by self report questionnaire. A sample of 30 will provide a power of > 0.9 for detecting a 5 point difference in motor coordination on the MABC-2 TIS scale (mean 17, sd = 5).

Discussion

This is the first trial to examine the impact of new virtual reality games on motor coordination in children with developmental coordination disorder. The findings will provide critical information to understand whether these electronic games can be used to have a positive impact on the physical and mental health of these children. Given the importance of adequate motor coordination, physical activity and mental health in childhood, this project can inform interventions which could have a profound impact on the long term health of this group of children.

Trial registration

Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12611000400965


Url:
DOI: 10.1186/1471-2458-11-654
PubMed: 21851587
PubMed Central: 3166932

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:3166932

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Rationale, design and methods for a randomised and controlled trial of the impact of virtual reality games on motor competence, physical activity, and mental health in children with developmental coordination disorder</title>
<author>
<name sortKey="Straker, Leon M" sort="Straker, Leon M" uniqKey="Straker L" first="Leon M" last="Straker">Leon M. Straker</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campbell, Amity C" sort="Campbell, Amity C" uniqKey="Campbell A" first="Amity C" last="Campbell">Amity C. Campbell</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jensen, Lyn M" sort="Jensen, Lyn M" uniqKey="Jensen L" first="Lyn M" last="Jensen">Lyn M. Jensen</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Metcalf, Deborah R" sort="Metcalf, Deborah R" uniqKey="Metcalf D" first="Deborah R" last="Metcalf">Deborah R. Metcalf</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, Anne J" sort="Smith, Anne J" uniqKey="Smith A" first="Anne J" last="Smith">Anne J. Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Abbott, Rebecca A" sort="Abbott, Rebecca A" uniqKey="Abbott R" first="Rebecca A" last="Abbott">Rebecca A. Abbott</name>
<affiliation wicri:level="1">
<nlm:aff id="I4">School of Human Movement Studies, The University of Queensland, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Human Movement Studies, The University of Queensland, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pollock, Clare M" sort="Pollock, Clare M" uniqKey="Pollock C" first="Clare M" last="Pollock">Clare M. Pollock</name>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I3">School of Psychology, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Piek, Jan P" sort="Piek, Jan P" uniqKey="Piek J" first="Jan P" last="Piek">Jan P. Piek</name>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I3">School of Psychology, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">21851587</idno>
<idno type="pmc">3166932</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166932</idno>
<idno type="RBID">PMC:3166932</idno>
<idno type="doi">10.1186/1471-2458-11-654</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001B90</idno>
<idno type="wicri:Area/Pmc/Curation">001B90</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Rationale, design and methods for a randomised and controlled trial of the impact of virtual reality games on motor competence, physical activity, and mental health in children with developmental coordination disorder</title>
<author>
<name sortKey="Straker, Leon M" sort="Straker, Leon M" uniqKey="Straker L" first="Leon M" last="Straker">Leon M. Straker</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campbell, Amity C" sort="Campbell, Amity C" uniqKey="Campbell A" first="Amity C" last="Campbell">Amity C. Campbell</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jensen, Lyn M" sort="Jensen, Lyn M" uniqKey="Jensen L" first="Lyn M" last="Jensen">Lyn M. Jensen</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Metcalf, Deborah R" sort="Metcalf, Deborah R" uniqKey="Metcalf D" first="Deborah R" last="Metcalf">Deborah R. Metcalf</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, Anne J" sort="Smith, Anne J" uniqKey="Smith A" first="Anne J" last="Smith">Anne J. Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="I1">School of Physiotherapy, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiotherapy, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Abbott, Rebecca A" sort="Abbott, Rebecca A" uniqKey="Abbott R" first="Rebecca A" last="Abbott">Rebecca A. Abbott</name>
<affiliation wicri:level="1">
<nlm:aff id="I4">School of Human Movement Studies, The University of Queensland, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Human Movement Studies, The University of Queensland, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pollock, Clare M" sort="Pollock, Clare M" uniqKey="Pollock C" first="Clare M" last="Pollock">Clare M. Pollock</name>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I3">School of Psychology, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Piek, Jan P" sort="Piek, Jan P" uniqKey="Piek J" first="Jan P" last="Piek">Jan P. Piek</name>
<affiliation wicri:level="1">
<nlm:aff id="I2">Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="I3">School of Psychology, Curtin University, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychology, Curtin University, Perth</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">BMC Public Health</title>
<idno type="eISSN">1471-2458</idno>
<imprint>
<date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>A healthy start to life requires adequate motor development and physical activity participation. Currently 5-15% of children have impaired motor development without any obvious disorder. These children are at greater risk of obesity, musculoskeletal disorders, low social confidence and poor mental health. Traditional electronic game use may impact on motor development and physical activity creating a vicious cycle. However new virtual reality (VR) game interfaces may provide motor experiences that enhance motor development and lead to an increase in motor coordination and better physical activity and mental health outcomes. VR games are beginning to be used for rehabilitation, however there is no reported trial of the impact of these games on motor coordination in children with developmental coordination disorder.</p>
</sec>
<sec>
<title>Methods</title>
<p>This cross-over randomised and controlled trial will examine whether motor coordination is enhanced by access to active electronic games and whether daily activity, attitudes to physical activity and mental health are also enhanced. Thirty children aged 10-12 years with poor motor coordination (≤ 15
<sup>th </sup>
percentile) will be recruited and randomised to a balanced ordering of 'no active electronic games' and 'active electronic games'. Each child will participate in both conditions for 16 weeks, and be assessed prior to participation and at the end of each condition. The primary outcome is motor coordination, assessed by kinematic and kinetic motion analysis laboratory measures. Physical activity and sedentary behaviour will be assessed by accelerometry, coordination in daily life by parent report questionnaire and attitudes to physical activity, self-confidence, anxiety and depressed mood will be assessed by self report questionnaire. A sample of 30 will provide a power of > 0.9 for detecting a 5 point difference in motor coordination on the MABC-2 TIS scale (mean 17, sd = 5).</p>
</sec>
<sec>
<title>Discussion</title>
<p>This is the first trial to examine the impact of new virtual reality games on motor coordination in children with developmental coordination disorder. The findings will provide critical information to understand whether these electronic games can be used to have a positive impact on the physical and mental health of these children. Given the importance of adequate motor coordination, physical activity and mental health in childhood, this project can inform interventions which could have a profound impact on the long term health of this group of children.</p>
</sec>
<sec>
<title>Trial registration</title>
<p>Australia and New Zealand Clinical Trials Register (ANZCTR):
<ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/ACTRN12611000400965.aspx">ACTRN12611000400965</ext-link>
</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Marshall, Sj" uniqKey="Marshall S">SJ Marshall</name>
</author>
<author>
<name sortKey="Gorely, T" uniqKey="Gorely T">T Gorely</name>
</author>
<author>
<name sortKey="Biddle, Sjh" uniqKey="Biddle S">SJH Biddle</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Roberts, Dl" uniqKey="Roberts D">DL Roberts</name>
</author>
<author>
<name sortKey="Foehr, Ug" uniqKey="Foehr U">UG Foehr</name>
</author>
<author>
<name sortKey="Rideout, V" uniqKey="Rideout V">V Rideout</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, L" uniqKey="Straker L">L Straker</name>
</author>
<author>
<name sortKey="Pollock, C" uniqKey="Pollock C">C Pollock</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Harrison, C" uniqKey="Harrison C">C Harrison</name>
</author>
<author>
<name sortKey="Comber, C" uniqKey="Comber C">C Comber</name>
</author>
<author>
<name sortKey="Fisher, T" uniqKey="Fisher T">T Fisher</name>
</author>
<author>
<name sortKey="Haw, K" uniqKey="Haw K">K Haw</name>
</author>
<author>
<name sortKey="Lewin, C" uniqKey="Lewin C">C Lewin</name>
</author>
<author>
<name sortKey="Lunzer, E" uniqKey="Lunzer E">E Lunzer</name>
</author>
<author>
<name sortKey="Mcfarlane, A" uniqKey="Mcfarlane A">A McFarlane</name>
</author>
<author>
<name sortKey="Mavers, D" uniqKey="Mavers D">D Mavers</name>
</author>
<author>
<name sortKey="Scrimshaw, P" uniqKey="Scrimshaw P">P Scrimshaw</name>
</author>
<author>
<name sortKey="Somekh, B" uniqKey="Somekh B">B Somekh</name>
</author>
<author>
<name sortKey="Watling, R" uniqKey="Watling R">R Watling</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Moseley, D" uniqKey="Moseley D">D Moseley</name>
</author>
<author>
<name sortKey="Mearns, N" uniqKey="Mearns N">N Mearns</name>
</author>
<author>
<name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Heft, Tm" uniqKey="Heft T">TM Heft</name>
</author>
<author>
<name sortKey="Swaminathan, S" uniqKey="Swaminathan S">S Swaminathan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Villani, Ss" uniqKey="Villani S">SS Villani</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Barrero, M" uniqKey="Barrero M">M Barrero</name>
</author>
<author>
<name sortKey="Hedge, A" uniqKey="Hedge A">A Hedge</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Harris, C" uniqKey="Harris C">C Harris</name>
</author>
<author>
<name sortKey="Straker, L" uniqKey="Straker L">L Straker</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, L" uniqKey="Straker L">L Straker</name>
</author>
<author>
<name sortKey="Briggs, A" uniqKey="Briggs A">A Briggs</name>
</author>
<author>
<name sortKey="Greig, A" uniqKey="Greig A">A Greig</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="White, Fa" uniqKey="White F">FA White</name>
</author>
<author>
<name sortKey="Hayes, Bk" uniqKey="Hayes B">BK Hayes</name>
</author>
<author>
<name sortKey="Livesey, Dj" uniqKey="Livesey D">DJ Livesey</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mckenzie, Tl" uniqKey="Mckenzie T">TL McKenzie</name>
</author>
<author>
<name sortKey="Alcaraz, Je" uniqKey="Alcaraz J">JE Alcaraz</name>
</author>
<author>
<name sortKey="Sallis, Jf" uniqKey="Sallis J">JF Sallis</name>
</author>
<author>
<name sortKey="Faucetter, Fn" uniqKey="Faucetter F">FN Faucetter</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Yuji, H" uniqKey="Yuji H">H Yuji</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Whitcomb, Gr" uniqKey="Whitcomb G">GR Whitcomb</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rosser, Jc" uniqKey="Rosser J">JC Rosser</name>
</author>
<author>
<name sortKey="Lynch, Pj" uniqKey="Lynch P">PJ Lynch</name>
</author>
<author>
<name sortKey="Cuddihy, L" uniqKey="Cuddihy L">L Cuddihy</name>
</author>
<author>
<name sortKey="Gentile, Da" uniqKey="Gentile D">DA Gentile</name>
</author>
<author>
<name sortKey="Klonsky, J" uniqKey="Klonsky J">J Klonsky</name>
</author>
<author>
<name sortKey="Merrell, R" uniqKey="Merrell R">R Merrell</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, Lm" uniqKey="Straker L">LM Straker</name>
</author>
<author>
<name sortKey="Pollock, Cm" uniqKey="Pollock C">CM Pollock</name>
</author>
<author>
<name sortKey="Zubrick, Sr" uniqKey="Zubrick S">SR Zubrick</name>
</author>
<author>
<name sortKey="Kurinczuk, Jj" uniqKey="Kurinczuk J">JJ Kurinczuk</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Polatajko, Hj" uniqKey="Polatajko H">HJ Polatajko</name>
</author>
<author>
<name sortKey="Fox, Am" uniqKey="Fox A">AM Fox</name>
</author>
<author>
<name sortKey="Missiuna, C" uniqKey="Missiuna C">C Missiuna</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilson, Ph" uniqKey="Wilson P">PH Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Piek, Jp" uniqKey="Piek J">JP Piek</name>
</author>
<author>
<name sortKey="Dyck, M" uniqKey="Dyck M">M Dyck</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilson, Ph" uniqKey="Wilson P">PH Wilson</name>
</author>
<author>
<name sortKey="Mckenzie, Be" uniqKey="Mckenzie B">BE McKenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Piek, Jp" uniqKey="Piek J">JP Piek</name>
</author>
<author>
<name sortKey="Skinner, Ra" uniqKey="Skinner R">RA Skinner</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rivilis, I" uniqKey="Rivilis I">I Rivilis</name>
</author>
<author>
<name sortKey="Hay, J" uniqKey="Hay J">J Hay</name>
</author>
<author>
<name sortKey="Cairney, J" uniqKey="Cairney J">J Cairney</name>
</author>
<author>
<name sortKey="Klentrou, P" uniqKey="Klentrou P">P Klentrou</name>
</author>
<author>
<name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author>
<name sortKey="Faught, Be" uniqKey="Faught B">BE Faught</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hay, Ja" uniqKey="Hay J">JA Hay</name>
</author>
<author>
<name sortKey="Hawes, R" uniqKey="Hawes R">R Hawes</name>
</author>
<author>
<name sortKey="Faught, Be" uniqKey="Faught B">BE Faught</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hillier, S" uniqKey="Hillier S">S Hillier</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hillier, S" uniqKey="Hillier S">S Hillier</name>
</author>
<author>
<name sortKey="Mcintyre, A" uniqKey="Mcintyre A">A McIntyre</name>
</author>
<author>
<name sortKey="Plummer, L" uniqKey="Plummer L">L Plummer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tsai, Cl" uniqKey="Tsai C">CL Tsai</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Harter, S" uniqKey="Harter S">S Harter</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Harter, S" uniqKey="Harter S">S Harter</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Doganis, G" uniqKey="Doganis G">G Doganis</name>
</author>
<author>
<name sortKey="Theodorakis, Y" uniqKey="Theodorakis Y">Y Theodorakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Abbott, Ra" uniqKey="Abbott R">RA Abbott</name>
</author>
<author>
<name sortKey="Macdonald, D" uniqKey="Macdonald D">D Macdonald</name>
</author>
<author>
<name sortKey="Mackinnon, L" uniqKey="Mackinnon L">L Mackinnon</name>
</author>
<author>
<name sortKey="Stubbs, Co" uniqKey="Stubbs C">CO Stubbs</name>
</author>
<author>
<name sortKey="Lee, Aj" uniqKey="Lee A">AJ Lee</name>
</author>
<author>
<name sortKey="Harper, C" uniqKey="Harper C">C Harper</name>
</author>
<author>
<name sortKey="Davies, Psw" uniqKey="Davies P">PSW Davies</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Biddle, Sj" uniqKey="Biddle S">SJ Biddle</name>
</author>
<author>
<name sortKey="Gorely, T" uniqKey="Gorely T">T Gorely</name>
</author>
<author>
<name sortKey="Stensel, Dj" uniqKey="Stensel D">DJ Stensel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cairney, J" uniqKey="Cairney J">J Cairney</name>
</author>
<author>
<name sortKey="Hay, Ja" uniqKey="Hay J">JA Hay</name>
</author>
<author>
<name sortKey="Faught, Be" uniqKey="Faught B">BE Faught</name>
</author>
<author>
<name sortKey="Hawes, R" uniqKey="Hawes R">R Hawes</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Poulsen, Aa" uniqKey="Poulsen A">AA Poulsen</name>
</author>
<author>
<name sortKey="Ziviani, Jm" uniqKey="Ziviani J">JM Ziviani</name>
</author>
<author>
<name sortKey="Cuskelly, M" uniqKey="Cuskelly M">M Cuskelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Piek, Jp" uniqKey="Piek J">JP Piek</name>
</author>
<author>
<name sortKey="Dworcan, M" uniqKey="Dworcan M">M Dworcan</name>
</author>
<author>
<name sortKey="Barrett, Nc" uniqKey="Barrett N">NC Barrett</name>
</author>
<author>
<name sortKey="Coleman, R" uniqKey="Coleman R">R Coleman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Skinner, Ra" uniqKey="Skinner R">RA Skinner</name>
</author>
<author>
<name sortKey="Piek, Jp" uniqKey="Piek J">JP Piek</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Francis, M" uniqKey="Francis M">M Francis</name>
</author>
<author>
<name sortKey="Piek, Jp" uniqKey="Piek J">JP Piek</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, L" uniqKey="Straker L">L Straker</name>
</author>
<author>
<name sortKey="Abbott, R" uniqKey="Abbott R">R Abbott</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, L" uniqKey="Straker L">L Straker</name>
</author>
<author>
<name sortKey="Pollock, C" uniqKey="Pollock C">C Pollock</name>
</author>
<author>
<name sortKey="Piek, J" uniqKey="Piek J">J Piek</name>
</author>
<author>
<name sortKey="Abbott, R" uniqKey="Abbott R">R Abbott</name>
</author>
<author>
<name sortKey="Skoss, R" uniqKey="Skoss R">R Skoss</name>
</author>
<author>
<name sortKey="Coleman, J" uniqKey="Coleman J">J Coleman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author>
<name sortKey="Atkins, Ms" uniqKey="Atkins M">MS Atkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Marshall, Sj" uniqKey="Marshall S">SJ Marshall</name>
</author>
<author>
<name sortKey="Biddle, Sj" uniqKey="Biddle S">SJ Biddle</name>
</author>
<author>
<name sortKey="Gorely, T" uniqKey="Gorely T">T Gorely</name>
</author>
<author>
<name sortKey="Cameron, N" uniqKey="Cameron N">N Cameron</name>
</author>
<author>
<name sortKey="Murdey, I" uniqKey="Murdey I">I Murdey</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Motl, Rw" uniqKey="Motl R">RW Motl</name>
</author>
<author>
<name sortKey="Mcauley, E" uniqKey="Mcauley E">E McAuley</name>
</author>
<author>
<name sortKey="Birnbaum, As" uniqKey="Birnbaum A">AS Birnbaum</name>
</author>
<author>
<name sortKey="Lytle, La" uniqKey="Lytle L">LA Lytle</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rey Lopez, Jp" uniqKey="Rey Lopez J">JP Rey-Lopez</name>
</author>
<author>
<name sortKey="Vicente Rodriguez, G" uniqKey="Vicente Rodriguez G">G Vicente-Rodriguez</name>
</author>
<author>
<name sortKey="Biosca, M" uniqKey="Biosca M">M Biosca</name>
</author>
<author>
<name sortKey="Moreno, La" uniqKey="Moreno L">LA Moreno</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, L" uniqKey="Straker L">L Straker</name>
</author>
<author>
<name sortKey="Coleman, J" uniqKey="Coleman J">J Coleman</name>
</author>
<author>
<name sortKey="Abbott, R" uniqKey="Abbott R">R Abbott</name>
</author>
<author>
<name sortKey="Piek, J" uniqKey="Piek J">J Piek</name>
</author>
<author>
<name sortKey="Pollock, C" uniqKey="Pollock C">C Pollock</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mccarron, L" uniqKey="Mccarron L">L McCarron</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Gomes, A" uniqKey="Gomes A">A Gomes</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Weiss, Pl" uniqKey="Weiss P">PL Weiss</name>
</author>
<author>
<name sortKey="Rand, D" uniqKey="Rand D">D Rand</name>
</author>
<author>
<name sortKey="Katz, N" uniqKey="Katz N">N Katz</name>
</author>
<author>
<name sortKey="Kizony, R" uniqKey="Kizony R">R Kizony</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lanningham Foster, L" uniqKey="Lanningham Foster L">L Lanningham-Foster</name>
</author>
<author>
<name sortKey="Jensen, Tb" uniqKey="Jensen T">TB Jensen</name>
</author>
<author>
<name sortKey="Foster, Rc" uniqKey="Foster R">RC Foster</name>
</author>
<author>
<name sortKey="Redmond, Ab" uniqKey="Redmond A">AB Redmond</name>
</author>
<author>
<name sortKey="Walker, Ba" uniqKey="Walker B">BA Walker</name>
</author>
<author>
<name sortKey="Heinz, D" uniqKey="Heinz D">D Heinz</name>
</author>
<author>
<name sortKey="Levine, Ja" uniqKey="Levine J">JA Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Maddison, R" uniqKey="Maddison R">R Maddison</name>
</author>
<author>
<name sortKey="Mhurchul, Cn" uniqKey="Mhurchul C">CN Mhurchul</name>
</author>
<author>
<name sortKey="Jull, A" uniqKey="Jull A">A Jull</name>
</author>
<author>
<name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author>
<name sortKey="Prapavessis, H" uniqKey="Prapavessis H">H Prapavessis</name>
</author>
<author>
<name sortKey="Rodgers, A" uniqKey="Rodgers A">A Rodgers</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Maddison, R" uniqKey="Maddison R">R Maddison</name>
</author>
<author>
<name sortKey="Foley, L" uniqKey="Foley L">L Foley</name>
</author>
<author>
<name sortKey="Ni Mhurchu, C" uniqKey="Ni Mhurchu C">C Ni Mhurchu</name>
</author>
<author>
<name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author>
<name sortKey="Jull, A" uniqKey="Jull A">A Jull</name>
</author>
<author>
<name sortKey="Prapavessis, H" uniqKey="Prapavessis H">H Prapavessis</name>
</author>
<author>
<name sortKey="Hohepa, M" uniqKey="Hohepa M">M Hohepa</name>
</author>
<author>
<name sortKey="Rodgers, A" uniqKey="Rodgers A">A Rodgers</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Straker, Lm" uniqKey="Straker L">LM Straker</name>
</author>
<author>
<name sortKey="Abbott, Ra" uniqKey="Abbott R">RA Abbott</name>
</author>
<author>
<name sortKey="Piek, Jp" uniqKey="Piek J">JP Piek</name>
</author>
<author>
<name sortKey="Pollock, Cm" uniqKey="Pollock C">CM Pollock</name>
</author>
<author>
<name sortKey="Davies, Ps" uniqKey="Davies P">PS Davies</name>
</author>
<author>
<name sortKey="Smith, Aj" uniqKey="Smith A">AJ Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sveistrup, H" uniqKey="Sveistrup H">H Sveistrup</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Reid, Dt" uniqKey="Reid D">DT Reid</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wann, Jp" uniqKey="Wann J">JP Wann</name>
</author>
<author>
<name sortKey="Rushton, Sk" uniqKey="Rushton S">SK Rushton</name>
</author>
<author>
<name sortKey="Smyth, M" uniqKey="Smyth M">M Smyth</name>
</author>
<author>
<name sortKey="Jones, D" uniqKey="Jones D">D Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Henderson, Se" uniqKey="Henderson S">SE Henderson</name>
</author>
<author>
<name sortKey="Sugden, Da" uniqKey="Sugden D">DA Sugden</name>
</author>
<author>
<name sortKey="Barnett, Al" uniqKey="Barnett A">AL Barnett</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Gueze, Rh" uniqKey="Gueze R">RH Gueze</name>
</author>
<author>
<name sortKey="Jongmans, Mj" uniqKey="Jongmans M">MJ Jongmans</name>
</author>
<author>
<name sortKey="Schoemaker, Mm" uniqKey="Schoemaker M">MM Schoemaker</name>
</author>
<author>
<name sortKey="Smits Engelsman, Bc" uniqKey="Smits Engelsman B">BC Smits-Engelsman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Laszlo, Ji" uniqKey="Laszlo J">JI Laszlo</name>
</author>
<author>
<name sortKey="Bairstow, Pj" uniqKey="Bairstow P">PJ Bairstow</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Smits Engelsman, Bcm" uniqKey="Smits Engelsman B">BCM Smits-Engelsman</name>
</author>
<author>
<name sortKey="Henderson, Se" uniqKey="Henderson S">SE Henderson</name>
</author>
<author>
<name sortKey="Michels, Cgj" uniqKey="Michels C">CGJ Michels</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Niemeijer, As" uniqKey="Niemeijer A">AS Niemeijer</name>
</author>
<author>
<name sortKey="Smits Engelsman, Bc" uniqKey="Smits Engelsman B">BC Smits-Engelsman</name>
</author>
<author>
<name sortKey="Schoemaker, Mm" uniqKey="Schoemaker M">MM Schoemaker</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wu, G" uniqKey="Wu G">G Wu</name>
</author>
<author>
<name sortKey="Siegler, S" uniqKey="Siegler S">S Siegler</name>
</author>
<author>
<name sortKey="Allard, P" uniqKey="Allard P">P Allard</name>
</author>
<author>
<name sortKey="Kirtley, C" uniqKey="Kirtley C">C Kirtley</name>
</author>
<author>
<name sortKey="Leardini, A" uniqKey="Leardini A">A Leardini</name>
</author>
<author>
<name sortKey="Rosenbaum, D" uniqKey="Rosenbaum D">D Rosenbaum</name>
</author>
<author>
<name sortKey="Whittle, M" uniqKey="Whittle M">M Whittle</name>
</author>
<author>
<name sortKey="D Lima, Dd" uniqKey="D Lima D">DD D'Lima</name>
</author>
<author>
<name sortKey="Cristofolini, L" uniqKey="Cristofolini L">L Cristofolini</name>
</author>
<author>
<name sortKey="Witte, H" uniqKey="Witte H">H Witte</name>
</author>
<author>
<name sortKey="Schmid, O" uniqKey="Schmid O">O Schmid</name>
</author>
<author>
<name sortKey="Stokes, I" uniqKey="Stokes I">I Stokes</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wu, G" uniqKey="Wu G">G Wu</name>
</author>
<author>
<name sortKey="Van Der Helm, Fct" uniqKey="Van Der Helm F">FCT van der Helm</name>
</author>
<author>
<name sortKey="Veeger, Hej" uniqKey="Veeger H">HEJ Veeger</name>
</author>
<author>
<name sortKey="Makhsous, M" uniqKey="Makhsous M">M Makhsous</name>
</author>
<author>
<name sortKey="Van Roy, P" uniqKey="Van Roy P">P Van Roy</name>
</author>
<author>
<name sortKey="Anglin, C" uniqKey="Anglin C">C Anglin</name>
</author>
<author>
<name sortKey="Nagels, J" uniqKey="Nagels J">J Nagels</name>
</author>
<author>
<name sortKey="Karduna, Ar" uniqKey="Karduna A">AR Karduna</name>
</author>
<author>
<name sortKey="Mcquade, K" uniqKey="Mcquade K">K McQuade</name>
</author>
<author>
<name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author>
<name sortKey="Werner, B" uniqKey="Werner B">B Werner</name>
</author>
<author>
<name sortKey="Buchholz, B" uniqKey="Buchholz B">B Buchholz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ulrich, Da" uniqKey="Ulrich D">DA Ulrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ameratunga, D" uniqKey="Ameratunga D">D Ameratunga</name>
</author>
<author>
<name sortKey="Johnston, L" uniqKey="Johnston L">L Johnston</name>
</author>
<author>
<name sortKey="Burns, Y" uniqKey="Burns Y">Y Burns</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chang, Jj" uniqKey="Chang J">JJ Chang</name>
</author>
<author>
<name sortKey="Wu, Ti" uniqKey="Wu T">TI Wu</name>
</author>
<author>
<name sortKey="Wu, Wl" uniqKey="Wu W">WL Wu</name>
</author>
<author>
<name sortKey="Su, Fc" uniqKey="Su F">FC Su</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilson, Bn" uniqKey="Wilson B">BN Wilson</name>
</author>
<author>
<name sortKey="Crawford, Sg" uniqKey="Crawford S">SG Crawford</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tseng, Mh" uniqKey="Tseng M">MH Tseng</name>
</author>
<author>
<name sortKey="Fu, Cp" uniqKey="Fu C">CP Fu</name>
</author>
<author>
<name sortKey="Wilson, Bn" uniqKey="Wilson B">BN Wilson</name>
</author>
<author>
<name sortKey="Hu, Fc" uniqKey="Hu F">FC Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wilson, Bn" uniqKey="Wilson B">BN Wilson</name>
</author>
<author>
<name sortKey="Crawford, Sg" uniqKey="Crawford S">SG Crawford</name>
</author>
<author>
<name sortKey="Green, D" uniqKey="Green D">D Green</name>
</author>
<author>
<name sortKey="Roberts, G" uniqKey="Roberts G">G Roberts</name>
</author>
<author>
<name sortKey="Aylott, A" uniqKey="Aylott A">A Aylott</name>
</author>
<author>
<name sortKey="Kaplan, Bj" uniqKey="Kaplan B">BJ Kaplan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Puyau, Mr" uniqKey="Puyau M">MR Puyau</name>
</author>
<author>
<name sortKey="Adolph, Al" uniqKey="Adolph A">AL Adolph</name>
</author>
<author>
<name sortKey="Vohra, Fa" uniqKey="Vohra F">FA Vohra</name>
</author>
<author>
<name sortKey="Butte, Nf" uniqKey="Butte N">NF Butte</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trost, Sg" uniqKey="Trost S">SG Trost</name>
</author>
<author>
<name sortKey="Pate, Rr" uniqKey="Pate R">RR Pate</name>
</author>
<author>
<name sortKey="Freedson, Ps" uniqKey="Freedson P">PS Freedson</name>
</author>
<author>
<name sortKey="Sallis, Jf" uniqKey="Sallis J">JF Sallis</name>
</author>
<author>
<name sortKey="Taylor, Wc" uniqKey="Taylor W">WC Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Motl, Rw" uniqKey="Motl R">RW Motl</name>
</author>
<author>
<name sortKey="Dishman, Rk" uniqKey="Dishman R">RK Dishman</name>
</author>
<author>
<name sortKey="Saunders, R" uniqKey="Saunders R">R Saunders</name>
</author>
<author>
<name sortKey="Dowda, M" uniqKey="Dowda M">M Dowda</name>
</author>
<author>
<name sortKey="Felton, G" uniqKey="Felton G">G Felton</name>
</author>
<author>
<name sortKey="Pate, Rr" uniqKey="Pate R">RR Pate</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kendzierski, D" uniqKey="Kendzierski D">D Kendzierski</name>
</author>
<author>
<name sortKey="Decarlo, Kj" uniqKey="Decarlo K">KJ DeCarlo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Dishman, Rk" uniqKey="Dishman R">RK Dishman</name>
</author>
<author>
<name sortKey="Motl, Rw" uniqKey="Motl R">RW Motl</name>
</author>
<author>
<name sortKey="Saunders, R" uniqKey="Saunders R">R Saunders</name>
</author>
<author>
<name sortKey="Felton, G" uniqKey="Felton G">G Felton</name>
</author>
<author>
<name sortKey="Ward, Ds" uniqKey="Ward D">DS Ward</name>
</author>
<author>
<name sortKey="Dowda, M" uniqKey="Dowda M">M Dowda</name>
</author>
<author>
<name sortKey="Pate, Rr" uniqKey="Pate R">RR Pate</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Moore, J" uniqKey="Moore J">J Moore</name>
</author>
<author>
<name sortKey="Yin, Z" uniqKey="Yin Z">Z Yin</name>
</author>
<author>
<name sortKey="Hanes, J" uniqKey="Hanes J">J Hanes</name>
</author>
<author>
<name sortKey="Duda, J" uniqKey="Duda J">J Duda</name>
</author>
<author>
<name sortKey="Gutin, B" uniqKey="Gutin B">B Gutin</name>
</author>
<author>
<name sortKey="Barbeau, P" uniqKey="Barbeau P">P Barbeau</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Harter, S" uniqKey="Harter S">S Harter</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Spence, Sh" uniqKey="Spence S">SH Spence</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Essau, Ca" uniqKey="Essau C">CA Essau</name>
</author>
<author>
<name sortKey="Muris, P" uniqKey="Muris P">P Muris</name>
</author>
<author>
<name sortKey="Ederer, Em" uniqKey="Ederer E">EM Ederer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Spence, Sh" uniqKey="Spence S">SH Spence</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Angold, A" uniqKey="Angold A">A Angold</name>
</author>
<author>
<name sortKey="Costello, E" uniqKey="Costello E">E Costello</name>
</author>
<author>
<name sortKey="Messer, S" uniqKey="Messer S">S Messer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sund, Am" uniqKey="Sund A">AM Sund</name>
</author>
<author>
<name sortKey="Larsson, B" uniqKey="Larsson B">B Larsson</name>
</author>
<author>
<name sortKey="Wichstrom, L" uniqKey="Wichstrom L">L Wichstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kent, L" uniqKey="Kent L">L Kent</name>
</author>
<author>
<name sortKey="Vostanis, P" uniqKey="Vostanis P">P Vostanis</name>
</author>
<author>
<name sortKey="Feehan, C" uniqKey="Feehan C">C Feehan</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">BMC Public Health</journal-id>
<journal-title-group>
<journal-title>BMC Public Health</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2458</issn>
<publisher>
<publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">21851587</article-id>
<article-id pub-id-type="pmc">3166932</article-id>
<article-id pub-id-type="publisher-id">1471-2458-11-654</article-id>
<article-id pub-id-type="doi">10.1186/1471-2458-11-654</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Study Protocol</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Rationale, design and methods for a randomised and controlled trial of the impact of virtual reality games on motor competence, physical activity, and mental health in children with developmental coordination disorder</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes" id="A1">
<name>
<surname>Straker</surname>
<given-names>Leon M</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>L.Straker@curtin.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A2">
<name>
<surname>Campbell</surname>
<given-names>Amity C</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>A.Campbell@curtin.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A3">
<name>
<surname>Jensen</surname>
<given-names>Lyn M</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>L.Jensen@curtin.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A4">
<name>
<surname>Metcalf</surname>
<given-names>Deborah R</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>D.Metcalf@curtin.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A5">
<name>
<surname>Smith</surname>
<given-names>Anne J</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>Anne.Smith@curtin.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A6">
<name>
<surname>Abbott</surname>
<given-names>Rebecca A</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>rebecca@hms.uq.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A7">
<name>
<surname>Pollock</surname>
<given-names>Clare M</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<xref ref-type="aff" rid="I3">3</xref>
<email>C.Pollock@curtin.edu.au</email>
</contrib>
<contrib contrib-type="author" id="A8">
<name>
<surname>Piek</surname>
<given-names>Jan P</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<xref ref-type="aff" rid="I3">3</xref>
<email>J.Piek@curtin.edu.au</email>
</contrib>
</contrib-group>
<aff id="I1">
<label>1</label>
School of Physiotherapy, Curtin University, Perth, Australia</aff>
<aff id="I2">
<label>2</label>
Curtin Health Innovation Research Institute, Curtin University, Perth, Australia</aff>
<aff id="I3">
<label>3</label>
School of Psychology, Curtin University, Perth, Australia</aff>
<aff id="I4">
<label>4</label>
School of Human Movement Studies, The University of Queensland, Brisbane, Australia</aff>
<pub-date pub-type="collection">
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>18</day>
<month>8</month>
<year>2011</year>
</pub-date>
<volume>11</volume>
<fpage>654</fpage>
<lpage>654</lpage>
<history>
<date date-type="received">
<day>15</day>
<month>6</month>
<year>2011</year>
</date>
<date date-type="accepted">
<day>18</day>
<month>8</month>
<year>2011</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright ©2011 Straker et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2011</copyright-year>
<copyright-holder>Straker et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1471-2458/11/654"></self-uri>
<abstract>
<sec>
<title>Background</title>
<p>A healthy start to life requires adequate motor development and physical activity participation. Currently 5-15% of children have impaired motor development without any obvious disorder. These children are at greater risk of obesity, musculoskeletal disorders, low social confidence and poor mental health. Traditional electronic game use may impact on motor development and physical activity creating a vicious cycle. However new virtual reality (VR) game interfaces may provide motor experiences that enhance motor development and lead to an increase in motor coordination and better physical activity and mental health outcomes. VR games are beginning to be used for rehabilitation, however there is no reported trial of the impact of these games on motor coordination in children with developmental coordination disorder.</p>
</sec>
<sec>
<title>Methods</title>
<p>This cross-over randomised and controlled trial will examine whether motor coordination is enhanced by access to active electronic games and whether daily activity, attitudes to physical activity and mental health are also enhanced. Thirty children aged 10-12 years with poor motor coordination (≤ 15
<sup>th </sup>
percentile) will be recruited and randomised to a balanced ordering of 'no active electronic games' and 'active electronic games'. Each child will participate in both conditions for 16 weeks, and be assessed prior to participation and at the end of each condition. The primary outcome is motor coordination, assessed by kinematic and kinetic motion analysis laboratory measures. Physical activity and sedentary behaviour will be assessed by accelerometry, coordination in daily life by parent report questionnaire and attitudes to physical activity, self-confidence, anxiety and depressed mood will be assessed by self report questionnaire. A sample of 30 will provide a power of > 0.9 for detecting a 5 point difference in motor coordination on the MABC-2 TIS scale (mean 17, sd = 5).</p>
</sec>
<sec>
<title>Discussion</title>
<p>This is the first trial to examine the impact of new virtual reality games on motor coordination in children with developmental coordination disorder. The findings will provide critical information to understand whether these electronic games can be used to have a positive impact on the physical and mental health of these children. Given the importance of adequate motor coordination, physical activity and mental health in childhood, this project can inform interventions which could have a profound impact on the long term health of this group of children.</p>
</sec>
<sec>
<title>Trial registration</title>
<p>Australia and New Zealand Clinical Trials Register (ANZCTR):
<ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/ACTRN12611000400965.aspx">ACTRN12611000400965</ext-link>
</p>
</sec>
</abstract>
</article-meta>
</front>
<body>
<sec>
<title>Background</title>
<sec>
<title>Computer use by children is a major change in our society</title>
<p>Nearly all Australian children now use computers and video games [
<xref ref-type="bibr" rid="B1">1</xref>
]. More than 79% of households with children have a computer and more than 60% have a video game machine [
<xref ref-type="bibr" rid="B2">2</xref>
]. A recent meta analysis of studies in affluent countries found boys' and girls' mean computer/video game use was 74 minutes a day [
<xref ref-type="bibr" rid="B3">3</xref>
]. Electronic game use is increasing rapidly, with Roberts et al. [
<xref ref-type="bibr" rid="B4">4</xref>
] reporting a doubling since the meta analysis studies.</p>
<p>In a recent review we [
<xref ref-type="bibr" rid="B5">5</xref>
] reported that the available evidence suggested computer use targeted on learning areas is associated with enhanced academic achievement (e.g. [
<xref ref-type="bibr" rid="B6">6</xref>
]) but that electronic game playing has a negative effect on school achievement [
<xref ref-type="bibr" rid="B7">7</xref>
]. We also found that game-related discourse may provide a stimulus for children's social development [
<xref ref-type="bibr" rid="B8">8</xref>
], although there are concerns about the potential negative effects of violence in electronic games [
<xref ref-type="bibr" rid="B9">9</xref>
].</p>
<p>Research on the impact of computer use on children's physical development has focused on postures during computer use at school [
<xref ref-type="bibr" rid="B10">10</xref>
], use of laptop computers [
<xref ref-type="bibr" rid="B11">11</xref>
] and the impact of workstation design on posture and muscle activity [
<xref ref-type="bibr" rid="B12">12</xref>
]. Whilst this research has suggested potential musculoskeletal problems associated with prolonged and constrained postures and repetitive small movements, there is no evidence available on the impact of computer or electronic game use on motor development. We have raised concerns that electronic game use may have a negative impact on gross motor development as it may displace other childhood leisure activities which provide critical practice of gross motor tasks and which facilitate motor development [
<xref ref-type="bibr" rid="B5">5</xref>
].</p>
</sec>
<sec>
<title>Electronic game use may have a negative impact on normal motor development</title>
<p>Normal motor development requires maturation of neural and muscular systems plus the opportunity to practise fine and gross motor skills, with studies on children with impoverished or enriched motor environments providing evidence for the importance of practice [
<xref ref-type="bibr" rid="B13">13</xref>
]. Gross motor experiences are usually associated with physical activity (PA) (defined as the movement of the limbs and torso by muscle activity resulting in energy expenditure). There is evidence that increased PA can provide the practice necessary to improve gross motor skill development in children with normal motor development [
<xref ref-type="bibr" rid="B14">14</xref>
]. However there are concerns amongst researchers and parents that electronic game playing reduces children's PA.</p>
<p>Traditional electronic game interfaces can provide motor experience, but fine rather than gross. Yuji [
<xref ref-type="bibr" rid="B15">15</xref>
] reported evidence that electronic games improved children's fine motor performance. In a review, Whitcomb [
<xref ref-type="bibr" rid="B16">16</xref>
] found electronic game playing lead to enhanced eye-hand coordination, dexterity and fine motor ability and increased reaction and movement speeds in elderly subjects and Rosser et al. [
<xref ref-type="bibr" rid="B17">17</xref>
] found a dose response relationship between video game experience and laproscopic surgery training performance (both speed and accuracy).</p>
<p>In contrast, traditional electronic game playing probably does not provide gross motor experience, and may lead to a decline in gross motor skill. In an epidemiological study of 1,600 five-year-olds we found that computer use did displace vigorous PA on weekends reducing overall gross motor experience [
<xref ref-type="bibr" rid="B18">18</xref>
] and suggesting a potential vicious cycle.</p>
</sec>
<sec>
<title>Children with DCD are at greater risk</title>
<p>Five to 15% of children have developmental coordination disorder (DCD), defined as lacking developmental, age-appropriate motor skills, and characterised by motor performance impairment that creates functional performance deficits not likely to be due the child's age, intellect, or other diagnosable neurological or psychiatric disorder [
<xref ref-type="bibr" rid="B19">19</xref>
,
<xref ref-type="bibr" rid="B20">20</xref>
]. Underlying deficits identified in children with DCD include poor sensory-motor integration [
<xref ref-type="bibr" rid="B21">21</xref>
] and in particular, poor visuomotor processing [
<xref ref-type="bibr" rid="B22">22</xref>
], or cross-modal integration (visual-kinaesthetic). Children with DCD also have poor timing and force control and it has been argued that there may be a disruption in the central timing mechanisms, usually linked with cerebellar function [
<xref ref-type="bibr" rid="B23">23</xref>
]. A recent review found that these children are less physically active and have lower levels of fitness [
<xref ref-type="bibr" rid="B24">24</xref>
]. Children with DCD are thus at greater risk of insufficient PA [
<xref ref-type="bibr" rid="B25">25</xref>
] and a downward spiral of poorer motor development, psychological and health outcomes (Figure
<xref ref-type="fig" rid="F1">1</xref>
).</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption>
<p>
<bold>Vicious cycle of physical activity, motor skill and self esteem</bold>
.</p>
</caption>
<graphic xlink:href="1471-2458-11-654-1"></graphic>
</fig>
</sec>
<sec>
<title>Motor skill can be improved in children with DCD</title>
<p>Whilst there are varying views as to the underlying pathology of DCD and no consensus on the correct approach to intervention, a recent review concluded that there is sufficient evidence of good quality to confirm that interventions are effective in improving motor skill in children with DCD [
<xref ref-type="bibr" rid="B26">26</xref>
]. Approaches ranging from perceptual-motor therapy, to sensory-integration therapy, mastery and physiotherapy are supported with little evidence of the superiority of any specific approach [
<xref ref-type="bibr" rid="B26">26</xref>
], although studies were of variable quality. Intervention doses range from 30 minutes weekly for 6 weeks [
<xref ref-type="bibr" rid="B27">27</xref>
] to 50 minutes 3 times a week for 10 weeks [
<xref ref-type="bibr" rid="B28">28</xref>
].</p>
</sec>
<sec>
<title>Motor skill is important for physical activity participation</title>
<p>Children need to have a certain degree of motor skill to feel confident to engage in PA. Harter's [
<xref ref-type="bibr" rid="B29">29</xref>
,
<xref ref-type="bibr" rid="B30">30</xref>
] competence motivation theory argues that children's motivation to engage in an activity (in this case, PA) is determined partly by the confidence they have in their ability to carry out these tasks. Hence, children who are more skilled would be more likely to engage in the activity. According to Doganis and Theordarakis [
<xref ref-type="bibr" rid="B31">31</xref>
], attitude theory best explains engagement in PA and sport. It is considered to comprise three elements, namely cognitive, affective and behavioural. A child's perception of their own ability is one component of the cognitive element. Their enjoyment of the activity, or the anxiety it generates, are part of the affective element. The behaviour component relates to the outcomes, good or bad, of participation and its reinforcement qualities. Therefore a vicious circle may develop for children where reduced PA results in reduced motor skill which further impedes PA participation.</p>
</sec>
<sec>
<title>Physical activity is important for health and development</title>
<p>Over 80% of Australian children do not meet national standards for adequate PA [
<xref ref-type="bibr" rid="B32">32</xref>
]. A lack of adequate PA has been linked with childhood health issues including obesity, bone mineral density, type II diabetes and cardiovascular risk factors [
<xref ref-type="bibr" rid="B25">25</xref>
,
<xref ref-type="bibr" rid="B33">33</xref>
]. Boys with DCD appear to be at greater risk of obesity [
<xref ref-type="bibr" rid="B34">34</xref>
].</p>
<p>Children with DCD have been found to engage less in PA than other children [
<xref ref-type="bibr" rid="B25">25</xref>
]. More recently Poulsen et al. [
<xref ref-type="bibr" rid="B35">35</xref>
] found a negative correlation between DCD and participation in social PA. It has been suggested that this is due to the fact that children with DCD do not like to display their poorer athletic skill to their peers [
<xref ref-type="bibr" rid="B34">34</xref>
], in line with Harter's [
<xref ref-type="bibr" rid="B29">29</xref>
,
<xref ref-type="bibr" rid="B30">30</xref>
] competence motivation theory. Our research [
<xref ref-type="bibr" rid="B36">36</xref>
] has demonstrated that children with DCD perceive themselves as poorer in the domain of athletic competence, and this has been linked to high levels of anxiety [
<xref ref-type="bibr" rid="B37">37</xref>
] and depressive symptomatology [
<xref ref-type="bibr" rid="B38">38</xref>
]. In line with attitude theory, this negative affect would then impact on the child's future interest in engaging in PA.</p>
</sec>
<sec>
<title>Electronic games have traditionally been sedentary</title>
<p>Electronic games have traditionally used keyboard/mouse and game pad interfaces which require very little movement. In a laboratory study of children with normal motor development we found energy expenditure during traditional electronic game playing to be similar to watching a DVD [
<xref ref-type="bibr" rid="B39">39</xref>
]. We also found minimal levels of muscle activity and movement during traditional electronic game playing [
<xref ref-type="bibr" rid="B40">40</xref>
]. Whilst traditional electronic games may have some positive physical impact on fine motor skills this may be offset by decreasing overall PA levels and reduced gross motor practice. Poorer PA outcomes may be associated with lower activity during actual game playing and by the displacement of more active leisure activities. Reduced gross motor practice may lead to poorer motor development. Whilst Li and Atkins [
<xref ref-type="bibr" rid="B41">41</xref>
] found some evidence of a relationship between poorer gross motor ability and increasing computer use in pre schoolers there is no direct evidence on the link between electronic games and poorer motor skills.</p>
<p>Marshall et al. [
<xref ref-type="bibr" rid="B42">42</xref>
] reviewed available studies and found 10 cross sectional studies showing a weak negative relationship (r = -0.14) between electronic games/computer use and PA. However the nature of computer use was not specified so included games and other uses. Recent reviews have included longitudinal studies and have also questioned whether electronic game use displaces more vigorous PA [
<xref ref-type="bibr" rid="B43">43</xref>
,
<xref ref-type="bibr" rid="B44">44</xref>
]. Despite no experimental evidence of a causal effect of electronic games on motor development, attitudes to PA or overall PA there is considerable community concern.</p>
<p>In a recent pilot study with 12 children (6 with DCD) [
<xref ref-type="bibr" rid="B45">45</xref>
] we found access to traditional electronic games for 8 weeks resulted in a trend for a 23.1% reduction in accelerometer assessed energy expenditure on non school days (p = .122) and significant reductions in both motor competence (McCarron Assessment of Neuromotor Disorders Neurodevelopmental Index [
<xref ref-type="bibr" rid="B46">46</xref>
] 7.3% p = .044) and liking of physical activity [
<xref ref-type="bibr" rid="B47">47</xref>
] (6.0% p = .048) compared to an 8 week period when electronic games were removed from the house of children with DCD (see Figure
<xref ref-type="fig" rid="F2">2</xref>
).</p>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption>
<p>
<bold>Liking of physical activity ratings in children with and without developmental coordination disorder following 8 weeks with no electronic games, 8 weeks with traditional electronic games and 8 weeks with active VR games</bold>
.</p>
</caption>
<graphic xlink:href="1471-2458-11-654-2"></graphic>
</fig>
</sec>
<sec>
<title>New opportunities with active virtual reality games</title>
<p>Virtual reality (VR) refers to a simulated interactive environment. VR aims to create a visual, auditory and sometimes tactile and olfactory environment that appears real and enables the human user to become immersed in the interactive experience. VR has been extensively used in commercial/military training applications such as flight and surgery simulators. It has also been used for arcade games and recently for patient rehabilitation. Until recently the only VR systems were expensive ($100,000+) laboratory based systems or large dedicated leisure simulators. However cheap (< $500) VR systems such as Eye and Move (Sony), Wii (Nintendo) and Kinect (Microsoft) have been released, making VR available to households.</p>
<p>Video capture VR (Eye, Kinect) uses a video camera to capture the user's image and movement and embed this into the virtual environment. Whilst it lacks haptic response and single camera systems (Eye) can only track movement in one plane, it requires no head mounted display or exoskeletion thus enabling movement free of encumbrance. Dual camera systems (Kinect) can track in three dimensions. It also provides a mirror view enabling immediate feedback on posture and quality of movement. Users report the interaction is intuitive and natural, with ratings of sense of presence and enjoyment equalling those of expensive laboratory based systems [
<xref ref-type="bibr" rid="B48">48</xref>
].</p>
</sec>
<sec>
<title>VR electronic games may lead to improved motor skill and PA outcomes</title>
<p>A critical feature of video capture VR games is that it requires arm, leg or whole body movement. It may therefore provide gross motor experiences that are not available when interacting using traditional interfaces such as keyboard, mouse or game pad. Video capture VR may thus enable children to play electronic games without the previously observed detrimental physical effects.</p>
<p>We and others have recently reported significant increases in energy expenditure, heart rate and ventilation volume when children played a game with video capture VR compared to a traditional interface [
<xref ref-type="bibr" rid="B39">39</xref>
,
<xref ref-type="bibr" rid="B49">49</xref>
,
<xref ref-type="bibr" rid="B50">50</xref>
]. Further, trials are being conducted to determine whether VR games in the home can enhance health outcomes for children [
<xref ref-type="bibr" rid="B51">51</xref>
,
<xref ref-type="bibr" rid="B52">52</xref>
].</p>
<p>VR electronic games can enhance motor skill in adults following brain injury with improved locomotion, upper and lower extremity function [
<xref ref-type="bibr" rid="B53">53</xref>
]. VR has demonstrated some improvements in motor performance in case studies of children with cerebral palsy [
<xref ref-type="bibr" rid="B54">54</xref>
]. Wann et al. [
<xref ref-type="bibr" rid="B55">55</xref>
] argue that VR is an ideal tool for remedial programs involving attention and movement disorders, and discuss its use in the context of stroke patients. VR may be particularly successful for children with DCD as it does not require the child to perform in front of other children. Lack of PA in children with DCD has been attributed to their unwillingness to display their poor skill to others. However, VR electronic games may improve these children's skill by providing gross motor practice involving a high level of visual-spatial integration, but in a context which is private, and provides strong motivation by enjoyment of the game and the challenge of self-competition. However this will only occur if the nature of the movement required is suitable.</p>
<p>Improvements in performance in VR are useful if they lead to improvements in real world performance. Whilst there is no available data on this in children, there is evidence of balance gains from VR training resulting in improved real world balance in elderly subjects undergoing rehabilitation [
<xref ref-type="bibr" rid="B53">53</xref>
]. VR training also leads to greater enjoyment of rehabilitation and improved motor confidence in the real world in adults. This suggests VR games could improve real world motor skill in children and could increase children's confidence, which would be additionally beneficial for children with DCD. However, there is no evidence of the effect of VR on children with DCD.</p>
<p>In our recent pilot study involving 6 children with DCD we found access to video capture VR games for 8 weeks tended to increase motor competence (MAND NDI 8.8%, p = .041) as well as accelerometer measured energy expenditure on non school days (54.3% p = .093), compared with access to traditional electronic games in children with DCD and no apparent effect on children without DCD (see Figure
<xref ref-type="fig" rid="F3">3</xref>
).</p>
<fig id="F3" position="float">
<label>Figure 3</label>
<caption>
<p>
<bold>Motor ability (MAND NDI) in children with and without developmental coordination disorder following 8 weeks with no electronic games, 8 weeks with traditional electronic games and 8 weeks with active VR games</bold>
.</p>
</caption>
<graphic xlink:href="1471-2458-11-654-3"></graphic>
</fig>
</sec>
<sec>
<title>Study Aim</title>
<p>Therefore the main aim of this study is to determine whether access to new high fidelity active VR electronic games can enhance motor coordination in children with motor impairment. Secondary aims include investigating whether increases in VR performance translate to increases in real world gross motor performance and increases in physical activity, attitudes to physical activity, self confidence and mental health.</p>
</sec>
</sec>
<sec>
<title>Methods/design</title>
<sec>
<title>Design and Aims</title>
<p>This study will use a cross over randomised controlled trial to assess the impact of active electronic game use on motor coordination and physical and mental health correlates in children with DCD by:</p>
<p>1) Comparing change in motor coordination over 16 weeks when children use active electronic games or no active electronic games. We hypothesise that motor coordination will improve more when children use active electronic games.</p>
<p>2) Comparing change in parent reports of motor coordination during activities of daily living over 16 weeks when children use active electronic games or no active electronic games. We hypothesise that parent reports of motor coordination will improve more when children use active electronic games.</p>
<p>3) Comparing change in physical activity and sedentary behaviour over 16 weeks when children use active electronic games or no active electronic games. We hypothesise that moderate/vigorous physical activity will increase and sedentary time will decrease more when children use active electronic games.</p>
<p>4) Comparing change in attitudes to physical activity over 16 weeks when children use active electronic games or no active electronic games. We hypothesise that attitudes to physical activity will improve more when children use active electronic games.</p>
<p>5) Comparing change in child reports of mental health over 16 weeks when children use active electronic games or no active electronic games. We hypothesise that mental health will improve more when children use active electronic games.</p>
</sec>
<sec>
<title>Sample</title>
<p>30 children (10-12 years of age) will be recruited by mass media, university and school notices and professional networks. This age group has been selected as they are able to provide detailed information in diary and questionnaires, have a high use of electronic games and are developing physical and mental behaviour patterns pre-puberty which may track into adulthood. Children of parents expressing interest will be screened to ensure they are willing to participate after being informed of the full study responsibilities and meet the inclusion and exclusion criteria. Inclusion criteria are: aged 10-12 years at start of study, able to use electronic games on most days and being classified as DCD. DCD status will be assessed using Movement Assessment Battery for Children-2 (MABC-2 [
<xref ref-type="bibr" rid="B56">56</xref>
]. The MABC-2 comprises 8 tasks, three measuring manual dexterity, 3 measuring aiming and catching and 2 measuring balance. Age norms based on a standardisation sample of 1,172 children are used to determine a standard total score (
<italic>M </italic>
= 10,
<italic>SD </italic>
= 3). Separate standard scores can be determined for each of the sub-tests. In addition to the total score, a set of qualitative observations allows the examiner to record the child's performance characteristics during the testing. Cut-offs for impairment scores are at or below the 5th percentile for definite motor difficulties, whilst scores above the 5th percentile but at or below the 15th percentile suggest borderline difficulties. The 15
<sup>th </sup>
percentile cut off will be used in this study as this is recommended for research purposes to prevent excluding children with mild DCD [
<xref ref-type="bibr" rid="B57">57</xref>
]. Minimum value of the test-retest reliability of the original MABC is 0.75 and the inter-tester reliability is 0.70. The original MABC has been found to correlate well with other movement tests [
<xref ref-type="bibr" rid="B58">58</xref>
,
<xref ref-type="bibr" rid="B59">59</xref>
]. The MABC-2 will be conducted at a location agreed to by parents, typically the child's home. Children will be excluded if they have a diagnosed disorder likely to impact their study participation, movement or electronic game use (other than developmental coordination disorder), live in a shared care arrangement where the child spends a significant amount of time in different houses and is unable to maintain game access condition, or live remote to the University campus. The child's age and sex will be recorded at baseline along with their experience with electronic games and computers using the Young people's Activity Questionnaire [
<xref ref-type="bibr" rid="B11">11</xref>
].</p>
<p>For power calculations, motor impairment (MABC-2 Total Impairment Score) was estimated at 17+5 with a minimum effect size of 5 considered important based on effects in prior studies [
<xref ref-type="bibr" rid="B60">60</xref>
]. If the variation in the motor impairment between repeated time points in each individual is normally distributed with standard deviation 5, and the true effect of game condition is 5, a study with 30 subjects will reject the null hypothesis that this response difference is zero with probability (power) 0.9027. The Type I error probability associated with this test of this null hypothesis is 0.01.</p>
<p>Volunteers and their parents will be provided with a detailed written description of the study purpose, procedures, risks and benefits and given an opportunity to ask research staff for clarification prior to signing assent (children) and consent (parents) to participate. The study has ethical approval from the Human Research Ethics Committee of Curtin University (approval number HR11/2011).</p>
</sec>
<sec>
<title>Intervention and control conditions</title>
<p>There will be two levels of electronic game access. 'No active electronic games' will involve all active input electronic games being removed from the family home with a contract that active electronic games will be avoided where possible at other locations. Participants will be able to play traditional electronic games using a game pad input during this period. 'Active electronic games' will involve the provision of a Sony PlayStation 3 with Move and Eye input devices and Microsoft Xbox360 with Kinect input device and a range of non-violent games. Children will be contacted regularly during the study and asked to report exposure to electronic games including games played, frequency and duration and level achieved. Children will also be asked about participation in other activities such as sports and hobbies.</p>
<p>A condition period of 16 weeks will allow time for improvements in motor impairment during the active electronic games condition whilst fitting in with school holiday schedules. A within subjects design allows reduced study numbers.</p>
</sec>
<sec>
<title>Outcome measures</title>
<sec>
<title>Motor coordination</title>
<p>Motor coordination will be assessed using the MABC-2 and during a series of tasks performed in a motion analysis laboratory. Detailed kinematic and kinetic data will be collected using a three-dimensional motion analysis system (Vicon; Oxford Metrics, inc.) and two AMTI force plates (Advanced Mechanical Technology, inc.). The large (0.6 * 1.2 m) and small (0.6*0.3 m) force plates are located in the middle of the laboratory directly next to one another and will be operated at 1000 Hz. The 14 camera Vicon motion analysis system will be calibrated to collect data in an approximately 5 m
<sup>2 </sup>
area in the middle of the laboratory, running at 250 Hz. Prior to trial performance each child will be fit with the custom full body marker set (seventy two 14 mm retro-reflective markers). This marker set (Table
<xref ref-type="table" rid="T1">1</xref>
) follows a cluster based protocol and allows the accurate calculation of full body joint kinematics and kinetics complicit with the International Society of Biomechanics recommendations [
<xref ref-type="bibr" rid="B61">61</xref>
,
<xref ref-type="bibr" rid="B62">62</xref>
].</p>
<table-wrap id="T1" position="float">
<label>Table 1</label>
<caption>
<p>Three-dimensional motion analysis marker set</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left">Marker</th>
<th align="left">Anatomical location</th>
<th align="left">Real (R) or Virtual (V)*</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" colspan="3">
<bold>Head markers</bold>
</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Eye markers</td>
<td align="left">Placed lateral to canthus of the left and right eyes</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Ear markers</td>
<td align="left">Placed above the tragus (or concha) of the left and right ears</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Nose marker</td>
<td align="left">Placed on the tip of the nose</td>
<td align="left">V</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" colspan="3">
<bold>Thorax/Back markers</bold>
</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Anterior thorax marker</td>
<td align="left">Sternal notch between the two clavicles</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Posterior thorax markers</td>
<td align="left">Placed on the 7
<sup>th </sup>
cervical and 6
<sup>th </sup>
thoracic vertebrae</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" colspan="3">
<bold>Pelvis:</bold>
</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Anterior pelvis</td>
<td align="left">Right and left anterior superior iliac crests</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Posterior pelvis</td>
<td align="left">Right and left posterior superior iliac crest</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" colspan="3">
<bold>Lower limbs</bold>
</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Thigh markers</td>
<td align="left">Three markers set on a t-bar cluster, with the long bar fixed mid-segment along the iliotibial band. The short bar raps medially onto the quadriceps.</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Tibia markers</td>
<td align="left">Three markers set on a t-bar cluster, with the long bar fixed mid-segment along the tibia. The short bar raps laterally towards the fibula.</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Knee markers</td>
<td align="left">Four markers placed on the right and left, medial and lateral femoral condyles</td>
<td align="left">V</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Feet markers</td>
<td align="left">Three markers placed on the calcaneus, talus hook and 5
<sup>th </sup>
metatarsal</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Ankle markers</td>
<td align="left">Four markers placed on the right and left, medial and lateral malleoli</td>
<td align="left">V</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" colspan="3">
<bold>Upper limbs</bold>
</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Shoulder markers</td>
<td align="left">Right and left, anterior and posterior shoulder markers</td>
<td align="left">V</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Right and left acromion markers</td>
<td align="left">Three markers placed on the posterior and anterior portion of the lateral border of the acromial plateau, with one marker placed laterally at the base of the acromioclavicular joint.</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Right and left upper arm markers</td>
<td align="left">Three markers set on a t-bar cluster, with the long bar fixed mid-segment on the lateral aspect of the upper arm. The short bar raps laterally towards the biceps.</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Elbow markers</td>
<td align="left">Right and left, medial lateral epicondyle markers</td>
<td align="left">V</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Forearm markers</td>
<td align="left">Three markers placed on the medial and lateral aspect of the distal third of the forearm, with one marker placed mid segment - between the radius and ulnar, midway up the forearm.</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Wrist markers</td>
<td align="left">Right and left, medial and lateral wrist markers placed on the ulnar and radial styloid processes</td>
<td align="left">V</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Hand markers</td>
<td align="left">Three markers, two placed mid-hand medially and laterally. The third marker is placed directly below the junction between the third metacarpal and third proximal phalange.</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Finger markers</td>
<td align="left">Two smaller markers (5 mm diameter) fixed to the most distal portion of the index finger, finger nail</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">
<bold>Equipment</bold>
</td>
<td></td>
<td></td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">Ball markers</td>
<td align="left">Three markers fixed to each ball; tennis ball, t-ball ball, soccer ball</td>
<td align="left">R</td>
</tr>
<tr>
<td colspan="3">
<hr></hr>
</td>
</tr>
<tr>
<td align="left">T-ball bat tip</td>
<td align="left">A single marker fixed to the tip of the t-ball bat</td>
<td align="left">R</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>* 'Virtual' markers are removed after one static trial. 'Real' markers remain throughout the motion analysis data collection</p>
</table-wrap-foot>
</table-wrap>
<p>Three tasks drawn from common motor performance tools will be used to assess whole body coordination: running, single leg stance and horizontal jump. Running will be performed using the Test of Gross Motor Development, 2
<sup>nd </sup>
edition (TGMD-2; [
<xref ref-type="bibr" rid="B63">63</xref>
]) protocol which involves running over the 10 meter laboratory runway with children instructed to run as fast as they can. Five trials will be performed. Trials will be deemed successful if the child strikes one of the force platforms with their preferred leg. The starting point of the runway will be adjusted in the instance successful foot strike does not occur and the child will not be informed of this requirement to facilitate natural running technique. Single leg stance will be performed using the MAND [
<xref ref-type="bibr" rid="B46">46</xref>
] protocol which involves balancing on their preferred foot with the arms free to move for balance, the unused leg held off the floor with slight knee flexion and pivoting allowed but hopping not. Children will be instructed to stand on the large force plate on their preferred foot for as long as they can or until told to stop. Two trials will be completed with a maximum period of 30 seconds for each trial. Horizontal jump will be performed using the TGMD-2 protocol which involves jumping with feet parallel at start and finish. Children will be instructed to jump as far as they can, while 'sticking' their landing and will perform 5 trials. The take-off will be performed from the middle of the small force plate.</p>
<p>Four tasks drawn from common motor performance tools will be used to assess limb coordination: finger-nose, ball strike, ball kick and ball bounce and catch. Finger-nose touch will be performed using the MAND protocol which involves children holding their non preferred arm out in front at shoulder level with the index finger pointed at right angles. The index finger of their preferred hand is used to touch the tip of their nose and the tip of the extended finger moving from supination to pronation. The children will be instructed that it is not a speed test. Ten trials will be performed. Ball strike will be performed using the TGMD-2 Tee ball task which involves a ball being placed on a tee at the height of the child's waist and struck with a bat. The child will be instructed to place their feet shoulder width apart, one on each force plate, facing perpendicular to the intended direction of the t-ball strike and then to hit the ball hard. This task will be repeated 5 times. Ball kick will be performed using the TRMD-2 soccer kick task which involves a ball being positioned on the ground slightly ahead (next to the small force plate) and to the preferred side. Children will be instructed to step forward, from the large force plate onto the small force plate, using their non preferred foot and kick the ball as hard as they can towards a goal. The task will be performed 5 times. The ball bounce and catch task is based on the TGMD-2 ball bounce task and requires the participant to stand on the large force plate and bounce the ball onto the small force plate. Children will be instructed to drop the ball with their preferred hand and catch it with both hands.</p>
<p>Four tasks will be used to assess coordination during active electronic game performance: Move table tennis, Move archery, Kinect table tennis and Kinect soccer penalty kick. For each electronic game task children will be instructed how to perform the task then allowed to practice the task a standard number of times specific to each game. Table tennis will be performed against a computer opponent, with 5 practice points and one game to 11 points repeated on both electronic game consoles. Move archery will be performed against a computer opponent for three trials of 45 seconds. The first set will be used as practice and the final two as assessment trials. The penalty kick trials, performed against a computer opponent, will include one practice trial and three assessment trials.</p>
<p>The primary outcome measures will be the MABC 2 Total Impairment Score, balance as characterised by the length of the path of the centre of mass during the single leg stance trial [
<xref ref-type="bibr" rid="B28">28</xref>
], and upper limb control as characterised by the normalised length of the trajectory of the finger in the finger-nose task [
<xref ref-type="bibr" rid="B64">64</xref>
].</p>
<p>Additionally, movement variability will be assessed using the standard deviation of magnitude and rate of change of kinematics and kinetics across the multiple trials of each task; movement smoothness will be assessed using motion pathway rate of change and jerk [
<xref ref-type="bibr" rid="B65">65</xref>
]; movement efficiency will be assessed using time to stability, out of plane motion and path distance; movement sequencing will be assessed with kinematic chain coupling and time of segmental movement onset; and movement accuracy will be assessed using target error distance. Game performance will also be recorded.</p>
</sec>
<sec>
<title>Impact of motor coordination on daily living</title>
<p>Parent report of child coordination difficulties interfering with daily life will be assessed with the revised Developmental Coordination Questionnaire (DCDQ-2007) [
<xref ref-type="bibr" rid="B66">66</xref>
], which assesses motor difficulties in individuals from 4 to 15 years of age. It has 15-items divided into three subscales: Control During Movement, Fine Motor/Handwriting and General Coordination, and uses a 5 point Likert scale ranging from 1: 'not at all like your child', to 5: 'extremely like your child'. The DCDQ-2007 is self-administered by parents, comparing their child's motor performance with that of their peers. Using translated versions of the DCDQ-2007 a correlation between test and retest of r = .94 was found (p < 0.001; n = 35) [
<xref ref-type="bibr" rid="B67">67</xref>
]. Factor analysis has verified the three subscales of the DCDQ-2007 explaining 79% of the variance [
<xref ref-type="bibr" rid="B68">68</xref>
], and concurrent validity has been demonstrated with a significant correlation of r = -.55 between the total score on the DCDQ-2007 and the original MABC [
<xref ref-type="bibr" rid="B68">68</xref>
].</p>
</sec>
<sec>
<title>Physical activity</title>
<p>Time spent in sedentary, light and moderate to vigorous intensity PA, as well as total movement, will be assessed over 7 days using an Actical accelerometer worn on the hip. The Respironics Actical is the most widely used and validated accelerometer in studies of children and adolescents [
<xref ref-type="bibr" rid="B69">69</xref>
]. Seven days of accelerometer measurement are recommended for the purposes of acceptable measurement of moderate to vigorous PA [
<xref ref-type="bibr" rid="B70">70</xref>
]. Total weekly activity as well as weekend activity and after school weekday activity will be assessed. Children will keep a brief diary recording accelerometer wear times and PA to assist with accelerometer data quality control and processing.</p>
</sec>
<sec>
<title>Attitudes to Physical Activity</title>
<p>Attitudes to PA will be assessed using the revised version [
<xref ref-type="bibr" rid="B71">71</xref>
] of the Physical Activity Enjoyment Scale [
<xref ref-type="bibr" rid="B72">72</xref>
]. Internal consistency, test-retest reliability and construct validity has been demonstrated [
<xref ref-type="bibr" rid="B71">71</xref>
,
<xref ref-type="bibr" rid="B73">73</xref>
,
<xref ref-type="bibr" rid="B74">74</xref>
].</p>
</sec>
<sec>
<title>Mental Health</title>
<p>Harter's Self-Perception Profile for Children [
<xref ref-type="bibr" rid="B75">75</xref>
] will assess self-perceptions across domains of Scholastic Competence, Social Acceptance, Athletic Competence, Physical Appearance and Behavioural Conduct, and it also includes a subscale designed to evaluate global self-worth that assesses self-esteem independent from the competence domains. It has been validated in samples of children from a wide range of cultural backgrounds, including in Australian children and has high levels of internal consistency ranging from .74 to .92 [
<xref ref-type="bibr" rid="B75">75</xref>
].</p>
<p>Spence Children's Anxiety Scale [
<xref ref-type="bibr" rid="B76">76</xref>
] assesses anxiety symptoms in children and consists of six subscales, namely panic attack and agoraphobia, separation anxiety disorder, social phobia, physical injury fears, obsessive compulsive disorder, and generalized anxiety disorder. This self report questionnaire consists of 45 items, 38 assessing specific anxiety symptoms and the remaining six items serve as positive 'filler' items in order to reduce negative response bias. Children are asked to indicate frequency with which each symptom occurs on a four-point scale ranging from Never (scored 0) to Always (scored 3). A total SCAS score is obtained by summing scores of the 38 anxiety symptom items. The scale has high internal consistency for the total score as well as for each subscale, with satisfactory test-retest reliability [
<xref ref-type="bibr" rid="B77">77</xref>
,
<xref ref-type="bibr" rid="B78">78</xref>
].</p>
<p>The Short Moods and Feelings Questionnaire [
<xref ref-type="bibr" rid="B79">79</xref>
] is a self report screening tool to assess depression in children and adolescents aged 8 to 16, that covers areas such as affective, vegetative and cognitive symptoms of depression. This asks the child to rate depressive symptoms in the past 2 weeks on a Likert scale ranging from 0 to 2, with possible responses of "not true," "sometimes true," and "true". It has 3-week and 3-month test-retest reliabilities of .84 and .80, respectively [
<xref ref-type="bibr" rid="B80">80</xref>
], high internal consistency [
<xref ref-type="bibr" rid="B80">80</xref>
] and validity with depressive diagnoses derived from standardized diagnostic interviews [
<xref ref-type="bibr" rid="B81">81</xref>
].</p>
</sec>
</sec>
<sec>
<title>Procedure</title>
<p>Following screening, participants will perform baseline assessments at the research centre after informed consent/assent from parent and child. Baseline assessments will include all measures described including laboratory biomechanical measures and questionnaires. Participants will be fitted with the accelerometer for wearing at home for the following week and receive check phone calls reminding the child to wear the accelerometer over the next week and to complete the activity diary. Half the participants will then be randomly allocated to the active electronic game conditions and half to the no electronic game (waitlist/normal care) condition by selection of an opaque sealed envelope. Randomisation will be balanced to equal numbers of boys and girls in both initial condition groups. A research officer (RO) will visit the home after one week and collect the accelerometers and instruct parent and child in the game condition. This will involve either removal of all active electronic games or setting up active electronic game equipment and instructing parent and child in its use. Follow-up phone calls will be made regularly to check participation, whether active game equipment is working correctly and electronic game exposure. Towards the end of the each condition the RO will visit again to set up the accelerometer assessments. After 16 weeks the child and parent will repeat assessments at the research centre. The RO will visit the participants and set up the other game condition. After 16 weeks in the other game condition the same assessments will occur. The family structure including number, age and sex of siblings will be recorded, and the behaviour of siblings during the trial will be assessed at debriefing interview. Accelerometer assessment will be scheduled to avoid school and public holidays where possible. Individualised reports will be provided to participants.</p>
</sec>
<sec>
<title>Trial flow</title>
<p>Figure
<xref ref-type="fig" rid="F4">4</xref>
provides an overview of the trial flow. Following recruitment, screening and consent and baseline assessments, participants are randomised to an order of electronic game conditions. Participants are setup in their first condition and are assessed at the end of the 16 week condition. Participants are then set up in their second condition for 16 weeks, again with assessment occurring at the end of the condition.</p>
<fig id="F4" position="float">
<label>Figure 4</label>
<caption>
<p>
<bold>Trial flow chart showing cross-over design and assessment points</bold>
.</p>
</caption>
<graphic xlink:href="1471-2458-11-654-4"></graphic>
</fig>
</sec>
<sec>
<title>Analysis</title>
<p>To examine hypothesis 1 (that motor coordination will be improved when children have access to active electronic games) changes from baseline in laboratory biomechanical and MABC-2 outcomes following both conditions will be compared with a repeated measures ANCOVA analysis with sex as a covariate. A critical alpha level of 0.01 will be used to balance type 1 and type 2 errors.</p>
<p>To assess hypotheses 2, 3, 4, 5 (that parent reports of motor coordination in daily living, physical activity and sedentary behaviour, attitudes to physical activity and measures of mental health will improve when children have access to active electronic games) changes from baseline in outcomes following both conditions will be compared with a repeated measures ANCOVA analysis with sex as a covariate. A critical alpha level of 0.01 will be used to balance type 1 and type 2 errors.</p>
</sec>
</sec>
<sec>
<title>Discussion</title>
<p>Children's increasing use of computers and especially electronic games may reduce their exposure to the large movement activities necessary for normal motor development and engagement in physical activity. Children with Developmental Coordination Disorder may be especially adversely affected. Persuading children to stop playing computer games is unlikely to be successful. However changing the nature of the movements they use when playing games may reduce the negative impact and potentially provide positive gains in motor ability, motor confidence and overall physical activity levels for children with normal and impaired motor development.</p>
<sec>
<title>Implications</title>
<p>This project will be the first to assess the longitudinal impact of providing VR electronic games to children with impaired motor development. The knowledge gained from this study will allow us to understand the potential of active VR games to provide children with the motor development and physical activity necessary for a healthy start to life.</p>
</sec>
</sec>
<sec>
<title>Abbreviations</title>
<p>ANCOVA: analysis of covariance; DCD: developmental coordination disorder; DCDQ: developmental coordination disorder questionnaire; MABC2: movement assessment battery for children - 2; MAND NDI: McCarron assessment of neuromotor disorder neurodevelopmental index; PA: physical activity; RO: research officer; SCAS: Spence children's anxiety scale; TGMD: test of gross motor development; TIS: total impairment scale; VR: virtual reality.</p>
</sec>
<sec>
<title>Competing interests</title>
<p>The authors declare that they have no competing interests.</p>
</sec>
<sec>
<title>Authors' contributions</title>
<p>All authors have contributed substantially to this protocol. LMS conceived the study, contributed to the study design and drafted the manuscript. ACC, LMJ, DRM, AJS, RAA, CMP and JPP contributed to the study design and revised the manuscript. All authors have read and approved the final manuscript.</p>
</sec>
<sec>
<title>Pre-publication history</title>
<p>The pre-publication history for this paper can be accessed here:</p>
<p>
<ext-link ext-link-type="uri" xlink:href="http://www.biomedcentral.com/1471-2458/11/654/prepub">http://www.biomedcentral.com/1471-2458/11/654/prepub</ext-link>
</p>
</sec>
</body>
<back>
<sec>
<title>Acknowledgements</title>
<p>This randomised and controlled trial is funded by the National Health and Medical Research Council (NHMRC) of Australia through project grant #533526. Professor Leon Straker and Doctor Anne Smith are supported by fellowships awarded from the NHMRC. No funding or other input to the study has been received from any electronic game design, manufacture or supply company.</p>
</sec>
<ref-list>
<ref id="B1">
<mixed-citation publication-type="book">
<collab>ABS</collab>
<source>Children's participation in cultural and leisure activities, Australia</source>
<year>2006</year>
<publisher-name>Canberra, ACT: Australian Bureau of Statistics</publisher-name>
</mixed-citation>
</ref>
<ref id="B2">
<mixed-citation publication-type="book">
<collab>ABS</collab>
<source>Household use of information technology, Australia 2001-2002</source>
<year>2003</year>
<publisher-name>Canberra, ACT: Australian Bureau of Statistics</publisher-name>
</mixed-citation>
</ref>
<ref id="B3">
<mixed-citation publication-type="journal">
<name>
<surname>Marshall</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Gorely</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Biddle</surname>
<given-names>SJH</given-names>
</name>
<article-title>A descriptive epidemiology of screen-based media use in youth: A review and critique</article-title>
<source>J Adolesc</source>
<year>2006</year>
<volume>29</volume>
<issue>3</issue>
<fpage>333</fpage>
<lpage>349</lpage>
<pub-id pub-id-type="doi">10.1016/j.adolescence.2005.08.016</pub-id>
<pub-id pub-id-type="pmid">16246411</pub-id>
</mixed-citation>
</ref>
<ref id="B4">
<mixed-citation publication-type="book">
<name>
<surname>Roberts</surname>
<given-names>DL</given-names>
</name>
<name>
<surname>Foehr</surname>
<given-names>UG</given-names>
</name>
<name>
<surname>Rideout</surname>
<given-names>V</given-names>
</name>
<source>Generation M: Media in the lives of 8-18 year olds</source>
<year>2005</year>
<publisher-name>Menlo Park, CA: The Henry J. Kaiser Family Foundation</publisher-name>
</mixed-citation>
</ref>
<ref id="B5">
<mixed-citation publication-type="journal">
<name>
<surname>Straker</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Pollock</surname>
<given-names>C</given-names>
</name>
<article-title>Optimizing the interaction of children with information and communication technologies</article-title>
<source>Ergonomics</source>
<year>2005</year>
<volume>48</volume>
<issue>5</issue>
<fpage>506</fpage>
<lpage>521</lpage>
<pub-id pub-id-type="doi">10.1080/00140130400029233</pub-id>
<pub-id pub-id-type="pmid">16040523</pub-id>
</mixed-citation>
</ref>
<ref id="B6">
<mixed-citation publication-type="book">
<name>
<surname>Harrison</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Comber</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Fisher</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Haw</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Lewin</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Lunzer</surname>
<given-names>E</given-names>
</name>
<name>
<surname>McFarlane</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Mavers</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Scrimshaw</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Somekh</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Watling</surname>
<given-names>R</given-names>
</name>
<source>ImpaCT2: The impact of information and communication technologies on pupil learning and attainment. A report to the Department for Education and Skills. ICT in school research and evaluation series - No. 9</source>
<year>2002</year>
<publisher-name>London: British Educational Communications and Technology Agency</publisher-name>
</mixed-citation>
</ref>
<ref id="B7">
<mixed-citation publication-type="journal">
<name>
<surname>Moseley</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Mearns</surname>
<given-names>N</given-names>
</name>
<name>
<surname>Tse</surname>
<given-names>H</given-names>
</name>
<article-title>Using computer at home and in the primary school: Where is the value added?</article-title>
<source>Educational and Child Psychology</source>
<year>2001</year>
<volume>18</volume>
<fpage>31</fpage>
<lpage>46</lpage>
</mixed-citation>
</ref>
<ref id="B8">
<mixed-citation publication-type="journal">
<name>
<surname>Heft</surname>
<given-names>TM</given-names>
</name>
<name>
<surname>Swaminathan</surname>
<given-names>S</given-names>
</name>
<article-title>The effects of computers on the social behavior of preschoolers</article-title>
<source>J Res Child Edu</source>
<year>2002</year>
<volume>16</volume>
<fpage>162</fpage>
<lpage>174</lpage>
<pub-id pub-id-type="doi">10.1080/02568540209594982</pub-id>
</mixed-citation>
</ref>
<ref id="B9">
<mixed-citation publication-type="journal">
<name>
<surname>Villani</surname>
<given-names>SS</given-names>
</name>
<article-title>Impact of media on children and adolescents: A 10-year review of the research</article-title>
<source>J Am Acad Child Adolesc Psychiatry</source>
<year>2001</year>
<volume>40</volume>
<issue>4</issue>
<fpage>392</fpage>
<lpage>401</lpage>
<pub-id pub-id-type="doi">10.1097/00004583-200104000-00007</pub-id>
<pub-id pub-id-type="pmid">11314564</pub-id>
</mixed-citation>
</ref>
<ref id="B10">
<mixed-citation publication-type="journal">
<name>
<surname>Barrero</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Hedge</surname>
<given-names>A</given-names>
</name>
<article-title>Computer environments for children: a review of design issues</article-title>
<source>Work</source>
<year>2002</year>
<volume>18</volume>
<issue>3</issue>
<fpage>227</fpage>
<lpage>237</lpage>
<pub-id pub-id-type="pmid">12441563</pub-id>
</mixed-citation>
</ref>
<ref id="B11">
<mixed-citation publication-type="journal">
<name>
<surname>Harris</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Straker</surname>
<given-names>L</given-names>
</name>
<article-title>Survey of physical ergonomics issues associated with school children's use of laptop computers</article-title>
<source>Int J Ind Ergon</source>
<year>2000</year>
<volume>26</volume>
<issue>3</issue>
<fpage>337</fpage>
<lpage>346</lpage>
<pub-id pub-id-type="doi">10.1016/S0169-8141(00)00009-3</pub-id>
</mixed-citation>
</ref>
<ref id="B12">
<mixed-citation publication-type="journal">
<name>
<surname>Straker</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Briggs</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Greig</surname>
<given-names>A</given-names>
</name>
<article-title>The effect of individually adjusted workstations on upper quadrant posture and muscle activity in school children</article-title>
<source>Work</source>
<year>2002</year>
<volume>18</volume>
<issue>3</issue>
<fpage>239</fpage>
<lpage>248</lpage>
<pub-id pub-id-type="pmid">12441564</pub-id>
</mixed-citation>
</ref>
<ref id="B13">
<mixed-citation publication-type="book">
<name>
<surname>White</surname>
<given-names>FA</given-names>
</name>
<name>
<surname>Hayes</surname>
<given-names>BK</given-names>
</name>
<name>
<surname>Livesey</surname>
<given-names>DJ</given-names>
</name>
<source>Developmental psychology: From infancy to adulthood</source>
<year>2005</year>
<publisher-name>Sydney: Pearson Education Australia</publisher-name>
</mixed-citation>
</ref>
<ref id="B14">
<mixed-citation publication-type="journal">
<name>
<surname>McKenzie</surname>
<given-names>TL</given-names>
</name>
<name>
<surname>Alcaraz</surname>
<given-names>JE</given-names>
</name>
<name>
<surname>Sallis</surname>
<given-names>JF</given-names>
</name>
<name>
<surname>Faucetter</surname>
<given-names>FN</given-names>
</name>
<article-title>Effects of a physical education program on children's manipulative skills</article-title>
<source>J of Teaching in Phys Ed</source>
<year>1998</year>
<volume>17</volume>
<issue>3</issue>
<fpage>327</fpage>
<lpage>341</lpage>
</mixed-citation>
</ref>
<ref id="B15">
<mixed-citation publication-type="journal">
<name>
<surname>Yuji</surname>
<given-names>H</given-names>
</name>
<article-title>Computer games and information-processing skills</article-title>
<source>Percept Mot Skills</source>
<year>1996</year>
<volume>83</volume>
<issue>2</issue>
<fpage>643</fpage>
<lpage>647</lpage>
<pub-id pub-id-type="pmid">8902044</pub-id>
</mixed-citation>
</ref>
<ref id="B16">
<mixed-citation publication-type="book">
<name>
<surname>Whitcomb</surname>
<given-names>GR</given-names>
</name>
<article-title>Computer games for the elderly</article-title>
<source>Proceedings of the Conference on Computers and the Quality of Life 1990; Washington, USA</source>
<year>1990</year>
<publisher-name>Association for Computing Machinery, ACM, New York, NY, USA</publisher-name>
<fpage>112</fpage>
<lpage>115</lpage>
</mixed-citation>
</ref>
<ref id="B17">
<mixed-citation publication-type="journal">
<name>
<surname>Rosser</surname>
<given-names>JC</given-names>
</name>
<name>
<surname>Lynch</surname>
<given-names>PJ</given-names>
</name>
<name>
<surname>Cuddihy</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Gentile</surname>
<given-names>DA</given-names>
</name>
<name>
<surname>Klonsky</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Merrell</surname>
<given-names>R</given-names>
</name>
<article-title>The impact of video games on training surgeons in the 21st century</article-title>
<source>Arch Surg</source>
<year>2007</year>
<volume>142</volume>
<issue>2</issue>
<fpage>181</fpage>
<lpage>186</lpage>
<pub-id pub-id-type="doi">10.1001/archsurg.142.2.181</pub-id>
<pub-id pub-id-type="pmid">17309970</pub-id>
</mixed-citation>
</ref>
<ref id="B18">
<mixed-citation publication-type="journal">
<name>
<surname>Straker</surname>
<given-names>LM</given-names>
</name>
<name>
<surname>Pollock</surname>
<given-names>CM</given-names>
</name>
<name>
<surname>Zubrick</surname>
<given-names>SR</given-names>
</name>
<name>
<surname>Kurinczuk</surname>
<given-names>JJ</given-names>
</name>
<article-title>The association between information and communication technology exposure and physical activity, musculoskeletal and visual symptoms and socio-economic status in 5-year-olds</article-title>
<source>Child Care Health Dev</source>
<year>2006</year>
<volume>32</volume>
<issue>3</issue>
<fpage>343</fpage>
<lpage>351</lpage>
<pub-id pub-id-type="doi">10.1111/j.1365-2214.2006.00599.x</pub-id>
<pub-id pub-id-type="pmid">16634979</pub-id>
</mixed-citation>
</ref>
<ref id="B19">
<mixed-citation publication-type="journal">
<name>
<surname>Polatajko</surname>
<given-names>HJ</given-names>
</name>
<name>
<surname>Fox</surname>
<given-names>AM</given-names>
</name>
<name>
<surname>Missiuna</surname>
<given-names>C</given-names>
</name>
<article-title>An international consensus on children with developmental coordination disorder</article-title>
<source>Can J Occup Ther</source>
<year>1995</year>
<volume>62</volume>
<fpage>3</fpage>
<lpage>6</lpage>
</mixed-citation>
</ref>
<ref id="B20">
<mixed-citation publication-type="journal">
<name>
<surname>Wilson</surname>
<given-names>PH</given-names>
</name>
<article-title>Practitioner review: approaches to assessment and treatment of children with DCD: an evaluative review</article-title>
<source>J Child Psychol Psychiatry</source>
<year>2005</year>
<volume>46</volume>
<issue>8</issue>
<fpage>806</fpage>
<lpage>823</lpage>
<pub-id pub-id-type="doi">10.1111/j.1469-7610.2005.01409.x</pub-id>
<pub-id pub-id-type="pmid">16033630</pub-id>
</mixed-citation>
</ref>
<ref id="B21">
<mixed-citation publication-type="journal">
<name>
<surname>Piek</surname>
<given-names>JP</given-names>
</name>
<name>
<surname>Dyck</surname>
<given-names>M</given-names>
</name>
<article-title>Sensory-motor deficits in children with developmental coordination disorder, attention deficit hyperactivity disorder & autistic disorder</article-title>
<source>Hum Mov Sci</source>
<year>2004</year>
<volume>23</volume>
<issue>3</issue>
<fpage>475</fpage>
<lpage>488</lpage>
<pub-id pub-id-type="doi">10.1016/j.humov.2004.08.019</pub-id>
<pub-id pub-id-type="pmid">15541530</pub-id>
</mixed-citation>
</ref>
<ref id="B22">
<mixed-citation publication-type="journal">
<name>
<surname>Wilson</surname>
<given-names>PH</given-names>
</name>
<name>
<surname>McKenzie</surname>
<given-names>BE</given-names>
</name>
<article-title>Information processing deficits associated with developmental coordination disorder: A meta-analysis of research findings</article-title>
<source>J Child Psychol Psychiatry</source>
<year>1998</year>
<volume>39</volume>
<issue>6</issue>
<fpage>829</fpage>
<lpage>840</lpage>
<pub-id pub-id-type="doi">10.1017/S0021963098002765</pub-id>
<pub-id pub-id-type="pmid">9758192</pub-id>
</mixed-citation>
</ref>
<ref id="B23">
<mixed-citation publication-type="journal">
<name>
<surname>Piek</surname>
<given-names>JP</given-names>
</name>
<name>
<surname>Skinner</surname>
<given-names>RA</given-names>
</name>
<article-title>Timing and force control during a sequential tapping task in children with and without motor coordination problems</article-title>
<source>J Int Neuropsychol Soc</source>
<year>1999</year>
<volume>5</volume>
<issue>4</issue>
<fpage>320</fpage>
<lpage>329</lpage>
<pub-id pub-id-type="pmid">10349295</pub-id>
</mixed-citation>
</ref>
<ref id="B24">
<mixed-citation publication-type="journal">
<name>
<surname>Rivilis</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Hay</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Cairney</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Klentrou</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Faught</surname>
<given-names>BE</given-names>
</name>
<article-title>Physical activity and fitness in children with developmental coordination disorder: a systematic review</article-title>
<source>Res Dev Disabil</source>
<year>2011</year>
<volume>32</volume>
<issue>3</issue>
<fpage>894</fpage>
<lpage>910</lpage>
<pub-id pub-id-type="doi">10.1016/j.ridd.2011.01.017</pub-id>
<pub-id pub-id-type="pmid">21310588</pub-id>
</mixed-citation>
</ref>
<ref id="B25">
<mixed-citation publication-type="journal">
<name>
<surname>Hay</surname>
<given-names>JA</given-names>
</name>
<name>
<surname>Hawes</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Faught</surname>
<given-names>BE</given-names>
</name>
<article-title>Evaluation of a screening instrument for developmental coordination disorder</article-title>
<source>J Adolesc Health</source>
<year>2004</year>
<volume>34</volume>
<issue>4</issue>
<fpage>308</fpage>
<lpage>313</lpage>
<pub-id pub-id-type="pmid">15041000</pub-id>
</mixed-citation>
</ref>
<ref id="B26">
<mixed-citation publication-type="journal">
<name>
<surname>Hillier</surname>
<given-names>S</given-names>
</name>
<article-title>Intervention for children with developmental coordination disorder: A systematic review</article-title>
<source>The Internet Journal of Allied Health Sciences and Practice</source>
<year>2007</year>
<volume>5</volume>
<issue>3</issue>
</mixed-citation>
</ref>
<ref id="B27">
<mixed-citation publication-type="journal">
<name>
<surname>Hillier</surname>
<given-names>S</given-names>
</name>
<name>
<surname>McIntyre</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Plummer</surname>
<given-names>L</given-names>
</name>
<article-title>Aquatic physical therapy for children with developmental coordination disorder: A pilot randomized controlled trial</article-title>
<source>Phys Occup Ther Pediatr</source>
<year>2010</year>
<volume>30</volume>
<issue>2</issue>
<fpage>111</fpage>
<lpage>124</lpage>
<pub-id pub-id-type="doi">10.3109/01942630903543575</pub-id>
<pub-id pub-id-type="pmid">20367516</pub-id>
</mixed-citation>
</ref>
<ref id="B28">
<mixed-citation publication-type="journal">
<name>
<surname>Tsai</surname>
<given-names>CL</given-names>
</name>
<article-title>The effectiveness of exercise intervention on inhibitory control in children with developmental coordination disorder: using a visuospatial attention paradigm as a model</article-title>
<source>Res Dev Disabil</source>
<year>2009</year>
<volume>30</volume>
<issue>6</issue>
<fpage>1268</fpage>
<lpage>1280</lpage>
<pub-id pub-id-type="doi">10.1016/j.ridd.2009.05.001</pub-id>
<pub-id pub-id-type="pmid">19497707</pub-id>
</mixed-citation>
</ref>
<ref id="B29">
<mixed-citation publication-type="journal">
<name>
<surname>Harter</surname>
<given-names>S</given-names>
</name>
<article-title>Effectance motivation reconsidered</article-title>
<source>Hum Dev</source>
<year>1978</year>
<volume>21</volume>
<fpage>34</fpage>
<lpage>64</lpage>
<pub-id pub-id-type="doi">10.1159/000271574</pub-id>
</mixed-citation>
</ref>
<ref id="B30">
<mixed-citation publication-type="book">
<name>
<surname>Harter</surname>
<given-names>S</given-names>
</name>
<person-group person-group-type="editor">Collins WA</person-group>
<article-title>A model of intrinsic mastery motivation in children: Individual differences and developmental change</article-title>
<source>Minnesota Symposia on Child Psychology</source>
<year>1981</year>
<volume>14</volume>
<publisher-name>Hillsdale, NJ: Erlbaum</publisher-name>
</mixed-citation>
</ref>
<ref id="B31">
<mixed-citation publication-type="book">
<name>
<surname>Doganis</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Theodorakis</surname>
<given-names>Y</given-names>
</name>
<person-group person-group-type="editor">Biddle S</person-group>
<article-title>The influence of attitude on exercise participation</article-title>
<source>European Perspectives on Exercise and Sport Psychology</source>
<year>1995</year>
<publisher-name>Champaign, IL: Human Kinetics</publisher-name>
</mixed-citation>
</ref>
<ref id="B32">
<mixed-citation publication-type="book">
<name>
<surname>Abbott</surname>
<given-names>RA</given-names>
</name>
<name>
<surname>Macdonald</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Mackinnon</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Stubbs</surname>
<given-names>CO</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>AJ</given-names>
</name>
<name>
<surname>Harper</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Davies</surname>
<given-names>PSW</given-names>
</name>
<source>Healthy Kids Queensland Survey 2006 -- Summary Report</source>
<year>2007</year>
<publisher-name>Brisbane, QLD</publisher-name>
</mixed-citation>
</ref>
<ref id="B33">
<mixed-citation publication-type="journal">
<name>
<surname>Biddle</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Gorely</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Stensel</surname>
<given-names>DJ</given-names>
</name>
<article-title>Health-enhancing physical activity and sedentary behaviour in children and adolescents</article-title>
<source>J Sports Sci</source>
<year>2004</year>
<volume>22</volume>
<issue>8</issue>
<fpage>679</fpage>
<lpage>701</lpage>
<pub-id pub-id-type="doi">10.1080/02640410410001712412</pub-id>
<pub-id pub-id-type="pmid">15370482</pub-id>
</mixed-citation>
</ref>
<ref id="B34">
<mixed-citation publication-type="journal">
<name>
<surname>Cairney</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Hay</surname>
<given-names>JA</given-names>
</name>
<name>
<surname>Faught</surname>
<given-names>BE</given-names>
</name>
<name>
<surname>Hawes</surname>
<given-names>R</given-names>
</name>
<article-title>Developmental coordination disorder and overweight and obesity in children aged 9-14 y</article-title>
<source>Int J Obes (Lond)</source>
<year>2005</year>
<volume>29</volume>
<issue>4</issue>
<fpage>369</fpage>
<lpage>372</lpage>
<pub-id pub-id-type="doi">10.1038/sj.ijo.0802893</pub-id>
</mixed-citation>
</ref>
<ref id="B35">
<mixed-citation publication-type="journal">
<name>
<surname>Poulsen</surname>
<given-names>AA</given-names>
</name>
<name>
<surname>Ziviani</surname>
<given-names>JM</given-names>
</name>
<name>
<surname>Cuskelly</surname>
<given-names>M</given-names>
</name>
<article-title>Perceived freedom in leisure and physical co-ordination ability: Impact on out-of-school activity participation and life satisfaction</article-title>
<source>Child Care Health Dev</source>
<year>2007</year>
<volume>33</volume>
<issue>4</issue>
<fpage>432</fpage>
<lpage>440</lpage>
<pub-id pub-id-type="doi">10.1111/j.1365-2214.2007.00730.x</pub-id>
<pub-id pub-id-type="pmid">17584399</pub-id>
</mixed-citation>
</ref>
<ref id="B36">
<mixed-citation publication-type="journal">
<name>
<surname>Piek</surname>
<given-names>JP</given-names>
</name>
<name>
<surname>Dworcan</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Barrett</surname>
<given-names>NC</given-names>
</name>
<name>
<surname>Coleman</surname>
<given-names>R</given-names>
</name>
<article-title>Determinants of self worth in children with and without DCD</article-title>
<source>International Journal of Disability, Development and Education</source>
<year>2000</year>
<volume>47</volume>
<issue>3</issue>
<fpage>259</fpage>
<lpage>272</lpage>
<pub-id pub-id-type="doi">10.1080/713671115</pub-id>
</mixed-citation>
</ref>
<ref id="B37">
<mixed-citation publication-type="journal">
<name>
<surname>Skinner</surname>
<given-names>RA</given-names>
</name>
<name>
<surname>Piek</surname>
<given-names>JP</given-names>
</name>
<article-title>Psychosocial implications of poor motor coordination in children and adolescents</article-title>
<source>Hum Mov Sci</source>
<year>2001</year>
<volume>20</volume>
<issue>1</issue>
<fpage>73</fpage>
<lpage>94</lpage>
<pub-id pub-id-type="doi">10.1016/S0167-9457(01)00029-X</pub-id>
<pub-id pub-id-type="pmid">11471399</pub-id>
</mixed-citation>
</ref>
<ref id="B38">
<mixed-citation publication-type="other">
<name>
<surname>Francis</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Piek</surname>
<given-names>JP</given-names>
</name>
<article-title>The effects of perceived social support and self-worth on depressive symptomatology in children with and without Developmental Coordination Disorder</article-title>
<source>38th APS Annual Conference: 2-5 October 2003 2003; Perth, Western Australia</source>
<year>2003</year>
</mixed-citation>
</ref>
<ref id="B39">
<mixed-citation publication-type="journal">
<name>
<surname>Straker</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Abbott</surname>
<given-names>R</given-names>
</name>
<article-title>Effect of screen-based media on energy expenditure and heart rate in 9- to 12-year-old children</article-title>
<source>Pediatr Exerc Sci</source>
<year>2007</year>
<volume>19</volume>
<issue>4</issue>
<fpage>459</fpage>
<lpage>471</lpage>
<pub-id pub-id-type="pmid">18089912</pub-id>
</mixed-citation>
</ref>
<ref id="B40">
<mixed-citation publication-type="journal">
<name>
<surname>Straker</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Pollock</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Piek</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Abbott</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Skoss</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Coleman</surname>
<given-names>J</given-names>
</name>
<article-title>Active-input provides more movement and muscle activity during electronic game playing by children</article-title>
<source>Int J Hum Comput Interact</source>
<year>2009</year>
<volume>25</volume>
<issue>8</issue>
<fpage>713</fpage>
<lpage>728</lpage>
<pub-id pub-id-type="doi">10.1080/10447310903025495</pub-id>
</mixed-citation>
</ref>
<ref id="B41">
<mixed-citation publication-type="journal">
<name>
<surname>Li</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Atkins</surname>
<given-names>MS</given-names>
</name>
<article-title>Early childhood computer experience and cognitive and motor development</article-title>
<source>Pediatrics</source>
<year>2004</year>
<volume>113</volume>
<issue>6</issue>
<fpage>1715</fpage>
<lpage>1722</lpage>
<pub-id pub-id-type="doi">10.1542/peds.113.6.1715</pub-id>
<pub-id pub-id-type="pmid">15173496</pub-id>
</mixed-citation>
</ref>
<ref id="B42">
<mixed-citation publication-type="journal">
<name>
<surname>Marshall</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Biddle</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Gorely</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Cameron</surname>
<given-names>N</given-names>
</name>
<name>
<surname>Murdey</surname>
<given-names>I</given-names>
</name>
<article-title>Relationships between media use, body fatness and physical activity in children and youth: a meta-analysis</article-title>
<source>Int J Obes Relat Metab Disord</source>
<year>2004</year>
<volume>28</volume>
<issue>10</issue>
<fpage>1238</fpage>
<lpage>1246</lpage>
<pub-id pub-id-type="doi">10.1038/sj.ijo.0802706</pub-id>
<pub-id pub-id-type="pmid">15314635</pub-id>
</mixed-citation>
</ref>
<ref id="B43">
<mixed-citation publication-type="journal">
<name>
<surname>Motl</surname>
<given-names>RW</given-names>
</name>
<name>
<surname>McAuley</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Birnbaum</surname>
<given-names>AS</given-names>
</name>
<name>
<surname>Lytle</surname>
<given-names>LA</given-names>
</name>
<article-title>Naturally occurring changes in time spent watching television are inversely related to frequency of physical activity during early adolescence</article-title>
<source>J Adolesc</source>
<year>2006</year>
<volume>29</volume>
<issue>1</issue>
<fpage>19</fpage>
<lpage>32</lpage>
<pub-id pub-id-type="doi">10.1016/j.adolescence.2005.01.005</pub-id>
<pub-id pub-id-type="pmid">16338428</pub-id>
</mixed-citation>
</ref>
<ref id="B44">
<mixed-citation publication-type="journal">
<name>
<surname>Rey-Lopez</surname>
<given-names>JP</given-names>
</name>
<name>
<surname>Vicente-Rodriguez</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Biosca</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Moreno</surname>
<given-names>LA</given-names>
</name>
<article-title>Sedentary behaviour and obesity development in children and adolescents</article-title>
<source>Nutr Metab Cardiovasc Dis</source>
<year>2008</year>
<volume>18</volume>
<issue>3</issue>
<fpage>242</fpage>
<lpage>251</lpage>
<pub-id pub-id-type="doi">10.1016/j.numecd.2007.07.008</pub-id>
<pub-id pub-id-type="pmid">18083016</pub-id>
</mixed-citation>
</ref>
<ref id="B45">
<mixed-citation publication-type="book">
<name>
<surname>Straker</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Coleman</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Abbott</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Piek</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Pollock</surname>
<given-names>C</given-names>
</name>
<article-title>A pilot study on the impact of electronic games on physical activity in children</article-title>
<source>CybErg 2008, the 5th International Cyberspace Conference on Ergonomics</source>
<year>2008</year>
<publisher-name>Sarawak, Malaysia</publisher-name>
</mixed-citation>
</ref>
<ref id="B46">
<mixed-citation publication-type="book">
<name>
<surname>McCarron</surname>
<given-names>L</given-names>
</name>
<source>McCarron assessment of neuromotor development: Fine and gross motor abilities</source>
<year>1997</year>
<edition>3</edition>
<publisher-name>TX, USA: Common Market Press</publisher-name>
</mixed-citation>
</ref>
<ref id="B47">
<mixed-citation publication-type="book">
<name>
<surname>Gomes</surname>
<given-names>A</given-names>
</name>
<source>Pre-adolescent participation in physical activity: Investigating the role of socialization factors</source>
<year>1999</year>
<publisher-name>Perth, WA.: Curtin University of Technology</publisher-name>
</mixed-citation>
</ref>
<ref id="B48">
<mixed-citation publication-type="journal">
<name>
<surname>Weiss</surname>
<given-names>PL</given-names>
</name>
<name>
<surname>Rand</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Katz</surname>
<given-names>N</given-names>
</name>
<name>
<surname>Kizony</surname>
<given-names>R</given-names>
</name>
<article-title>Video capture virtual reality as a flexible and effective rehabilitation tool</article-title>
<source>J Neuroeng Rehabil</source>
<year>2004</year>
<volume>1</volume>
<issue>12</issue>
</mixed-citation>
</ref>
<ref id="B49">
<mixed-citation publication-type="journal">
<name>
<surname>Lanningham-Foster</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Jensen</surname>
<given-names>TB</given-names>
</name>
<name>
<surname>Foster</surname>
<given-names>RC</given-names>
</name>
<name>
<surname>Redmond</surname>
<given-names>AB</given-names>
</name>
<name>
<surname>Walker</surname>
<given-names>BA</given-names>
</name>
<name>
<surname>Heinz</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Levine</surname>
<given-names>JA</given-names>
</name>
<article-title>Energy expenditure of sedentary screen time compared with active screen time for children</article-title>
<source>Pediatrics</source>
<year>2006</year>
<volume>118</volume>
<issue>6</issue>
<fpage>1831</fpage>
<lpage>1835</lpage>
<pub-id pub-id-type="doi">10.1542/peds.2006-1087</pub-id>
</mixed-citation>
</ref>
<ref id="B50">
<mixed-citation publication-type="journal">
<name>
<surname>Maddison</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Mhurchul</surname>
<given-names>CN</given-names>
</name>
<name>
<surname>Jull</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Jiang</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Prapavessis</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Rodgers</surname>
<given-names>A</given-names>
</name>
<article-title>Energy expended playing video console games: An opportunity to increase children's physical activity?</article-title>
<source>Pediatr Exerc Sci</source>
<year>2007</year>
<volume>19</volume>
<issue>3</issue>
<fpage>1</fpage>
<lpage>24</lpage>
<pub-id pub-id-type="pmid">17554152</pub-id>
</mixed-citation>
</ref>
<ref id="B51">
<mixed-citation publication-type="other">
<name>
<surname>Maddison</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Foley</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Ni Mhurchu</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Jiang</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Jull</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Prapavessis</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Hohepa</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Rodgers</surname>
<given-names>A</given-names>
</name>
<article-title>Effects of active video games on body composition: a randomized controlled trial</article-title>
<source>Am J Clin Nutr</source>
<year>2011</year>
</mixed-citation>
</ref>
<ref id="B52">
<mixed-citation publication-type="journal">
<name>
<surname>Straker</surname>
<given-names>LM</given-names>
</name>
<name>
<surname>Abbott</surname>
<given-names>RA</given-names>
</name>
<name>
<surname>Piek</surname>
<given-names>JP</given-names>
</name>
<name>
<surname>Pollock</surname>
<given-names>CM</given-names>
</name>
<name>
<surname>Davies</surname>
<given-names>PS</given-names>
</name>
<name>
<surname>Smith</surname>
<given-names>AJ</given-names>
</name>
<article-title>Rationale, design and methods for a randomised and controlled trial to investigate whether home access to electronic games decreases children's physical activity</article-title>
<source>BMC Public Health</source>
<year>2009</year>
<volume>9</volume>
<fpage>212</fpage>
<pub-id pub-id-type="doi">10.1186/1471-2458-9-212</pub-id>
<pub-id pub-id-type="pmid">19563680</pub-id>
</mixed-citation>
</ref>
<ref id="B53">
<mixed-citation publication-type="journal">
<name>
<surname>Sveistrup</surname>
<given-names>H</given-names>
</name>
<article-title>Motor rehabilitation using virtual reality</article-title>
<source>J Neuroeng Rehabil</source>
<year>2004</year>
<volume>1</volume>
<issue>1</issue>
<fpage>10</fpage>
<pub-id pub-id-type="doi">10.1186/1743-0003-1-10</pub-id>
<pub-id pub-id-type="pmid">15679945</pub-id>
</mixed-citation>
</ref>
<ref id="B54">
<mixed-citation publication-type="journal">
<name>
<surname>Reid</surname>
<given-names>DT</given-names>
</name>
<article-title>The use of virtual reality to improve upper-extremity efficiency skills in children with cerebral palsy: A pilot study</article-title>
<source>Technol Disabil</source>
<year>2002</year>
<volume>14</volume>
<fpage>53</fpage>
<lpage>61</lpage>
</mixed-citation>
</ref>
<ref id="B55">
<mixed-citation publication-type="journal">
<name>
<surname>Wann</surname>
<given-names>JP</given-names>
</name>
<name>
<surname>Rushton</surname>
<given-names>SK</given-names>
</name>
<name>
<surname>Smyth</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Jones</surname>
<given-names>D</given-names>
</name>
<article-title>Rehabilitative environments for attention and movement disorders</article-title>
<source>Commun ACM</source>
<year>1997</year>
<volume>40</volume>
<issue>8</issue>
<fpage>49</fpage>
<lpage>52</lpage>
<pub-id pub-id-type="doi">10.1145/257874.257885</pub-id>
</mixed-citation>
</ref>
<ref id="B56">
<mixed-citation publication-type="book">
<name>
<surname>Henderson</surname>
<given-names>SE</given-names>
</name>
<name>
<surname>Sugden</surname>
<given-names>DA</given-names>
</name>
<name>
<surname>Barnett</surname>
<given-names>AL</given-names>
</name>
<source>Movement Assessment Battery for Children-2</source>
<year>2007</year>
<publisher-name>London, UK: Harcourt Assessment</publisher-name>
</mixed-citation>
</ref>
<ref id="B57">
<mixed-citation publication-type="journal">
<name>
<surname>Gueze</surname>
<given-names>RH</given-names>
</name>
<name>
<surname>Jongmans</surname>
<given-names>MJ</given-names>
</name>
<name>
<surname>Schoemaker</surname>
<given-names>MM</given-names>
</name>
<name>
<surname>Smits-Engelsman</surname>
<given-names>BC</given-names>
</name>
<article-title>Clinical and research diagnostic criteria for developmental coordination disorder: a review and discussion</article-title>
<source>Hum Mov Sci</source>
<year>2001</year>
<volume>20</volume>
<issue>1-2</issue>
<fpage>7</fpage>
<lpage>47</lpage>
<pub-id pub-id-type="doi">10.1016/S0167-9457(01)00027-6</pub-id>
<pub-id pub-id-type="pmid">11471398</pub-id>
</mixed-citation>
</ref>
<ref id="B58">
<mixed-citation publication-type="book">
<name>
<surname>Laszlo</surname>
<given-names>JI</given-names>
</name>
<name>
<surname>Bairstow</surname>
<given-names>PJ</given-names>
</name>
<person-group person-group-type="editor">Laszlo JI, Bairstow PJ</person-group>
<article-title>Control of skilled movement: processes underlying acquisition and performance</article-title>
<source>Perceptual-motor behaviour: Developmental assessment and therapy</source>
<year>1985</year>
<publisher-name>London: Holt, Rinehart & Winston</publisher-name>
<fpage>11</fpage>
<lpage>124</lpage>
</mixed-citation>
</ref>
<ref id="B59">
<mixed-citation publication-type="journal">
<name>
<surname>Smits-Engelsman</surname>
<given-names>BCM</given-names>
</name>
<name>
<surname>Henderson</surname>
<given-names>SE</given-names>
</name>
<name>
<surname>Michels</surname>
<given-names>CGJ</given-names>
</name>
<article-title>The assessment of children with Developmental Coordination Disorders in the Netherlands: The relationship between the Movement Assessment Battery for Children and the Körperkoordinations Test für Kinder</article-title>
<source>Hum Mov Sci</source>
<year>1998</year>
<volume>17</volume>
<issue>4-5</issue>
<fpage>699</fpage>
<lpage>709</lpage>
<pub-id pub-id-type="doi">10.1016/S0167-9457(98)00019-0</pub-id>
</mixed-citation>
</ref>
<ref id="B60">
<mixed-citation publication-type="journal">
<name>
<surname>Niemeijer</surname>
<given-names>AS</given-names>
</name>
<name>
<surname>Smits-Engelsman</surname>
<given-names>BC</given-names>
</name>
<name>
<surname>Schoemaker</surname>
<given-names>MM</given-names>
</name>
<article-title>Neuromotor task training for children with developmental coordination disorder: a controlled trial</article-title>
<source>Dev Med Child Neurol</source>
<year>2007</year>
<volume>49</volume>
<issue>6</issue>
<fpage>406</fpage>
<lpage>411</lpage>
<pub-id pub-id-type="doi">10.1111/j.1469-8749.2007.00406.x</pub-id>
<pub-id pub-id-type="pmid">17518923</pub-id>
</mixed-citation>
</ref>
<ref id="B61">
<mixed-citation publication-type="journal">
<name>
<surname>Wu</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Siegler</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Allard</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Kirtley</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Leardini</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Rosenbaum</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Whittle</surname>
<given-names>M</given-names>
</name>
<name>
<surname>D'Lima</surname>
<given-names>DD</given-names>
</name>
<name>
<surname>Cristofolini</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Witte</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Schmid</surname>
<given-names>O</given-names>
</name>
<name>
<surname>Stokes</surname>
<given-names>I</given-names>
</name>
<article-title>ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion- part I: ankle, hip and spine</article-title>
<source>J Biomech</source>
<year>2002</year>
<volume>35</volume>
<fpage>543</fpage>
<lpage>548</lpage>
<pub-id pub-id-type="doi">10.1016/S0021-9290(01)00222-6</pub-id>
<pub-id pub-id-type="pmid">11934426</pub-id>
</mixed-citation>
</ref>
<ref id="B62">
<mixed-citation publication-type="journal">
<name>
<surname>Wu</surname>
<given-names>G</given-names>
</name>
<name>
<surname>van der Helm</surname>
<given-names>FCT</given-names>
</name>
<name>
<surname>Veeger</surname>
<given-names>HEJ</given-names>
</name>
<name>
<surname>Makhsous</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Van Roy</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Anglin</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Nagels</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Karduna</surname>
<given-names>AR</given-names>
</name>
<name>
<surname>McQuade</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Werner</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Buchholz</surname>
<given-names>B</given-names>
</name>
<article-title>ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion - Part II: Shoulder, elbow, wrist and hand</article-title>
<source>J Biomech</source>
<year>2005</year>
<volume>38</volume>
<fpage>981</fpage>
<lpage>992</lpage>
<pub-id pub-id-type="doi">10.1016/j.jbiomech.2004.05.042</pub-id>
<pub-id pub-id-type="pmid">15844264</pub-id>
</mixed-citation>
</ref>
<ref id="B63">
<mixed-citation publication-type="book">
<name>
<surname>Ulrich</surname>
<given-names>DA</given-names>
</name>
<source>Test of Gross Motor Development - 2nd edition. Examiner's Manual</source>
<year>2000</year>
<edition>Second</edition>
<publisher-name>Austin TX: Pro-Ed</publisher-name>
</mixed-citation>
</ref>
<ref id="B64">
<mixed-citation publication-type="journal">
<name>
<surname>Ameratunga</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Johnston</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Burns</surname>
<given-names>Y</given-names>
</name>
<article-title>Goal-directed upper limb movements by children with and without DCD: A window into perceptuo-motor dysfunction?</article-title>
<source>Physiother Res Int</source>
<year>2004</year>
<volume>9</volume>
<issue>1</issue>
<fpage>1</fpage>
<lpage>12</lpage>
<pub-id pub-id-type="doi">10.1002/pri.295</pub-id>
<pub-id pub-id-type="pmid">15132023</pub-id>
</mixed-citation>
</ref>
<ref id="B65">
<mixed-citation publication-type="journal">
<name>
<surname>Chang</surname>
<given-names>JJ</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>TI</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>WL</given-names>
</name>
<name>
<surname>Su</surname>
<given-names>FC</given-names>
</name>
<article-title>Kinematical measure for spastic reaching in children with cerebral palsy</article-title>
<source>Clin Biomech</source>
<year>2005</year>
<volume>20</volume>
<issue>4</issue>
<fpage>381</fpage>
<lpage>388</lpage>
<pub-id pub-id-type="doi">10.1016/j.clinbiomech.2004.11.015</pub-id>
</mixed-citation>
</ref>
<ref id="B66">
<mixed-citation publication-type="book">
<name>
<surname>Wilson</surname>
<given-names>BN</given-names>
</name>
<name>
<surname>Crawford</surname>
<given-names>SG</given-names>
</name>
<source>The Developmental Coordination Disorder Questionnaire 2007 (DCDQ'07). Administrative manual for the DCDQ'07 with psychometric properties</source>
<year>2010</year>
<publisher-name>Calgary, Canada: Alberta Health Services</publisher-name>
<pub-id pub-id-type="pmid">17975453</pub-id>
</mixed-citation>
</ref>
<ref id="B67">
<mixed-citation publication-type="journal">
<name>
<surname>Tseng</surname>
<given-names>MH</given-names>
</name>
<name>
<surname>Fu</surname>
<given-names>CP</given-names>
</name>
<name>
<surname>Wilson</surname>
<given-names>BN</given-names>
</name>
<name>
<surname>Hu</surname>
<given-names>FC</given-names>
</name>
<article-title>Psychometric properties of a Chinese version of the Developmental Coordination Disorder Questionnaire in community-based children</article-title>
<source>Res Dev Disabil</source>
<year>2010</year>
<volume>31</volume>
<issue>1</issue>
<fpage>33</fpage>
<lpage>45</lpage>
<pub-id pub-id-type="doi">10.1016/j.ridd.2009.07.018</pub-id>
<pub-id pub-id-type="pmid">19709853</pub-id>
</mixed-citation>
</ref>
<ref id="B68">
<mixed-citation publication-type="journal">
<name>
<surname>Wilson</surname>
<given-names>BN</given-names>
</name>
<name>
<surname>Crawford</surname>
<given-names>SG</given-names>
</name>
<name>
<surname>Green</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Roberts</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Aylott</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Kaplan</surname>
<given-names>BJ</given-names>
</name>
<article-title>Psychometric properties of the revised Developmental Coordination Disorder Questionnaire</article-title>
<source>Phys Occup Ther Pediatr</source>
<year>2009</year>
<volume>29</volume>
<issue>2</issue>
<fpage>182</fpage>
<lpage>202</lpage>
<pub-id pub-id-type="doi">10.1080/01942630902784761</pub-id>
<pub-id pub-id-type="pmid">19401931</pub-id>
</mixed-citation>
</ref>
<ref id="B69">
<mixed-citation publication-type="journal">
<name>
<surname>Puyau</surname>
<given-names>MR</given-names>
</name>
<name>
<surname>Adolph</surname>
<given-names>AL</given-names>
</name>
<name>
<surname>Vohra</surname>
<given-names>FA</given-names>
</name>
<name>
<surname>Butte</surname>
<given-names>NF</given-names>
</name>
<article-title>Validation and calibration of physical activity monitors in children</article-title>
<source>Obes Res</source>
<year>2002</year>
<volume>10</volume>
<issue>3</issue>
<fpage>150</fpage>
<lpage>157</lpage>
<pub-id pub-id-type="doi">10.1038/oby.2002.24</pub-id>
<pub-id pub-id-type="pmid">11886937</pub-id>
</mixed-citation>
</ref>
<ref id="B70">
<mixed-citation publication-type="journal">
<name>
<surname>Trost</surname>
<given-names>SG</given-names>
</name>
<name>
<surname>Pate</surname>
<given-names>RR</given-names>
</name>
<name>
<surname>Freedson</surname>
<given-names>PS</given-names>
</name>
<name>
<surname>Sallis</surname>
<given-names>JF</given-names>
</name>
<name>
<surname>Taylor</surname>
<given-names>WC</given-names>
</name>
<article-title>Using objective physical activity measures with youth: how many days of monitoring are needed?</article-title>
<source>Med Sci Sports Exerc</source>
<year>2000</year>
<volume>32</volume>
<issue>2</issue>
<fpage>426</fpage>
<lpage>431</lpage>
<pub-id pub-id-type="doi">10.1097/00005768-200002000-00025</pub-id>
<pub-id pub-id-type="pmid">10694127</pub-id>
</mixed-citation>
</ref>
<ref id="B71">
<mixed-citation publication-type="journal">
<name>
<surname>Motl</surname>
<given-names>RW</given-names>
</name>
<name>
<surname>Dishman</surname>
<given-names>RK</given-names>
</name>
<name>
<surname>Saunders</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Dowda</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Felton</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Pate</surname>
<given-names>RR</given-names>
</name>
<article-title>Measuring enjoyment of physical activity in adolescent girls</article-title>
<source>Am J Prev Med</source>
<year>2001</year>
<volume>21</volume>
<issue>2</issue>
<fpage>110</fpage>
<lpage>117</lpage>
<pub-id pub-id-type="doi">10.1016/S0749-3797(01)00326-9</pub-id>
<pub-id pub-id-type="pmid">11457630</pub-id>
</mixed-citation>
</ref>
<ref id="B72">
<mixed-citation publication-type="journal">
<name>
<surname>Kendzierski</surname>
<given-names>D</given-names>
</name>
<name>
<surname>DeCarlo</surname>
<given-names>KJ</given-names>
</name>
<article-title>Physical Activity Enjoyment Scale: Two validation studies</article-title>
<source>J Sport Exerc Psychol</source>
<year>1991</year>
<volume>13</volume>
<issue>1</issue>
<fpage>50</fpage>
<lpage>64</lpage>
</mixed-citation>
</ref>
<ref id="B73">
<mixed-citation publication-type="journal">
<name>
<surname>Dishman</surname>
<given-names>RK</given-names>
</name>
<name>
<surname>Motl</surname>
<given-names>RW</given-names>
</name>
<name>
<surname>Saunders</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Felton</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Ward</surname>
<given-names>DS</given-names>
</name>
<name>
<surname>Dowda</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Pate</surname>
<given-names>RR</given-names>
</name>
<article-title>Enjoyment mediates effects of a school-based physical-activity intervention</article-title>
<source>Med Sci Sports Exerc</source>
<year>2005</year>
<volume>37</volume>
<issue>3</issue>
<fpage>478</fpage>
<lpage>487</lpage>
<pub-id pub-id-type="doi">10.1249/01.MSS.0000155391.62733.A7</pub-id>
<pub-id pub-id-type="pmid">15741848</pub-id>
</mixed-citation>
</ref>
<ref id="B74">
<mixed-citation publication-type="journal">
<name>
<surname>Moore</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Yin</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Hanes</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Duda</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Gutin</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Barbeau</surname>
<given-names>P</given-names>
</name>
<article-title>Measuring enjoyment of physical activity in children: Validation of the Physical Activity Enjoyment Scale</article-title>
<source>J Appl Sport Psychol</source>
<year>2009</year>
<volume>21</volume>
<issue>S1</issue>
<fpage>116</fpage>
<lpage>129</lpage>
</mixed-citation>
</ref>
<ref id="B75">
<mixed-citation publication-type="book">
<name>
<surname>Harter</surname>
<given-names>S</given-names>
</name>
<source>Manual for the self-perception profile for children: Revision of the Perceived Competence Scale for Children</source>
<year>1985</year>
<publisher-name>Denver, USA: University of Denver</publisher-name>
</mixed-citation>
</ref>
<ref id="B76">
<mixed-citation publication-type="journal">
<name>
<surname>Spence</surname>
<given-names>SH</given-names>
</name>
<article-title>Structure of anxiety symptoms among children: a confirmatory factor-analytic study</article-title>
<source>J Abnorm Psychol</source>
<year>1997</year>
<volume>106</volume>
<issue>2</issue>
<fpage>280</fpage>
<lpage>297</lpage>
<pub-id pub-id-type="pmid">9131848</pub-id>
</mixed-citation>
</ref>
<ref id="B77">
<mixed-citation publication-type="journal">
<name>
<surname>Essau</surname>
<given-names>CA</given-names>
</name>
<name>
<surname>Muris</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Ederer</surname>
<given-names>EM</given-names>
</name>
<article-title>Reliability and validity of the Spence Children's Anxiety Scale and the Screen for Child Anxiety Related Emotional Disorders in German children</article-title>
<source>J Behav Ther Exp Psychiatry</source>
<year>2002</year>
<volume>33</volume>
<issue>1</issue>
<fpage>1</fpage>
<lpage>18</lpage>
<pub-id pub-id-type="doi">10.1016/S0005-7916(02)00005-8</pub-id>
<pub-id pub-id-type="pmid">12389796</pub-id>
</mixed-citation>
</ref>
<ref id="B78">
<mixed-citation publication-type="journal">
<name>
<surname>Spence</surname>
<given-names>SH</given-names>
</name>
<article-title>A measure of anxiety symptoms among children</article-title>
<source>Behav Res Ther</source>
<year>1998</year>
<volume>36</volume>
<issue>5</issue>
<fpage>545</fpage>
<lpage>566</lpage>
<pub-id pub-id-type="doi">10.1016/S0005-7967(98)00034-5</pub-id>
<pub-id pub-id-type="pmid">9648330</pub-id>
</mixed-citation>
</ref>
<ref id="B79">
<mixed-citation publication-type="journal">
<name>
<surname>Angold</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Costello</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Messer</surname>
<given-names>S</given-names>
</name>
<article-title>Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents</article-title>
<source>Int J Methods Psychiatr Res</source>
<year>1995</year>
<volume>5</volume>
<fpage>237</fpage>
<lpage>249</lpage>
</mixed-citation>
</ref>
<ref id="B80">
<mixed-citation publication-type="journal">
<name>
<surname>Sund</surname>
<given-names>AM</given-names>
</name>
<name>
<surname>Larsson</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Wichstrom</surname>
<given-names>L</given-names>
</name>
<article-title>Psychosocial correlates of depressive symptoms among 12-14-year-old Norwegian adolescents</article-title>
<source>J Child Psychol Psychiatry</source>
<year>2003</year>
<volume>44</volume>
<issue>4</issue>
<fpage>588</fpage>
<lpage>597</lpage>
<pub-id pub-id-type="doi">10.1111/1469-7610.00147</pub-id>
<pub-id pub-id-type="pmid">12751850</pub-id>
</mixed-citation>
</ref>
<ref id="B81">
<mixed-citation publication-type="journal">
<name>
<surname>Kent</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Vostanis</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Feehan</surname>
<given-names>C</given-names>
</name>
<article-title>Detection of major and minor depression in children and adolescents: evaluation of the Mood and Feelings Questionnaire</article-title>
<source>J Child Psychol Psychiatry</source>
<year>1997</year>
<volume>38</volume>
<issue>5</issue>
<fpage>565</fpage>
<lpage>573</lpage>
<pub-id pub-id-type="doi">10.1111/j.1469-7610.1997.tb01543.x</pub-id>
<pub-id pub-id-type="pmid">9255700</pub-id>
</mixed-citation>
</ref>
</ref-list>
</back>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B90 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001B90 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    HapticV1
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:3166932
   |texte=   Rationale, design and methods for a randomised and controlled trial of the impact of virtual reality games on motor competence, physical activity, and mental health in children with developmental coordination disorder
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:21851587" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a HapticV1 

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Mon Jun 13 01:09:46 2016. Site generation: Wed Mar 6 09:54:07 2024