Adaptive Calibration of Dynamic Accommodation—Implications for Accommodating Intraocular Lenses
Identifieur interne : 001079 ( Pmc/Curation ); précédent : 001078; suivant : 001080Adaptive Calibration of Dynamic Accommodation—Implications for Accommodating Intraocular Lenses
Auteurs : Clifton M. Schor ; Shrikant R. BharadwajSource :
- Journal of refractive surgery (Thorofare, N.J. : 1995) [ 1081-597X ] ; 2008.
Abstract
When the aging lens is replaced with prosthetic accommodating intraocular lenses (IOLs), with effective viscoelasticities different from those of the natural lens, mismatches could arise between the neural control of accommodation and the biomechanical properties of the new lens. These mismatches could lead to either unstable oscillations or sluggishness of dynamic accommodation. Using computer simulations, we investigated whether optimal accommodative responses could be restored through recalibration of the neural control of accommodation. Using human experiments, we also investigated whether the accommodative system has the capacity for adaptive recalibration in response to changes in lens biomechanics.
Dynamic performance of two accommodating IOL prototypes was simulated for a 45-year-old accommodative system, before and after neural recalibration, using a dynamic model of accommodation. Accommodating IOL I, a prototype for an injectable accommodating IOL, was less stiff and less viscous than the natural 45-year-old lens. Accommodating IOL II, a prototype for a translating accommodating IOL, was less stiff and more viscous than the natural 45-year-old lens. Short-term adaptive recalibration of dynamic accommodation was stimulated using a double-step adaptation paradigm that optically induced changes in neuromuscular effort mimicking responses to changes in lens biomechanics.
Model simulations indicate that the unstable oscillations or sluggishness of dynamic accommodation resulting from mismatches between neural control and lens biomechanics might be restored through neural recalibration.
Empirical measures reveal that the accommodative system is capable of adaptive recalibration in response to optical loads that simulate effects of changing lens biomechanics.
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PubMed: 19044245
PubMed Central: 2615681
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adaptive Calibration of Dynamic Accommodation—Implications for Accommodating Intraocular Lenses</title><author><name sortKey="Schor, Clifton M" sort="Schor, Clifton M" uniqKey="Schor C" first="Clifton M." last="Schor">Clifton M. Schor</name></author><author><name sortKey="Bharadwaj, Shrikant R" sort="Bharadwaj, Shrikant R" uniqKey="Bharadwaj S" first="Shrikant R." last="Bharadwaj">Shrikant R. Bharadwaj</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19044245</idno><idno type="pmc">2615681</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615681</idno><idno type="RBID">PMC:2615681</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001079</idno><idno type="wicri:Area/Pmc/Curation">001079</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adaptive Calibration of Dynamic Accommodation—Implications for Accommodating Intraocular Lenses</title><author><name sortKey="Schor, Clifton M" sort="Schor, Clifton M" uniqKey="Schor C" first="Clifton M." last="Schor">Clifton M. Schor</name></author><author><name sortKey="Bharadwaj, Shrikant R" sort="Bharadwaj, Shrikant R" uniqKey="Bharadwaj S" first="Shrikant R." last="Bharadwaj">Shrikant R. Bharadwaj</name></author></analytic><series><title level="j">Journal of refractive surgery (Thorofare, N.J. : 1995)</title><idno type="ISSN">1081-597X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>PURPOSE</title><p id="P2">When the aging lens is replaced with prosthetic accommodating intraocular lenses (IOLs), with effective viscoelasticities different from those of the natural lens, mismatches could arise between the neural control of accommodation and the biomechanical properties of the new lens. These mismatches could lead to either unstable oscillations or sluggishness of dynamic accommodation. Using computer simulations, we investigated whether optimal accommodative responses could be restored through recalibration of the neural control of accommodation. Using human experiments, we also investigated whether the accommodative system has the capacity for adaptive recalibration in response to changes in lens biomechanics.</p></sec><sec sec-type="methods" id="S2"><title>METHODS</title><p id="P3">Dynamic performance of two accommodating IOL prototypes was simulated for a 45-year-old accommodative system, before and after neural recalibration, using a dynamic model of accommodation. Accommodating IOL I, a prototype for an injectable accommodating IOL, was less stiff and less viscous than the natural 45-year-old lens. Accommodating IOL II, a prototype for a translating accommodating IOL, was less stiff and more viscous than the natural 45-year-old lens. Short-term adaptive recalibration of dynamic accommodation was stimulated using a double-step adaptation paradigm that optically induced changes in neuromuscular effort mimicking responses to changes in lens biomechanics.</p></sec><sec id="S3"><title>RESULTS</title><p id="P4">Model simulations indicate that the unstable oscillations or sluggishness of dynamic accommodation resulting from mismatches between neural control and lens biomechanics might be restored through neural recalibration.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P5">Empirical measures reveal that the accommodative system is capable of adaptive recalibration in response to optical loads that simulate effects of changing lens biomechanics.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9505927</journal-id><journal-id journal-id-type="pubmed-jr-id">20169</journal-id><journal-id journal-id-type="nlm-ta">J Refract Surg</journal-id><journal-title>Journal of refractive surgery (Thorofare, N.J. : 1995)</journal-title><issn pub-type="ppub">1081-597X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19044245</article-id><article-id pub-id-type="pmc">2615681</article-id><article-id pub-id-type="manuscript">NIHMS84009</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Adaptive Calibration of Dynamic Accommodation—Implications for Accommodating Intraocular Lenses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schor</surname><given-names>Clifton M.</given-names></name><degrees>OD, PhD, FAAO</degrees></contrib><contrib contrib-type="author"><name><surname>Bharadwaj</surname><given-names>Shrikant R.</given-names></name><degrees>PhD</degrees></contrib><aff id="A1">From the School of Optometry & Vision Science, Berkeley, Calif (Schor); and the School of Optometry & Vision Science, Bloomington, Ind (Bharadwaj).</aff></contrib-group><author-notes><corresp id="CR1">Correspondence: Clifton M. Schor, OD, PhD, FAAO, School of Optometry & Vision Science, 360 Minor Hall, University of California at Berkeley, Berkeley, CA 94720. Tel: 510.642.1130; Fax: 510.643.5109; E-mail: <email>schor@socrates.berkeley.edu</email></corresp><fn id="FN1"><p id="P1">The authors have no commercial or proprietary interest in the materials presented herein.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>1</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2009</year></pub-date><volume>24</volume><issue>9</issue><fpage>984</fpage><lpage>990</lpage><abstract><sec id="S1"><title>PURPOSE</title><p id="P2">When the aging lens is replaced with prosthetic accommodating intraocular lenses (IOLs), with effective viscoelasticities different from those of the natural lens, mismatches could arise between the neural control of accommodation and the biomechanical properties of the new lens. These mismatches could lead to either unstable oscillations or sluggishness of dynamic accommodation. Using computer simulations, we investigated whether optimal accommodative responses could be restored through recalibration of the neural control of accommodation. Using human experiments, we also investigated whether the accommodative system has the capacity for adaptive recalibration in response to changes in lens biomechanics.</p></sec><sec sec-type="methods" id="S2"><title>METHODS</title><p id="P3">Dynamic performance of two accommodating IOL prototypes was simulated for a 45-year-old accommodative system, before and after neural recalibration, using a dynamic model of accommodation. Accommodating IOL I, a prototype for an injectable accommodating IOL, was less stiff and less viscous than the natural 45-year-old lens. Accommodating IOL II, a prototype for a translating accommodating IOL, was less stiff and more viscous than the natural 45-year-old lens. Short-term adaptive recalibration of dynamic accommodation was stimulated using a double-step adaptation paradigm that optically induced changes in neuromuscular effort mimicking responses to changes in lens biomechanics.</p></sec><sec id="S3"><title>RESULTS</title><p id="P4">Model simulations indicate that the unstable oscillations or sluggishness of dynamic accommodation resulting from mismatches between neural control and lens biomechanics might be restored through neural recalibration.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P5">Empirical measures reveal that the accommodative system is capable of adaptive recalibration in response to optical loads that simulate effects of changing lens biomechanics.</p></sec></abstract><contract-num rid="EY1">R01 EY017678-01A2</contract-num><contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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