Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Identifieur interne : 000661 ( Pmc/Curation ); précédent : 000660; suivant : 000662Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
Auteurs : Jan Henkel [Australie] ; Maria A. Woodruff [Australie] ; Devakara R. Epari [Australie] ; Roland Steck [Australie] ; Vaida Glatt [Australie] ; Ian C. Dickinson [Australie] ; Peter F. M. Choong [Australie] ; Michael A. Schuetz [Australie] ; Dietmar W. Hutmacher [Australie, États-Unis]Source :
- Bone Research [ 2095-4700 ] ; 2013.
Abstract
The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and
Url:
DOI: 10.4248/BR201303002
PubMed: 26273505
PubMed Central: 4472104
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<author><name sortKey="Epari, Devakara R" sort="Epari, Devakara R" uniqKey="Epari D" first="Devakara R." last="Epari">Devakara R. Epari</name>
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<series><title level="j">Bone Research</title>
<idno type="ISSN">2095-4700</idno>
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<front><div type="abstract" xml:lang="en"><p>The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and <italic>in situ</italic>
tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental “origin” require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.</p>
</div>
</front>
</TEI>
<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Bone Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Bone Res</journal-id>
<journal-title-group><journal-title>Bone Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">2095-4700</issn>
<issn pub-type="epub">2095-6231</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
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<article-meta><article-id pub-id-type="pmid">26273505</article-id>
<article-id pub-id-type="pmc">4472104</article-id>
<article-id pub-id-type="pii">boneres201317</article-id>
<article-id pub-id-type="doi">10.4248/BR201303002</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Henkel</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woodruff</surname>
<given-names>Maria A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Epari</surname>
<given-names>Devakara R.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Steck</surname>
<given-names>Roland</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glatt</surname>
<given-names>Vaida</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dickinson</surname>
<given-names>Ian C.</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Choong</surname>
<given-names>Peter F. M.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff4">4</xref>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schuetz</surname>
<given-names>Michael A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hutmacher</surname>
<given-names>Dietmar W.</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff7">7</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Institute of Health & Biomedical Innovation, Queensland University of Technology</institution>
, Brisbane, Queensland,<country>Australia</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Orthopaedic Oncology Service, Princess Alexandra Hospital</institution>
, Brisbane,<country>Australia</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Department of Surgery, University of Melbourne, St. Vincent's Hospital</institution>
, Melbourne,<country>Australia</country>
</aff>
<aff id="aff4"><label>4</label>
<institution>Department of Orthopaedics, St. Vincent's Hospital</institution>
, Melbourne,<country>Australia</country>
</aff>
<aff id="aff5"><label>5</label>
<institution>Bone and Soft Tissue Sarcoma Service, Peter MacCallum Cancer Centre</institution>
, Melbourne,<country>Australia</country>
</aff>
<aff id="aff6"><label>6</label>
<institution>Orthopaedic and Trauma Services, Princess Alexandra Hospital</institution>
, Brisbane,<country>Australia</country>
</aff>
<aff id="aff7"><label>7</label>
<institution>George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology</institution>
, Atlanta, GA,<country>USA</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
E-mail: <email>dietmar.hutmacher@qut.edu.au</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><month>09</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>09</month>
<year>2013</year>
</pub-date>
<volume>1</volume>
<issue>3</issue>
<fpage>216</fpage>
<lpage>248</lpage>
<history><date date-type="received"><day>11</day>
<month>06</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>20</day>
<month>07</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 Sichuan University</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>Sichuan University</copyright-holder>
</permissions>
<abstract><p>The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and <italic>in situ</italic>
tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental “origin” require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.</p>
</abstract>
<kwd-group><kwd>bone tissue engineering</kwd>
<kwd>regenerative medicine</kwd>
<kwd>additve manufacturing</kwd>
<kwd>clinical translation</kwd>
<kwd>scaffolds</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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