Precocious Alterations of Brain Oscillatory Activity in Alzheimer’s Disease: A Window of Opportunity for Early Diagnosis and Treatment
Identifieur interne : 000409 ( Pmc/Curation ); précédent : 000408; suivant : 000410Precocious Alterations of Brain Oscillatory Activity in Alzheimer’s Disease: A Window of Opportunity for Early Diagnosis and Treatment
Auteurs : Valentine Hamm [France] ; Céline Héraud [France] ; Jean-Christophe Cassel [France] ; Chantal Mathis [France] ; Romain Goutagny [France]Source :
- Frontiers in Cellular Neuroscience [ 1662-5102 ] ; 2015.
Abstract
Alzheimer’s disease (AD) is the most common form of neurodegenerative dementia accounting for 50–80% of all age-related dementia. This pathology is characterized by the progressive and irreversible alteration of cognitive functions, such as memory, leading inexorably to the loss of autonomy for patients with AD. The pathology is linked with aging and occurs most commonly around 65 years old. Its prevalence (5% over 65 years of age and 20% after 80 years) constitutes an economic and social burden for AD patients and their family. At the present, there is still no cure for AD, actual treatments being moderately effective only in early stages of the pathology. A lot of efforts have been deployed with the aim of defining new AD biomarkers. Successful early detection of mild cognitive impairment (MCI) linked to AD requires the identification of biomarkers capable of distinguishing individuals with early stages of AD from other pathologies impacting cognition such as depression. In this article, we will review recent evidence suggesting that electroencephalographic (EEG) recordings, coupled with behavioral assessments, could be a useful approach and easily implementable for a precocious detection of AD.
Url:
DOI: 10.3389/fncel.2015.00491
PubMed: 26733816
PubMed Central: 4685112
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<front><div type="abstract" xml:lang="en"><p>Alzheimer’s disease (AD) is the most common form of neurodegenerative dementia accounting for 50–80% of all age-related dementia. This pathology is characterized by the progressive and irreversible alteration of cognitive functions, such as memory, leading inexorably to the loss of autonomy for patients with AD. The pathology is linked with aging and occurs most commonly around 65 years old. Its prevalence (5% over 65 years of age and 20% after 80 years) constitutes an economic and social burden for AD patients and their family. At the present, there is still no cure for AD, actual treatments being moderately effective only in early stages of the pathology. A lot of efforts have been deployed with the aim of defining new AD biomarkers. Successful early detection of mild cognitive impairment (MCI) linked to AD requires the identification of biomarkers capable of distinguishing individuals with early stages of AD from other pathologies impacting cognition such as depression. In this article, we will review recent evidence suggesting that electroencephalographic (EEG) recordings, coupled with behavioral assessments, could be a useful approach and easily implementable for a precocious detection of AD.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Axmacher, N" uniqKey="Axmacher N">N. Axmacher</name>
</author>
<author><name sortKey="Henseler, M M" uniqKey="Henseler M">M. M. Henseler</name>
</author>
<author><name sortKey="Jensen, O" uniqKey="Jensen O">O. Jensen</name>
</author>
<author><name sortKey="Weinreich, I" uniqKey="Weinreich I">I. Weinreich</name>
</author>
<author><name sortKey="Elger, C E" uniqKey="Elger C">C. E. Elger</name>
</author>
<author><name sortKey="Fell, J" uniqKey="Fell J">J. Fell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bland, B H" uniqKey="Bland B">B. H. Bland</name>
</author>
<author><name sortKey="Whishaw, I Q" uniqKey="Whishaw I">I. Q. Whishaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name>
</author>
<author><name sortKey="Rieger, F" uniqKey="Rieger F">F. Rieger</name>
</author>
<author><name sortKey="Prudhomme, D" uniqKey="Prudhomme D">D. Prudhomme</name>
</author>
<author><name sortKey="Fisher, A" uniqKey="Fisher A">A. Fisher</name>
</author>
<author><name sortKey="Krause, K H" uniqKey="Krause K">K.-H. Krause</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borisyuk, R" uniqKey="Borisyuk R">R. Borisyuk</name>
</author>
<author><name sortKey="Denham, M" uniqKey="Denham M">M. Denham</name>
</author>
<author><name sortKey="Denham, S" uniqKey="Denham S">S. Denham</name>
</author>
<author><name sortKey="Hoppensteadt, F" uniqKey="Hoppensteadt F">F. Hoppensteadt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bott, J B" uniqKey="Bott J">J.-B. Bott</name>
</author>
<author><name sortKey="Muller, M A" uniqKey="Muller M">M.-A. Muller</name>
</author>
<author><name sortKey="Jackson, J" uniqKey="Jackson J">J. Jackson</name>
</author>
<author><name sortKey="Aubert, J" uniqKey="Aubert J">J. Aubert</name>
</author>
<author><name sortKey="Cassel, J C" uniqKey="Cassel J">J.-C. Cassel</name>
</author>
<author><name sortKey="Mathis, C" uniqKey="Mathis C">C. Mathis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bragin, A" uniqKey="Bragin A">A. Bragin</name>
</author>
<author><name sortKey="Jand, G" uniqKey="Jand G">G. Jandó</name>
</author>
<author><name sortKey="Nadasdy, Z" uniqKey="Nadasdy Z">Z. Nádasdy</name>
</author>
<author><name sortKey="Hetke, J" uniqKey="Hetke J">J. Hetke</name>
</author>
<author><name sortKey="Wise, K" uniqKey="Wise K">K. Wise</name>
</author>
<author><name sortKey="Buzsaki, G" uniqKey="Buzsaki G">G. Buzsáki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canolty, R T" uniqKey="Canolty R">R. T. Canolty</name>
</author>
<author><name sortKey="Edwards, E" uniqKey="Edwards E">E. Edwards</name>
</author>
<author><name sortKey="Dalal, S S" uniqKey="Dalal S">S. S. Dalal</name>
</author>
<author><name sortKey="Soltani, M" uniqKey="Soltani M">M. Soltani</name>
</author>
<author><name sortKey="Nagarajan, S S" uniqKey="Nagarajan S">S. S. Nagarajan</name>
</author>
<author><name sortKey="Kirsch, H E" uniqKey="Kirsch H">H. E. Kirsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canolty, R T" uniqKey="Canolty R">R. T. Canolty</name>
</author>
<author><name sortKey="Ganguly, K" uniqKey="Ganguly K">K. Ganguly</name>
</author>
<author><name sortKey="Kennerley, S W" uniqKey="Kennerley S">S. W. Kennerley</name>
</author>
<author><name sortKey="Cadieu, C F" uniqKey="Cadieu C">C. F. Cadieu</name>
</author>
<author><name sortKey="Koepsell, K" uniqKey="Koepsell K">K. Koepsell</name>
</author>
<author><name sortKey="Wallis, J D" uniqKey="Wallis J">J. D. Wallis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cornwell, B R" uniqKey="Cornwell B">B. R. Cornwell</name>
</author>
<author><name sortKey="Johnson, L L" uniqKey="Johnson L">L. L. Johnson</name>
</author>
<author><name sortKey="Holroyd, T" uniqKey="Holroyd T">T. Holroyd</name>
</author>
<author><name sortKey="Carver, F W" uniqKey="Carver F">F. W. Carver</name>
</author>
<author><name sortKey="Grillon, C" uniqKey="Grillon C">C. Grillon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Czigler, B" uniqKey="Czigler B">B. Czigler</name>
</author>
<author><name sortKey="Csik S, D" uniqKey="Csik S D">D. Csikós</name>
</author>
<author><name sortKey="Hidasi, Z" uniqKey="Hidasi Z">Z. Hidasi</name>
</author>
<author><name sortKey="Anna Gaal, Z" uniqKey="Anna Gaal Z">Z. Anna Gaál</name>
</author>
<author><name sortKey="Csibri, E" uniqKey="Csibri E">E. Csibri</name>
</author>
<author><name sortKey="Kiss, E" uniqKey="Kiss E">E. Kiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debener, S" uniqKey="Debener S">S. Debener</name>
</author>
<author><name sortKey="Herrmann, C S" uniqKey="Herrmann C">C. S. Herrmann</name>
</author>
<author><name sortKey="Kranczioch, C" uniqKey="Kranczioch C">C. Kranczioch</name>
</author>
<author><name sortKey="Gembris, D" uniqKey="Gembris D">D. Gembris</name>
</author>
<author><name sortKey="Engel, A K" uniqKey="Engel A">A. K. Engel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Denham, M J" uniqKey="Denham M">M. J. Denham</name>
</author>
<author><name sortKey="Borisyuk, R M" uniqKey="Borisyuk R">R. M. Borisyuk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Didic, M" uniqKey="Didic M">M. Didic</name>
</author>
<author><name sortKey="Barbeau, E J" uniqKey="Barbeau E">E. J. Barbeau</name>
</author>
<author><name sortKey="Felician, O" uniqKey="Felician O">O. Felician</name>
</author>
<author><name sortKey="Tramoni, E" uniqKey="Tramoni E">E. Tramoni</name>
</author>
<author><name sortKey="Guedj, E" uniqKey="Guedj E">E. Guedj</name>
</author>
<author><name sortKey="Poncet, M" uniqKey="Poncet M">M. Poncet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Etienne, S" uniqKey="Etienne S">S. Etienne</name>
</author>
<author><name sortKey="Guthrie, M" uniqKey="Guthrie M">M. Guthrie</name>
</author>
<author><name sortKey="Goillandeau, M" uniqKey="Goillandeau M">M. Goillandeau</name>
</author>
<author><name sortKey="Nguyen, T H" uniqKey="Nguyen T">T. H. Nguyen</name>
</author>
<author><name sortKey="Orignac, H" uniqKey="Orignac H">H. Orignac</name>
</author>
<author><name sortKey="Gross, C" uniqKey="Gross C">C. Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fellous, J M" uniqKey="Fellous J">J. M. Fellous</name>
</author>
<author><name sortKey="Sejnowski, T J" uniqKey="Sejnowski T">T. J. Sejnowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fisahn, A" uniqKey="Fisahn A">A. Fisahn</name>
</author>
<author><name sortKey="Pike, F G" uniqKey="Pike F">F. G. Pike</name>
</author>
<author><name sortKey="Buhl, E H" uniqKey="Buhl E">E. H. Buhl</name>
</author>
<author><name sortKey="Paulsen, O" uniqKey="Paulsen O">O. Paulsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fries, P" uniqKey="Fries P">P. Fries</name>
</author>
<author><name sortKey="Reynolds, J H" uniqKey="Reynolds J">J. H. Reynolds</name>
</author>
<author><name sortKey="Rorie, A E" uniqKey="Rorie A">A. E. Rorie</name>
</author>
<author><name sortKey="Desimone, R" uniqKey="Desimone R">R. Desimone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garn, H" uniqKey="Garn H">H. Garn</name>
</author>
<author><name sortKey="Waser, M" uniqKey="Waser M">M. Waser</name>
</author>
<author><name sortKey="Deistler, M" uniqKey="Deistler M">M. Deistler</name>
</author>
<author><name sortKey="Schmidt, R" uniqKey="Schmidt R">R. Schmidt</name>
</author>
<author><name sortKey="Dal Bianco, P" uniqKey="Dal Bianco P">P. Dal-Bianco</name>
</author>
<author><name sortKey="Ransmayr, G" uniqKey="Ransmayr G">G. Ransmayr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giannakopoulos, P" uniqKey="Giannakopoulos P">P. Giannakopoulos</name>
</author>
<author><name sortKey="Silhol, S" uniqKey="Silhol S">S. Silhol</name>
</author>
<author><name sortKey="Jallageas, V" uniqKey="Jallageas V">V. Jallageas</name>
</author>
<author><name sortKey="Mallet, J" uniqKey="Mallet J">J. Mallet</name>
</author>
<author><name sortKey="Bons, N" uniqKey="Bons N">N. Bons</name>
</author>
<author><name sortKey="Bouras, C" uniqKey="Bouras C">C. Bouras</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gianotti, L R R" uniqKey="Gianotti L">L. R. R. Gianotti</name>
</author>
<author><name sortKey="Kunig, G" uniqKey="Kunig G">G. Künig</name>
</author>
<author><name sortKey="Lehmann, D" uniqKey="Lehmann D">D. Lehmann</name>
</author>
<author><name sortKey="Faber, P L" uniqKey="Faber P">P. L. Faber</name>
</author>
<author><name sortKey="Pascual Marqui, R D" uniqKey="Pascual Marqui R">R. D. Pascual-Marqui</name>
</author>
<author><name sortKey="Kochi, K" uniqKey="Kochi K">K. Kochi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gloveli, T" uniqKey="Gloveli T">T. Gloveli</name>
</author>
<author><name sortKey="Dugladze, T" uniqKey="Dugladze T">T. Dugladze</name>
</author>
<author><name sortKey="Saha, S" uniqKey="Saha S">S. Saha</name>
</author>
<author><name sortKey="Monyer, H" uniqKey="Monyer H">H. Monyer</name>
</author>
<author><name sortKey="Heinemann, U" uniqKey="Heinemann U">U. Heinemann</name>
</author>
<author><name sortKey="Traub, R D" uniqKey="Traub R">R. D. Traub</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goutagny, R" uniqKey="Goutagny R">R. Goutagny</name>
</author>
<author><name sortKey="Gu, N" uniqKey="Gu N">N. Gu</name>
</author>
<author><name sortKey="Cavanagh, C" uniqKey="Cavanagh C">C. Cavanagh</name>
</author>
<author><name sortKey="Jackson, J" uniqKey="Jackson J">J. Jackson</name>
</author>
<author><name sortKey="Chabot, J G" uniqKey="Chabot J">J.-G. Chabot</name>
</author>
<author><name sortKey="Quirion, R" uniqKey="Quirion R">R. Quirion</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goutagny, R" uniqKey="Goutagny R">R. Goutagny</name>
</author>
<author><name sortKey="Jackson, J" uniqKey="Jackson J">J. Jackson</name>
</author>
<author><name sortKey="Williams, S" uniqKey="Williams S">S. Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goutagny, R" uniqKey="Goutagny R">R. Goutagny</name>
</author>
<author><name sortKey="Krantic, S" uniqKey="Krantic S">S. Krantic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grunwald, M" uniqKey="Grunwald M">M. Grunwald</name>
</author>
<author><name sortKey="Busse, F" uniqKey="Busse F">F. Busse</name>
</author>
<author><name sortKey="Hensel, A" uniqKey="Hensel A">A. Hensel</name>
</author>
<author><name sortKey="Riedel Heller, S" uniqKey="Riedel Heller S">S. Riedel-Heller</name>
</author>
<author><name sortKey="Kruggel, F" uniqKey="Kruggel F">F. Kruggel</name>
</author>
<author><name sortKey="Arendt, T" uniqKey="Arendt T">T. Arendt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="H Ndel, B" uniqKey="H Ndel B">B. Händel</name>
</author>
<author><name sortKey="Haarmeier, T" uniqKey="Haarmeier T">T. Haarmeier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hardy, J" uniqKey="Hardy J">J. Hardy</name>
</author>
<author><name sortKey="Selkoe, D J" uniqKey="Selkoe D">D. J. Selkoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hazra, A" uniqKey="Hazra A">A. Hazra</name>
</author>
<author><name sortKey="Gu, F" uniqKey="Gu F">F. Gu</name>
</author>
<author><name sortKey="Aulakh, A" uniqKey="Aulakh A">A. Aulakh</name>
</author>
<author><name sortKey="Berridge, C" uniqKey="Berridge C">C. Berridge</name>
</author>
<author><name sortKey="Eriksen, J L" uniqKey="Eriksen J">J. L. Eriksen</name>
</author>
<author><name sortKey="Ziburkus, J" uniqKey="Ziburkus J">J. Ziburkus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herrmann, C S" uniqKey="Herrmann C">C. S. Herrmann</name>
</author>
<author><name sortKey="Demiralp, T" uniqKey="Demiralp T">T. Demiralp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herrmann, C S" uniqKey="Herrmann C">C. S. Herrmann</name>
</author>
<author><name sortKey="Lenz, D" uniqKey="Lenz D">D. Lenz</name>
</author>
<author><name sortKey="Junge, S" uniqKey="Junge S">S. Junge</name>
</author>
<author><name sortKey="Busch, N A" uniqKey="Busch N">N. A. Busch</name>
</author>
<author><name sortKey="Maess, B" uniqKey="Maess B">B. Maess</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herrmann, C S" uniqKey="Herrmann C">C. S. Herrmann</name>
</author>
<author><name sortKey="Munk, M H J" uniqKey="Munk M">M. H. J. Munk</name>
</author>
<author><name sortKey="Engel, A K" uniqKey="Engel A">A. K. Engel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herrmann, C S" uniqKey="Herrmann C">C. S. Herrmann</name>
</author>
<author><name sortKey="Mecklinger, A" uniqKey="Mecklinger A">A. Mecklinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huxter, J" uniqKey="Huxter J">J. Huxter</name>
</author>
<author><name sortKey="Burgess, N" uniqKey="Burgess N">N. Burgess</name>
</author>
<author><name sortKey="O Eefe, J" uniqKey="O Eefe J">J. O’Keefe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inestrosa, N C" uniqKey="Inestrosa N">N. C. Inestrosa</name>
</author>
<author><name sortKey="Reyes, A E" uniqKey="Reyes A">A. E. Reyes</name>
</author>
<author><name sortKey="Chac N, M A" uniqKey="Chac N M">M. A. Chacón</name>
</author>
<author><name sortKey="Cerpa, W" uniqKey="Cerpa W">W. Cerpa</name>
</author>
<author><name sortKey="Villal N, A" uniqKey="Villal N A">A. Villalón</name>
</author>
<author><name sortKey="Montiel, J" uniqKey="Montiel J">J. Montiel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jackson, J" uniqKey="Jackson J">J. Jackson</name>
</author>
<author><name sortKey="Goutagny, R" uniqKey="Goutagny R">R. Goutagny</name>
</author>
<author><name sortKey="Williams, S" uniqKey="Williams S">S. Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacobs, J" uniqKey="Jacobs J">J. Jacobs</name>
</author>
<author><name sortKey="Korolev, I O" uniqKey="Korolev I">I. O. Korolev</name>
</author>
<author><name sortKey="Caplan, J B" uniqKey="Caplan J">J. B. Caplan</name>
</author>
<author><name sortKey="Ekstrom, A D" uniqKey="Ekstrom A">A. D. Ekstrom</name>
</author>
<author><name sortKey="Litt, B" uniqKey="Litt B">B. Litt</name>
</author>
<author><name sortKey="Baltuch, G" uniqKey="Baltuch G">G. Baltuch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jelic, V" uniqKey="Jelic V">V. Jelic</name>
</author>
<author><name sortKey="Johansson, S E" uniqKey="Johansson S">S. E. Johansson</name>
</author>
<author><name sortKey="Almkvist, O" uniqKey="Almkvist O">O. Almkvist</name>
</author>
<author><name sortKey="Shigeta, M" uniqKey="Shigeta M">M. Shigeta</name>
</author>
<author><name sortKey="Julin, P" uniqKey="Julin P">P. Julin</name>
</author>
<author><name sortKey="Nordberg, A" uniqKey="Nordberg A">A. Nordberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kai, T" uniqKey="Kai T">T. Kai</name>
</author>
<author><name sortKey="Asai, Y" uniqKey="Asai Y">Y. Asai</name>
</author>
<author><name sortKey="Sakuma, K" uniqKey="Sakuma K">K. Sakuma</name>
</author>
<author><name sortKey="Koeda, T" uniqKey="Koeda T">T. Koeda</name>
</author>
<author><name sortKey="Nakashima, K" uniqKey="Nakashima K">K. Nakashima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalova, E" uniqKey="Kalova E">E. Kalová</name>
</author>
<author><name sortKey="Vlcek, K" uniqKey="Vlcek K">K. Vlcek</name>
</author>
<author><name sortKey="Jarolimova, E" uniqKey="Jarolimova E">E. Jarolímová</name>
</author>
<author><name sortKey="Bures, J" uniqKey="Bures J">J. Bures</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klimesch, W" uniqKey="Klimesch W">W. Klimesch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konopacki, J" uniqKey="Konopacki J">J. Konopacki</name>
</author>
<author><name sortKey="Maciver, M B" uniqKey="Maciver M">M. B. MacIver</name>
</author>
<author><name sortKey="Bland, B H" uniqKey="Bland B">B. H. Bland</name>
</author>
<author><name sortKey="Roth, S H" uniqKey="Roth S">S. H. Roth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kramis, R" uniqKey="Kramis R">R. Kramis</name>
</author>
<author><name sortKey="Vanderwolf, C H" uniqKey="Vanderwolf C">C. H. Vanderwolf</name>
</author>
<author><name sortKey="Bland, B H" uniqKey="Bland B">B. H. Bland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kurudenkandy, F R" uniqKey="Kurudenkandy F">F. R. Kurudenkandy</name>
</author>
<author><name sortKey="Zilberter, M" uniqKey="Zilberter M">M. Zilberter</name>
</author>
<author><name sortKey="Biverst L, H" uniqKey="Biverst L H">H. Biverstål</name>
</author>
<author><name sortKey="Presto, J" uniqKey="Presto J">J. Presto</name>
</author>
<author><name sortKey="Honcharenko, D" uniqKey="Honcharenko D">D. Honcharenko</name>
</author>
<author><name sortKey="Stromberg, R" uniqKey="Stromberg R">R. Strömberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lacz, J" uniqKey="Lacz J">J. Laczó</name>
</author>
<author><name sortKey="Andel, R" uniqKey="Andel R">R. Andel</name>
</author>
<author><name sortKey="Vl Ek, K" uniqKey="Vl Ek K">K. Vlček</name>
</author>
<author><name sortKey="Macoska, V" uniqKey="Macoska V">V. Macoška</name>
</author>
<author><name sortKey="Vyhnalek, M" uniqKey="Vyhnalek M">M. Vyhnálek</name>
</author>
<author><name sortKey="Tolar, M" uniqKey="Tolar M">M. Tolar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lahiri, D K" uniqKey="Lahiri D">D. K. Lahiri</name>
</author>
<author><name sortKey="Kotwal, G J" uniqKey="Kotwal G">G. J. Kotwal</name>
</author>
<author><name sortKey="Farlow, M R" uniqKey="Farlow M">M. R. Farlow</name>
</author>
<author><name sortKey="Sima, A" uniqKey="Sima A">A. Sima</name>
</author>
<author><name sortKey="Kupsky, W" uniqKey="Kupsky W">W. Kupsky</name>
</author>
<author><name sortKey="Sarkar, F H" uniqKey="Sarkar F">F. H. Sarkar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lauritzen, I" uniqKey="Lauritzen I">I. Lauritzen</name>
</author>
<author><name sortKey="Pardossi Piquard, R" uniqKey="Pardossi Piquard R">R. Pardossi-Piquard</name>
</author>
<author><name sortKey="Bauer, C" uniqKey="Bauer C">C. Bauer</name>
</author>
<author><name sortKey="Brigham, E" uniqKey="Brigham E">E. Brigham</name>
</author>
<author><name sortKey="Abraham, J D" uniqKey="Abraham J">J.-D. Abraham</name>
</author>
<author><name sortKey="Ranaldi, S" uniqKey="Ranaldi S">S. Ranaldi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lithfous, S" uniqKey="Lithfous S">S. Lithfous</name>
</author>
<author><name sortKey="Dufour, A" uniqKey="Dufour A">A. Dufour</name>
</author>
<author><name sortKey="Despres, O" uniqKey="Despres O">O. Després</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mathis, D M" uniqKey="Mathis D">D. M. Mathis</name>
</author>
<author><name sortKey="Furman, J L" uniqKey="Furman J">J. L. Furman</name>
</author>
<author><name sortKey="Norris, C M" uniqKey="Norris C">C. M. Norris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mikulca, J A" uniqKey="Mikulca J">J. A. Mikulca</name>
</author>
<author><name sortKey="Nguyen, V" uniqKey="Nguyen V">V. Nguyen</name>
</author>
<author><name sortKey="Gajdosik, D A" uniqKey="Gajdosik D">D. A. Gajdosik</name>
</author>
<author><name sortKey="Teklu, S G" uniqKey="Teklu S">S. G. Teklu</name>
</author>
<author><name sortKey="Giunta, E A" uniqKey="Giunta E">E. A. Giunta</name>
</author>
<author><name sortKey="Lessa, E A" uniqKey="Lessa E">E. A. Lessa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molter, C" uniqKey="Molter C">C. Molter</name>
</author>
<author><name sortKey="O Eill, J" uniqKey="O Eill J">J. O’Neill</name>
</author>
<author><name sortKey="Yamaguchi, Y" uniqKey="Yamaguchi Y">Y. Yamaguchi</name>
</author>
<author><name sortKey="Hirase, H" uniqKey="Hirase H">H. Hirase</name>
</author>
<author><name sortKey="Leinekugel, X" uniqKey="Leinekugel X">X. Leinekugel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moodley, K" uniqKey="Moodley K">K. Moodley</name>
</author>
<author><name sortKey="Minati, L" uniqKey="Minati L">L. Minati</name>
</author>
<author><name sortKey="Contarino, V" uniqKey="Contarino V">V. Contarino</name>
</author>
<author><name sortKey="Prioni, S" uniqKey="Prioni S">S. Prioni</name>
</author>
<author><name sortKey="Wood, R" uniqKey="Wood R">R. Wood</name>
</author>
<author><name sortKey="Cooper, R" uniqKey="Cooper R">R. Cooper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moretti, D V" uniqKey="Moretti D">D. V. Moretti</name>
</author>
<author><name sortKey="Pievani, M" uniqKey="Pievani M">M. Pievani</name>
</author>
<author><name sortKey="Geroldi, C" uniqKey="Geroldi C">C. Geroldi</name>
</author>
<author><name sortKey="Binetti, G" uniqKey="Binetti G">G. Binetti</name>
</author>
<author><name sortKey="Zanetti, O" uniqKey="Zanetti O">O. Zanetti</name>
</author>
<author><name sortKey="Rossini, P M" uniqKey="Rossini P">P. M. Rossini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palop, J J" uniqKey="Palop J">J. J. Palop</name>
</author>
<author><name sortKey="Mucke, L" uniqKey="Mucke L">L. Mucke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, J" uniqKey="Park J">J. Park</name>
</author>
<author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name>
</author>
<author><name sortKey="Kim, T" uniqKey="Kim T">T. Kim</name>
</author>
<author><name sortKey="Park, G Y" uniqKey="Park G">G. Y. Park</name>
</author>
<author><name sortKey="Lee, E M" uniqKey="Lee E">E. M. Lee</name>
</author>
<author><name sortKey="Baek, S" uniqKey="Baek S">S. Baek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfurtscheller, G" uniqKey="Pfurtscheller G">G. Pfurtscheller</name>
</author>
<author><name sortKey="Zalaudek, K" uniqKey="Zalaudek K">K. Zalaudek</name>
</author>
<author><name sortKey="Neuper, C" uniqKey="Neuper C">C. Neuper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pimplikar, S W" uniqKey="Pimplikar S">S. W. Pimplikar</name>
</author>
<author><name sortKey="Nixon, R A" uniqKey="Nixon R">R. A. Nixon</name>
</author>
<author><name sortKey="Robakis, N K" uniqKey="Robakis N">N. K. Robakis</name>
</author>
<author><name sortKey="Shen, J" uniqKey="Shen J">J. Shen</name>
</author>
<author><name sortKey="Tsai, L H" uniqKey="Tsai L">L.-H. Tsai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Price, D L" uniqKey="Price D">D. L. Price</name>
</author>
<author><name sortKey="Tanzi, R E" uniqKey="Tanzi R">R. E. Tanzi</name>
</author>
<author><name sortKey="Borchelt, D R" uniqKey="Borchelt D">D. R. Borchelt</name>
</author>
<author><name sortKey="Sisodia, S S" uniqKey="Sisodia S">S. S. Sisodia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prichep, L S" uniqKey="Prichep L">L. S. Prichep</name>
</author>
<author><name sortKey="John, E R" uniqKey="John E">E. R. John</name>
</author>
<author><name sortKey="Ferris, S H" uniqKey="Ferris S">S. H. Ferris</name>
</author>
<author><name sortKey="Rausch, L" uniqKey="Rausch L">L. Rausch</name>
</author>
<author><name sortKey="Fang, Z" uniqKey="Fang Z">Z. Fang</name>
</author>
<author><name sortKey="Cancro, R" uniqKey="Cancro R">R. Cancro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sauseng, P" uniqKey="Sauseng P">P. Sauseng</name>
</author>
<author><name sortKey="Griesmayr, B" uniqKey="Griesmayr B">B. Griesmayr</name>
</author>
<author><name sortKey="Freunberger, R" uniqKey="Freunberger R">R. Freunberger</name>
</author>
<author><name sortKey="Klimesch, W" uniqKey="Klimesch W">W. Klimesch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schneider, F" uniqKey="Schneider F">F. Schneider</name>
</author>
<author><name sortKey="Baldauf, K" uniqKey="Baldauf K">K. Baldauf</name>
</author>
<author><name sortKey="Wetzel, W" uniqKey="Wetzel W">W. Wetzel</name>
</author>
<author><name sortKey="Reymann, K G" uniqKey="Reymann K">K. G. Reymann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scott, L" uniqKey="Scott L">L. Scott</name>
</author>
<author><name sortKey="Feng, J" uniqKey="Feng J">J. Feng</name>
</author>
<author><name sortKey="Kiss, T" uniqKey="Kiss T">T. Kiss</name>
</author>
<author><name sortKey="Needle, E" uniqKey="Needle E">E. Needle</name>
</author>
<author><name sortKey="Atchison, K" uniqKey="Atchison K">K. Atchison</name>
</author>
<author><name sortKey="Kawabe, T T" uniqKey="Kawabe T">T. T. Kawabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snider, J" uniqKey="Snider J">J. Snider</name>
</author>
<author><name sortKey="Plank, M" uniqKey="Plank M">M. Plank</name>
</author>
<author><name sortKey="Lynch, G" uniqKey="Lynch G">G. Lynch</name>
</author>
<author><name sortKey="Halgren, E" uniqKey="Halgren E">E. Halgren</name>
</author>
<author><name sortKey="Poizner, H" uniqKey="Poizner H">H. Poizner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stefanova, N A" uniqKey="Stefanova N">N. A. Stefanova</name>
</author>
<author><name sortKey="Kozhevnikova, O S" uniqKey="Kozhevnikova O">O. S. Kozhevnikova</name>
</author>
<author><name sortKey="Vitovtov, A O" uniqKey="Vitovtov A">A. O. Vitovtov</name>
</author>
<author><name sortKey="Maksimova, K Y" uniqKey="Maksimova K">K. Y. Maksimova</name>
</author>
<author><name sortKey="Logvinov, S V" uniqKey="Logvinov S">S. V. Logvinov</name>
</author>
<author><name sortKey="Rudnitskaya, E A" uniqKey="Rudnitskaya E">E. A. Rudnitskaya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stefanova, N A" uniqKey="Stefanova N">N. A. Stefanova</name>
</author>
<author><name sortKey="Muraleva, N A" uniqKey="Muraleva N">N. A. Muraleva</name>
</author>
<author><name sortKey="Korbolina, E E" uniqKey="Korbolina E">E. E. Korbolina</name>
</author>
<author><name sortKey="Kiseleva, E" uniqKey="Kiseleva E">E. Kiseleva</name>
</author>
<author><name sortKey="Maksimova, K Y" uniqKey="Maksimova K">K. Y. Maksimova</name>
</author>
<author><name sortKey="Kolosova, N G" uniqKey="Kolosova N">N. G. Kolosova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Strittmatter, W J" uniqKey="Strittmatter W">W. J. Strittmatter</name>
</author>
<author><name sortKey="Saunders, A M" uniqKey="Saunders A">A. M. Saunders</name>
</author>
<author><name sortKey="Schmechel, D" uniqKey="Schmechel D">D. Schmechel</name>
</author>
<author><name sortKey="Pericak Vance, M" uniqKey="Pericak Vance M">M. Pericak-Vance</name>
</author>
<author><name sortKey="Enghild, J" uniqKey="Enghild J">J. Enghild</name>
</author>
<author><name sortKey="Salvesen, G S" uniqKey="Salvesen G">G. S. Salvesen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamayev, R" uniqKey="Tamayev R">R. Tamayev</name>
</author>
<author><name sortKey="Matsuda, S" uniqKey="Matsuda S">S. Matsuda</name>
</author>
<author><name sortKey="Arancio, O" uniqKey="Arancio O">O. Arancio</name>
</author>
<author><name sortKey="D Damio, L" uniqKey="D Damio L">L. D’Adamio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tiitinen, H" uniqKey="Tiitinen H">H. Tiitinen</name>
</author>
<author><name sortKey="Sinkkonen, J" uniqKey="Sinkkonen J">J. Sinkkonen</name>
</author>
<author><name sortKey="Reinikainen, K" uniqKey="Reinikainen K">K. Reinikainen</name>
</author>
<author><name sortKey="Alho, K" uniqKey="Alho K">K. Alho</name>
</author>
<author><name sortKey="Lavikainen, J" uniqKey="Lavikainen J">J. Lavikainen</name>
</author>
<author><name sortKey="N T Nen, R" uniqKey="N T Nen R">R. Näätänen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toledano, A" uniqKey="Toledano A">A. Toledano</name>
</author>
<author><name sortKey="Alvarez, M I" uniqKey="Alvarez M">M. I. Álvarez</name>
</author>
<author><name sortKey="L Pez Rodriguez, A B" uniqKey="L Pez Rodriguez A">A. B. López-Rodríguez</name>
</author>
<author><name sortKey="Toledano Diaz, A" uniqKey="Toledano Diaz A">A. Toledano-Díaz</name>
</author>
<author><name sortKey="Fernandez Verdecia, C I" uniqKey="Fernandez Verdecia C">C. I. Fernández-Verdecia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tort, A B L" uniqKey="Tort A">A. B. L. Tort</name>
</author>
<author><name sortKey="Komorowski, R W" uniqKey="Komorowski R">R. W. Komorowski</name>
</author>
<author><name sortKey="Manns, J R" uniqKey="Manns J">J. R. Manns</name>
</author>
<author><name sortKey="Kopell, N J" uniqKey="Kopell N">N. J. Kopell</name>
</author>
<author><name sortKey="Eichenbaum, H" uniqKey="Eichenbaum H">H. Eichenbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tort, A B L" uniqKey="Tort A">A. B. L. Tort</name>
</author>
<author><name sortKey="Kramer, M A" uniqKey="Kramer M">M. A. Kramer</name>
</author>
<author><name sortKey="Thorn, C" uniqKey="Thorn C">C. Thorn</name>
</author>
<author><name sortKey="Gibson, D J" uniqKey="Gibson D">D. J. Gibson</name>
</author>
<author><name sortKey="Kubota, Y" uniqKey="Kubota Y">Y. Kubota</name>
</author>
<author><name sortKey="Graybiel, A M" uniqKey="Graybiel A">A. M. Graybiel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Traub, R D" uniqKey="Traub R">R. D. Traub</name>
</author>
<author><name sortKey="Bibbig, A" uniqKey="Bibbig A">A. Bibbig</name>
</author>
<author><name sortKey="Lebeau, F E N" uniqKey="Lebeau F">F. E. N. LeBeau</name>
</author>
<author><name sortKey="Cunningham, M O" uniqKey="Cunningham M">M. O. Cunningham</name>
</author>
<author><name sortKey="Whittington, M A" uniqKey="Whittington M">M. A. Whittington</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Cauwenberghe, C" uniqKey="Van Cauwenberghe C">C. Van Cauwenberghe</name>
</author>
<author><name sortKey="Van Broeckhoven, C" uniqKey="Van Broeckhoven C">C. Van Broeckhoven</name>
</author>
<author><name sortKey="Sleegers, K" uniqKey="Sleegers K">K. Sleegers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Hiele, K" uniqKey="Van Der Hiele K">K. van der Hiele</name>
</author>
<author><name sortKey="Vein, A A" uniqKey="Vein A">A. A. Vein</name>
</author>
<author><name sortKey="Van Der Welle, A" uniqKey="Van Der Welle A">A. van der Welle</name>
</author>
<author><name sortKey="Van Der Grond, J" uniqKey="Van Der Grond J">J. van der Grond</name>
</author>
<author><name sortKey="Westendorp, R G J" uniqKey="Westendorp R">R. G. J. Westendorp</name>
</author>
<author><name sortKey="Bollen, E L E M" uniqKey="Bollen E">E. L. E. M. Bollen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verret, L" uniqKey="Verret L">L. Verret</name>
</author>
<author><name sortKey="Krezymon, A" uniqKey="Krezymon A">A. Krezymon</name>
</author>
<author><name sortKey="Halley, H" uniqKey="Halley H">H. Halley</name>
</author>
<author><name sortKey="Trouche, S" uniqKey="Trouche S">S. Trouche</name>
</author>
<author><name sortKey="Zerwas, M" uniqKey="Zerwas M">M. Zerwas</name>
</author>
<author><name sortKey="Lazouret, M" uniqKey="Lazouret M">M. Lazouret</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X J" uniqKey="Wang X">X.-J. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weniger, G" uniqKey="Weniger G">G. Weniger</name>
</author>
<author><name sortKey="Ruhleder, M" uniqKey="Ruhleder M">M. Ruhleder</name>
</author>
<author><name sortKey="Lange, C" uniqKey="Lange C">C. Lange</name>
</author>
<author><name sortKey="Wolf, S" uniqKey="Wolf S">S. Wolf</name>
</author>
<author><name sortKey="Irle, E" uniqKey="Irle E">E. Irle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Willem, M" uniqKey="Willem M">M. Willem</name>
</author>
<author><name sortKey="Tahirovic, S" uniqKey="Tahirovic S">S. Tahirovic</name>
</author>
<author><name sortKey="Busche, M A" uniqKey="Busche M">M. A. Busche</name>
</author>
<author><name sortKey="Ovsepian, S V" uniqKey="Ovsepian S">S. V. Ovsepian</name>
</author>
<author><name sortKey="Chafai, M" uniqKey="Chafai M">M. Chafai</name>
</author>
<author><name sortKey="Kootar, S" uniqKey="Kootar S">S. Kootar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Womelsdorf, T" uniqKey="Womelsdorf T">T. Womelsdorf</name>
</author>
<author><name sortKey="Schoffelen, J M" uniqKey="Schoffelen J">J.-M. Schoffelen</name>
</author>
<author><name sortKey="Oostenveld, R" uniqKey="Oostenveld R">R. Oostenveld</name>
</author>
<author><name sortKey="Singer, W" uniqKey="Singer W">W. Singer</name>
</author>
<author><name sortKey="Desimone, R" uniqKey="Desimone R">R. Desimone</name>
</author>
<author><name sortKey="Engel, A K" uniqKey="Engel A">A. K. Engel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wulff, P" uniqKey="Wulff P">P. Wulff</name>
</author>
<author><name sortKey="Ponomarenko, A A" uniqKey="Ponomarenko A">A. A. Ponomarenko</name>
</author>
<author><name sortKey="Bartos, M" uniqKey="Bartos M">M. Bartos</name>
</author>
<author><name sortKey="Korotkova, T M" uniqKey="Korotkova T">T. M. Korotkova</name>
</author>
<author><name sortKey="Fuchs, E C" uniqKey="Fuchs E">E. C. Fuchs</name>
</author>
<author><name sortKey="B Hner, F" uniqKey="B Hner F">F. Bähner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, W" uniqKey="Xu W">W. Xu</name>
</author>
<author><name sortKey="Fitzgerald, S" uniqKey="Fitzgerald S">S. Fitzgerald</name>
</author>
<author><name sortKey="Nixon, R A" uniqKey="Nixon R">R. A. Nixon</name>
</author>
<author><name sortKey="Levy, E" uniqKey="Levy E">E. Levy</name>
</author>
<author><name sortKey="Wilson, D A" uniqKey="Wilson D">D. A. Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yeung, S T" uniqKey="Yeung S">S. T. Yeung</name>
</author>
<author><name sortKey="Martinez Coria, H" uniqKey="Martinez Coria H">H. Martinez-Coria</name>
</author>
<author><name sortKey="Ager, R R" uniqKey="Ager R">R. R. Ager</name>
</author>
<author><name sortKey="Rodriguez Ortiz, C J" uniqKey="Rodriguez Ortiz C">C. J. Rodriguez-Ortiz</name>
</author>
<author><name sortKey="Baglietto Vargas, D" uniqKey="Baglietto Vargas D">D. Baglietto-Vargas</name>
</author>
<author><name sortKey="Laferla, F M" uniqKey="Laferla F">F. M. LaFerla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yordanova, J" uniqKey="Yordanova J">J. Yordanova</name>
</author>
<author><name sortKey="Kolev, V" uniqKey="Kolev V">V. Kolev</name>
</author>
<author><name sortKey="Demiralp, T" uniqKey="Demiralp T">T. Demiralp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yordanova, J" uniqKey="Yordanova J">J. Yordanova</name>
</author>
<author><name sortKey="Kolev, V" uniqKey="Kolev V">V. Kolev</name>
</author>
<author><name sortKey="Demiralp, T" uniqKey="Demiralp T">T. Demiralp</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Cell Neurosci</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Cell Neurosci</journal-id>
<journal-id journal-id-type="publisher-id">Front. Cell. Neurosci.</journal-id>
<journal-title-group><journal-title>Frontiers in Cellular Neuroscience</journal-title>
</journal-title-group>
<issn pub-type="epub">1662-5102</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26733816</article-id>
<article-id pub-id-type="pmc">4685112</article-id>
<article-id pub-id-type="doi">10.3389/fncel.2015.00491</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject>
<subj-group><subject>Mini Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Precocious Alterations of Brain Oscillatory Activity in Alzheimer’s Disease: A Window of Opportunity for Early Diagnosis and Treatment</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hamm</surname>
<given-names>Valentine</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/278898/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Héraud</surname>
<given-names>Céline</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/301668/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Cassel</surname>
<given-names>Jean-Christophe</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/241958/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Mathis</surname>
<given-names>Chantal</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/218563/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Goutagny</surname>
<given-names>Romain</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/26868/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Centre National de la Recherche Scientifique UMR 7364, Laboratoire de Neurosciences Cognitives et Adaptatives</institution>
<country>Strasbourg, France</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Université de Strasbourg, Neuropôle de Strasbourg</institution>
<country>Strasbourg, France</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: <italic>Lydia Jimenez-Diaz, University of Castilla La Mancha, Spain</italic>
</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: <italic>Andre Fisahn, Karolinska Institutet, Sweden; Valentina Kitchigina, Institute of Theoretical and Experimental Biophysics Russian Academy of Sciences, Russia</italic>
</p>
</fn>
<corresp id="fn001">*Correspondence: <italic>Valentine Hamm, <email xlink:type="simple">valentinehamm@hotmail.com</email>
; Romain Goutagny, <email xlink:type="simple">goutagny@unistra.fr</email>
</italic>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>21</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>9</volume>
<elocation-id>491</elocation-id>
<history><date date-type="received"><day>30</day>
<month>9</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>04</day>
<month>12</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 Hamm, Héraud, Cassel, Mathis and Goutagny.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Hamm, Héraud, Cassel, Mathis and Goutagny</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Alzheimer’s disease (AD) is the most common form of neurodegenerative dementia accounting for 50–80% of all age-related dementia. This pathology is characterized by the progressive and irreversible alteration of cognitive functions, such as memory, leading inexorably to the loss of autonomy for patients with AD. The pathology is linked with aging and occurs most commonly around 65 years old. Its prevalence (5% over 65 years of age and 20% after 80 years) constitutes an economic and social burden for AD patients and their family. At the present, there is still no cure for AD, actual treatments being moderately effective only in early stages of the pathology. A lot of efforts have been deployed with the aim of defining new AD biomarkers. Successful early detection of mild cognitive impairment (MCI) linked to AD requires the identification of biomarkers capable of distinguishing individuals with early stages of AD from other pathologies impacting cognition such as depression. In this article, we will review recent evidence suggesting that electroencephalographic (EEG) recordings, coupled with behavioral assessments, could be a useful approach and easily implementable for a precocious detection of AD.</p>
</abstract>
<kwd-group><kwd>Alzheimer’s disease</kwd>
<kwd>mild cognitive impairment</kwd>
<kwd>recognition memory</kwd>
<kwd>spatial navigation memory</kwd>
<kwd>oscillatory activity</kwd>
<kwd>electroencephalography</kwd>
</kwd-group>
<counts><fig-count count="0"></fig-count>
<table-count count="0"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="83"></ref-count>
<page-count count="6"></page-count>
<word-count count="0"></word-count>
</counts>
</article-meta>
</front>
<body><sec><title>Introduction</title>
<p>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that starts with mild short-term memory deficits before progressively culminating in total loss of cognitive and executive functions. Currently, the precise etiology of the pathology is not known and there is no cure. Genetic studies (<xref rid="B57" ref-type="bibr">Price et al., 1998</xref>
; <xref rid="B72" ref-type="bibr">Van Cauwenberghe et al., 2015</xref>
) have identified mutations in the genes of the transmembrane amyloid peptide precursor protein (APP) and those of presenilins 1 and 2 (PS1, PS2) responsible for rare dominantly inherited early onset familial AD (FAD). Proteolytic processing of APP first by the β-site APP cleaving enzyme, followed by the PS-containing γ-secretase complex, generates amyloid-β (Aβ) peptides that deposit in amyloid plaques. Many studies showed an increased production of more amyloidogenic Aβ peptides associated with FAD-linked mutations, providing strong support for the amyloid hypothesis (<xref rid="B27" ref-type="bibr">Hardy and Selkoe, 2002</xref>
). According to this conceptual framework, it would be the early accumulation of soluble Aβ in specific brain areas that elicits abnormal patterns of neuronal activity leading to cognitive decline (<xref rid="B53" ref-type="bibr">Palop and Mucke, 2010</xref>
). Therefore, a lot of efforts have been deployed in order to lower Aβ levels as a possible therapy for AD. Various types of treatments have been tested including the use of γ-secretase inhibitors and immunization against Aβ. Unfortunately, these drugs were less successful than expected, inducing no improvement, or even a worsening of cognitive functions, often accompanied by drastic side-effects that preclude their use as suitable therapeutics for AD (<xref rid="B49" ref-type="bibr">Mikulca et al., 2014</xref>
). Diverse hypothesis were put forward to explain the disappointing results obtained by current anti-Aβ treatments. First, other APP fragments, like the β-carboxy terminal fragment (β-CTF; <xref rid="B45" ref-type="bibr">Lahiri et al., 2002</xref>
; <xref rid="B56" ref-type="bibr">Pimplikar et al., 2010</xref>
; <xref rid="B46" ref-type="bibr">Lauritzen et al., 2012</xref>
; <xref rid="B66" ref-type="bibr">Tamayev et al., 2012</xref>
; <xref rid="B22" ref-type="bibr">Goutagny et al., 2013</xref>
), the amyloid intracellular domain (AICD), or the recently described CTF-η (<xref rid="B77" ref-type="bibr">Willem et al., 2015</xref>
), might play key roles in AD pathogenesis and associated cognitive symptoms. A second hypothesis highlights the fact that treatments were given too late in the time-course of AD, when neuronal damages are already too extensive and irreversible. However, these two points are closely linked. We need to develop new early biomarkers, independent of the amyloid hypothesis, that do not entirely rely on Aβ dosage. In this article, we will review recent evidences indicating that the characterization of oscillatory activity in patients using electroencephalographic (EEG) recordings, a cost-efficient and easily implementable strategy, might represent a new opportunity for the early detection of AD. In addition, we propose that characterization of cross-frequency coupling (CFC), a specific motif of oscillatory interactions, might represent an extremely sensitive early biomarker.</p>
</sec>
<sec><title>Brain Oscillatory Activity</title>
<p>Cognitive processes (i.e., information processing and storage by brain networks) require a highly coordinated operation of multiple neuronal groups. One likely mechanism is through the coordinated rhythmic activity of neuronal populations, which give rise to oscillations (<xref rid="B78" ref-type="bibr">Womelsdorf et al., 2007</xref>
). These oscillations can be recorded using various techniques, such as electrocorticography, local field potential, magnetoencephalography, or EEG. Rhythmic fluctuations of electric potentials measured by these technics are generated by the spatial summation of highly synchronized post-synaptic potentials occurring in large clusters of neurons. They have an excellent temporal resolution (in the millisecond timescale) and now, new analytic methods allow locating generators of these oscillations with a decent spatial resolution even using EEG (around one voxel with the LORETA method in human EEG; <xref rid="B20" ref-type="bibr">Gianotti et al., 2007</xref>
).</p>
<p>The spectral content of EEG is classically divided in five frequency bands: δ (from 1 to 4 Hz), θ (4 to 7 Hz), α (8 to 12 Hz), β (15 to 30 Hz), and γ (>30 Hz). On a functional level, these diverse oscillations are associated with different brain states. Oscillatory activities are related to global states (i.e., δ waves are mainly present during sleep) or specific behaviors (i.e., β rhythm is usually associated to motor tasks and is thought to reflect the activity of motor cortices; <xref rid="B55" ref-type="bibr">Pfurtscheller et al., 1998</xref>
). Some frequency domains are more closely related to cognitive processes. First, θ oscillations are thought to play a key role in working memory processes (<xref rid="B59" ref-type="bibr">Sauseng et al., 2010</xref>
). θ phase affects memory processing through the modulation of neuronal plasticity within hippocampal and cortical areas and plays a modulatory role in the induction of long-term-potentiation (LTP), a long lasting enhancement of synaptic efficacy which may constitute one of the cellular substrates for learning and memory. In addition, θ rhythm is also strongly linked to hippocampal pyramidal cells that code for spatiotemporal aspects of the animal’s environment (<xref rid="B33" ref-type="bibr">Huxter et al., 2003</xref>
). Second, α oscillations are more related to attentional processes by filtering out irrelevant informations and preventing interference from conflicting stimuli (<xref rid="B40" ref-type="bibr">Klimesch, 2012</xref>
). Finally, γ oscillations are modulated by a variety of cognitive processes such as object recognition and working memory (<xref rid="B67" ref-type="bibr">Tiitinen et al., 1993</xref>
; <xref rid="B82" ref-type="bibr">Yordanova et al., 1997a</xref>
,<xref rid="B83" ref-type="bibr">b</xref>
; <xref rid="B32" ref-type="bibr">Herrmann and Mecklinger, 2000</xref>
; <xref rid="B17" ref-type="bibr">Fries et al., 2001</xref>
; <xref rid="B11" ref-type="bibr">Debener et al., 2003</xref>
; <xref rid="B30" ref-type="bibr">Herrmann et al., 2004a</xref>
,<xref rid="B31" ref-type="bibr">b</xref>
) and are thought to temporally link distributed cell assemblies from different sources that are processing related informations.</p>
<p>Slow and fast oscillatory activities are not independent. Indeed, slow and fast rhythms interact with each other, the phase of slow oscillations (mainly θ rhythm) being able to modulate the amplitude of fast oscillations (β and γ rhythms). This phenomenon, known as CFC, is positively associated with cognitive processes in humans (<xref rid="B7" ref-type="bibr">Canolty et al., 2006</xref>
; <xref rid="B26" ref-type="bibr">Händel and Haarmeier, 2009</xref>
; <xref rid="B1" ref-type="bibr">Axmacher et al., 2010</xref>
), monkeys (<xref rid="B8" ref-type="bibr">Canolty et al., 2010</xref>
), rats (<xref rid="B70" ref-type="bibr">Tort et al., 2008</xref>
, <xref rid="B69" ref-type="bibr">2009</xref>
) and mice (<xref rid="B79" ref-type="bibr">Wulff et al., 2009</xref>
). More specifically, it is hypothesized that at fast frequencies, CFC would allow distributed brain regions to be synchronized (using the slow one as a “carrier”), which consequently facilitates communication.</p>
<p>Given the key role played by oscillatory activities on cognitive processes such as memory, numerous studies have closely looked at brain oscillatory alterations in AD patients, as well as in animal models of the pathology. In the next parts of this article, we will review recent findings on oscillatory activity alterations in the time course of AD.</p>
</sec>
<sec><title>Oscillatory Activity in Mild Cognitive Impairment (MCI) and AD Patients</title>
<p>More than 980 articles in the last 40 years have looked at EEG activity in mild cognitive impairment (MCI) and/or AD patients. Indeed, with the development of new analytic methods that can account for different confounding results (for example, volume conduction), EEG activity seems sensitive enough for an early detection of preclinical AD and predictive of future conversion from MCI to AD.</p>
<p>The majority of studies focusing on EEG characterization in AD patients have been done using resting state paradigms. Resting state EEG corresponds to recordings performed in the motionless subject with eyes closed. This task is a fully standardized procedure and can therefore be done in highly comparable experimental conditions. Compared to age-matched healthy control subjects, both MCI and AD patients exhibit an increase in relative power of slow oscillations (δ and θ rhythms) associated with a decrease in relative power of fast oscillations (α, β, and γ rhythms; <xref rid="B73" ref-type="bibr">van der Hiele et al., 2007</xref>
; <xref rid="B10" ref-type="bibr">Czigler et al., 2008</xref>
; <xref rid="B52" ref-type="bibr">Moretti et al., 2010</xref>
). The relative amplitude of θ oscillations has been proposed as a marker for AD as it allows the correct classification of 85% of MCI subjects, distinguishing the ones who progress to clinically manifested AD from those who remain stable (<xref rid="B37" ref-type="bibr">Jelic et al., 2000</xref>
). Furthermore, increased θ power is already present in subjects with subjective complaints 7 years before decline to the MCI state (<xref rid="B58" ref-type="bibr">Prichep et al., 2006</xref>
).</p>
<p>However, differences in resting state EEG might not be specific to AD. Indeed, multiple types of dementia could also be characterized by similar global network alterations. As an example, an increase in relative θ power is also found in dementia with Lewy bodies (<xref rid="B38" ref-type="bibr">Kai et al., 2005</xref>
) and a decrease in relative γ power is also found in normal aging, after a brain injury or a stroke (<xref rid="B29" ref-type="bibr">Herrmann and Demiralp, 2005</xref>
).</p>
<p>Therefore, and to achieve higher specificity, it could be suitable to combine behavioral paradigms in real time with electrophysiological recordings. During behavioral tasks, memory-related activation reveals specific EEG functional differences between MCI patients and control ones that facilitates the early diagnostic of probable AD. As an example, haptic tasks are sensitive to early perceptive-cognitive and functional deficits in MCI patients. Indeed, during tactile tasks, θ-power over right occipital regions is a suitable marker to distinguish healthy subjects from MCI patients (<xref rid="B25" ref-type="bibr">Grunwald et al., 2002</xref>
). In addition, in a face-name encoding mnemonic task, the recording of EEG alterations is associated with the Mini-Mental State Examination and may serve as a clinically valuable marker for disease severity (<xref rid="B18" ref-type="bibr">Garn et al., 2014</xref>
).</p>
<p>However, multiple forms of memory are affected in AD (<xref rid="B13" ref-type="bibr">Didic et al., 2011</xref>
) and episodic memory impairment is not specific to AD but is also found in other types of dementia and psychiatric disorders. It was proposed that navigation deficits could help to distinguish patients at higher risk of developing AD from individuals with normal cognitive aging and those with other neurodegenerative diseases (<xref rid="B47" ref-type="bibr">Lithfous et al., 2013</xref>
). Indeed, spatial disorientation is already present at MCI and early AD stages. Specific spatial tasks in both virtual or real world paradigms may possibly predict the conversion from normal aging to MCI and from MCI to dementia (<xref rid="B39" ref-type="bibr">Kalová et al., 2005</xref>
; <xref rid="B44" ref-type="bibr">Laczó et al., 2011</xref>
; <xref rid="B76" ref-type="bibr">Weniger et al., 2011</xref>
; <xref rid="B51" ref-type="bibr">Moodley et al., 2015</xref>
). Spatial navigation depends on θ (<xref rid="B9" ref-type="bibr">Cornwell et al., 2008</xref>
; <xref rid="B36" ref-type="bibr">Jacobs et al., 2010</xref>
; <xref rid="B62" ref-type="bibr">Snider et al., 2013</xref>
) and γ (<xref rid="B54" ref-type="bibr">Park et al., 2014</xref>
) oscillations. Therefore, behavioral assessments of spatial memory processes combined with EEG techniques might represent a promising strategy for an early detection of preclinical AD with a high specificity.</p>
</sec>
<sec><title>Oscillatory Activity in Animal Models of AD</title>
<p>In spite of the considerable restriction that few spontaneous animal models recapitulate the entire spectrum of the sporadic form of AD (<xref rid="B65" ref-type="bibr">Strittmatter et al., 1993</xref>
; <xref rid="B19" ref-type="bibr">Giannakopoulos et al., 1997</xref>
; <xref rid="B34" ref-type="bibr">Inestrosa et al., 2005</xref>
; <xref rid="B3" ref-type="bibr">Bons et al., 2006</xref>
; <xref rid="B68" ref-type="bibr">Toledano et al., 2014</xref>
; <xref rid="B63" ref-type="bibr">Stefanova et al., 2014</xref>
, <xref rid="B64" ref-type="bibr">2015</xref>
), parallel research on animals has provided an essential contribution in understanding the mechanisms underlying abnormal oscillatory patterns in AD.</p>
<p>Hippocampal slices preparations from rodents and transgenic mice models of AD constitutes a useful tool for investigating mammalian synaptic alterations during amyloid pathology (<xref rid="B48" ref-type="bibr">Mathis et al., 2011</xref>
; <xref rid="B28" ref-type="bibr">Hazra et al., 2013</xref>
). However, spontaneous oscillations are not present in hippocampal slices. Indeed, hippocampal oscillatory activity is the product of multiple intra- and extra-hippocampal oscillators (the hippocampus and the medial septum for θ oscillations; <xref rid="B4" ref-type="bibr">Borisyuk et al., 1999</xref>
; <xref rid="B12" ref-type="bibr">Denham and Borisyuk, 2000</xref>
; <xref rid="B75" ref-type="bibr">Wang, 2002</xref>
; <xref rid="B23" ref-type="bibr">Goutagny et al., 2009</xref>
) and an intra-hippocampal excitation/inhibition loop, together with inputs from the entorhinal cortex for γ rhythms (<xref rid="B6" ref-type="bibr">Bragin et al., 1995</xref>
). The study of hippocampal oscillations in slices requires the application of a cholinergic or glutamatergic (kainate receptor) agonist to increase cellular excitability. With such a type of approach, it was shown that application of Aβ<sub>1-42</sub>
reduced the power of kainate-induced γ oscillations in mice (<xref rid="B43" ref-type="bibr">Kurudenkandy et al., 2014</xref>
). However, the utility of these models must be considered in light of how well they mimic the actual phenomenon. A bath application of carbachol to hippocampal slices can generate either θ or γ rhythms depending on experimental parameters such as: slice orientation, thickness, drug concentration, and temperature (<xref rid="B41" ref-type="bibr">Konopacki et al., 1987</xref>
; <xref rid="B16" ref-type="bibr">Fisahn et al., 1998</xref>
; <xref rid="B15" ref-type="bibr">Fellous and Sejnowski, 2000</xref>
). However, there is no evidence that in freely moving animals θ and γ rhythms require cholinergic neurotransmission. Another popular model of hippocampal γ rhythms uses kainite receptor activation (<xref rid="B71" ref-type="bibr">Traub et al., 2005</xref>
). Once again, although robust γ can be observed in hippocampal preparations, it does not appear as though <italic>in vivo</italic>
γ rhythms are mediated by kainate receptors. Only one report has generated a model of simultaneous θ and γ rhythms in the presence of kainic acid (<xref rid="B21" ref-type="bibr">Gloveli et al., 2005</xref>
) which required a unique hippocampal slice containing transverse and longitudinal circuitries. The recent development of a new <italic>in vitro</italic>
preparation, which respects the complex three-dimensional organization of intrinsic hippocampal circuits, has circumvented most of the issues aforementioned. Using this preparation, it is possible to characterize spontaneously occurring θ (<xref rid="B23" ref-type="bibr">Goutagny et al., 2009</xref>
) and γ (<xref rid="B35" ref-type="bibr">Jackson et al., 2011</xref>
) oscillations. In a transgenic mouse model of AD, the TgCRND8 mice, hippocampal θ-γ uncoupling was shown to precede soluble Aβ and plaque accumulation (<xref rid="B22" ref-type="bibr">Goutagny et al., 2013</xref>
).</p>
<p>Oscillatory activities can also be measured in anesthetized animals (<xref rid="B80" ref-type="bibr">Xu et al., 2015</xref>
). In this paradigm, θ oscillations can be recorded under urethane anesthesia either spontaneously or after sensory stimulation (tail or paw pinches) or electric stimulation of the brainstem <italic>nucleus pontis oralis</italic>
(<xref rid="B2" ref-type="bibr">Bland and Whishaw, 1976</xref>
). With this approach, it was shown that APP/PS1 transgenic mice showed an age-dependent decrease in hippocampal θ activity correlating with plaque load (<xref rid="B61" ref-type="bibr">Scott et al., 2012</xref>
). However, under urethane anesthesia, θ oscillations are exclusively of type II (atropine-sensitive) and no type I θ (atropine-resistant) is present (<xref rid="B42" ref-type="bibr">Kramis et al., 1975</xref>
). Therefore, in order to fully capture possible alterations in hippocampal oscillatory activity in animal models of AD, recordings in freely moving animals are required.</p>
<p>Many cognitive paradigms used in MCI and early AD diagnoses are based on verbal episodic memory tasks that present a translational problem for animal studies. Indeed, episodic memory, which is characterized by conscious recollection of context-rich events, is rather difficult to probe in animals. Several episodic-memory-like paradigms are currently being developed in rodents and apes but their extrapolation and dependence on a similar set of temporal lobe structures than human episodic memory still need to be confirmed. Fortunately, nature knows best, the hippocampus and the parahippocampal formation, responsible for episodic memory in humans, seem to have anatomical and functional homologs across mammal species. As an example, these brain regions are implicated in the encoding and retrieval of information related to environment during spatial navigation in rodents (<xref rid="B50" ref-type="bibr">Molter et al., 2012</xref>
). In a recent study, rhesus monkeys learned how to freely drive a wheelchair to navigate through a complex maze, providing a strong support for an electrophysiological investigation of spatial navigation in the real world (<xref rid="B14" ref-type="bibr">Etienne et al., 2014</xref>
). In rodents as in humans, spatial representations are related to modulation of θ oscillations as well as θ-γ coupling (<xref rid="B33" ref-type="bibr">Huxter et al., 2003</xref>
; <xref rid="B5" ref-type="bibr">Bott et al., 2015</xref>
). Interestingly, in a transgenic mouse model of AD, the Tg5xFAD mice, a decrease of θ and γ frequencies precedes disturbances in learning performances in a navigation task (<xref rid="B60" ref-type="bibr">Schneider et al., 2014</xref>
).</p>
</sec>
<sec><title>Conclusion</title>
<p>To conclude, with the support of the previously described results obtained both on animal models and patients, we propose that CFC alterations might constitute a promising early biomarker of AD. Indeed, modifications in hippocampal θ-γ coupling during spatial navigation might occur in the very first stages of AD and serve as a possible predictor for the pathology (<xref rid="B24" ref-type="bibr">Goutagny and Krantic, 2013</xref>
). Future research aimed at identifying biomarkers based on combined EEG and behavioral testing approaches should integrate the fact that spatial navigation memory tasks used to diagnose AD in patients can be transposed to animals. In this way, animal studies leave the door open on diagnostic and therapeutic pathways that could be transposable in patients. Moreover, independently of progress made on earlier disease targets, it may be assumed that patients diagnosed at the most precocious stage of the pathology still have enough brain plasticity resources to sustain effective responses to therapeutic interventions, including environmental enrichment (<xref rid="B74" ref-type="bibr">Verret et al., 2013</xref>
; <xref rid="B81" ref-type="bibr">Yeung et al., 2015</xref>
), to stop the progression of AD or even reverse it.</p>
</sec>
<sec><title>Author Contributions</title>
<p>VH and RG wrote the review. CM provided critical inputs. CH and JC helped to correct the manuscript.</p>
</sec>
<sec><title>Conflict of Interest Statement</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
</body>
<back><ack><p>This work was supported by the University of Strasbourg, the Centre National de la Recherche Scientifique (CNRS) and by grants from the Fondation Fyssen, the European Research Executive Agency, the NARSAD young investigator award and Neurex.</p>
</ack>
<ref-list><title>References</title>
<ref id="B1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Axmacher</surname>
<given-names>N.</given-names>
</name>
<name><surname>Henseler</surname>
<given-names>M. M.</given-names>
</name>
<name><surname>Jensen</surname>
<given-names>O.</given-names>
</name>
<name><surname>Weinreich</surname>
<given-names>I.</given-names>
</name>
<name><surname>Elger</surname>
<given-names>C. E.</given-names>
</name>
<name><surname>Fell</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Cross-frequency coupling supports multi-item working memory in the human hippocampus.</article-title>
<source><italic>Proc. Natl. Acad. Sci. U.S.A.</italic>
</source>
<volume>107</volume>
<fpage>3228</fpage>
–<lpage>3233</lpage>
. <pub-id pub-id-type="doi">10.1073/pnas.0911531107</pub-id>
<pub-id pub-id-type="pmid">20133762</pub-id>
</mixed-citation>
</ref>
<ref id="B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bland</surname>
<given-names>B. H.</given-names>
</name>
<name><surname>Whishaw</surname>
<given-names>I. Q.</given-names>
</name>
</person-group>
(<year>1976</year>
). <article-title>Generators and topography of hippocampal theta (RSA) in the anaesthetized and freely moving rat.</article-title>
<source><italic>Brain Res.</italic>
</source>
<volume>118</volume>
<fpage>259</fpage>
–<lpage>280</lpage>
. <pub-id pub-id-type="doi">10.1016/0006-8993(76)90711-3</pub-id>
</mixed-citation>
</ref>
<ref id="B3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bons</surname>
<given-names>N.</given-names>
</name>
<name><surname>Rieger</surname>
<given-names>F.</given-names>
</name>
<name><surname>Prudhomme</surname>
<given-names>D.</given-names>
</name>
<name><surname>Fisher</surname>
<given-names>A.</given-names>
</name>
<name><surname>Krause</surname>
<given-names>K.-H.</given-names>
</name>
</person-group>
(<year>2006</year>
). <article-title>Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer’s disease?</article-title>
<source><italic>Genes Brain Behav.</italic>
</source>
<volume>5</volume>
<fpage>120</fpage>
–<lpage>130</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1601-183X.2005.00149.x</pub-id>
<pub-id pub-id-type="pmid">16507003</pub-id>
</mixed-citation>
</ref>
<ref id="B4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Borisyuk</surname>
<given-names>R.</given-names>
</name>
<name><surname>Denham</surname>
<given-names>M.</given-names>
</name>
<name><surname>Denham</surname>
<given-names>S.</given-names>
</name>
<name><surname>Hoppensteadt</surname>
<given-names>F.</given-names>
</name>
</person-group>
(<year>1999</year>
). <article-title>Computational models of predictive and memory-related functions of the hippocampus.</article-title>
<source><italic>Rev. Neurosci.</italic>
</source>
<volume>10</volume>
<fpage>213</fpage>
–<lpage>232</lpage>
. <pub-id pub-id-type="doi">10.1515/REVNEURO.1999.10.3-4.213</pub-id>
</mixed-citation>
</ref>
<ref id="B5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bott</surname>
<given-names>J.-B.</given-names>
</name>
<name><surname>Muller</surname>
<given-names>M.-A.</given-names>
</name>
<name><surname>Jackson</surname>
<given-names>J.</given-names>
</name>
<name><surname>Aubert</surname>
<given-names>J.</given-names>
</name>
<name><surname>Cassel</surname>
<given-names>J.-C.</given-names>
</name>
<name><surname>Mathis</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>Spatial reference memory is associated with modulation of theta-gamma coupling in the dentate gyrus.</article-title>
<source><italic>Cereb. Cortex</italic>
</source>
<pub-id pub-id-type="doi">10.1093/cercor/bhv177</pub-id>
<comment>[Epub ahead of print]</comment>
.</mixed-citation>
</ref>
<ref id="B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bragin</surname>
<given-names>A.</given-names>
</name>
<name><surname>Jandó</surname>
<given-names>G.</given-names>
</name>
<name><surname>Nádasdy</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Hetke</surname>
<given-names>J.</given-names>
</name>
<name><surname>Wise</surname>
<given-names>K.</given-names>
</name>
<name><surname>Buzsáki</surname>
<given-names>G.</given-names>
</name>
</person-group>
(<year>1995</year>
). <article-title>Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>15</volume>
<fpage>47</fpage>
–<lpage>60</lpage>
.</mixed-citation>
</ref>
<ref id="B7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Canolty</surname>
<given-names>R. T.</given-names>
</name>
<name><surname>Edwards</surname>
<given-names>E.</given-names>
</name>
<name><surname>Dalal</surname>
<given-names>S. S.</given-names>
</name>
<name><surname>Soltani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Nagarajan</surname>
<given-names>S. S.</given-names>
</name>
<name><surname>Kirsch</surname>
<given-names>H. E.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2006</year>
). <article-title>High gamma power is phase-locked to theta oscillations in human neocortex.</article-title>
<source><italic>Science</italic>
</source>
<volume>313</volume>
<fpage>1626</fpage>
–<lpage>1628</lpage>
. <pub-id pub-id-type="doi">10.1126/science.1128115</pub-id>
<pub-id pub-id-type="pmid">16973878</pub-id>
</mixed-citation>
</ref>
<ref id="B8"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Canolty</surname>
<given-names>R. T.</given-names>
</name>
<name><surname>Ganguly</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kennerley</surname>
<given-names>S. W.</given-names>
</name>
<name><surname>Cadieu</surname>
<given-names>C. F.</given-names>
</name>
<name><surname>Koepsell</surname>
<given-names>K.</given-names>
</name>
<name><surname>Wallis</surname>
<given-names>J. D.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2010</year>
). <article-title>Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies.</article-title>
<source><italic>Proc. Natl. Acad. Sci. U.S.A.</italic>
</source>
<volume>107</volume>
<fpage>17356</fpage>
–<lpage>17361</lpage>
. <pub-id pub-id-type="doi">10.1073/pnas.1008306107</pub-id>
<pub-id pub-id-type="pmid">20855620</pub-id>
</mixed-citation>
</ref>
<ref id="B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cornwell</surname>
<given-names>B. R.</given-names>
</name>
<name><surname>Johnson</surname>
<given-names>L. L.</given-names>
</name>
<name><surname>Holroyd</surname>
<given-names>T.</given-names>
</name>
<name><surname>Carver</surname>
<given-names>F. W.</given-names>
</name>
<name><surname>Grillon</surname>
<given-names>C.</given-names>
</name>
</person-group>
(<year>2008</year>
). <article-title>Human hippocampal and parahippocampal theta (θ) during goal-directed spatial navigation predicts performance on a virtual Morris water maze.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>28</volume>
<fpage>5983</fpage>
–<lpage>5990</lpage>
. <pub-id pub-id-type="doi">10.1523/JNEUROSCI.5001-07.2008</pub-id>
<pub-id pub-id-type="pmid">18524903</pub-id>
</mixed-citation>
</ref>
<ref id="B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Czigler</surname>
<given-names>B.</given-names>
</name>
<name><surname>Csikós</surname>
<given-names>D.</given-names>
</name>
<name><surname>Hidasi</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Anna Gaál</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Csibri</surname>
<given-names>E.</given-names>
</name>
<name><surname>Kiss</surname>
<given-names>E.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2008</year>
). <article-title>Quantitative EEG in early Alzheimer’s disease patients – power spectrum and complexity features.</article-title>
<source><italic>Int. J. Psychophysiol.</italic>
</source>
<volume>68</volume>
<fpage>75</fpage>
–<lpage>80</lpage>
. <pub-id pub-id-type="doi">10.1016/j.ijpsycho.2007.11.002</pub-id>
<pub-id pub-id-type="pmid">18093675</pub-id>
</mixed-citation>
</ref>
<ref id="B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Debener</surname>
<given-names>S.</given-names>
</name>
<name><surname>Herrmann</surname>
<given-names>C. S.</given-names>
</name>
<name><surname>Kranczioch</surname>
<given-names>C.</given-names>
</name>
<name><surname>Gembris</surname>
<given-names>D.</given-names>
</name>
<name><surname>Engel</surname>
<given-names>A. K.</given-names>
</name>
</person-group>
(<year>2003</year>
). <article-title>Top-down attentional processing enhances auditory evoked gamma band activity.</article-title>
<source><italic>Neuroreport</italic>
</source>
<volume>14</volume>
<fpage>683</fpage>
–<lpage>686</lpage>
. <pub-id pub-id-type="doi">10.1097/01.wnr.0000064987.96259.5c</pub-id>
<pub-id pub-id-type="pmid">12692463</pub-id>
</mixed-citation>
</ref>
<ref id="B12"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Denham</surname>
<given-names>M. J.</given-names>
</name>
<name><surname>Borisyuk</surname>
<given-names>R. M.</given-names>
</name>
</person-group>
(<year>2000</year>
). <article-title>A model of theta rhythm production in the septal-hippocampal system and its modulation by ascending brain stem pathways.</article-title>
<source><italic>Hippocampus</italic>
</source>
<volume>10</volume>
<fpage>698</fpage>
–<lpage>716</lpage>
. <pub-id pub-id-type="doi">10.1002/1098-1063(2000)10:6<698::AID-HIPO1008>3.0.CO;2-Z</pub-id>
<pub-id pub-id-type="pmid">11153716</pub-id>
</mixed-citation>
</ref>
<ref id="B13"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Didic</surname>
<given-names>M.</given-names>
</name>
<name><surname>Barbeau</surname>
<given-names>E. J.</given-names>
</name>
<name><surname>Felician</surname>
<given-names>O.</given-names>
</name>
<name><surname>Tramoni</surname>
<given-names>E.</given-names>
</name>
<name><surname>Guedj</surname>
<given-names>E.</given-names>
</name>
<name><surname>Poncet</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2011</year>
). <article-title>Which memory system is impaired first in Alzheimer’s disease?</article-title>
<source><italic>J. Alzheimers Dis.</italic>
</source>
<volume>27</volume>
<fpage>11</fpage>
–<lpage>22</lpage>
. <pub-id pub-id-type="doi">10.3233/JAD-2011-110557</pub-id>
<pub-id pub-id-type="pmid">21799246</pub-id>
</mixed-citation>
</ref>
<ref id="B14"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Etienne</surname>
<given-names>S.</given-names>
</name>
<name><surname>Guthrie</surname>
<given-names>M.</given-names>
</name>
<name><surname>Goillandeau</surname>
<given-names>M.</given-names>
</name>
<name><surname>Nguyen</surname>
<given-names>T. H.</given-names>
</name>
<name><surname>Orignac</surname>
<given-names>H.</given-names>
</name>
<name><surname>Gross</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Easy rider: monkeys learn to drive a wheelchair to navigate through a complex maze.</article-title>
<source><italic>PLoS ONE</italic>
</source>
<volume>9</volume>
:<issue>e96275</issue>
<pub-id pub-id-type="doi">10.1371/journal.pone.0096275</pub-id>
</mixed-citation>
</ref>
<ref id="B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fellous</surname>
<given-names>J. M.</given-names>
</name>
<name><surname>Sejnowski</surname>
<given-names>T. J.</given-names>
</name>
</person-group>
(<year>2000</year>
). <article-title>Cholinergic induction of oscillations in the hippocampal slice in the slow (0.5-2 Hz), theta (5-12 Hz), and gamma (35-70 Hz) bands.</article-title>
<source><italic>Hippocampus</italic>
</source>
<volume>10</volume>
<fpage>187</fpage>
–<lpage>197</lpage>
. <pub-id pub-id-type="doi">10.1002/(SICI)1098-1063(2000)10:2<187::AID-HIPO8>3.0.CO;2-M</pub-id>
<pub-id pub-id-type="pmid">10791841</pub-id>
</mixed-citation>
</ref>
<ref id="B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fisahn</surname>
<given-names>A.</given-names>
</name>
<name><surname>Pike</surname>
<given-names>F. G.</given-names>
</name>
<name><surname>Buhl</surname>
<given-names>E. H.</given-names>
</name>
<name><surname>Paulsen</surname>
<given-names>O.</given-names>
</name>
</person-group>
(<year>1998</year>
). <article-title>Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro.</article-title>
<source><italic>Nature</italic>
</source>
<volume>394</volume>
<fpage>186</fpage>
–<lpage>189</lpage>
. <pub-id pub-id-type="doi">10.1038/28179</pub-id>
<pub-id pub-id-type="pmid">9671302</pub-id>
</mixed-citation>
</ref>
<ref id="B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fries</surname>
<given-names>P.</given-names>
</name>
<name><surname>Reynolds</surname>
<given-names>J. H.</given-names>
</name>
<name><surname>Rorie</surname>
<given-names>A. E.</given-names>
</name>
<name><surname>Desimone</surname>
<given-names>R.</given-names>
</name>
</person-group>
(<year>2001</year>
). <article-title>Modulation of oscillatory neuronal synchronization by selective visual attention.</article-title>
<source><italic>Science</italic>
</source>
<volume>291</volume>
<fpage>1560</fpage>
–<lpage>1563</lpage>
. <pub-id pub-id-type="doi">10.1126/science.291.5508.1560</pub-id>
<pub-id pub-id-type="pmid">11222864</pub-id>
</mixed-citation>
</ref>
<ref id="B18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garn</surname>
<given-names>H.</given-names>
</name>
<name><surname>Waser</surname>
<given-names>M.</given-names>
</name>
<name><surname>Deistler</surname>
<given-names>M.</given-names>
</name>
<name><surname>Schmidt</surname>
<given-names>R.</given-names>
</name>
<name><surname>Dal-Bianco</surname>
<given-names>P.</given-names>
</name>
<name><surname>Ransmayr</surname>
<given-names>G.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Quantitative EEG in Alzheimer’s disease: cognitive state, resting state and association with disease severity.</article-title>
<source><italic>Int. J. Psychophysiol.</italic>
</source>
<volume>93</volume>
<fpage>390</fpage>
–<lpage>397</lpage>
. <pub-id pub-id-type="doi">10.1016/j.ijpsycho.2014.06.003</pub-id>
<pub-id pub-id-type="pmid">24933410</pub-id>
</mixed-citation>
</ref>
<ref id="B19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Giannakopoulos</surname>
<given-names>P.</given-names>
</name>
<name><surname>Silhol</surname>
<given-names>S.</given-names>
</name>
<name><surname>Jallageas</surname>
<given-names>V.</given-names>
</name>
<name><surname>Mallet</surname>
<given-names>J.</given-names>
</name>
<name><surname>Bons</surname>
<given-names>N.</given-names>
</name>
<name><surname>Bouras</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
(<year>1997</year>
). <article-title>Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, <italic>Microcebus murinus</italic>
.</article-title>
<source><italic>Acta Neuropathol. (Berl.)</italic>
</source>
<volume>94</volume>
<fpage>131</fpage>
–<lpage>139</lpage>
. <pub-id pub-id-type="doi">10.1007/s004010050684</pub-id>
</mixed-citation>
</ref>
<ref id="B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gianotti</surname>
<given-names>L. R. R.</given-names>
</name>
<name><surname>Künig</surname>
<given-names>G.</given-names>
</name>
<name><surname>Lehmann</surname>
<given-names>D.</given-names>
</name>
<name><surname>Faber</surname>
<given-names>P. L.</given-names>
</name>
<name><surname>Pascual-Marqui</surname>
<given-names>R. D.</given-names>
</name>
<name><surname>Kochi</surname>
<given-names>K.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2007</year>
). <article-title>Correlation between disease severity and brain electric LORETA tomography in Alzheimer’s disease.</article-title>
<source><italic>Clin. Neurophysiol.</italic>
</source>
<volume>118</volume>
<fpage>186</fpage>
–<lpage>196</lpage>
. <pub-id pub-id-type="doi">10.1016/j.clinph.2006.09.007</pub-id>
</mixed-citation>
</ref>
<ref id="B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gloveli</surname>
<given-names>T.</given-names>
</name>
<name><surname>Dugladze</surname>
<given-names>T.</given-names>
</name>
<name><surname>Saha</surname>
<given-names>S.</given-names>
</name>
<name><surname>Monyer</surname>
<given-names>H.</given-names>
</name>
<name><surname>Heinemann</surname>
<given-names>U.</given-names>
</name>
<name><surname>Traub</surname>
<given-names>R. D.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2005</year>
). <article-title>Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro.</article-title>
<source><italic>J. Physiol.</italic>
</source>
<volume>562</volume>
<fpage>131</fpage>
–<lpage>147</lpage>
. <pub-id pub-id-type="doi">10.1113/jphysiol.2004.073007</pub-id>
</mixed-citation>
</ref>
<ref id="B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goutagny</surname>
<given-names>R.</given-names>
</name>
<name><surname>Gu</surname>
<given-names>N.</given-names>
</name>
<name><surname>Cavanagh</surname>
<given-names>C.</given-names>
</name>
<name><surname>Jackson</surname>
<given-names>J.</given-names>
</name>
<name><surname>Chabot</surname>
<given-names>J.-G.</given-names>
</name>
<name><surname>Quirion</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2013</year>
). <article-title>Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer’s disease.</article-title>
<source><italic>Eur. J. Neurosci.</italic>
</source>
<volume>37</volume>
<fpage>1896</fpage>
–<lpage>1902</lpage>
. <pub-id pub-id-type="doi">10.1111/ejn.12233</pub-id>
</mixed-citation>
</ref>
<ref id="B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goutagny</surname>
<given-names>R.</given-names>
</name>
<name><surname>Jackson</surname>
<given-names>J.</given-names>
</name>
<name><surname>Williams</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2009</year>
). <article-title>Self-generated theta oscillations in the hippocampus.</article-title>
<source><italic>Nat. Neurosci.</italic>
</source>
<volume>12</volume>
<fpage>1491</fpage>
–<lpage>1493</lpage>
. <pub-id pub-id-type="doi">10.1038/nn.2440</pub-id>
<pub-id pub-id-type="pmid">19881503</pub-id>
</mixed-citation>
</ref>
<ref id="B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goutagny</surname>
<given-names>R.</given-names>
</name>
<name><surname>Krantic</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Hippocampal oscillatory activity in Alzheimer’s disease: toward the identification of early biomarkers?</article-title>
<source><italic>Aging Dis.</italic>
</source>
<volume>4</volume>
<fpage>134</fpage>
–<lpage>140</lpage>
.</mixed-citation>
</ref>
<ref id="B25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grunwald</surname>
<given-names>M.</given-names>
</name>
<name><surname>Busse</surname>
<given-names>F.</given-names>
</name>
<name><surname>Hensel</surname>
<given-names>A.</given-names>
</name>
<name><surname>Riedel-Heller</surname>
<given-names>S.</given-names>
</name>
<name><surname>Kruggel</surname>
<given-names>F.</given-names>
</name>
<name><surname>Arendt</surname>
<given-names>T.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2002</year>
). <article-title>Theta-power differences in patients with mild cognitive impairment under rest condition and during haptic tasks.</article-title>
<source><italic>Alzheimer Dis. Assoc. Disord.</italic>
</source>
<volume>16</volume>
<fpage>40</fpage>
–<lpage>48</lpage>
. <pub-id pub-id-type="doi">10.1097/00002093-200201000-00006</pub-id>
<pub-id pub-id-type="pmid">11882748</pub-id>
</mixed-citation>
</ref>
<ref id="B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Händel</surname>
<given-names>B.</given-names>
</name>
<name><surname>Haarmeier</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>2009</year>
). <article-title>Cross-frequency coupling of brain oscillations indicates the success in visual motion discrimination.</article-title>
<source><italic>Neuroimage</italic>
</source>
<volume>45</volume>
<fpage>1040</fpage>
–<lpage>1046</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neuroimage.2008.12.013</pub-id>
</mixed-citation>
</ref>
<ref id="B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hardy</surname>
<given-names>J.</given-names>
</name>
<name><surname>Selkoe</surname>
<given-names>D. J.</given-names>
</name>
</person-group>
(<year>2002</year>
). <article-title>The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics.</article-title>
<source><italic>Science</italic>
</source>
<volume>297</volume>
<fpage>353</fpage>
–<lpage>356</lpage>
. <pub-id pub-id-type="doi">10.1126/science.1072994</pub-id>
</mixed-citation>
</ref>
<ref id="B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hazra</surname>
<given-names>A.</given-names>
</name>
<name><surname>Gu</surname>
<given-names>F.</given-names>
</name>
<name><surname>Aulakh</surname>
<given-names>A.</given-names>
</name>
<name><surname>Berridge</surname>
<given-names>C.</given-names>
</name>
<name><surname>Eriksen</surname>
<given-names>J. L.</given-names>
</name>
<name><surname>Ziburkus</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer’s disease.</article-title>
<source><italic>PLoS ONE</italic>
</source>
<volume>8</volume>
:<issue>e64318</issue>
<pub-id pub-id-type="doi">10.1371/journal.pone.0064318</pub-id>
</mixed-citation>
</ref>
<ref id="B29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herrmann</surname>
<given-names>C. S.</given-names>
</name>
<name><surname>Demiralp</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Human EEG gamma oscillations in neuropsychiatric disorders.</article-title>
<source><italic>Clin. Neurophysiol.</italic>
</source>
<volume>116</volume>
<fpage>2719</fpage>
–<lpage>2733</lpage>
. <pub-id pub-id-type="doi">10.1016/j.clinph.2005.07.007</pub-id>
</mixed-citation>
</ref>
<ref id="B30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herrmann</surname>
<given-names>C. S.</given-names>
</name>
<name><surname>Lenz</surname>
<given-names>D.</given-names>
</name>
<name><surname>Junge</surname>
<given-names>S.</given-names>
</name>
<name><surname>Busch</surname>
<given-names>N. A.</given-names>
</name>
<name><surname>Maess</surname>
<given-names>B.</given-names>
</name>
</person-group>
(<year>2004a</year>
). <article-title>Memory-matches evoke human gamma-responses.</article-title>
<source><italic>BMC Neurosci.</italic>
</source>
<volume>5</volume>
:<issue>13</issue>
<pub-id pub-id-type="doi">10.1186/1471-2202-5-13</pub-id>
</mixed-citation>
</ref>
<ref id="B31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herrmann</surname>
<given-names>C. S.</given-names>
</name>
<name><surname>Munk</surname>
<given-names>M. H. J.</given-names>
</name>
<name><surname>Engel</surname>
<given-names>A. K.</given-names>
</name>
</person-group>
(<year>2004b</year>
). <article-title>Cognitive functions of gamma-band activity: memory match and utilization.</article-title>
<source><italic>Trends Cogn. Sci.</italic>
</source>
<volume>8</volume>
<fpage>347</fpage>
–<lpage>355</lpage>
. <pub-id pub-id-type="doi">10.1016/j.tics.2004.06.006</pub-id>
</mixed-citation>
</ref>
<ref id="B32"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Herrmann</surname>
<given-names>C. S.</given-names>
</name>
<name><surname>Mecklinger</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2000</year>
). <article-title>Magnetoencephalographic responses to illusory figures: early evoked gamma is affected by processing of stimulus features.</article-title>
<source><italic>Int. J. Psychophysiol.</italic>
</source>
<volume>38</volume>
<fpage>265</fpage>
–<lpage>281</lpage>
. <pub-id pub-id-type="doi">10.1016/S0167-8760(00)00170-7</pub-id>
</mixed-citation>
</ref>
<ref id="B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huxter</surname>
<given-names>J.</given-names>
</name>
<name><surname>Burgess</surname>
<given-names>N.</given-names>
</name>
<name><surname>O’Keefe</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2003</year>
). <article-title>Independent rate and temporal coding in hippocampal pyramidal cells.</article-title>
<source><italic>Nature</italic>
</source>
<volume>425</volume>
<fpage>828</fpage>
–<lpage>832</lpage>
. <pub-id pub-id-type="doi">10.1038/nature02058</pub-id>
<pub-id pub-id-type="pmid">14574410</pub-id>
</mixed-citation>
</ref>
<ref id="B34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Inestrosa</surname>
<given-names>N. C.</given-names>
</name>
<name><surname>Reyes</surname>
<given-names>A. E.</given-names>
</name>
<name><surname>Chacón</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Cerpa</surname>
<given-names>W.</given-names>
</name>
<name><surname>Villalón</surname>
<given-names>A.</given-names>
</name>
<name><surname>Montiel</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2005</year>
). <article-title>Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type <italic>Octodon degu</italic>
.</article-title>
<source><italic>Neurobiol. Aging</italic>
</source>
<volume>26</volume>
<fpage>1023</fpage>
–<lpage>1028</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2004.09.016</pub-id>
</mixed-citation>
</ref>
<ref id="B35"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jackson</surname>
<given-names>J.</given-names>
</name>
<name><surname>Goutagny</surname>
<given-names>R.</given-names>
</name>
<name><surname>Williams</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Fast and slow γ rhythms are intrinsically and independently generated in the subiculum.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>31</volume>
<fpage>12104</fpage>
–<lpage>12117</lpage>
. <pub-id pub-id-type="doi">10.1523/JNEUROSCI.1370-11.2011</pub-id>
<pub-id pub-id-type="pmid">21865453</pub-id>
</mixed-citation>
</ref>
<ref id="B36"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jacobs</surname>
<given-names>J.</given-names>
</name>
<name><surname>Korolev</surname>
<given-names>I. O.</given-names>
</name>
<name><surname>Caplan</surname>
<given-names>J. B.</given-names>
</name>
<name><surname>Ekstrom</surname>
<given-names>A. D.</given-names>
</name>
<name><surname>Litt</surname>
<given-names>B.</given-names>
</name>
<name><surname>Baltuch</surname>
<given-names>G.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2010</year>
). <article-title>Right-lateralized brain oscillations in human spatial navigation.</article-title>
<source><italic>J. Cogn. Neurosci.</italic>
</source>
<volume>22</volume>
<fpage>824</fpage>
–<lpage>836</lpage>
. <pub-id pub-id-type="doi">10.1162/jocn.2009.21240</pub-id>
<pub-id pub-id-type="pmid">19400683</pub-id>
</mixed-citation>
</ref>
<ref id="B37"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jelic</surname>
<given-names>V.</given-names>
</name>
<name><surname>Johansson</surname>
<given-names>S. E.</given-names>
</name>
<name><surname>Almkvist</surname>
<given-names>O.</given-names>
</name>
<name><surname>Shigeta</surname>
<given-names>M.</given-names>
</name>
<name><surname>Julin</surname>
<given-names>P.</given-names>
</name>
<name><surname>Nordberg</surname>
<given-names>A.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2000</year>
). <article-title>Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer’s disease.</article-title>
<source><italic>Neurobiol. Aging</italic>
</source>
<volume>21</volume>
<fpage>533</fpage>
–<lpage>540</lpage>
. <pub-id pub-id-type="doi">10.1016/S0197-4580(00)00153-6</pub-id>
<pub-id pub-id-type="pmid">10924766</pub-id>
</mixed-citation>
</ref>
<ref id="B38"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Asai</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Sakuma</surname>
<given-names>K.</given-names>
</name>
<name><surname>Koeda</surname>
<given-names>T.</given-names>
</name>
<name><surname>Nakashima</surname>
<given-names>K.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Quantitative electroencephalogram analysis in dementia with Lewy bodies and Alzheimer’s disease.</article-title>
<source><italic>J. Neurol. Sci.</italic>
</source>
<volume>237</volume>
<fpage>89</fpage>
–<lpage>95</lpage>
. <pub-id pub-id-type="doi">10.1016/j.jns.2005.05.017</pub-id>
<pub-id pub-id-type="pmid">16019033</pub-id>
</mixed-citation>
</ref>
<ref id="B39"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalová</surname>
<given-names>E.</given-names>
</name>
<name><surname>Vlcek</surname>
<given-names>K.</given-names>
</name>
<name><surname>Jarolímová</surname>
<given-names>E.</given-names>
</name>
<name><surname>Bures</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer’s disease: corresponding results in real space tests and computer tests.</article-title>
<source><italic>Behav. Brain Res.</italic>
</source>
<volume>159</volume>
<fpage>175</fpage>
–<lpage>186</lpage>
. <pub-id pub-id-type="doi">10.1016/j.bbr.2004.10.016</pub-id>
<pub-id pub-id-type="pmid">15817181</pub-id>
</mixed-citation>
</ref>
<ref id="B40"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Klimesch</surname>
<given-names>W.</given-names>
</name>
</person-group>
(<year>2012</year>
). <article-title>α-band oscillations, attention, and controlled access to stored information.</article-title>
<source><italic>Trends Cogn. Sci.</italic>
</source>
<volume>16</volume>
<fpage>606</fpage>
–<lpage>617</lpage>
. <pub-id pub-id-type="doi">10.1016/j.tics.2012.10.007</pub-id>
<pub-id pub-id-type="pmid">23141428</pub-id>
</mixed-citation>
</ref>
<ref id="B41"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Konopacki</surname>
<given-names>J.</given-names>
</name>
<name><surname>MacIver</surname>
<given-names>M. B.</given-names>
</name>
<name><surname>Bland</surname>
<given-names>B. H.</given-names>
</name>
<name><surname>Roth</surname>
<given-names>S. H.</given-names>
</name>
</person-group>
(<year>1987</year>
). <article-title>Carbachol-induced EEG “theta” activity in hippocampal brain slices.</article-title>
<source><italic>Brain Res.</italic>
</source>
<volume>405</volume>
<fpage>196</fpage>
–<lpage>198</lpage>
. <pub-id pub-id-type="doi">10.1016/0006-8993(87)91009-2</pub-id>
<pub-id pub-id-type="pmid">3567594</pub-id>
</mixed-citation>
</ref>
<ref id="B42"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kramis</surname>
<given-names>R.</given-names>
</name>
<name><surname>Vanderwolf</surname>
<given-names>C. H.</given-names>
</name>
<name><surname>Bland</surname>
<given-names>B. H.</given-names>
</name>
</person-group>
(<year>1975</year>
). <article-title>Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital.</article-title>
<source><italic>Exp. Neurol.</italic>
</source>
<volume>49</volume>
<fpage>58</fpage>
–<lpage>85</lpage>
. <pub-id pub-id-type="doi">10.1016/0014-4886(75)90195-8</pub-id>
<pub-id pub-id-type="pmid">1183532</pub-id>
</mixed-citation>
</ref>
<ref id="B43"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kurudenkandy</surname>
<given-names>F. R.</given-names>
</name>
<name><surname>Zilberter</surname>
<given-names>M.</given-names>
</name>
<name><surname>Biverstål</surname>
<given-names>H.</given-names>
</name>
<name><surname>Presto</surname>
<given-names>J.</given-names>
</name>
<name><surname>Honcharenko</surname>
<given-names>D.</given-names>
</name>
<name><surname>Strömberg</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>34</volume>
<fpage>11416</fpage>
–<lpage>11425</lpage>
. <pub-id pub-id-type="doi">10.1523/JNEUROSCI.1195-14.2014</pub-id>
<pub-id pub-id-type="pmid">25143621</pub-id>
</mixed-citation>
</ref>
<ref id="B44"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Laczó</surname>
<given-names>J.</given-names>
</name>
<name><surname>Andel</surname>
<given-names>R.</given-names>
</name>
<name><surname>Vlček</surname>
<given-names>K.</given-names>
</name>
<name><surname>Macoška</surname>
<given-names>V.</given-names>
</name>
<name><surname>Vyhnálek</surname>
<given-names>M.</given-names>
</name>
<name><surname>Tolar</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2011</year>
). <article-title>Spatial navigation and APOE in amnestic mild cognitive impairment.</article-title>
<source><italic>Neurodegener. Dis.</italic>
</source>
<volume>8</volume>
<fpage>169</fpage>
–<lpage>177</lpage>
. <pub-id pub-id-type="doi">10.1159/000321581</pub-id>
<pub-id pub-id-type="pmid">21124005</pub-id>
</mixed-citation>
</ref>
<ref id="B45"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lahiri</surname>
<given-names>D. K.</given-names>
</name>
<name><surname>Kotwal</surname>
<given-names>G. J.</given-names>
</name>
<name><surname>Farlow</surname>
<given-names>M. R.</given-names>
</name>
<name><surname>Sima</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kupsky</surname>
<given-names>W.</given-names>
</name>
<name><surname>Sarkar</surname>
<given-names>F. H.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2002</year>
). <article-title>The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer’s disease.</article-title>
<source><italic>Ann. N. Y. Acad. Sci.</italic>
</source>
<volume>973</volume>
<fpage>334</fpage>
–<lpage>339</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1749-6632.2002.tb04661.x</pub-id>
</mixed-citation>
</ref>
<ref id="B46"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lauritzen</surname>
<given-names>I.</given-names>
</name>
<name><surname>Pardossi-Piquard</surname>
<given-names>R.</given-names>
</name>
<name><surname>Bauer</surname>
<given-names>C.</given-names>
</name>
<name><surname>Brigham</surname>
<given-names>E.</given-names>
</name>
<name><surname>Abraham</surname>
<given-names>J.-D.</given-names>
</name>
<name><surname>Ranaldi</surname>
<given-names>S.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2012</year>
). <article-title>The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>32</volume>
<fpage>16243</fpage>
–<lpage>16255</lpage>
. <pub-id pub-id-type="doi">10.1523/JNEUROSCI.2775-12.2012</pub-id>
</mixed-citation>
</ref>
<ref id="B47"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lithfous</surname>
<given-names>S.</given-names>
</name>
<name><surname>Dufour</surname>
<given-names>A.</given-names>
</name>
<name><surname>Després</surname>
<given-names>O.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Spatial navigation in normal aging and the prodromal stage of Alzheimer’s disease: insights from imaging and behavioral studies.</article-title>
<source><italic>Ageing Res. Rev.</italic>
</source>
<volume>12</volume>
<fpage>201</fpage>
–<lpage>213</lpage>
. <pub-id pub-id-type="doi">10.1016/j.arr.2012.04.007</pub-id>
</mixed-citation>
</ref>
<ref id="B48"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mathis</surname>
<given-names>D. M.</given-names>
</name>
<name><surname>Furman</surname>
<given-names>J. L.</given-names>
</name>
<name><surname>Norris</surname>
<given-names>C. M.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Preparation of acute hippocampal slices from rats and transgenic mice for the study of synaptic alterations during aging and amyloid pathology.</article-title>
<source><italic>J. Vis. Exp.</italic>
</source>
<volume>23</volume>
:<issue>pii</issue>
:2330. <pub-id pub-id-type="doi">10.3791/2330</pub-id>
</mixed-citation>
</ref>
<ref id="B49"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mikulca</surname>
<given-names>J. A.</given-names>
</name>
<name><surname>Nguyen</surname>
<given-names>V.</given-names>
</name>
<name><surname>Gajdosik</surname>
<given-names>D. A.</given-names>
</name>
<name><surname>Teklu</surname>
<given-names>S. G.</given-names>
</name>
<name><surname>Giunta</surname>
<given-names>E. A.</given-names>
</name>
<name><surname>Lessa</surname>
<given-names>E. A.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches.</article-title>
<source><italic>J. Clin. Pharm. Ther.</italic>
</source>
<volume>39</volume>
<fpage>25</fpage>
–<lpage>37</lpage>
. <pub-id pub-id-type="doi">10.1111/jcpt.12112</pub-id>
<pub-id pub-id-type="pmid">24313554</pub-id>
</mixed-citation>
</ref>
<ref id="B50"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Molter</surname>
<given-names>C.</given-names>
</name>
<name><surname>O’Neill</surname>
<given-names>J.</given-names>
</name>
<name><surname>Yamaguchi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Hirase</surname>
<given-names>H.</given-names>
</name>
<name><surname>Leinekugel</surname>
<given-names>X.</given-names>
</name>
</person-group>
(<year>2012</year>
). <article-title>Rhythmic modulation of θ oscillations supports encoding of spatial and behavioral information in the rat hippocampus.</article-title>
<source><italic>Neuron</italic>
</source>
<volume>75</volume>
<fpage>889</fpage>
–<lpage>903</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neuron.2012.06.036</pub-id>
<pub-id pub-id-type="pmid">22958828</pub-id>
</mixed-citation>
</ref>
<ref id="B51"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moodley</surname>
<given-names>K.</given-names>
</name>
<name><surname>Minati</surname>
<given-names>L.</given-names>
</name>
<name><surname>Contarino</surname>
<given-names>V.</given-names>
</name>
<name><surname>Prioni</surname>
<given-names>S.</given-names>
</name>
<name><surname>Wood</surname>
<given-names>R.</given-names>
</name>
<name><surname>Cooper</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>Diagnostic differentiation of mild cognitive impairment due to Alzheimer’s disease using a hippocampus-dependent test of spatial memory.</article-title>
<source><italic>Hippocampus</italic>
</source>
<volume>25</volume>
<fpage>939</fpage>
–<lpage>951</lpage>
. <pub-id pub-id-type="doi">10.1002/hipo.22417</pub-id>
<pub-id pub-id-type="pmid">25605659</pub-id>
</mixed-citation>
</ref>
<ref id="B52"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moretti</surname>
<given-names>D. V.</given-names>
</name>
<name><surname>Pievani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Geroldi</surname>
<given-names>C.</given-names>
</name>
<name><surname>Binetti</surname>
<given-names>G.</given-names>
</name>
<name><surname>Zanetti</surname>
<given-names>O.</given-names>
</name>
<name><surname>Rossini</surname>
<given-names>P. M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2010</year>
). <article-title>EEG markers discriminate among different subgroup of patients with mild cognitive impairment.</article-title>
<source><italic>Am. J. Alzheimers Dis. Other Demen.</italic>
</source>
<volume>25</volume>
<fpage>58</fpage>
–<lpage>73</lpage>
. <pub-id pub-id-type="doi">10.1177/1533317508329814</pub-id>
<pub-id pub-id-type="pmid">19204371</pub-id>
</mixed-citation>
</ref>
<ref id="B53"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Palop</surname>
<given-names>J. J.</given-names>
</name>
<name><surname>Mucke</surname>
<given-names>L.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Amyloid-β induced neuronal dysfunction in alzheimer’s disease: from synapses toward neural networks.</article-title>
<source><italic>Nat. Neurosci.</italic>
</source>
<volume>13</volume>
<fpage>812</fpage>
–<lpage>818</lpage>
. <pub-id pub-id-type="doi">10.1038/nn.2583</pub-id>
</mixed-citation>
</ref>
<ref id="B54"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>H.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>T.</given-names>
</name>
<name><surname>Park</surname>
<given-names>G. Y.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>E. M.</given-names>
</name>
<name><surname>Baek</surname>
<given-names>S.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Role of low- and high-frequency oscillations in the human hippocampus for encoding environmental novelty during a spatial navigation task.</article-title>
<source><italic>Hippocampus</italic>
</source>
<volume>24</volume>
<fpage>1341</fpage>
–<lpage>1352</lpage>
. <pub-id pub-id-type="doi">10.1002/hipo.22315</pub-id>
</mixed-citation>
</ref>
<ref id="B55"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pfurtscheller</surname>
<given-names>G.</given-names>
</name>
<name><surname>Zalaudek</surname>
<given-names>K.</given-names>
</name>
<name><surname>Neuper</surname>
<given-names>C.</given-names>
</name>
</person-group>
(<year>1998</year>
). <article-title>Event-related beta synchronization after wrist, finger and thumb movement.</article-title>
<source><italic>Electroencephalogr. Clin. Neurophysiol.</italic>
</source>
<volume>109</volume>
<fpage>154</fpage>
–<lpage>160</lpage>
. <pub-id pub-id-type="doi">10.1016/S0924-980X(97)00070-2</pub-id>
</mixed-citation>
</ref>
<ref id="B56"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pimplikar</surname>
<given-names>S. W.</given-names>
</name>
<name><surname>Nixon</surname>
<given-names>R. A.</given-names>
</name>
<name><surname>Robakis</surname>
<given-names>N. K.</given-names>
</name>
<name><surname>Shen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Tsai</surname>
<given-names>L.-H.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Amyloid-independent mechanisms in Alzheimer’s disease pathogenesis.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>30</volume>
<fpage>14946</fpage>
–<lpage>14954</lpage>
. <pub-id pub-id-type="doi">10.1523/JNEUROSCI.4305-10.2010</pub-id>
</mixed-citation>
</ref>
<ref id="B57"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Price</surname>
<given-names>D. L.</given-names>
</name>
<name><surname>Tanzi</surname>
<given-names>R. E.</given-names>
</name>
<name><surname>Borchelt</surname>
<given-names>D. R.</given-names>
</name>
<name><surname>Sisodia</surname>
<given-names>S. S.</given-names>
</name>
</person-group>
(<year>1998</year>
). <article-title>Alzheimer’s disease: genetic studies and transgenic models.</article-title>
<source><italic>Annu. Rev. Genet.</italic>
</source>
<volume>32</volume>
<fpage>461</fpage>
–<lpage>493</lpage>
. <pub-id pub-id-type="doi">10.1146/annurev.genet.32.1.461</pub-id>
</mixed-citation>
</ref>
<ref id="B58"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prichep</surname>
<given-names>L. S.</given-names>
</name>
<name><surname>John</surname>
<given-names>E. R.</given-names>
</name>
<name><surname>Ferris</surname>
<given-names>S. H.</given-names>
</name>
<name><surname>Rausch</surname>
<given-names>L.</given-names>
</name>
<name><surname>Fang</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Cancro</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2006</year>
). <article-title>Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging.</article-title>
<source><italic>Neurobiol. Aging</italic>
</source>
<volume>27</volume>
<fpage>471</fpage>
–<lpage>481</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2005.07.021</pub-id>
</mixed-citation>
</ref>
<ref id="B59"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sauseng</surname>
<given-names>P.</given-names>
</name>
<name><surname>Griesmayr</surname>
<given-names>B.</given-names>
</name>
<name><surname>Freunberger</surname>
<given-names>R.</given-names>
</name>
<name><surname>Klimesch</surname>
<given-names>W.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Control mechanisms in working memory: a possible function of EEG theta oscillations.</article-title>
<source><italic>Neurosci. Biobehav. Rev.</italic>
</source>
<volume>34</volume>
<fpage>1015</fpage>
–<lpage>1022</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neubiorev.2009.12.006</pub-id>
</mixed-citation>
</ref>
<ref id="B60"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schneider</surname>
<given-names>F.</given-names>
</name>
<name><surname>Baldauf</surname>
<given-names>K.</given-names>
</name>
<name><surname>Wetzel</surname>
<given-names>W.</given-names>
</name>
<name><surname>Reymann</surname>
<given-names>K. G.</given-names>
</name>
</person-group>
(<year>2014</year>
). <article-title>Behavioral and EEG changes in male 5xFAD mice.</article-title>
<source><italic>Physiol. Behav.</italic>
</source>
<volume>135</volume>
<fpage>25</fpage>
–<lpage>33</lpage>
. <pub-id pub-id-type="doi">10.1016/j.physbeh.2014.05.041</pub-id>
</mixed-citation>
</ref>
<ref id="B61"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scott</surname>
<given-names>L.</given-names>
</name>
<name><surname>Feng</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kiss</surname>
<given-names>T.</given-names>
</name>
<name><surname>Needle</surname>
<given-names>E.</given-names>
</name>
<name><surname>Atchison</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kawabe</surname>
<given-names>T. T.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2012</year>
). <article-title>Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice.</article-title>
<source><italic>Neurobiol. Aging</italic>
</source>
<volume>33</volume>
<issue>1481</issue>
<fpage>e13</fpage>
–<lpage>e23</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2011.12.010</pub-id>
<pub-id pub-id-type="pmid">22227005</pub-id>
</mixed-citation>
</ref>
<ref id="B62"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Snider</surname>
<given-names>J.</given-names>
</name>
<name><surname>Plank</surname>
<given-names>M.</given-names>
</name>
<name><surname>Lynch</surname>
<given-names>G.</given-names>
</name>
<name><surname>Halgren</surname>
<given-names>E.</given-names>
</name>
<name><surname>Poizner</surname>
<given-names>H.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Human Cortical θ during free exploration encodes space and predicts subsequent memory.</article-title>
<source><italic>J. Neurosci.</italic>
</source>
<volume>33</volume>
<fpage>15056</fpage>
–<lpage>15068</lpage>
. <pub-id pub-id-type="doi">10.1523/JNEUROSCI.0268-13.2013</pub-id>
<pub-id pub-id-type="pmid">24048836</pub-id>
</mixed-citation>
</ref>
<ref id="B63"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stefanova</surname>
<given-names>N. A.</given-names>
</name>
<name><surname>Kozhevnikova</surname>
<given-names>O. S.</given-names>
</name>
<name><surname>Vitovtov</surname>
<given-names>A. O.</given-names>
</name>
<name><surname>Maksimova</surname>
<given-names>K. Y.</given-names>
</name>
<name><surname>Logvinov</surname>
<given-names>S. V.</given-names>
</name>
<name><surname>Rudnitskaya</surname>
<given-names>E. A.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease.</article-title>
<source><italic>Cell Cycle</italic>
</source>
<volume>13</volume>
<fpage>898</fpage>
–<lpage>909</lpage>
. <pub-id pub-id-type="doi">10.4161/cc.28255</pub-id>
<pub-id pub-id-type="pmid">24552807</pub-id>
</mixed-citation>
</ref>
<ref id="B64"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stefanova</surname>
<given-names>N. A.</given-names>
</name>
<name><surname>Muraleva</surname>
<given-names>N. A.</given-names>
</name>
<name><surname>Korbolina</surname>
<given-names>E. E.</given-names>
</name>
<name><surname>Kiseleva</surname>
<given-names>E.</given-names>
</name>
<name><surname>Maksimova</surname>
<given-names>K. Y.</given-names>
</name>
<name><surname>Kolosova</surname>
<given-names>N. G.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats.</article-title>
<source><italic>Oncotarget</italic>
</source>
<volume>6</volume>
<fpage>1396</fpage>
–<lpage>1413</lpage>
. <pub-id pub-id-type="doi">10.18632/oncotarget.2751</pub-id>
<pub-id pub-id-type="pmid">25595891</pub-id>
</mixed-citation>
</ref>
<ref id="B65"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Strittmatter</surname>
<given-names>W. J.</given-names>
</name>
<name><surname>Saunders</surname>
<given-names>A. M.</given-names>
</name>
<name><surname>Schmechel</surname>
<given-names>D.</given-names>
</name>
<name><surname>Pericak-Vance</surname>
<given-names>M.</given-names>
</name>
<name><surname>Enghild</surname>
<given-names>J.</given-names>
</name>
<name><surname>Salvesen</surname>
<given-names>G. S.</given-names>
</name>
<etal></etal>
</person-group>
(<year>1993</year>
). <article-title>Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.</article-title>
<source><italic>Proc. Natl. Acad. Sci. U.S.A.</italic>
</source>
<volume>90</volume>
<fpage>1977</fpage>
–<lpage>1981</lpage>
. <pub-id pub-id-type="doi">10.1073/pnas.90.17.8098</pub-id>
<pub-id pub-id-type="pmid">8446617</pub-id>
</mixed-citation>
</ref>
<ref id="B66"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tamayev</surname>
<given-names>R.</given-names>
</name>
<name><surname>Matsuda</surname>
<given-names>S.</given-names>
</name>
<name><surname>Arancio</surname>
<given-names>O.</given-names>
</name>
<name><surname>D’Adamio</surname>
<given-names>L.</given-names>
</name>
</person-group>
(<year>2012</year>
). <article-title>β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.</article-title>
<source><italic>EMBO Mol. Med.</italic>
</source>
<volume>4</volume>
<fpage>171</fpage>
–<lpage>179</lpage>
. <pub-id pub-id-type="doi">10.1002/emmm.201100195</pub-id>
<pub-id pub-id-type="pmid">22170863</pub-id>
</mixed-citation>
</ref>
<ref id="B67"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tiitinen</surname>
<given-names>H.</given-names>
</name>
<name><surname>Sinkkonen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Reinikainen</surname>
<given-names>K.</given-names>
</name>
<name><surname>Alho</surname>
<given-names>K.</given-names>
</name>
<name><surname>Lavikainen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Näätänen</surname>
<given-names>R.</given-names>
</name>
</person-group>
(<year>1993</year>
). <article-title>Selective attention enhances the auditory 40-Hz transient response in humans.</article-title>
<source><italic>Nature</italic>
</source>
<volume>364</volume>
<fpage>59</fpage>
–<lpage>60</lpage>
. <pub-id pub-id-type="doi">10.1038/364059a0</pub-id>
<pub-id pub-id-type="pmid">8316297</pub-id>
</mixed-citation>
</ref>
<ref id="B68"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Toledano</surname>
<given-names>A.</given-names>
</name>
<name><surname>Álvarez</surname>
<given-names>M. I.</given-names>
</name>
<name><surname>López-Rodríguez</surname>
<given-names>A. B.</given-names>
</name>
<name><surname>Toledano-Díaz</surname>
<given-names>A.</given-names>
</name>
<name><surname>Fernández-Verdecia</surname>
<given-names>C. I.</given-names>
</name>
</person-group>
(<year>2014</year>
). <article-title>[Does Alzheimer’s disease exist in all primates? Alzheimer pathology in non-human primates and its pathophysiological implications (II)].</article-title>
<source><italic>Neuroligia</italic>
</source>
<volume>29</volume>
<fpage>42</fpage>
–<lpage>55</lpage>
. <pub-id pub-id-type="doi">10.1016/j.nrl.2011.05.004</pub-id>
</mixed-citation>
</ref>
<ref id="B69"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tort</surname>
<given-names>A. B. L.</given-names>
</name>
<name><surname>Komorowski</surname>
<given-names>R. W.</given-names>
</name>
<name><surname>Manns</surname>
<given-names>J. R.</given-names>
</name>
<name><surname>Kopell</surname>
<given-names>N. J.</given-names>
</name>
<name><surname>Eichenbaum</surname>
<given-names>H.</given-names>
</name>
</person-group>
(<year>2009</year>
). <article-title>Theta–gamma coupling increases during the learning of item–context associations.</article-title>
<source><italic>Proc. Natl. Acad. Sci. U.S.A.</italic>
</source>
<volume>106</volume>
<fpage>20942</fpage>
–<lpage>20947</lpage>
. <pub-id pub-id-type="doi">10.1073/pnas.0911331106</pub-id>
<pub-id pub-id-type="pmid">19934062</pub-id>
</mixed-citation>
</ref>
<ref id="B70"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tort</surname>
<given-names>A. B. L.</given-names>
</name>
<name><surname>Kramer</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Thorn</surname>
<given-names>C.</given-names>
</name>
<name><surname>Gibson</surname>
<given-names>D. J.</given-names>
</name>
<name><surname>Kubota</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Graybiel</surname>
<given-names>A. M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2008</year>
). <article-title>Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task.</article-title>
<source><italic>Proc. Natl. Acad. Sci. U.S.A.</italic>
</source>
<volume>105</volume>
<fpage>20517</fpage>
–<lpage>20522</lpage>
. <pub-id pub-id-type="doi">10.1073/pnas.0810524105</pub-id>
<pub-id pub-id-type="pmid">19074268</pub-id>
</mixed-citation>
</ref>
<ref id="B71"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Traub</surname>
<given-names>R. D.</given-names>
</name>
<name><surname>Bibbig</surname>
<given-names>A.</given-names>
</name>
<name><surname>LeBeau</surname>
<given-names>F. E. N.</given-names>
</name>
<name><surname>Cunningham</surname>
<given-names>M. O.</given-names>
</name>
<name><surname>Whittington</surname>
<given-names>M. A.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model.</article-title>
<source><italic>J. Physiol.</italic>
</source>
<volume>562</volume>
<fpage>3</fpage>
–<lpage>8</lpage>
. <pub-id pub-id-type="doi">10.1113/jphysiol.2004.074641</pub-id>
<pub-id pub-id-type="pmid">15489250</pub-id>
</mixed-citation>
</ref>
<ref id="B72"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Cauwenberghe</surname>
<given-names>C.</given-names>
</name>
<name><surname>Van Broeckhoven</surname>
<given-names>C.</given-names>
</name>
<name><surname>Sleegers</surname>
<given-names>K.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>The genetic landscape of Alzheimer disease: clinical implications and perspectives.</article-title>
<source><italic>Genet. Med.</italic>
</source>
<pub-id pub-id-type="doi">10.1038/gim.2015.117</pub-id>
<comment>[Epub ahead of print]</comment>
.</mixed-citation>
</ref>
<ref id="B73"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van der Hiele</surname>
<given-names>K.</given-names>
</name>
<name><surname>Vein</surname>
<given-names>A. A.</given-names>
</name>
<name><surname>van der Welle</surname>
<given-names>A.</given-names>
</name>
<name><surname>van der Grond</surname>
<given-names>J.</given-names>
</name>
<name><surname>Westendorp</surname>
<given-names>R. G. J.</given-names>
</name>
<name><surname>Bollen</surname>
<given-names>E. L. E. M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2007</year>
). <article-title>EEG and MRI correlates of mild cognitive impairment and Alzheimer’s disease.</article-title>
<source><italic>Neurobiol. Aging</italic>
</source>
<volume>28</volume>
<fpage>1322</fpage>
–<lpage>1329</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2006.06.006</pub-id>
<pub-id pub-id-type="pmid">16854500</pub-id>
</mixed-citation>
</ref>
<ref id="B74"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Verret</surname>
<given-names>L.</given-names>
</name>
<name><surname>Krezymon</surname>
<given-names>A.</given-names>
</name>
<name><surname>Halley</surname>
<given-names>H.</given-names>
</name>
<name><surname>Trouche</surname>
<given-names>S.</given-names>
</name>
<name><surname>Zerwas</surname>
<given-names>M.</given-names>
</name>
<name><surname>Lazouret</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2013</year>
). <article-title>Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice.</article-title>
<source><italic>Neurobiol. Aging</italic>
</source>
<volume>34</volume>
<fpage>211</fpage>
–<lpage>225</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2012.05.013</pub-id>
<pub-id pub-id-type="pmid">22727275</pub-id>
</mixed-citation>
</ref>
<ref id="B75"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname>
<given-names>X.-J.</given-names>
</name>
</person-group>
(<year>2002</year>
). <article-title>Pacemaker neurons for the theta rhythm and their synchronization in the septohippocampal reciprocal loop.</article-title>
<source><italic>J. Neurophysiol.</italic>
</source>
<volume>87</volume>
<fpage>889</fpage>
–<lpage>900</lpage>
.<pub-id pub-id-type="pmid">11826054</pub-id>
</mixed-citation>
</ref>
<ref id="B76"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weniger</surname>
<given-names>G.</given-names>
</name>
<name><surname>Ruhleder</surname>
<given-names>M.</given-names>
</name>
<name><surname>Lange</surname>
<given-names>C.</given-names>
</name>
<name><surname>Wolf</surname>
<given-names>S.</given-names>
</name>
<name><surname>Irle</surname>
<given-names>E.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Egocentric and allocentric memory as assessed by virtual reality in individuals with amnestic mild cognitive impairment.</article-title>
<source><italic>Neuropsychologia</italic>
</source>
<volume>49</volume>
<fpage>518</fpage>
–<lpage>527</lpage>
. <pub-id pub-id-type="doi">10.1016/j.neuropsychologia.2010.12.031</pub-id>
<pub-id pub-id-type="pmid">21185847</pub-id>
</mixed-citation>
</ref>
<ref id="B77"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Willem</surname>
<given-names>M.</given-names>
</name>
<name><surname>Tahirovic</surname>
<given-names>S.</given-names>
</name>
<name><surname>Busche</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Ovsepian</surname>
<given-names>S. V.</given-names>
</name>
<name><surname>Chafai</surname>
<given-names>M.</given-names>
</name>
<name><surname>Kootar</surname>
<given-names>S.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>η-Secretase processing of APP inhibits neuronal activity in the hippocampus.</article-title>
<source><italic>Nature</italic>
</source>
<volume>526</volume>
<fpage>443</fpage>
–<lpage>447</lpage>
. <pub-id pub-id-type="doi">10.1038/nature14864</pub-id>
<pub-id pub-id-type="pmid">26322584</pub-id>
</mixed-citation>
</ref>
<ref id="B78"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Womelsdorf</surname>
<given-names>T.</given-names>
</name>
<name><surname>Schoffelen</surname>
<given-names>J.-M.</given-names>
</name>
<name><surname>Oostenveld</surname>
<given-names>R.</given-names>
</name>
<name><surname>Singer</surname>
<given-names>W.</given-names>
</name>
<name><surname>Desimone</surname>
<given-names>R.</given-names>
</name>
<name><surname>Engel</surname>
<given-names>A. K.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2007</year>
). <article-title>Modulation of neuronal interactions through neuronal synchronization.</article-title>
<source><italic>Science</italic>
</source>
<volume>316</volume>
<fpage>1609</fpage>
–<lpage>1612</lpage>
. <pub-id pub-id-type="doi">10.1126/science.1139597</pub-id>
<pub-id pub-id-type="pmid">17569862</pub-id>
</mixed-citation>
</ref>
<ref id="B79"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wulff</surname>
<given-names>P.</given-names>
</name>
<name><surname>Ponomarenko</surname>
<given-names>A. A.</given-names>
</name>
<name><surname>Bartos</surname>
<given-names>M.</given-names>
</name>
<name><surname>Korotkova</surname>
<given-names>T. M.</given-names>
</name>
<name><surname>Fuchs</surname>
<given-names>E. C.</given-names>
</name>
<name><surname>Bähner</surname>
<given-names>F.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2009</year>
). <article-title>Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons.</article-title>
<source><italic>Proc. Natl. Acad. Sci. U.S.A.</italic>
</source>
<volume>106</volume>
<fpage>3561</fpage>
–<lpage>3566</lpage>
. <pub-id pub-id-type="doi">10.1073/pnas.0813176106</pub-id>
<pub-id pub-id-type="pmid">19204281</pub-id>
</mixed-citation>
</ref>
<ref id="B80"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname>
<given-names>W.</given-names>
</name>
<name><surname>Fitzgerald</surname>
<given-names>S.</given-names>
</name>
<name><surname>Nixon</surname>
<given-names>R. A.</given-names>
</name>
<name><surname>Levy</surname>
<given-names>E.</given-names>
</name>
<name><surname>Wilson</surname>
<given-names>D. A.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer’s disease.</article-title>
<source><italic>Exp. Neurol.</italic>
</source>
<volume>264</volume>
<fpage>82</fpage>
–<lpage>91</lpage>
. <pub-id pub-id-type="doi">10.1016/j.expneurol.2014.12.008</pub-id>
</mixed-citation>
</ref>
<ref id="B81"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yeung</surname>
<given-names>S. T.</given-names>
</name>
<name><surname>Martinez-Coria</surname>
<given-names>H.</given-names>
</name>
<name><surname>Ager</surname>
<given-names>R. R.</given-names>
</name>
<name><surname>Rodriguez-Ortiz</surname>
<given-names>C. J.</given-names>
</name>
<name><surname>Baglietto-Vargas</surname>
<given-names>D.</given-names>
</name>
<name><surname>LaFerla</surname>
<given-names>F. M.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model.</article-title>
<source><italic>Brain Res. Bull.</italic>
</source>
<volume>117</volume>
<fpage>10</fpage>
–<lpage>15</lpage>
. <pub-id pub-id-type="doi">10.1016/j.brainresbull.2015.07.001</pub-id>
<pub-id pub-id-type="pmid">26162480</pub-id>
</mixed-citation>
</ref>
<ref id="B82"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yordanova</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kolev</surname>
<given-names>V.</given-names>
</name>
<name><surname>Demiralp</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>1997a</year>
). <article-title>Effects of task variables on the amplitude and phase-locking of auditory gamma band responses in human.</article-title>
<source><italic>Int. J. Neurosci.</italic>
</source>
<volume>92</volume>
<fpage>241</fpage>
–<lpage>258</lpage>
. <pub-id pub-id-type="doi">10.3109/00207459708986404</pub-id>
<pub-id pub-id-type="pmid">9522269</pub-id>
</mixed-citation>
</ref>
<ref id="B83"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yordanova</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kolev</surname>
<given-names>V.</given-names>
</name>
<name><surname>Demiralp</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>1997b</year>
). <article-title>The phase-locking of auditory gamma band responses in humans is sensitive to task processing.</article-title>
<source><italic>Neuroreport</italic>
</source>
<volume>8</volume>
<fpage>3999</fpage>
–<lpage>4004</lpage>
. <pub-id pub-id-type="doi">10.1097/00001756-199712220-00029</pub-id>
<pub-id pub-id-type="pmid">9462481</pub-id>
</mixed-citation>
</ref>
</ref-list>
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