Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping
Identifieur interne : 000106 ( Pmc/Curation ); précédent : 000105; suivant : 000107Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping
Auteurs : Zheng Wang [États-Unis] ; Grant C. Magnon [États-Unis] ; Stormi P. White [États-Unis] ; Rachel K. Greene [États-Unis] ; David E. Vaillancourt [États-Unis] ; Matthew W. Mosconi [États-Unis]Source :
- Journal of Neurophysiology [ 0022-3077 ] ; 2014.
Abstract
Sensorimotor impairments are common in autism spectrum disorder (ASD), but they are not well understood. Here we examined force control during initial pulses and the subsequent rise, sustained, and relaxation phases of precision gripping in 34 individuals with ASD and 25 healthy control subjects. Participants pressed on opposing load cells with their thumb and index finger while receiving visual feedback regarding their performance. They completed 2- and 8-s trials during which they pressed at 15%, 45%, or 85% of their maximum force. Initial pulses guided by feedforward control mechanisms, sustained force output controlled by visual feedback processes, and force relaxation rates all were examined. Control subjects favored an initial pulse strategy characterized by a rapid increase in and then relaxation of force when the target force was low (
Url:
DOI: 10.1152/jn.00661.2014
PubMed: 25552638
PubMed Central: 4416549
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000106
Links to Exploration step
PMC:4416549Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping</title>
<author><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Magnon, Grant C" sort="Magnon, Grant C" uniqKey="Magnon G" first="Grant C." last="Magnon">Grant C. Magnon</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Stormi P" sort="White, Stormi P" uniqKey="White S" first="Stormi P." last="White">Stormi P. White</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Greene, Rachel K" sort="Greene, Rachel K" uniqKey="Greene R" first="Rachel K." last="Greene">Rachel K. Greene</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3">Department of Neurology, University of Florida, Gainesville, Florida;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff4">Department of Biomedical Engineering, University of Florida, Gainesville, Florida</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mosconi, Matthew W" sort="Mosconi, Matthew W" uniqKey="Mosconi M" first="Matthew W." last="Mosconi">Matthew W. Mosconi</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff5">Departments of Psychiatry and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Departments of Psychiatry and Pediatrics, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25552638</idno>
<idno type="pmc">4416549</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416549</idno>
<idno type="RBID">PMC:4416549</idno>
<idno type="doi">10.1152/jn.00661.2014</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000106</idno>
<idno type="wicri:Area/Pmc/Curation">000106</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping</title>
<author><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Magnon, Grant C" sort="Magnon, Grant C" uniqKey="Magnon G" first="Grant C." last="Magnon">Grant C. Magnon</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="White, Stormi P" sort="White, Stormi P" uniqKey="White S" first="Stormi P." last="White">Stormi P. White</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Greene, Rachel K" sort="Greene, Rachel K" uniqKey="Greene R" first="Rachel K." last="Greene">Rachel K. Greene</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3">Department of Neurology, University of Florida, Gainesville, Florida;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff4">Department of Biomedical Engineering, University of Florida, Gainesville, Florida</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mosconi, Matthew W" sort="Mosconi, Matthew W" uniqKey="Mosconi M" first="Matthew W." last="Mosconi">Matthew W. Mosconi</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff5">Departments of Psychiatry and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Departments of Psychiatry and Pediatrics, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Neurophysiology</title>
<idno type="ISSN">0022-3077</idno>
<idno type="eISSN">1522-1598</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Sensorimotor impairments are common in autism spectrum disorder (ASD), but they are not well understood. Here we examined force control during initial pulses and the subsequent rise, sustained, and relaxation phases of precision gripping in 34 individuals with ASD and 25 healthy control subjects. Participants pressed on opposing load cells with their thumb and index finger while receiving visual feedback regarding their performance. They completed 2- and 8-s trials during which they pressed at 15%, 45%, or 85% of their maximum force. Initial pulses guided by feedforward control mechanisms, sustained force output controlled by visual feedback processes, and force relaxation rates all were examined. Control subjects favored an initial pulse strategy characterized by a rapid increase in and then relaxation of force when the target force was low (<italic>Type 1</italic>
). When the target force level or duration of trials was increased, control subjects transitioned to a strategy in which they more gradually increased their force, paused, and then increased their force again. Individuals with ASD showed a more persistent bias toward the <italic>Type 1</italic>
strategy at higher force levels and during longer trials, and their initial force output was less accurate than that of control subjects. Patients showed increased force variability compared with control subjects when attempting to sustain a constant force level. During the relaxation phase, they showed reduced rates of force decrease. These findings suggest that both feedforward and feedback motor control mechanisms are compromised in ASD and these deficits may contribute to the dyspraxia and sensorimotor abnormalities often seen in this disorder.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurophysiol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Neurophysiol</journal-id>
<journal-id journal-id-type="hwp">jn</journal-id>
<journal-id journal-id-type="pmc">jn</journal-id>
<journal-id journal-id-type="publisher-id">JN</journal-id>
<journal-title-group><journal-title>Journal of Neurophysiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-3077</issn>
<issn pub-type="epub">1522-1598</issn>
<publisher><publisher-name>American Physiological Society</publisher-name>
<publisher-loc>Bethesda, MD</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25552638</article-id>
<article-id pub-id-type="pmc">4416549</article-id>
<article-id pub-id-type="publisher-id">JN-00661-2014</article-id>
<article-id pub-id-type="doi">10.1152/jn.00661.2014</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Control of Movement</subject>
</subj-group>
</article-categories>
<title-group><article-title>Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-2265-0891</contrib-id>
<name><surname>Wang</surname>
<given-names>Zheng</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Magnon</surname>
<given-names>Grant C.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>White</surname>
<given-names>Stormi P.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Greene</surname>
<given-names>Rachel K.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vaillancourt</surname>
<given-names>David E.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Mosconi</surname>
<given-names>Matthew W.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<aff id="aff1"><sup>1</sup>
Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, Texas;</aff>
<aff id="aff2"><sup>2</sup>
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida;</aff>
<aff id="aff3"><sup>3</sup>
Department of Neurology, University of Florida, Gainesville, Florida;</aff>
<aff id="aff4"><sup>4</sup>
Department of Biomedical Engineering, University of Florida, Gainesville, Florida; and</aff>
<aff id="aff5"><sup>5</sup>
Departments of Psychiatry and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas</aff>
</contrib-group>
<author-notes><corresp id="cor1">Address for reprint requests and other correspondence: M. W. Mosconi, <addr-line>Center for Autism and Developmental Disabilities (CADD), Univ. of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9086</addr-line>
(e-mail: <email>matt.mosconi@utsouthwestern.edu</email>
).</corresp>
</author-notes>
<pub-date pub-type="epub"><day>31</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and
0 days and was based on the . </pmc-comment>
<volume>113</volume>
<issue>7</issue>
<fpage>1989</fpage>
<lpage>2001</lpage>
<history><date date-type="received"><day>4</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>26</day>
<month>12</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 the American Physiological Society</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>American Physiological Society</copyright-holder>
</permissions>
<self-uri content-type="pdf" xlink:href="z9k00715001989.pdf"></self-uri>
<abstract><p>Sensorimotor impairments are common in autism spectrum disorder (ASD), but they are not well understood. Here we examined force control during initial pulses and the subsequent rise, sustained, and relaxation phases of precision gripping in 34 individuals with ASD and 25 healthy control subjects. Participants pressed on opposing load cells with their thumb and index finger while receiving visual feedback regarding their performance. They completed 2- and 8-s trials during which they pressed at 15%, 45%, or 85% of their maximum force. Initial pulses guided by feedforward control mechanisms, sustained force output controlled by visual feedback processes, and force relaxation rates all were examined. Control subjects favored an initial pulse strategy characterized by a rapid increase in and then relaxation of force when the target force was low (<italic>Type 1</italic>
). When the target force level or duration of trials was increased, control subjects transitioned to a strategy in which they more gradually increased their force, paused, and then increased their force again. Individuals with ASD showed a more persistent bias toward the <italic>Type 1</italic>
strategy at higher force levels and during longer trials, and their initial force output was less accurate than that of control subjects. Patients showed increased force variability compared with control subjects when attempting to sustain a constant force level. During the relaxation phase, they showed reduced rates of force decrease. These findings suggest that both feedforward and feedback motor control mechanisms are compromised in ASD and these deficits may contribute to the dyspraxia and sensorimotor abnormalities often seen in this disorder.</p>
</abstract>
<kwd-group><kwd>autism spectrum disorder</kwd>
<kwd>precision grip</kwd>
<kwd>visuomotor deficit</kwd>
<kwd>feedforward motor control</kwd>
<kwd>feedback motor control</kwd>
<kwd>cerebellum</kwd>
</kwd-group>
<funding-group><award-group id="award1"><funding-source><named-content content-type="funder-id">100006545</named-content>
HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD)</funding-source>
<award-id>092696</award-id>
</award-group>
<award-group id="award2"><funding-source>Department of Defense Autism Research Program</funding-source>
<award-id>W81XWH-11-1-0738</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000106 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000106 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4416549 |texte= Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:25552638" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |