Vascularised composite allotransplants: Transplant of upper extremities and face
Identifieur interne : 000085 ( Pmc/Curation ); précédent : 000084; suivant : 000086Vascularised composite allotransplants: Transplant of upper extremities and face
Auteurs : Subramania Iyer [Inde]Source :
- Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India [ 0970-0358 ] ; 2015.
Abstract
Transplantation of solid organs and bone marrow has become a highly acceptable and often the only available clinical solution in many situations. It has been practiced across the globe for quite a long time since the first kidney transplant in 1954. Transplantation of tissues other than these, which was termed composite tissue allotransplantation and currently as vascularised composite allotransplantation (VCA) is gaining acceptance as a solution for complex reconstructive problems. This involves the transfer of multiple types of tissue such as bone, muscle, nerve, skin and blood vessels. The advantage of these over the conventional reconstructive methods is its ability to give aesthetically and functionally superior equal composite substitute to the missing or deformed part. The composite tissues transplanted commonly include the upper extremities, face and abdominal wall. Among these, hand transplants were the first to be done and have been carried out more than any other VCA. This article reviews the current scenario of VCA especially of the hand and face, in the light of experience of the two bilateral hand transplants done recently in India.
Url:
DOI: 10.4103/0970-0358.163037
PubMed: 26424972
PubMed Central: 4564491
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000085
Links to Exploration step
PMC:4564491Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vascularised composite allotransplants: Transplant of upper extremities and face</title><author><name sortKey="Iyer, Subramania" sort="Iyer, Subramania" uniqKey="Iyer S" first="Subramania" last="Iyer">Subramania Iyer</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26424972</idno><idno type="pmc">4564491</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564491</idno><idno type="RBID">PMC:4564491</idno><idno type="doi">10.4103/0970-0358.163037</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000085</idno><idno type="wicri:Area/Pmc/Curation">000085</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Vascularised composite allotransplants: Transplant of upper extremities and face</title><author><name sortKey="Iyer, Subramania" sort="Iyer, Subramania" uniqKey="Iyer S" first="Subramania" last="Iyer">Subramania Iyer</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala</wicri:regionArea></affiliation></author></analytic><series><title level="j">Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India</title><idno type="ISSN">0970-0358</idno><idno type="eISSN">1998-376X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Transplantation of solid organs and bone marrow has become a highly acceptable and often the only available clinical solution in many situations. It has been practiced across the globe for quite a long time since the first kidney transplant in 1954. Transplantation of tissues other than these, which was termed composite tissue allotransplantation and currently as vascularised composite allotransplantation (VCA) is gaining acceptance as a solution for complex reconstructive problems. This involves the transfer of multiple types of tissue such as bone, muscle, nerve, skin and blood vessels. The advantage of these over the conventional reconstructive methods is its ability to give aesthetically and functionally superior equal composite substitute to the missing or deformed part. The composite tissues transplanted commonly include the upper extremities, face and abdominal wall. Among these, hand transplants were the first to be done and have been carried out more than any other VCA. This article reviews the current scenario of VCA especially of the hand and face, in the light of experience of the two bilateral hand transplants done recently in India.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Harrison, Jh" uniqKey="Harrison J">JH Harrison</name></author><author><name sortKey="Merrill, Jp" uniqKey="Merrill J">JP Merrill</name></author><author><name sortKey="Murray, Je" uniqKey="Murray J">JE Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merrill, Jp" uniqKey="Merrill J">JP Merrill</name></author><author><name sortKey="Murray, Je" uniqKey="Murray J">JE Murray</name></author><author><name sortKey="Harrison, Jh" uniqKey="Harrison J">JH Harrison</name></author><author><name sortKey="Guild, Wr" uniqKey="Guild W">WR Guild</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peacock, Ee" uniqKey="Peacock E">EE Peacock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, R" uniqKey="Gilbert R">R Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, R" uniqKey="Gilbert R">R Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubernard, Jm" uniqKey="Dubernard J">JM Dubernard</name></author><author><name sortKey="Owen, E" uniqKey="Owen E">E Owen</name></author><author><name sortKey="Herzberg, G" uniqKey="Herzberg G">G Herzberg</name></author><author><name sortKey="Lanzetta, M" uniqKey="Lanzetta M">M Lanzetta</name></author><author><name sortKey="Martin, X" uniqKey="Martin X">X Martin</name></author><author><name sortKey="Kapila, H" uniqKey="Kapila H">H Kapila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duquesnoy, Rj" uniqKey="Duquesnoy R">RJ Duquesnoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneeberger, S" uniqKey="Schneeberger S">S Schneeberger</name></author><author><name sortKey="Gorantla, Vs" uniqKey="Gorantla V">VS Gorantla</name></author><author><name sortKey="Brandacher, G" uniqKey="Brandacher G">G Brandacher</name></author><author><name sortKey="Zeevi, A" uniqKey="Zeevi A">A Zeevi</name></author><author><name sortKey="Demetris, Aj" uniqKey="Demetris A">AJ Demetris</name></author><author><name sortKey="Lunz, Jg" uniqKey="Lunz J">JG Lunz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorantla, Vs" uniqKey="Gorantla V">VS Gorantla</name></author><author><name sortKey="Brandacher, G" uniqKey="Brandacher G">G Brandacher</name></author><author><name sortKey="Schneeberger, S" uniqKey="Schneeberger S">S Schneeberger</name></author><author><name sortKey="Zheng, Xx" uniqKey="Zheng X">XX Zheng</name></author><author><name sortKey="Donnenberg, Ad" uniqKey="Donnenberg A">AD Donnenberg</name></author><author><name sortKey="Losee, Je" uniqKey="Losee J">JE Losee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorantla, Vs" uniqKey="Gorantla V">VS Gorantla</name></author><author><name sortKey="Demetris, Aj" uniqKey="Demetris A">AJ Demetris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cendales, Lc" uniqKey="Cendales L">LC Cendales</name></author><author><name sortKey="Kanitakis, J" uniqKey="Kanitakis J">J Kanitakis</name></author><author><name sortKey="Schneeberger, S" uniqKey="Schneeberger S">S Schneeberger</name></author><author><name sortKey="Burns, C" uniqKey="Burns C">C Burns</name></author><author><name sortKey="Ruiz, P" uniqKey="Ruiz P">P Ruiz</name></author><author><name sortKey="Landin, L" uniqKey="Landin L">L Landin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petruzzo, P" uniqKey="Petruzzo P">P Petruzzo</name></author><author><name sortKey="Lanzetta, M" uniqKey="Lanzetta M">M Lanzetta</name></author><author><name sortKey="Dubernard, Jm" uniqKey="Dubernard J">JM Dubernard</name></author><author><name sortKey="Landin, L" uniqKey="Landin L">L Landin</name></author><author><name sortKey="Cavadas, P" uniqKey="Cavadas P">P Cavadas</name></author><author><name sortKey="Margreiter, R" uniqKey="Margreiter R">R Margreiter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Bd" uniqKey="Murphy B">BD Murphy</name></author><author><name sortKey="Zuker, Rm" uniqKey="Zuker R">RM Zuker</name></author><author><name sortKey="Borschel, Gh" uniqKey="Borschel G">GH Borschel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Jw" uniqKey="Jones J">JW Jones</name></author><author><name sortKey="Gruber, Sa" uniqKey="Gruber S">SA Gruber</name></author><author><name sortKey="Barker, Jh" uniqKey="Barker J">JH Barker</name></author><author><name sortKey="Breidenbach, Wc" uniqKey="Breidenbach W">WC Breidenbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken, Ta" uniqKey="Kuiken T">TA Kuiken</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author><author><name sortKey="Lock, Ba" uniqKey="Lock B">BA Lock</name></author><author><name sortKey="Lipschutz, Rd" uniqKey="Lipschutz R">RD Lipschutz</name></author><author><name sortKey="Miller, La" uniqKey="Miller L">LA Miller</name></author><author><name sortKey="Stubblefield, Ka" uniqKey="Stubblefield K">KA Stubblefield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harvey, Zt" uniqKey="Harvey Z">ZT Harvey</name></author><author><name sortKey="Loomis, Ga" uniqKey="Loomis G">GA Loomis</name></author><author><name sortKey="Mitsch, S" uniqKey="Mitsch S">S Mitsch</name></author><author><name sortKey="Murphy, Ic" uniqKey="Murphy I">IC Murphy</name></author><author><name sortKey="Griffin, Sc" uniqKey="Griffin S">SC Griffin</name></author><author><name sortKey="Potter, Bk" uniqKey="Potter B">BK Potter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, Tw" uniqKey="Wright T">TW Wright</name></author><author><name sortKey="Hagen, Ad" uniqKey="Hagen A">AD Hagen</name></author><author><name sortKey="Wood, Mb" uniqKey="Wood M">MB Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcfarland, Lv" uniqKey="Mcfarland L">LV McFarland</name></author><author><name sortKey="Hubbard Winkler, Sl" uniqKey="Hubbard Winkler S">SL Hubbard Winkler</name></author><author><name sortKey="Heinemann, Aw" uniqKey="Heinemann A">AW Heinemann</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name></author><author><name sortKey="Esquenazi, A" uniqKey="Esquenazi A">A Esquenazi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tintle, Sm" uniqKey="Tintle S">SM Tintle</name></author><author><name sortKey="Potter, Bk" uniqKey="Potter B">BK Potter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashvetiya, T" uniqKey="Ashvetiya T">T Ashvetiya</name></author><author><name sortKey="Mundinger, Gs" uniqKey="Mundinger G">GS Mundinger</name></author><author><name sortKey="Kukuruga, D" uniqKey="Kukuruga D">D Kukuruga</name></author><author><name sortKey="Bojovic, B" uniqKey="Bojovic B">B Bojovic</name></author><author><name sortKey="Christy, Mr" uniqKey="Christy M">MR Christy</name></author><author><name sortKey="Dorafshar, Ah" uniqKey="Dorafshar A">AH Dorafshar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paramesh, As" uniqKey="Paramesh A">AS Paramesh</name></author><author><name sortKey="Sullivan, K" uniqKey="Sullivan K">K Sullivan</name></author><author><name sortKey="Heneghan, J" uniqKey="Heneghan J">J Heneghan</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Ranum, K" uniqKey="Ranum K">K Ranum</name></author><author><name sortKey="Haydel, T" uniqKey="Haydel T">T Haydel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brandacher, G" uniqKey="Brandacher G">G Brandacher</name></author><author><name sortKey="Ninkovic, M" uniqKey="Ninkovic M">M Ninkovic</name></author><author><name sortKey="Piza Katzer, H" uniqKey="Piza Katzer H">H Piza-Katzer</name></author><author><name sortKey="Gabl, M" uniqKey="Gabl M">M Gabl</name></author><author><name sortKey="Hussl, H" uniqKey="Hussl H">H Hussl</name></author><author><name sortKey="Rieger, M" uniqKey="Rieger M">M Rieger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hautz, T" uniqKey="Hautz T">T Hautz</name></author><author><name sortKey="Brandacher, G" uniqKey="Brandacher G">G Brandacher</name></author><author><name sortKey="Zelger, B" uniqKey="Zelger B">B Zelger</name></author><author><name sortKey="Gorantla, Vs" uniqKey="Gorantla V">VS Gorantla</name></author><author><name sortKey="Lee, Aw" uniqKey="Lee A">AW Lee</name></author><author><name sortKey="Pratschke, J" uniqKey="Pratschke J">J Pratschke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petruzzo, P" uniqKey="Petruzzo P">P Petruzzo</name></author><author><name sortKey="Dubernard, Jm" uniqKey="Dubernard J">JM Dubernard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shores, Jt" uniqKey="Shores J">JT Shores</name></author><author><name sortKey="Brandacher, G" uniqKey="Brandacher G">G Brandacher</name></author><author><name sortKey="Lee, Wp" uniqKey="Lee W">WP Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubernard, Jm" uniqKey="Dubernard J">JM Dubernard</name></author><author><name sortKey="Lengele, B" uniqKey="Lengele B">B Lengelé</name></author><author><name sortKey="Morelon, E" uniqKey="Morelon E">E Morelon</name></author><author><name sortKey="Testelin, S" uniqKey="Testelin S">S Testelin</name></author><author><name sortKey="Badet, L" uniqKey="Badet L">L Badet</name></author><author><name sortKey="Moure, C" uniqKey="Moure C">C Moure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barret, Jp" uniqKey="Barret J">JP Barret</name></author><author><name sortKey="Gavalda, J" uniqKey="Gavalda J">J Gavaldà</name></author><author><name sortKey="Bueno, J" uniqKey="Bueno J">J Bueno</name></author><author><name sortKey="Nuvials, X" uniqKey="Nuvials X">X Nuvials</name></author><author><name sortKey="Pont, T" uniqKey="Pont T">T Pont</name></author><author><name sortKey="Masnou, N" uniqKey="Masnou N">N Masnou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smeets, R" uniqKey="Smeets R">R Smeets</name></author><author><name sortKey="Rendenbach, C" uniqKey="Rendenbach C">C Rendenbach</name></author><author><name sortKey="Birkelbach, M" uniqKey="Birkelbach M">M Birkelbach</name></author><author><name sortKey="Al Dam, A" uniqKey="Al Dam A">A Al-Dam</name></author><author><name sortKey="Grobe, A" uniqKey="Grobe A">A Gröbe</name></author><author><name sortKey="Hanken, H" uniqKey="Hanken H">H Hanken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, S" uniqKey="Fischer S">S Fischer</name></author><author><name sortKey="Kueckelhaus, M" uniqKey="Kueckelhaus M">M Kueckelhaus</name></author><author><name sortKey="Pauzenberger, R" uniqKey="Pauzenberger R">R Pauzenberger</name></author><author><name sortKey="Bueno, Em" uniqKey="Bueno E">EM Bueno</name></author><author><name sortKey="Pomahac, B" uniqKey="Pomahac B">B Pomahac</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="other"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Plast Surg</journal-id><journal-id journal-id-type="iso-abbrev">Indian J Plast Surg</journal-id><journal-id journal-id-type="publisher-id">IJPS</journal-id><journal-title-group><journal-title>Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India</journal-title></journal-title-group><issn pub-type="ppub">0970-0358</issn><issn pub-type="epub">1998-376X</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26424972</article-id><article-id pub-id-type="pmc">4564491</article-id><article-id pub-id-type="publisher-id">IJPS-48-111</article-id><article-id pub-id-type="doi">10.4103/0970-0358.163037</article-id><article-categories><subj-group subj-group-type="heading"><subject>Prof. Mira Sen (Banerji) CME Article</subject></subj-group></article-categories><title-group><article-title>Vascularised composite allotransplants: Transplant of upper extremities and face</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Iyer</surname><given-names>Subramania</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1">Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Subramania Iyer, Amrita Institute of Medical Sciences, Kochi, Kerala, India. E-mail: <email xlink:href="subu.amrita@gmail.com">subu.amrita@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>May-Aug</season><year>2015</year></pub-date><volume>48</volume><issue>2</issue><fpage>111</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright: © Indian Journal of Plastic Surgery</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Transplantation of solid organs and bone marrow has become a highly acceptable and often the only available clinical solution in many situations. It has been practiced across the globe for quite a long time since the first kidney transplant in 1954. Transplantation of tissues other than these, which was termed composite tissue allotransplantation and currently as vascularised composite allotransplantation (VCA) is gaining acceptance as a solution for complex reconstructive problems. This involves the transfer of multiple types of tissue such as bone, muscle, nerve, skin and blood vessels. The advantage of these over the conventional reconstructive methods is its ability to give aesthetically and functionally superior equal composite substitute to the missing or deformed part. The composite tissues transplanted commonly include the upper extremities, face and abdominal wall. Among these, hand transplants were the first to be done and have been carried out more than any other VCA. This article reviews the current scenario of VCA especially of the hand and face, in the light of experience of the two bilateral hand transplants done recently in India.</p></abstract><kwd-group><title>KEY WORDS</title><kwd>Face transplant</kwd><kwd>hand transplant</kwd><kwd>vascularised composite allotransplantation</kwd></kwd-group></article-meta></front><body><sec id="sec1-1"><title>HISTORICAL PERSPECTIVES</title><p>The first successful organ transplant was performed at Boston in 1954 by a team led by a Plastic Surgeon Joseph E. Murray along with John P. Merrill and J. Hartwell Harrison. This was carried out on identical twins and hence did not need immunosuppression.[<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref2" ref-type="bibr">2</xref>] The use of homologous flexor tendon mechanisms in humans after animal experiments by Peacock was the first successful ‘composite tissue allograft’.[<xref rid="ref3" ref-type="bibr">3</xref>] The first hand transplant in which immunosuppression was used, was performed by Gilbert in Ecuador in 1963. Unfortunately, the hand survived only for 3 weeks due to the inadequate immunosuppression. The immunosuppressants used were azathioprine and prednisone.[<xref rid="ref4" ref-type="bibr">4</xref><xref rid="ref5" ref-type="bibr">5</xref>] The discovery of cyclosporine in 1976 gave a boost to organ transplantation, as an effective immunosuppression being available. In 1998, the first successful hand transplant in the modern immunosuppressant era was performed in Lyon, France.[<xref rid="ref6" ref-type="bibr">6</xref>] Since then, over 150 vascularised composite allotransplantation (VCA) procedures have been performed worldwide including more than 80 upper limbs and 24 partial/complete faces. There have been reports of abdominal wall, tongue, larynx, penis, bone and joint transplants and recently that of combined skull and scalp. The experience with hand and face transplantation has been encouraging with long-term success reported in most of the cases.</p></sec><sec id="sec1-2"><title>BASIC IMMUNOLOGIC CONSIDERATIONS IN COMPOSITE TISSUE ALLOTRANSPLANTATION</title><sec id="sec2-1"><title>Rejection of allotransplants</title><p>Recognition and rejection of the allogeneic tissue by the recipient's immune system (alloimmune response) remains the main barrier to successful transplantation. ABO (blood group) antigens and the human leucocyte antigens (HLA) initiate these immune responses. HLAs are cell surface glycoproteins encoded by the major histocompatibility complex located on chromosome 6. HLA class 1 antigens (HLA-A, HLA-B and HLA-C) are expressed on all nucleated cells. HLA class 2 antigens (HLA-DR, HLA-DP and HLA-DQ) are expressed on antigen presenting cells (APCs) such as B lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells and activated T cells. HLA and ABO antigens determine the compatibility of transplants.</p><p>APCs present the ‘non-self’ antigens to the recipient T-cells and activate them. T-cell response is central to the pathogenesis of transplant rejection. T-cell activation can occur directly (donor APC's migrate to host lymphoid tissue and activate recipient T-cells) or indirectly (recipient APCs process donor antigens and present them to T-cells). The indirect pathway is of greater significance in the pathogenesis of graft rejection.</p><p>Unlike a solid organ transplant, heterogeneous tissues in composite tissue allotransplantation express different amounts of MHC antigens and hence elicit a stronger degree of host immune response. In general, skin and bone marrow are rejected earlier and more aggressively than muscle, cartilage, tendon, nerve or bone.[<xref rid="ref7" ref-type="bibr">7</xref>]</p><p>After the transplantation the immunologically active cells could be of donor or recipient origin which recognises the non-self-antigens. The immune reaction following this could result in the host versus graft reaction (commoner) or the graft versus host reaction which is rather uncommon in VCA. The resultant immune responses lead to mainly two types of rejection in the acute and the chronic rejections. These rejections can be either cellular mediated or antibody mediated.</p></sec><sec id="sec2-2"><title>Immunosuppression protocols</title><p>Immunosuppression protocols are not standard in the various VCA programme across the world. These protocols are similar to that used in solid organs and rely on the two-phase induction and maintenance regime. The induction phase aims at depleting the T-cell and B-cell population, as well as to suppress, the antibody responses at the time of transplantation, when the immune load is at the maximum. The maintenance phase is to prevent the acute and chronic rejections throughout the lifespan of the transplant. The induction regimes mostly depend on using polyclonal anti thymoglobulin (ATG) or monoclonal agents such as Basilixumab and Alemtuzumab. Steroids play an important role in the induction, maintenance, as well as addressing the rejection episodes; the maintenance regime deploys steroids along with tacrolimus (calcineurin inhibitors) and mycophenolate mofetil (MMF) (antimetabolite). The pattern of steroid use is variable in different regimes, with an effort by many to reduce the amount or totally wean them of in the long term. Sirolimus has been used by some to wean the patients from tacrolimus with the aim to reduce the renal toxicity associated with the latter. The recent research looks at the possibility of inducing tolerance to reduce the amount of immunosuppression needed. Notable in this, is the Pittsburgh protocol in which infusion of donor vertebral bone marrow was used allowing a tacrolimus monotherapy for maintenance.[<xref rid="ref8" ref-type="bibr">8</xref><xref rid="ref9" ref-type="bibr">9</xref>]</p><p>Monitoring for rejections and managing them is important to have a successful outcome of allotransplantation. In fact, the majority of the hand transplants that have failed, may have had some non compliance in the long-term maintenance of the immunosuppression protocol. The advantages of VCA over solid organ transplants are the skin acts as a visible marker for detecting the rejections. Of the tissues included in the VCA the skin evokes the most antigenic response. The rejections could be cell-mediated or antibody-mediated. The cell-mediated rejections are common in the early phase and are dominated by lymphocytic infiltration and the skin is the target organ. The skin changes are characterised by erythema and vesiculation of the skin. The skin biopsy shows an initially perivascular infiltration by lymphocytes with rejection at its extreme showing epidermolysis. The antibody-mediated rejection is characterised by microvascular injury and tissue destruction. They are detected by immunohistochemical methods. In general, the cell-mediated rejections are treated by increasing the immunosuppressant doses, bolus doses of methyl prednisolone or ATG. The cell-mediated rejections could be in addition reversed by agents like rituximab.</p><p>Chronic rejection occurs due to a long-term immunologic rejection response to the tissues. In solid organs, lot of factors have been implicated as the reason for chronic rejection. These include repeated acute rejection episodes, higher antibody levels of the recipient, prolonged cold ischaemia and non-compliance to immunosuppression. This has not been extrapolated to VCA due to the smaller number and the lower follow-up period in the VCA. In hand transplant, the deep major vessels can also be the target of the pathologic changes, which was cited as the cause for chronic rejection in one case.[<xref rid="ref10" ref-type="bibr">10</xref>]</p></sec><sec id="sec2-3"><title>Monitoring rejection</title><p>The rejection episodes are monitored by skin biopsy from the transplanted area. These are done on a protocol basis at frequent intervals initially and also when there is clinical suspicion of rejection. These biopsies, in fact help to detect rejections sufficiently early and allow their successful management in the skin containing VCA. During the time of transplant, some centres transplant a free flap like radial forearm into a less conspicuous area which serves as the biopsy site. This becomes important in face transplants, to avoid repeated scarring of the facial skin for the biopsy.</p><p>The histologic features of the skin biopsy have been codified by consensus meetings culminating in the BANNF grading for rejection.[<xref rid="ref11" ref-type="bibr">11</xref>] The histological findings are graded as follows:</p><p><list list-type="bullet"><list-item><p>Grade 0: None — Rare inflammatory infiltrates.</p></list-item><list-item><p>Grade 1: Mild — Mild perivascular lymphocytic and eosinophilic infiltrates. No involvement of overlying epidermis.</p></list-item><list-item><p>Grade 2: Moderate — Moderate to severe perivascular inflammation with or without mild epidermal and/or adnexal involvement.</p></list-item><list-item><p>Grade 3: Severe — Dense inflammation and epidermal involvement with epithelial apoptosis dyskeratosis and/or keratinolysis.</p></list-item><list-item><p>Grade 4: Necrotising acute rejection — Necrosis of single keratinocytes and focal dermal-epidermal separation.</p></list-item></list></p></sec></sec><sec id="sec1-3"><title>ISSUES WITH IMMUNOSUPPRESSION</title><p>The main criticism against VCA has been issues associated with immunosuppression. Although solid organ transplants are lifesaving, the VCA are non-vital and are done to enhance the quality of life, except in the transplant of abdominal wall along with intestinal transplants where closure of abdominal wall is not possible. The common complications of immunosuppression are opportunistic infections and systemic complications. Infections include cytomegalovirus, clostridium difficile enteritis, herpes simplex, cutaneous mycosis and osteomyelitis. The metabolic complications include hyperglycaemia, diabetes, hyperlipidaemia, hyperparathyroidism, Cushing syndrome, osteonecrosis and impaired renal function.[<xref rid="ref12" ref-type="bibr">12</xref>] The quantity of skin and tissue being transplanted might have an influence in the complications associated with transplantation. Attempts to transplant two upper extremities and a lower extremity in a single operation resulted in the removal of the lower extremity in the early post-operative period. Moreover, there was a death reported 3 days after an attempted quadruple limb transplant.[<xref rid="ref13" ref-type="bibr">13</xref>]</p><p>Most transplant programmes incorporate prophylactic antimicrobial therapy and surveillance for metabolic disorders and malignancies. Malignancies though reported in renal transplant patients are uncommon in VCA. One case of lymphoproliferative disorder in a lower limb transplant and skin cancer in another have been so far reported. Prophylactic antimicrobial therapy is a part of the drug regime and this includes valgancyclovir 900 mg/day for 6 months against cytomegalovirus and co-trimoxazole 400 mg/day for 6 months against <italic>Pneumocystis carinii</italic>.</p></sec><sec id="sec1-4"><title>HAND TRANSPLANTS</title><p>The first-hand transplant of the modern immunosuppressive era was carried out in Lyon in 1999[<xref rid="ref6" ref-type="bibr">6</xref>] and the second one in Louisville in 1999.[<xref rid="ref14" ref-type="bibr">14</xref>] The first transplant was a unilateral transplant on a patient whose compliance for the post-operative immunosuppression, and rehabilitation regime was poor. This resulted in its amputation after few years on request. The second-hand transplant patient till date has been successful, making the patient the longest surviving transplant of a VCA. The patient has been rehabilitated into normal activities and life. Since then more than 90 transplants have been done worldwide, including the 72 listed in the international hand transplant registry. The level of transplant has been in the majority, at the forearm/wrist level. The number of upper arm transplants has been less.</p></sec><sec id="sec1-5"><title>ETHICAL ISSUES</title><p>The use of a treatment modality with known life-shortening complications while other safer rehabilitation methods are available has been one of the ethical issues debated in hand transplantation. The alternatives for rehabilitation include conventional reconstructive surgery or prosthetic limbs. Whereas the former plays a limited role, advances in prosthetic limbs have been tremendous. These include better neural-control interfaces, devices having terminals with multiple-degrees-of-freedom and haptic feedback mechanisms.[<xref rid="ref15" ref-type="bibr">15</xref><xref rid="ref16" ref-type="bibr">16</xref>] However, the acceptability of these prosthesis is still not high. The users of these prosthesis complain about its weight, absence of tactile feedback, and the cumbersome nature of wearing it for a long time.[<xref rid="ref17" ref-type="bibr">17</xref><xref rid="ref18" ref-type="bibr">18</xref>] After the successful transplant in our centre, we have had several patients coming to us enquiring about the feasibility of hand transplants. Among them are a few already using the myoelectric prosthesis. The common reason put forward by them for being dissatisfied with the use of prosthesis was the inability to use for day to day activities specially the activities needing close contact with water. Hence, considering the risk to benefit ratio, it might be justifiable for a bilateral amputee to be offered a bilateral hand transplant as a rehabilitative measure. In fact, several centres list hand transplant as the standard of care for bilateral amputees. In cases of unilateral amputee this may not be true. At our centre, when we started the programme we had considered several factors before we decided to whom to offer hand transplants. These factors included lack of available information on the effect of immunosuppression in VCA in the Indian population, our inexperience and concern about the lack adequate social support for lifelong immunosuppression. Hence, we decided to embark on hand transplant only in bilateral amputees, till further evidence for the superiority of benefit over risk emerged for implementing it in unilateral amputees. Preliminary social and psychological assessment in bilateral amputees prior to listing for transplantation revealed a profound effect of the amputation in their day to day living.</p></sec><sec id="sec1-6"><title>DONOR AND RECIPIENT SELECTION</title><p>Recipients for hand transplants should be carefully screened and selected. The indications are not yet well defined, but include bilateral and unilateral amputations. The level of amputation if in the wrist and forearm has been generally preferred, but arm transplantations have been done with a successful outcome. The American Society for Reconstructive Transplantation (ASRT) has put forwards guidelines[<xref rid="ref19" ref-type="bibr">19</xref>] in the selection of patients fit for consideration of the upper extremity transplants. The group which is to be excluded is:</p><p><list list-type="alpha-lower"><list-item><p>Unilateral amputee with no functional, social or financial impairment</p></list-item><list-item><p>Congenital deformities-currently no clear evidence is available about the neural plasticity which may allow return of functions</p></list-item><list-item><p>Paediatric amputees — the available information does not justify the risk benefit in the paediatric population for the prolonged immunosuppression along with the ethical conflicts in proceeding with it with parental consent alone.</p></list-item></list></p><p>The final outcome of hand transplantation depends a lot on patient factors. Apart from the compliance to lifelong immunosuppression with its associated medical and financial implications, a serious commitment to the hand therapy regime is essential. Even in solid organ transplants compliance to medications is a problem, in spite of the fact, that the successful outcome is essentially lifesaving. Hence repeated detailed psychosocial counselling and preparation is essential before a candidate is accepted into the programme. The social support available should be verified to the satisfaction of the transplant team. In our case, the team leaders had made several visits to the home and the community of the first recipient to assess the support and, as well as sensitise the local community.</p><p>In general, a prior period using myoelectric prosthesis has been advised before the candidate is accepted into the programme. This has been suggested by the ASRT in its guidelines.[<xref rid="ref19" ref-type="bibr">19</xref>] However, the availability and its relative high cost can be a deterrent to use this in our population. Our first transplant patient was offered the same, but declined it after trying it out.</p></sec><sec id="sec1-7"><title>DONOR SELECTION</title><p>Deceased donors for VCA are more difficult than that for solid organs. This might not be a great problem in the western population where organ donation after brain death has been in vogue for several decades. The concept of deceased person organ donation is only catching up in the Indian subcontinent and lags way behind other countries even in the donation of solid organs. The donation of externally visible organs such as face and hands is still a difficult subject to discuss with the families at the time of counselling. In our cases, discussing the functional issues faced by the probable recipients, as well as showing, the family the prosthetic limbs to be fixed after donation helped.</p><p>HLA matching and compatibility testing have been practiced differently in various centres.[<xref rid="ref20" ref-type="bibr">20</xref>] The matching has generally been similar to that adopted in kidney transplants. The common methods available are flow cytometry, virtual cross matching, complement dependent cytotoxicity and Luminex assay. The tissue for matching has been donor lymphocytes either from the peripheral blood or the lymph nodes harvested, usually from the inguinal region. Cross matching using peripheral blood carries the risk of false negatives in donors who have had multiple blood transfusions. The antigenic responses of the lymphocytes may be altered due to the prior brain death status of the donor, which may reflect on the matching.[<xref rid="ref21" ref-type="bibr">21</xref>] In spite of this, majority of the centres carrying out VCA, including ours use the peripheral blood than lymph nodes due to logistic reasons.</p></sec><sec id="sec1-8"><title>IMMUNOSUPPRESSION REGIMENS IN HAND TRANSPLANT</title><p>Both ATG or agents such as basiliximab (interleukin-2 receptor blocker) or alemtuzumab (anti-CD52 monoclonal antibody) has been used for induction. There is a tend towards using agents other than ATG by different groups. The Innsbruck report of the four cases states that they used ATG for first two cases, and alemtuzumab in the next two.[<xref rid="ref22" ref-type="bibr">22</xref>] The Louisville group initially used basiliximab for first 2 patients as induction agent but later on used alemtuzumab. The maintenance immunosuppressive regimen commonly used has been triple regime comprising of low-dose steroid with tacrolimus and MMF. However, some teams to wean off tacrolimus to limit the nephrotoxicity have used sirolimus. We depended on ATG induction along with methyl prednisolone and triple regime immunosuppression in both our cases. Topical medications such as tacrolimus and steroid creams sometimes can be utilised to treat acute cutaneous rejection, reversing or preventing rejection episodes with minimal systemic effects.[<xref rid="ref23" ref-type="bibr">23</xref>]</p></sec><sec id="sec1-9"><title>REHABILITATION</title><p>The rehabilitation protocols used vary between centres, and mostly reflect the protocols used for rehabilitation of replanted hands. In principle, they are all aimed at providing splintage for the initial days along with passive movements followed by active movements to provide tendon gliding and muscle strengthening. The patient receives physical therapy up to 3-6 h a day for 5 days a week. From the second post-operative week onwards, the patient is progressively encouraged to engage in activities of daily living. Electrical stimulation of the muscles is started during the 2<sup>nd</sup> month to strengthen them. The rehabilitation measures continue under supervision for at least 1-year depending on the recovery, patient compliance and reliability.</p></sec><sec id="sec1-10"><title>DOCUMENTATION AND ASSESSMENT OF RESULTS</title><p>The International Hand and Composite Tissue Transplantation (IRHCTT) were founded in 2002 with the main purpose of acting as a body to collect information from each case of vascularised composite allotransplantation. The registry allows to analyse the experience so far, and keeps updating regarding what is new happening in this field.</p><p>The IRHCTT has its own functional scoring system — Hand Transplant Scoring System (HTSS). The system has six domains that are, appearance, sensibility, movement, psychological and social acceptance, daily activities and work status and patient satisfaction. Based on the HTSS scale, the majority of patients’ demonstrated good results from the hand transplant procedure. All the 31 patients analysed at 1-year developed protective sensations, and 90% had tactile sensibility. The recovery of motor function was very good in the larger muscle groups but was variable in intrinsic muscles. However, all the patients were able to perform most daily activities in 1-year time and most of them returned to work. The Disabilities of the Arm, Shoulder and Hand (DASH) score is another common modality used by all centres for evaluating the outcome. The DASH Outcome Measure is a 30-item, self-report questionnaire, designed to measure physical function and symptoms in people with any of several musculoskeletal disorders of the upper limb. This measures the function of all major joints of the upper extremity. All the patients have reported improvement in DASH score with initial years this being more marked than later years.[<xref rid="ref24" ref-type="bibr">24</xref><xref rid="ref25" ref-type="bibr">25</xref>] As may be expected, absolute gains were more significant in patients receiving bilateral transplants than those receiving a single extremity.</p></sec><sec id="sec1-11"><title>FACE TRANSPLANT</title><p>The team led by Dubernard in Amiens, France did the first partial face allotransplantation in 2005. A full face consisting of soft tissue and bony structures, was performed by a team led by Barret <italic>et al.</italic> in Barcelona, Spain in 2010.[<xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref27" ref-type="bibr">27</xref>] To date, over 35 facial allotransplantations have been reported from France, USA, Spain and China. Unlike hand transplantation, facial transplantation has got more issues of concern to be addressed. Ethically the legal and social concerns on the identity are not clear in many countries including India. Technical difficulties also could be more than that of hand transplants, where the anatomy is simple and experience acquired with replant helped a lot. The availability of large mucosal areas which may be a target area for host rejection responses is added worry since this may be areas for microbial onslaught after mucosal aberrations.</p><p>A systematic review by Smeets <italic>et al.</italic> in 2014[<xref rid="ref28" ref-type="bibr">28</xref>] on the published reports of face transplants gives an interesting insight into the behaviour of these transplants. A total of 36 articles published till 2013 reported 27 worldwide face transplantations. Ten of the 27 cases were full face transplants, and the remainder were partial face transplants. There was no report of graft loss, hyperacute (within the first 48 h) or chronic rejection or graft-versus-host disease. However, all of the patients during their 1<sup>st</sup> year post-transplant had at least one episode of acute rejection. The main complications as in the case of hand transplants were related to immunosuppressive therapy, leading to opportunistic infections, metabolic disorders, and increased incidence of malignancy. There have been three reported cases of malignancy to date. There were three deaths in transplant recipients. The reasons were an infection due to lack of compliance with immunosuppressive therapy, multidrug-resistant infection and graft necrosis, and recurrent cancer. The review reported that functional recovery was good with, tactile sensitivity recovering in a mean of 4.1 months after surgery when nerve repair was performed, and a mean of 7.3 months otherwise. With nerve repair, temperature sensitivity recovered a mean of 4.3 months and this happened in a mean of 12.5 months if sensory nerves were not repaired. Motor recovery began a mean of 7.8 months after surgery. The first face transplant recipient was able to fully open her mouth, smile, speak, chew and swallow after 5 years of follow-up. Furthermore, in 2014, Fischer <italic>et al.</italic> in 2014[<xref rid="ref29" ref-type="bibr">29</xref>] reported the functional outcomes in five patients treated at their centre. Each patient's pre- and post-surgical functioning was compared. All five patients had compromised respiration, breathing, sensation and facial expression before surgery which showed substantial recovery after surgery. The five patients were able to breathe through their noses after the surgery and tracheostomy could be decannulated in two of them who had it prior to the surgery. Sensory recovery started by 3 months and light touch and temperature sensitivity came to some extent by 3-9 months. All patients showed recovery of facial expression, including the ability to smile, all patients were capable of oral food intake 3-29 days after surgery, and 3-12 months after surgery, all had unrestricted or nearly unrestricted eating and drinking. With two patients even reporting regaining of their lost smelling power to some extent. They reviewed the results of 24 face transplants reported so far and found that all had bettered smelling eating and sensory capabilities and all patients who required gastrostomy and 91% of patients depending on tracheostomy were decannulated.</p></sec><sec id="sec1-12"><title>FUTURE OF VASCULARISED COMPOSITE ALLOTRANSPLANTATION PROGRAMME IN INDIA</title><p>The first two hand transplants done in India were challenging tasks to undertake. Both were double hand transplants and needed a large team to make it succeed [<xref ref-type="fig" rid="F1">Figure 1</xref>]. The logistics of arranging four operation theatres with the surgical teams synchronously working, managing the patients in the immediate post-transplant period, managing the immunosuppression and its attendant problems and instituting proper rehabilitation measures was all daunting tasks. However, more than these, the logistics of preparing the centre, obtaining the statutory authorisations, counselling the patients, choosing the right recipients, and above all procuring suitable hands from deceased donors was more daunting. In spite of these, the immediate successful outcome, the excellent compliance of the recipients and the return of function as would have been expected has given a good start to the VCA programme in the country. These transplants have brought in a welcome attention to the deceased donor organ donation drive in the country. With the public attention being focussed on these transplants there has been great demand for hand transplants from different parts of the country. The functional recovery in face transplants, as discussed earlier is very good and may be a boon to a large number of patients in the country with grossly deformed and functionally compromised faces. A lot of other tissues are reported to be transplanted successfully in different parts of the world. These include abdominal wall along with intestinal transplants, penis, uterus, trachea and skull with the scalp. With such rising expectations come the added responsibilities the VCA programme faces in the country. However, for moving forwards in this lot needs to be done which includes sensitising the public and the health policy makers on various aspects of VCA programme. The programme is to be judiciously implemented elsewhere in the country in well-equipped centres maintaining high ethical standards. The legal issues related to the transplant act needs to be addressed. The recent amendments to transplant act have brought in a lot of welcome changes in the law related to deceased organ transplants. Although, the role for VCA that is, the hands and face have not been defined it which needs to be looked into. Research in the field of VCA is virtually absent in the country and needs to be taken up vigorously to look at the needs and peculiarities pertaining to our population. This will enable us to embrace the technique of VCA as a tool for reconstruction and rehabilitation. As expressed succinctly by Murphy <italic>et al.</italic>[<xref rid="ref13" ref-type="bibr">13</xref>] a balance must be achieved between the quality of life gained from VCA and the quantity and quality of life lost from the complications of the procedure and the necessary lifelong immunosuppression.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Amrita hand transplant team</p></caption><graphic xlink:href="IJPS-48-111-g001"></graphic></fig><sec id="sec2-4"><title>Financial support and sponsorship</title><p>Nil.</p></sec><sec id="sec2-5"><title>Conflicts of interest</title><p>There are no conflicts of interest.</p></sec></sec></body><back><ref-list><title>REFERENCES</title><ref id="ref1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harrison</surname><given-names>JH</given-names></name><name><surname>Merrill</surname><given-names>JP</given-names></name><name><surname>Murray</surname><given-names>JE</given-names></name></person-group><article-title>Renal homotransplantation in identical twins</article-title><source>Surg Forum</source><year>1956</year><volume>6</volume><fpage>432</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">13391513</pub-id></element-citation></ref><ref id="ref2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Merrill</surname><given-names>JP</given-names></name><name><surname>Murray</surname><given-names>JE</given-names></name><name><surname>Harrison</surname><given-names>JH</given-names></name><name><surname>Guild</surname><given-names>WR</given-names></name></person-group><article-title>Successful homotransplantation of the human kidney between identical twins</article-title><source>J Am Med Assoc</source><year>1956</year><volume>160</volume><fpage>277</fpage><lpage>82</lpage><pub-id pub-id-type="pmid">13278189</pub-id></element-citation></ref><ref id="ref3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peacock</surname><given-names>EE</given-names><suffix>Jr</suffix></name></person-group><article-title>Restoration of finger flexion with homologous composite tissue tendon grafts of the digital flexor mechanism in human beings</article-title><source>Trans Bull</source><year>1960</year><volume>7</volume><fpage>418</fpage></element-citation></ref><ref id="ref4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gilbert</surname><given-names>R</given-names></name></person-group><article-title>Transplant is successful with cadaver forearm</article-title><source>Med Trib Med News</source><year>1964</year><volume>5</volume><fpage>20</fpage></element-citation></ref><ref id="ref5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gilbert</surname><given-names>R</given-names></name></person-group><article-title>Hand transplanted from cadaver is reamputated</article-title><source>Med Trib Med News</source><year>1964</year><volume>5</volume><fpage>23</fpage></element-citation></ref><ref id="ref6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dubernard</surname><given-names>JM</given-names></name><name><surname>Owen</surname><given-names>E</given-names></name><name><surname>Herzberg</surname><given-names>G</given-names></name><name><surname>Lanzetta</surname><given-names>M</given-names></name><name><surname>Martin</surname><given-names>X</given-names></name><name><surname>Kapila</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Human hand allograft: Report on first 6 months</article-title><source>Lancet</source><year>1999</year><volume>353</volume><fpage>1315</fpage><lpage>20</lpage><pub-id pub-id-type="pmid">10218530</pub-id></element-citation></ref><ref id="ref7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Duquesnoy</surname><given-names>RJ</given-names></name></person-group><article-title>Is histocompatibility testing needed for composite tissue transplantation?</article-title><source>Transplant Proc</source><year>1998</year><volume>30</volume><fpage>2724</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">9745555</pub-id></element-citation></ref><ref id="ref8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schneeberger</surname><given-names>S</given-names></name><name><surname>Gorantla</surname><given-names>VS</given-names></name><name><surname>Brandacher</surname><given-names>G</given-names></name><name><surname>Zeevi</surname><given-names>A</given-names></name><name><surname>Demetris</surname><given-names>AJ</given-names></name><name><surname>Lunz</surname><given-names>JG</given-names></name><etal></etal></person-group><article-title>Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression</article-title><source>Ann Surg</source><year>2013</year><volume>257</volume><fpage>345</fpage><lpage>51</lpage><pub-id pub-id-type="pmid">23001085</pub-id></element-citation></ref><ref id="ref9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gorantla</surname><given-names>VS</given-names></name><name><surname>Brandacher</surname><given-names>G</given-names></name><name><surname>Schneeberger</surname><given-names>S</given-names></name><name><surname>Zheng</surname><given-names>XX</given-names></name><name><surname>Donnenberg</surname><given-names>AD</given-names></name><name><surname>Losee</surname><given-names>JE</given-names></name><etal></etal></person-group><article-title>Favoring the risk-benefit balance for upper extremity transplantation — the Pittsburgh protocol</article-title><source>Hand Clin</source><year>2011</year><volume>27</volume><fpage>511</fpage><lpage>20</lpage><comment>ix-x</comment><pub-id pub-id-type="pmid">22051391</pub-id></element-citation></ref><ref id="ref10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gorantla</surname><given-names>VS</given-names></name><name><surname>Demetris</surname><given-names>AJ</given-names></name></person-group><article-title>Acute and chronic rejection in upper extremity transplantation: What have we learned?</article-title><source>Hand Clin</source><year>2011</year><volume>27</volume><fpage>481</fpage><lpage>93</lpage><comment>ix</comment><pub-id pub-id-type="pmid">22051389</pub-id></element-citation></ref><ref id="ref11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cendales</surname><given-names>LC</given-names></name><name><surname>Kanitakis</surname><given-names>J</given-names></name><name><surname>Schneeberger</surname><given-names>S</given-names></name><name><surname>Burns</surname><given-names>C</given-names></name><name><surname>Ruiz</surname><given-names>P</given-names></name><name><surname>Landin</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>The Banff 2007 working classification of skin-containing composite tissue allograft pathology</article-title><source>Am J Transplant</source><year>2008</year><volume>8</volume><fpage>1396</fpage><lpage>400</lpage><pub-id pub-id-type="pmid">18444912</pub-id></element-citation></ref><ref id="ref12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Petruzzo</surname><given-names>P</given-names></name><name><surname>Lanzetta</surname><given-names>M</given-names></name><name><surname>Dubernard</surname><given-names>JM</given-names></name><name><surname>Landin</surname><given-names>L</given-names></name><name><surname>Cavadas</surname><given-names>P</given-names></name><name><surname>Margreiter</surname><given-names>R</given-names></name><etal></etal></person-group><article-title>The International Registry on Hand and Composite Tissue Transplantation</article-title><source>Transplantation</source><year>2010</year><volume>90</volume><fpage>1590</fpage><lpage>4</lpage><pub-id pub-id-type="pmid">21052038</pub-id></element-citation></ref><ref id="ref13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murphy</surname><given-names>BD</given-names></name><name><surname>Zuker</surname><given-names>RM</given-names></name><name><surname>Borschel</surname><given-names>GH</given-names></name></person-group><article-title>Vascularized composite allotransplantation: An update on medical and surgical progress and remaining challenges</article-title><source>J Plast Reconstr Aesthet Surg</source><year>2013</year><volume>66</volume><fpage>1449</fpage><lpage>55</lpage><pub-id pub-id-type="pmid">23867239</pub-id></element-citation></ref><ref id="ref14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jones</surname><given-names>JW</given-names></name><name><surname>Gruber</surname><given-names>SA</given-names></name><name><surname>Barker</surname><given-names>JH</given-names></name><name><surname>Breidenbach</surname><given-names>WC</given-names></name></person-group><article-title>Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team</article-title><source>N Engl J Med</source><year>2000</year><volume>343</volume><fpage>468</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">10950668</pub-id></element-citation></ref><ref id="ref15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuiken</surname><given-names>TA</given-names></name><name><surname>Li</surname><given-names>G</given-names></name><name><surname>Lock</surname><given-names>BA</given-names></name><name><surname>Lipschutz</surname><given-names>RD</given-names></name><name><surname>Miller</surname><given-names>LA</given-names></name><name><surname>Stubblefield</surname><given-names>KA</given-names></name><etal></etal></person-group><article-title>Targeted muscle reinnervation for real-time myoelectric control of multifunction artificial arms</article-title><source>JAMA</source><year>2009</year><volume>301</volume><fpage>619</fpage><lpage>28</lpage><pub-id pub-id-type="pmid">19211469</pub-id></element-citation></ref><ref id="ref16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harvey</surname><given-names>ZT</given-names></name><name><surname>Loomis</surname><given-names>GA</given-names></name><name><surname>Mitsch</surname><given-names>S</given-names></name><name><surname>Murphy</surname><given-names>IC</given-names></name><name><surname>Griffin</surname><given-names>SC</given-names></name><name><surname>Potter</surname><given-names>BK</given-names></name><etal></etal></person-group><article-title>Advanced rehabilitation techniques for the multi-limb amputee</article-title><source>J Surg Orthop Adv</source><year>2012</year><volume>21</volume><fpage>50</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">22381511</pub-id></element-citation></ref><ref id="ref17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wright</surname><given-names>TW</given-names></name><name><surname>Hagen</surname><given-names>AD</given-names></name><name><surname>Wood</surname><given-names>MB</given-names></name></person-group><article-title>Prosthetic usage in major upper extremity amputations</article-title><source>J Hand Surg Am</source><year>1995</year><volume>20</volume><fpage>619</fpage><lpage>22</lpage><pub-id pub-id-type="pmid">7594289</pub-id></element-citation></ref><ref id="ref18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>McFarland</surname><given-names>LV</given-names></name><name><surname>Hubbard Winkler</surname><given-names>SL</given-names></name><name><surname>Heinemann</surname><given-names>AW</given-names></name><name><surname>Jones</surname><given-names>M</given-names></name><name><surname>Esquenazi</surname><given-names>A</given-names></name></person-group><article-title>Unilateral upper-limb loss: Satisfaction and prosthetic-device use in veterans and servicemembers from Vietnam and OIF/OEF conflicts</article-title><source>J Rehabil Res Dev</source><year>2010</year><volume>47</volume><fpage>299</fpage><lpage>316</lpage><pub-id pub-id-type="pmid">20803400</pub-id></element-citation></ref><ref id="ref19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tintle</surname><given-names>SM</given-names></name><name><surname>Potter</surname><given-names>BK</given-names></name></person-group><article-title>Hand transplantation</article-title><source>JBJS Rev</source><year>2014</year><volume>2</volume><fpage>1</fpage><lpage>9</lpage></element-citation></ref><ref id="ref20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ashvetiya</surname><given-names>T</given-names></name><name><surname>Mundinger</surname><given-names>GS</given-names></name><name><surname>Kukuruga</surname><given-names>D</given-names></name><name><surname>Bojovic</surname><given-names>B</given-names></name><name><surname>Christy</surname><given-names>MR</given-names></name><name><surname>Dorafshar</surname><given-names>AH</given-names></name><etal></etal></person-group><article-title>Donor-recipient human leukocyte antigen matching practices in vascularized composite tissue allotransplantation: A survey of major transplantation centers</article-title><source>Plast Reconstr Surg</source><year>2014</year><volume>134</volume><fpage>121</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">25028821</pub-id></element-citation></ref><ref id="ref21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paramesh</surname><given-names>AS</given-names></name><name><surname>Sullivan</surname><given-names>K</given-names></name><name><surname>Heneghan</surname><given-names>J</given-names></name><name><surname>Zhang</surname><given-names>R</given-names></name><name><surname>Ranum</surname><given-names>K</given-names></name><name><surname>Haydel</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>A direct comparison of donor peripheral blood vs. lymph nodes as a source of crossmatching material for kidney transplantation, abstract publication</article-title><source>Am J Transplant</source><year>2012</year><volume>12</volume><fpage>337</fpage></element-citation></ref><ref id="ref22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brandacher</surname><given-names>G</given-names></name><name><surname>Ninkovic</surname><given-names>M</given-names></name><name><surname>Piza-Katzer</surname><given-names>H</given-names></name><name><surname>Gabl</surname><given-names>M</given-names></name><name><surname>Hussl</surname><given-names>H</given-names></name><name><surname>Rieger</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>The Innsbruck hand transplant program: Update at 8 years after the first transplant</article-title><source>Transplant Proc</source><year>2009</year><volume>41</volume><fpage>491</fpage><lpage>4</lpage><pub-id pub-id-type="pmid">19328910</pub-id></element-citation></ref><ref id="ref23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hautz</surname><given-names>T</given-names></name><name><surname>Brandacher</surname><given-names>G</given-names></name><name><surname>Zelger</surname><given-names>B</given-names></name><name><surname>Gorantla</surname><given-names>VS</given-names></name><name><surname>Lee</surname><given-names>AW</given-names></name><name><surname>Pratschke</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Immunologic aspects and rejection in solid organ versus reconstructive transplantation</article-title><source>Transplant Proc</source><year>2010</year><volume>42</volume><fpage>3347</fpage><lpage>53</lpage><pub-id pub-id-type="pmid">21094778</pub-id></element-citation></ref><ref id="ref24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Petruzzo</surname><given-names>P</given-names></name><name><surname>Dubernard</surname><given-names>JM</given-names></name></person-group><article-title>The International Registry on Hand and Composite Tissue allotransplantation</article-title><source>Clin Transpl</source><year>2011</year><fpage>247</fpage><lpage>53</lpage><pub-id pub-id-type="pmid">22755418</pub-id></element-citation></ref><ref id="ref25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shores</surname><given-names>JT</given-names></name><name><surname>Brandacher</surname><given-names>G</given-names></name><name><surname>Lee</surname><given-names>WP</given-names></name></person-group><article-title>Hand and upper extremity transplantation: An update of outcomes in the worldwide experience</article-title><source>Plast Reconstr Surg</source><year>2015</year><volume>135</volume><fpage>351e</fpage><lpage>60e</lpage></element-citation></ref><ref id="ref26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dubernard</surname><given-names>JM</given-names></name><name><surname>Lengelé</surname><given-names>B</given-names></name><name><surname>Morelon</surname><given-names>E</given-names></name><name><surname>Testelin</surname><given-names>S</given-names></name><name><surname>Badet</surname><given-names>L</given-names></name><name><surname>Moure</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>Outcomes 18 months after the first human partial face transplantation</article-title><source>N Engl J Med</source><year>2007</year><volume>357</volume><fpage>2451</fpage><lpage>60</lpage><pub-id pub-id-type="pmid">18077810</pub-id></element-citation></ref><ref id="ref27"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barret</surname><given-names>JP</given-names></name><name><surname>Gavaldà</surname><given-names>J</given-names></name><name><surname>Bueno</surname><given-names>J</given-names></name><name><surname>Nuvials</surname><given-names>X</given-names></name><name><surname>Pont</surname><given-names>T</given-names></name><name><surname>Masnou</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>Full face transplant: The first case report</article-title><source>Ann Surg</source><year>2011</year><volume>254</volume><fpage>252</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">21772126</pub-id></element-citation></ref><ref id="ref28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smeets</surname><given-names>R</given-names></name><name><surname>Rendenbach</surname><given-names>C</given-names></name><name><surname>Birkelbach</surname><given-names>M</given-names></name><name><surname>Al-Dam</surname><given-names>A</given-names></name><name><surname>Gröbe</surname><given-names>A</given-names></name><name><surname>Hanken</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Face transplantation: On the verge of becoming clinical routine?</article-title><source>Biomed Res Int 2014</source><year>2014</year><fpage>907272</fpage></element-citation></ref><ref id="ref29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fischer</surname><given-names>S</given-names></name><name><surname>Kueckelhaus</surname><given-names>M</given-names></name><name><surname>Pauzenberger</surname><given-names>R</given-names></name><name><surname>Bueno</surname><given-names>EM</given-names></name><name><surname>Pomahac</surname><given-names>B</given-names></name></person-group><article-title>Functional outcomes of face transplantation</article-title><source>Am J Transplant</source><year>2015</year><volume>15</volume><fpage>220</fpage><lpage>33</lpage><pub-id pub-id-type="pmid">25359281</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000085 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000085 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4564491
|texte= Vascularised composite allotransplants: Transplant of upper extremities and face
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26424972" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a HapticV1
| This area was generated with Dilib version V0.6.23. |  |